WO2000060062A3 - Human signal transduction serine/threonine protein kinase - Google Patents

Human signal transduction serine/threonine protein kinase Download PDF

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Publication number
WO2000060062A3
WO2000060062A3 PCT/GB2000/001183 GB0001183W WO0060062A3 WO 2000060062 A3 WO2000060062 A3 WO 2000060062A3 GB 0001183 W GB0001183 W GB 0001183W WO 0060062 A3 WO0060062 A3 WO 0060062A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
signal transduction
threonine protein
well
human signal
Prior art date
Application number
PCT/GB2000/001183
Other languages
French (fr)
Other versions
WO2000060062A2 (en
Inventor
Tyrrell Errick Norris
William Craig Moore
David Shay Silberstein
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Priority to AU35662/00A priority Critical patent/AU3566200A/en
Publication of WO2000060062A2 publication Critical patent/WO2000060062A2/en
Publication of WO2000060062A3 publication Critical patent/WO2000060062A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

An isolated and purified human signal transduction serine threonine protein kinase is described. A cDNA sequence which encodes the native signal transduction polypeptide is disclosed as well as the structural coding region and the amino acid residue sequence of the protein kinase. Methods are provided which employ the novel sequences to identify compounds that modulate the biological and/or pharmacological activity of the signal transduction protein kinase and hence regulate cellular and tissue physiology. Biologically-effective antisense molecules, as well as dominant negative mutant versions of the protein kinase, are described which are suitable for therapeutic use. The invention is also related to the diagnosis, study, prevention, and treatment of pathophysiological disorders related to or mediated by the signal transduction molecule.
PCT/GB2000/001183 1999-04-01 2000-03-28 Human signal transduction serine/threonine protein kinase WO2000060062A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU35662/00A AU3566200A (en) 1999-04-01 2000-03-28 Human signal transduction serine/threonine protein kinase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28395699A 1999-04-01 1999-04-01
US09/283,956 1999-04-01

Publications (2)

Publication Number Publication Date
WO2000060062A2 WO2000060062A2 (en) 2000-10-12
WO2000060062A3 true WO2000060062A3 (en) 2001-01-18

Family

ID=23088302

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/001183 WO2000060062A2 (en) 1999-04-01 2000-03-28 Human signal transduction serine/threonine protein kinase

Country Status (2)

Country Link
AU (1) AU3566200A (en)
WO (1) WO2000060062A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7049118B2 (en) 2001-01-03 2006-05-23 Bayer Healthcare Ag Regulation of human serine-threonine protein kinase
WO2003033708A2 (en) * 2001-10-15 2003-04-24 Bayer Healthcare Ag Regulation of human serine/threonine protein kinase
WO2003037910A2 (en) * 2001-10-30 2003-05-08 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US7482134B2 (en) 2002-06-05 2009-01-27 Seoul National University Industry Foundation Signals and molecular species involved in senescence
RU2345089C2 (en) 2002-08-06 2009-01-27 Санофи-Авентис Дойчланд Гмбх PURIFIED 145 kDa-PROTEIN, ABLE TO BIND CHOLESTEROL AND/OR INHIBITORS OF CHOLESTEROL ABSORPTION, METHODS OF ITS OBTAINING AND PURIFICATION AND APPLICATION OF kDa-PROTEIN
US7364887B2 (en) 2003-07-18 2008-04-29 Sanofi-Aventis Deutschland Gmbh Use of PAK inhibitor for the treatment of a joint disease
EP1498133A1 (en) * 2003-07-18 2005-01-19 Aventis Pharma Deutschland GmbH Use of a pak inhibitor for the treatment of a joint disease
US7998688B2 (en) 2008-03-07 2011-08-16 OSI Pharmaceuticals, LLC Inhibition of EMT induction in tumor cells by anti-cancer agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053036A2 (en) * 1998-04-14 1999-10-21 Sugen, Inc. Ste20-related protein kinases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053036A2 (en) * 1998-04-14 1999-10-21 Sugen, Inc. Ste20-related protein kinases

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ABO A. ET AL.: "PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia", THE EMBO JOURNAL, vol. 17, no. 22, November 1998 (1998-11-01), pages 6527 - 6540, XP002147782 *
BAGRODIA S. ET AL.: "Pak to the future", TRENDS IN CELL BIOLOGY, vol. 9, no. 9, September 1999 (1999-09-01), pages 350 - 355, XP000925936 *
HILLIER L. ET AL.: "The WashU-Merck EST Project; yf64a05.s1 Soares infant brain 1NIB Homo sapiens cDNA clone IMAGE:26963 3', mRNA sequence", EMBL DATABASE ENTRY HS772102; ACCESSION NO. R37772, 4 May 1995 (1995-05-04), XP002147781 *
HILLIER L. ET AL.: "The WashU-Merck EST Project; ym92f08.r1 Soares adult brain N2b4HB55Y Homo sapiens cDNA clone IMAGE:166407 5', mRNA sequence", EMBL DATABASE ENTRY HS460188; ACCESSION NO. R88460, 24 August 1995 (1995-08-24), XP002147780 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. XV. THE COMPLETE SEQUENCES OF 100 NEW CDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, vol. 6, no. 5, 29 October 1999 (1999-10-29), pages 337 - 345, XP000865804, ISSN: 1340-2838 *
OHARA O. ET AL.: "Homo sapiens mRNA for KIAA1264 protein, partial cds.", EMBL DATABASE ENTRY AB033090; ACCESSION NO. AB033090, XP002147972 *
ROE B.A.: "Homo sapiens Chromosome 22q11.2 PAC Clone p201m18 In DGCR Region; complete sequence", EMBL DATABASE ENTRY HSAC97; ACCESSION NO. AC000097, 7 December 1996 (1996-12-07), XP002147852 *
WILLIAM S.: "Human DNA sequence from clone RP1-80N2 on chromosome 6p24.1-25.3. Contains the gene for MD-1, part of a putative novel gene, ESTs,STSs, GSSs and three putative GpG islands.", EMBL DATABASE ENTRY HS80N2; ACCESSION NO. AL031123, 24 July 1998 (1998-07-24), XP002147853 *

Also Published As

Publication number Publication date
AU3566200A (en) 2000-10-23
WO2000060062A2 (en) 2000-10-12

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