WO2000058715A3 - Système de dosage - Google Patents

Système de dosage Download PDF

Info

Publication number
WO2000058715A3
WO2000058715A3 PCT/GB2000/001050 GB0001050W WO0058715A3 WO 2000058715 A3 WO2000058715 A3 WO 2000058715A3 GB 0001050 W GB0001050 W GB 0001050W WO 0058715 A3 WO0058715 A3 WO 0058715A3
Authority
WO
WIPO (PCT)
Prior art keywords
assays
disclosed
samples
assay system
absorbence
Prior art date
Application number
PCT/GB2000/001050
Other languages
English (en)
Other versions
WO2000058715A2 (fr
Inventor
Jonathan Mark Cooper
Vincent Benoit
James Stewart Aitchison
Original Assignee
Univ Glasgow
Jonathan Mark Cooper
Vincent Benoit
James Stewart Aitchison
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Glasgow, Jonathan Mark Cooper, Vincent Benoit, James Stewart Aitchison filed Critical Univ Glasgow
Priority to JP2000608162A priority Critical patent/JP2002540423A/ja
Priority to AU34409/00A priority patent/AU3440900A/en
Priority to EP00912758A priority patent/EP1166092A2/fr
Publication of WO2000058715A2 publication Critical patent/WO2000058715A2/fr
Publication of WO2000058715A3 publication Critical patent/WO2000058715A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne un procédé et un appareil destinés à effectuer simultanément des dosages biologiques multiples. L'appareil (40) comprend une source de lumière laser (42), un réseau de diffraction (48) servant à diffracter la lumière pour obtenir des faisceaux d'excitation multiples, un support d'échantillons (50) contenant plusieurs échantillons (52) destinés au dosage et un dispositif de détection (60) servant à détecter le rayonnement émis ou transmis par les échantillons. L'application de l'invention concerne des dosages par fluorescence ou par absorbance tels que les ELISAs. L'invention concerne aussi des supports d'échantillons utilisés dans ce procédé de même que des réseaux de diffraction. Une autre modification comprend la description de l'utilisation du procédé de génération de puces ADN et similaires par procédé de photochimie.
PCT/GB2000/001050 1999-03-26 2000-03-27 Système de dosage WO2000058715A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2000608162A JP2002540423A (ja) 1999-03-26 2000-03-27 分析システム
AU34409/00A AU3440900A (en) 1999-03-26 2000-03-27 Assay system
EP00912758A EP1166092A2 (fr) 1999-03-26 2000-03-27 Syst me de dosage

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9906929.6A GB9906929D0 (en) 1999-03-26 1999-03-26 Assay system
GB9906929.6 1999-03-26

Publications (2)

Publication Number Publication Date
WO2000058715A2 WO2000058715A2 (fr) 2000-10-05
WO2000058715A3 true WO2000058715A3 (fr) 2001-03-08

Family

ID=10850367

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/001050 WO2000058715A2 (fr) 1999-03-26 2000-03-27 Système de dosage

Country Status (5)

Country Link
EP (1) EP1166092A2 (fr)
JP (1) JP2002540423A (fr)
AU (1) AU3440900A (fr)
GB (1) GB9906929D0 (fr)
WO (1) WO2000058715A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
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US9285318B2 (en) 1999-05-17 2016-03-15 Applied Biosystems, Llc Optical instrument including excitation source

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US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US7423750B2 (en) 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US7387891B2 (en) 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
EP1409721A2 (fr) * 2000-11-13 2004-04-21 Gnothis Holding SA Identification de polymorphismes d'acide nucleique
DE10126083A1 (de) * 2001-05-29 2002-12-05 Gnothis Holding Sa Ecublens Verwendung von optischen Diffraktionselementen in Nachweisverfahren
JP4834242B2 (ja) * 2001-05-30 2011-12-14 オリンパス株式会社 蛍光読み取り装置
US7223985B2 (en) 2001-08-28 2007-05-29 Rudolf Rigler Single-channel multicolored correlation analysis
US6744502B2 (en) 2001-09-28 2004-06-01 Pe Corporation (Ny) Shaped illumination geometry and intensity using a diffractive optical element
US7635588B2 (en) 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
DE10160987B4 (de) * 2001-12-05 2005-08-04 Siemens Ag Baueinheit zur simultanen, optischen Beleuchtung einer Vielzahl von Proben
DE10200499A1 (de) * 2002-01-03 2003-07-10 Zeiss Carl Jena Gmbh Verfahren und/oder Anordnung zur Identifikation von fluoreszierenden, lumineszierenden und/oder absorbierenden Substanzen auf und/oder in Probenträgern
US9157860B2 (en) 2002-05-16 2015-10-13 Applied Biosystems, Llc Achromatic lens array
US6982166B2 (en) * 2002-05-16 2006-01-03 Applera Corporation Lens assembly for biological testing
AU2003243281A1 (en) * 2002-05-17 2003-12-02 Applera Corporation Optical instrument includung excitation source
JP2005526253A (ja) 2002-05-17 2005-09-02 アプレラ コーポレイション 励起波長による複数の蛍光シグナルを分化するための装置および方法
US6750963B2 (en) * 2002-05-21 2004-06-15 Agilent Technologies, Inc. Imaging systems for signals on a surface
JP2004257737A (ja) * 2003-02-24 2004-09-16 Mitsui Eng & Shipbuild Co Ltd バイオチップ読み取り装置
US7173701B2 (en) * 2004-02-13 2007-02-06 Kaiwood Technology Co., Ltd. CCD-based biochip reader
BRPI0518876A2 (pt) * 2004-12-10 2008-12-16 Koninkl Philips Electronics Nv aparelho e mÉtodo para tratamento de uma amostra de material com luz
CZ299489B6 (cs) * 2005-01-12 2008-08-13 Ústav fotoniky a elektroniky AV CR, v. v. i. Zpusob spektroskopie povrchových plazmonu pro senzory s povrchovými plazmony a senzorový element k provádení tohoto zpusobu
WO2007010469A1 (fr) 2005-07-21 2007-01-25 Koninklijke Philips Electronics N. V. Dispositif pour detecter une excitation faisant appel a un agencement de plusieurs points lumineux
US7805081B2 (en) * 2005-08-11 2010-09-28 Pacific Biosciences Of California, Inc. Methods and systems for monitoring multiple optical signals from a single source
US7851770B2 (en) 2005-11-23 2010-12-14 Koninklijke Philips Electronics N.V. Device for optical excitation using a multiple wavelength arrangement
US20100014296A1 (en) * 2008-07-16 2010-01-21 Chuang Ping Han Light distribution board having gratings with multiple focuses
WO2010150167A1 (fr) * 2009-06-24 2010-12-29 Koninklijke Philips Electronics N.V. Biocapteur optique avec éléments optiques de mise au point
CN102865999B (zh) * 2011-07-08 2015-03-04 中国科学院微电子研究所 Led光学特性检测方法及检测装置
CN103969188A (zh) * 2013-02-01 2014-08-06 苏州英敏基生物技术有限公司 基于ccd或cmos图像传感器的酶标仪检测系统
US9863880B2 (en) * 2013-11-17 2018-01-09 Quantum-Si Incorporated Optical system and assay chip for probing, detecting and analyzing molecules
EP3137878A1 (fr) * 2014-04-30 2017-03-08 Instrumentation Laboratory Company Procédés et systèmes de tests de coagulation de lieu de soins par détection optique
US10190981B2 (en) 2014-05-08 2019-01-29 The Governing Council Of The University Of Toronto Multimode spectroscopy apparatuses and methods
CN106353320A (zh) * 2016-09-12 2017-01-25 北京纳迅科技股份有限公司 便携式生物芯片阅读仪
NL2020621B1 (en) * 2018-01-08 2019-07-15 Illumina Inc Multiplexing of an active sensor detector using structured illumination
EP4379355A1 (fr) * 2022-11-29 2024-06-05 Gnothis Holding AG Analyse à haut débit d'événements de molécule unique

Citations (13)

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Publication number Priority date Publication date Assignee Title
JPS6035205A (ja) * 1983-08-05 1985-02-23 Machida Oputo Giken:Kk 物体各部までの距離検出方法及びこれに使用する回折スポツト投影部
EP0217632A2 (fr) * 1985-09-30 1987-04-08 Molecular Devices Corporation Système de mesure photométrique multi-sites comprenant une source unique
US5053619A (en) * 1988-08-12 1991-10-01 Hitachi, Ltd. Variable density scanning apparatus
DE4030699C1 (fr) * 1990-09-28 1991-10-10 Bruker Analytische Messtechnik Gmbh, 7512 Rheinstetten, De
EP0723146A1 (fr) * 1992-09-14 1996-07-24 Sri International Rapporteurs à conversion vers le hauts destinés à des dosages biologiques et autres effectués à l'aide de techniques d'excitation au laser
WO1997034171A2 (fr) * 1996-02-28 1997-09-18 Johnson Kenneth C Scanner a microlentilles pour la microlithographie et la microscopie confocale a champ large
WO1997039151A1 (fr) * 1996-04-17 1997-10-23 Affymetrix, Inc. Procedes de synthese de matrices polymeres photolabiles
GB2315131A (en) * 1996-07-10 1998-01-21 Cambridge Imaging Ltd Fibre optic coupling plate for checking fluorescence in a sample
DE29810554U1 (de) * 1998-06-09 1998-10-29 Krauser, Peter J., 66271 Kleinblittersdorf Platte
DE19725050A1 (de) * 1997-06-13 1998-12-17 Fraunhofer Ges Forschung Anordnung zur Detektion biochemischer oder chemischer Substanzen mittels Fluoreszenzlichtanregung und Verfahren zu dessen Herstellung
DE19748211A1 (de) * 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
EP0947249A1 (fr) * 1998-03-18 1999-10-06 Corning Incorporated Plaque matrice à haute densitée
WO2000031518A1 (fr) * 1998-11-24 2000-06-02 Cambridge Research & Instrumentation, Inc. Systeme et technique de dosage a polarisation de fluorescence

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6035205A (ja) * 1983-08-05 1985-02-23 Machida Oputo Giken:Kk 物体各部までの距離検出方法及びこれに使用する回折スポツト投影部
EP0217632A2 (fr) * 1985-09-30 1987-04-08 Molecular Devices Corporation Système de mesure photométrique multi-sites comprenant une source unique
US5053619A (en) * 1988-08-12 1991-10-01 Hitachi, Ltd. Variable density scanning apparatus
DE4030699C1 (fr) * 1990-09-28 1991-10-10 Bruker Analytische Messtechnik Gmbh, 7512 Rheinstetten, De
EP0723146A1 (fr) * 1992-09-14 1996-07-24 Sri International Rapporteurs à conversion vers le hauts destinés à des dosages biologiques et autres effectués à l'aide de techniques d'excitation au laser
WO1997034171A2 (fr) * 1996-02-28 1997-09-18 Johnson Kenneth C Scanner a microlentilles pour la microlithographie et la microscopie confocale a champ large
WO1997039151A1 (fr) * 1996-04-17 1997-10-23 Affymetrix, Inc. Procedes de synthese de matrices polymeres photolabiles
GB2315131A (en) * 1996-07-10 1998-01-21 Cambridge Imaging Ltd Fibre optic coupling plate for checking fluorescence in a sample
DE19725050A1 (de) * 1997-06-13 1998-12-17 Fraunhofer Ges Forschung Anordnung zur Detektion biochemischer oder chemischer Substanzen mittels Fluoreszenzlichtanregung und Verfahren zu dessen Herstellung
DE19748211A1 (de) * 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
EP0947249A1 (fr) * 1998-03-18 1999-10-06 Corning Incorporated Plaque matrice à haute densitée
DE29810554U1 (de) * 1998-06-09 1998-10-29 Krauser, Peter J., 66271 Kleinblittersdorf Platte
WO2000031518A1 (fr) * 1998-11-24 2000-06-02 Cambridge Research & Instrumentation, Inc. Systeme et technique de dosage a polarisation de fluorescence

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Title
J.M. STONE: "Radiation and Optics", 1963, MCGRAW-HILL BOOK COMPANY INC., NEW YORK, XP002144814 *
M: BURKHARDT ET AL.: "Illuminator design for printing of regular contact patterns", MICROELECTRONIC ENGINEERING., vol. 41-42, 1998, ELSEVIER PUBLISHERS BV., AMSTERDAM., NL, pages 91 - 95, XP004111724, ISSN: 0167-9317 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9285318B2 (en) 1999-05-17 2016-03-15 Applied Biosystems, Llc Optical instrument including excitation source

Also Published As

Publication number Publication date
EP1166092A2 (fr) 2002-01-02
GB9906929D0 (en) 1999-05-19
AU3440900A (en) 2000-10-16
JP2002540423A (ja) 2002-11-26
WO2000058715A2 (fr) 2000-10-05

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