BR0010594A - nucleic acids encoding new truncated carton proteins, corresponding to truncated carton polypeptides or their use for therapeutic and diagnostic purposes - Google Patents

nucleic acids encoding new truncated carton proteins, corresponding to truncated carton polypeptides or their use for therapeutic and diagnostic purposes

Info

Publication number
BR0010594A
BR0010594A BR0010594-5A BR0010594A BR0010594A BR 0010594 A BR0010594 A BR 0010594A BR 0010594 A BR0010594 A BR 0010594A BR 0010594 A BR0010594 A BR 0010594A
Authority
BR
Brazil
Prior art keywords
truncated
cart
proteins
protein
carton
Prior art date
Application number
BR0010594-5A
Other languages
Portuguese (pt)
Inventor
Alistair Dixon
James Hamer Murray
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0010594A publication Critical patent/BR0010594A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: "áCIDOS NUCLéICOS CODIFICANDO NOVAS PROTEìNAS DE CART TRUNCADAS, CORRESPONDENDO A POLI-PEPTìDEOS DE CART TRUNCADOS OU SEU USO PARA PROPóSITOS TERAPêUTICOS E DE DIAGNóSTICOS". A presente invenção é direcionada a ácidos nucléicos codificando polipeptídos de CART truncados novos, particularmente proteínas de CART tendo 88 aminoácidos em comprimento, bem como fragmentos de ácido nucléico disso. A invenção também pertence a uma família de vetores recombinantes contendo um ácido nucléico tal polipeptídeo de CART truncado e para células de hospedeiros recombinantes tais vetores recombinantes. A invenção também lida com uma proteína de CART truncada particularmente uma proteína de CART truncada tendo pelo menos 88 aminoácidos em comprimento bem como anticorpos especialmente direcionados contra este proteína, estes anticorpos sendo úteis como reagentes diagnósticos. A invenção também refere-se ao uso de proteína de CART particularmente uma proteína de CART truncada tendo 88 aminoácidos em comprimento ou fragmentos para a identificação ou caracterização de ligandos os quais aglutinam a proteína de CART ou seu(s) receptor(es). A invenção também refere-se a ao uso de ácidos nucléicos codificando as proteínas truncadas da invenção ou as proteínas de CART truncadas por si só para propósitos terapêuticos e particularmente para diminuir ou prevenir degeneração neuronal e para promover regeneração neuronal e restauração de função, para tratar vício auxiliando liberação do polipeptídeo ou suas formas truncadas in vitro ou in vivo e também a fim de regular ingestão de alimento.Invention Patent: "NUCLEIC ACIDS CODING NEW TRUNCATED CART PROTEINS, CORRESPONDING TO TRUNCATED CART POLYPEPTIDES OR THEIR USE FOR THERAPEUTIC AND DIAGNOSTIC PURPOSES". The present invention is directed to nucleic acids encoding new truncated CART polypeptides, particularly CART proteins having 88 amino acids in length, as well as fragments of nucleic acid thereof. The invention also belongs to a family of recombinant vectors containing a nucleic acid such a truncated CART polypeptide and for cells of recombinant hosts such recombinant vectors. The invention also deals with a truncated CART protein, particularly a truncated CART protein having at least 88 amino acids in length as well as antibodies specially directed against this protein, these antibodies being useful as diagnostic reagents. The invention also relates to the use of CART protein particularly a truncated CART protein having 88 amino acids in length or fragments for the identification or characterization of ligands which agglutinate the CART protein or its receptor (s). The invention also relates to the use of nucleic acids encoding the truncated proteins of the invention or the CART proteins truncated by themselves for therapeutic purposes and particularly to decrease or prevent neuronal degeneration and to promote neuronal regeneration and function restoration, to treat addiction assisting release of the polypeptide or its truncated forms in vitro or in vivo and also in order to regulate food intake.

BR0010594-5A 1999-04-15 2000-04-14 nucleic acids encoding new truncated carton proteins, corresponding to truncated carton polypeptides or their use for therapeutic and diagnostic purposes BR0010594A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12947999P 1999-04-15 1999-04-15
PCT/GB2000/001445 WO2000063370A2 (en) 1999-04-15 2000-04-14 Nucleic acids coding for novel truncated cart proteins, corresponding truncated cart polypeptides and their use for therapeutic and diagnostic purposes

Publications (1)

Publication Number Publication Date
BR0010594A true BR0010594A (en) 2002-02-19

Family

ID=22440165

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010594-5A BR0010594A (en) 1999-04-15 2000-04-14 nucleic acids encoding new truncated carton proteins, corresponding to truncated carton polypeptides or their use for therapeutic and diagnostic purposes

Country Status (7)

Country Link
EP (1) EP1169451A2 (en)
JP (1) JP2002541842A (en)
AU (1) AU4580600A (en)
BR (1) BR0010594A (en)
CA (1) CA2373359A1 (en)
MX (1) MXPA01010483A (en)
WO (1) WO2000063370A2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798258A (en) * 1995-05-04 1998-08-25 Oregon Health Sciences University Cart protein and DNA encoding therefor
AU5630896A (en) * 1995-05-04 1996-11-21 Amgen, Inc. Methods of preventing neuron degeneration and promoting neur on regeneration
WO1998048824A1 (en) * 1997-05-01 1998-11-05 Emory University Bioactive peptides derived from cocaine and amphetamine regulated transcript protein

Also Published As

Publication number Publication date
MXPA01010483A (en) 2002-09-18
CA2373359A1 (en) 2000-10-26
WO2000063370A2 (en) 2000-10-26
EP1169451A2 (en) 2002-01-09
AU4580600A (en) 2000-11-02
WO2000063370A3 (en) 2001-09-13
JP2002541842A (en) 2002-12-10

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired