WO2000054887A1 - Appareil et procede de distribution d'un spray medicamenteux - Google Patents

Appareil et procede de distribution d'un spray medicamenteux Download PDF

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Publication number
WO2000054887A1
WO2000054887A1 PCT/US2000/006935 US0006935W WO0054887A1 WO 2000054887 A1 WO2000054887 A1 WO 2000054887A1 US 0006935 W US0006935 W US 0006935W WO 0054887 A1 WO0054887 A1 WO 0054887A1
Authority
WO
WIPO (PCT)
Prior art keywords
swirl
chamber
spray
pin
actuator
Prior art date
Application number
PCT/US2000/006935
Other languages
English (en)
Inventor
Robert Schultz
Original Assignee
Emsar, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emsar, Inc. filed Critical Emsar, Inc.
Priority to AU37517/00A priority Critical patent/AU3751700A/en
Publication of WO2000054887A1 publication Critical patent/WO2000054887A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
    • B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
    • B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
    • B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
    • B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
    • B05B1/3436—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a plane perpendicular to the outlet axis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details

Definitions

  • the present invention relates to an apparatus and method for dispensing a medicinal spray. More specifically, the invention is directed to a nasal spray actuator that includes a swirl pin that provides for both ease of assembly and manufacture of the actuator and, additionally, safety for a user when using the actuator.
  • Nasal spray actuators are known for dispensing medication from a container to the nostrils of a user.
  • Currently known actuators are available that atomize the liquid that is dispensed from the container so that a fine mist is provided to the user.
  • drawbacks exist with the currently known nasal actuators.
  • One type of known actuator includes a disposable nozzle adaptor that is attached to a nozzle which extends from the container which stores the medication to be dispensed.
  • the nozzle adaptor includes a body, a rod arranged in a cylindrical chamber defined by the body, and a spray nozzle tip which is fitted in the top of the chamber and snap-fitted onto the rod.
  • the spray nozzle tip includes swirl grooves which impart a swirling motion to the liquid as it is dispensed from the nozzle adaptor.
  • a drawback with this known type of actuator is that the rod is inserted into the adaptor body at the distal end of the adaptor body, i.e., that end of the adaptor body that is inserted into the nostril of the user. After the rod is inserted into the adaptor body, the spray nozzle tip is then fitted into the adaptor body and onto the rod.
  • the spray nozzle tip and rod may be ejected from the adaptor body and into the nostril of the user. Serious injury to the user could result.
  • a nasal actuator that could reduce the risk of injury to the user from its use.
  • Other types of actuators are known which reduce the risk of injury to the user, however, these actuators have drawbacks as well.
  • These actuators reduce the risk of injury to the user by incorporating a design where the rod is inserted into the body of the actuator from the proximal end of the adaptor body, i.e., that end which is not inserted into the nostril of the user.
  • the distal end of the adaptor body is formed as a single structural unit with an orifice formed in it for dispensing the medication from the container to the nostril of the user. Because the orifice has a diameter that is less than the diameter of the rod, the rod cannot be ejected through the orifice and thus, the risk of injury to the user can be significantly reduced.
  • a rod 110 As illustrated in Figures 1 and 2, with this second type of actuator 100, which is used with the Vicks Sinex product, a rod 110, or pin, includes radially extending structure 115 on a proximal end 112 of rod 110 to "break-up" the liquid so that it may travel along the chamber 120 of actuator 100.
  • the proximal end 112 of rod 110 is positioned at the proximal end 122 of chamber 120 and engages with a shoulder 124 formed in actuator 100 to assist in longitudinally positioning rod 110 within chamber 120.
  • the structure of actuator 100 that defines orifice 102 defines a swirl chamber 104, as can be seen in Figure 3.
  • the swirl chamber 104 imparts a swirling motion to the dispensed liquid.
  • a drawback with the above-described design is that, because two separately configured structures are required in the actuator to dispense the liquid, i.e., the "break-up' structure on the pin and the swirl chamber in the distal end of the actuator, complexity is added to the manufacturing process for the actuator. Additionally, because the pin must be inserted into the actuator in a particular orientation, i.e., so that the "break-up" structure is positioned at the proximal end of the actuator's chamber, complexity is added to the assembly process for the actuator. Positioning of the pin within the chamber can also be a problem.
  • the apparatus may include a body which defines a longitudinal chamber and an integrally formed spray orifice The spray orifice is disposed at a distal end of the body and is in communication with the chamber
  • a swirl member having a first end and a second end is disposed within the chamber The first end includes a first swirl structure and the second end includes a second swirl structure
  • the method may include dispensing a pressurized spray volume from a pump stem of a container into a plurality of pathways, the spray volume entering the plurality of pathways by traveling over a first swirl structure where the first swirl structure is included on a first end of a swirl member
  • the swirl member is disposed within a chamber in the spray actuator
  • a circular motion is imparted to the spray volume by directing the spray volume into a second swirl structure where the second swirl structure is included on a second end of the swirl member
  • the spray volume is then expelled from the spray orifice Brief Description of the Drawings
  • Fig 1 is a cross -sectional view of a prior art nasal spray actuator
  • Fig 2 is a perspective view of the pin of the actuator of Fig 1
  • Fig 3 is a cross-sectional view of the swirl chamber of the actuator of Fig 1 as taken along line 3-3 of Fig 1,
  • Fig 4 is a cross-sectional view of a nasal spray actuator in accordance with the present invention
  • Fig 5 is a cross-sectional view of the nasal spray actuator as taken along line 5-5 of Fig 4
  • Fig 6 is a side view of the swirl member of Fig 4,
  • Fig 7 is a left end view of the swirl member of Fig 4 illustrating the first swirl structure
  • Fig 8 is a right end view of the swirl member of Fig 4 illustrating the second swirl structure
  • Fig 9 is an enlarged end view of the swirl structure of Fig 7, and Fig 10 is a cross-sectional view of the nasal spray actuator as taken along line 10-10 of Fig 4
  • nasal spray actuator 200 includes an external body portion 210 and an internal body portion 216 Body portion 210 defines an orifice 230 at a distal end 212 of body portion 210 Internal body portion 216 defines chamber 220 Chamber 220 extends longitudinally within nasal spray actuator 200 and receives within it an elongated member, or swirl pin, 250 A spray volume that is dispensed from nasal spray actuator 200 travels from pump stem 240 (shown in phantom in Fig 4) through chamber 220, where it is expelled through orifice 230 and into, for example, the nostril of a user of the actuator
  • nasal spray actuator 200 also includes three outer ribs, of which ribs 211 A and 21 IB can be seen in Fig 4 The outer ribs extend longitudinally internal from external body portion 210 to internal body portion 216 Ribs 211 A, 21 IB are rigid members and serve to maintain the internal body
  • orifice 230 is integrally formed in body portion 210 Additionally, it can be seen that the body portion that defines orifice 230 has a smooth interior surface, I e , there are no swirl paths included in the body portion Thus, the swirl paths of the present invention are included on a swirl pin 250 that is disposed within chamber 220 and are not included on the body portion of the actuator
  • swirl pin 250 is centrally disposed within chamber 220 along its entire length and engages with the head 242 of pump stem 240 at its first end 254 and with the structure at distal end 212 of body portion 210 that defines orifice 230 at its second end 256 Since the cross-sectional diameter of swirl pin 250 is less than the diameter of chamber 220, the structures of the swirl pin 250 and internal body portion 216 define pathways within chamber 220 which extend along the longitudinal length of chamber 220 The spray volume that is dispensed from pump stem 240 travels through the pathways that are defined within chamber 220 In one embodiment of the present invention, three pathways are defined within chamber 220, of which, pathway 222 and pathway 224 are visible in Fig 4
  • swirl pin 250 includes a mid-portion 252 and, as discussed previously, a first end 254 and a second end 256
  • First end 254 of swirl pin 250 defines a first swirl structure, or chamber, 260 and second end 256 of swirl pin 250 defines a second swirl structure, or chamber, 270
  • Each of the first and second swirl chambers 260, 270, respectively, are similarly formed
  • first end 254 or second end 256 may be disposed at the distal end 212 of body 210 and, consequently, the other of the ends may be disposed at the proximal end 214 of body 210.
  • the present invention provides for ease of assembly of nasal spray actuator 200 since either end of swirl pin 250 may be positioned within either end of body 210 and no assembly step is required which orients an end of the swirl pin 250.
  • the designation in this specification of one end of swirl pin 250 being the "first end” and the other end being the “second end” is provided for reference purposes only. It does not imply that the described position for each end of the swirl pin within the actuator is the only position in which each particular end can be positioned.
  • swirl pin 250 is inserted into chamber 220 from the proximal end 214 of the actuator body. After swirl pin 250 is inserted within chamber 220, nasal spray actuator 200 is installed onto pump stem 240. Thus, swirl pin 250 is positioned between head 242 of pump stem 240 and the distal end 212 of body portion 210. Because swirl pin 250 is supported along the major portion of its length by ribs which extend from internal body portion 216 into chamber 220, as will be further explained, and engages with the pump stem 240 at its first end 254 and with distal end 212 of body portion 210 at its second end 256, no shoulders are required within nasal spray actuator 200 in order to longitudinally position swirl pin 250 within chamber 220.
  • swirl pin 250 is inserted into nasal spray actuator 200 from the proximal end 214 of body portion 210. Since orifice 230 is integrally formed within body portion 210, i.e., it is not an insert that is fitted into distal end 212 of body portion 210, and since orifice 230 has a significantly smaller diameter than the diameter of swirl pin 250, swirl pin 250 is constrained against being ejected out of the distal end 212 of nasal spray actuator 200. Thus, because swirl pin 250 cannot be ejected from distal end 212, which is the end of the nasal spray actuator that is inserted into the nostril of a user, the nasal spray actuator of the present invention significantly reduces the possibility of injury to a user of the actuator. Figs.
  • swirl pin 250 includes a mid-portion 252 and first and second end portions 254, 256, respectively.
  • First end portion 254 defines first swirl structure 260 and second end portion 256 defines second swirl structure 270.
  • it has an overall length I ⁇ of 1.025 inches and a diameter D, of 0.0910 inches.
  • the present invention is not limited to these dimensions for swirl pin 250.
  • swirl pin 250 may have a length of between 0.50 and 1.50 inches.
  • each swirl structure 260, 270 includes channels that are cut a depth L 2 of 0.0150 inches into swirl pin 250.
  • swirl structure 260 defines a plurality of swirl paths.
  • three swirl paths 262, 264, and 266 are provided.
  • each of the swirl paths are defined by a channel that is cut into first end 254 of swirl pin 250.
  • each swirl path has a depth of 0.015 inches and generally extends radially from the center of the swirl structure.
  • the depth of the swirl paths will vary in different embodiments depending upon the particular type of spray product that is to be dispensed from the spray actuator. Depths of between, for example, 0.0050-0.0200 inches may be utilized for the swirl paths.
  • the swirl paths are formed such that, as the spray volume travels through the swirl structure that is disposed at the distal end 212 of body portion 210, a circular or swirling motion will be imparted to the spray volume as it is expelled from orifice 230.
  • second swirl structure 270 is formed similar to first swirl structure 260.
  • swirl structure 270 includes three swirl paths 272, 274, and 276.
  • the present invention is not limited to any particular number of swirl paths, however, it is desirable that at least three swirl paths are provided in each swirl structure, for purposes which will be discussed later in this specification. Fig.
  • FIG. 9 illustrates additional dimensional detail for the embodiment of swirl structure 260
  • the present invention is not limited to the precise dimensions disclosed, it is desirable to include relatively small channels within the swirl structures and small pathways so that an excess amount of product, i e , an amount greater than what is medically required, is not dispensed from the actuator
  • channels 262, 264, and 266 are included in swirl structure 260
  • structures 267, 268, and 269 define channels 262, 264, and 266
  • the structures which define the channels As discussed previously, the diameter D, of swirl structure 260 is 0 0910 inches
  • a first edge 267A of structure 267 is positioned a distance S, of 0 010 inches from a central axis 261 which extends through the geometric center of swirl structure 260 and parallel to edge 267
  • a Second edge 267B of structure 267 is positioned a distance S 2 of 0 0330 inches from the outermost circumferential edge
  • Fig 10 is a cross-sectional view of the proximal end of the nasal spray actuator
  • the assembled configuration of swirl pin 250 within chamber 220 can be clearly seen
  • swirl pin 250 is centrally disposed within chamber 220 and is supported along a majority of its length by ribs 216A, 216B, and 216C, which extend from internal body portion 216 and into chamber 220
  • the ribs may be of such a length that they support the swirl pin along approximately 60-80% of its length from the distal end of the swirl pin
  • the ribs are only required to be long enough to adequately support swirl pin 250 such that the swirl pin is centrally disposed within chamber 220
  • Each rib is thinly formed in cross-section and may include a tapered end which engages with swirl pin 250
  • the ribs is thinly formed in cross-section and may include a tapered end which engages with swirl pin 250
  • the combined structures of internal body portion 216 and the outer circumference of swirl pin 250 define pathways between the two structures within chamber 220.
  • the pathways are defined by that volume of chamber 220 that is not occupied by swirl pin 250.
  • three equally spaced ribs 216A, 216B, and 216C extend from internal body portion 216 and engage with swirl pin 250, three separate pathways 222, 224, and 226 are formed within chamber 220.
  • the number of pathways that are defined within chamber 220 must correlate to the number of ribs that extend from internal body portion 216 in order to equalize the flow of spray through the pathways.
  • each pathway has a radial width of approximately 0.005 to 0.010 inches.
  • each pathway extends along the longitudinal length of chamber 220, along swirl pin 250, to the distal end 212 of actuator 200.
  • the spray volume that is to be dispensed from actuator 200 exits head 242 of pump stem 240 and travels through first swirl structure 260 and into the three pathways .
  • the spray volume travels through the pathways, is directed into second swirl structure 270 at the distal end 212 of body portion 210, and is ultimately expelled out of orifice 230.
  • first swirl structure 260 As can be seen in Fig. 10 in the illustrated embodiment, and as discussed previously, three ribs are provided and three swirl paths are included within first swirl structure 260. This is desirable in order to provide for directing a substantially equivalent volume of spray into each pathway. For example, if three ribs, and thus three pathways, were provided within nasal spray actuator 200 and only one swirl path was provided in first swirl structure 260, this configuration could result in no volume of spray being provided to two of the pathways. Should this occur, a less than optimal spray pattern could be expelled from the nasal spray actuator. Thus, whereas the present invention is not limited to any particular number of pathways and swirl paths, it is desirable that the number of pathways, and thus the number of ribs, correlate to the number of swirl paths that are included within first swirl structure 260.
  • swirl pin 250 is inserted into chamber 220 of nasal spray actuator 200 from the proximal end 214 of body portion 210. Again, either end of swirl pin 250 may be positioned at either end of chamber 220 since the swirl structures at each end of swirl pin 250 are similarly formed. Swirl pin 250 is centrally disposed within chamber 220 by ribs 216A, 216B, and 216C, which extend within chamber 220 from internal body portion 216. Swirl pin 250 is supported along a majority of its length by the ribs. The assembled nasal spray actuator 200 is then positioned onto head 242 of pump stem 240.
  • first end 254 of swirl pin 250 engages with head 242 of pump stem 240 and second end 256 of swirl pin 250 engages with the structure at distal end 212 of body portion 210 which defines orifice 230.
  • swirl pin 250 engages with both the pump stem and the structure which defines orifice 230.
  • no shoulders are required within nasal spray actuator 200 for longitudinally positioning swirl pin 250 within chamber 220.
  • a pressurized spray volume is dispensed from pump stem 240 and travels through first swirl structure 260 where it is distributed, substantially equally, into the three pathways that are defined within chamber 220. Because of the relative sizes of the pump stem orifice and the diameter of chamber 220 at the proximal end 214 of body 210, i.e., that portion of chamber 220 that has first swirl structure 260 disposed in it, as the pressurized spray volume passes through first swirl structure 260, no swirling motion is imparted to the pressurized spray volume as it is apportioned into the pathways.
  • the spray volume is traveling from the smaller orifice in the pump stem into the larger volume of the chamber 220 and the pathways, which does not result in an increase in the velocity of the spray volume, and thus no swirling of the spray volume as it passes through the first swirl structure, as occurs when the spray volume passes through the second swirl structure at the distal end of the actuator. More particularly, when the spray volume passes through the first swirl structure, the spray travels from a position inside the swirl structure to a location outside of the swirl structure through the swirl paths. This is a path of travel which is opposite the path of travel of the spray volume as it passes through the second swirl structure where the spray travels from a position outside the swirl structure where it then passes through the swirl paths and out of the orifice 230.
  • the path of travel for the spray volume through the first swirl structure is opposite that of the path of travel through the second swirl structure.
  • the "swirl structure” does not act as a structure that imparts a swirling motion to the spray volume. Rather, the swirl structure assists in making the spray volume that is dispensed from the pump stem more uniform where it is then equally distributed into the three pathways.
  • a swirl structure can be provided at the proximal end of the nasal spray actuator chamber without deleteriously impacting the flow of the spray volume. Consequently, swirl structures may be provided at both ends of the swirl pin, which advantageously allows a user to insert the swirl pin into the actuator without being concerned about which end of the swirl pin is disposed in which end of the actuator.
  • the actuator may be more easily assembled.
  • the spray volume is traveling from a larger diameter orifice, i.e., the pathways in chamber 220, into the smaller orifices of the swirl paths in the second swirl structure 270, the spray volume is accelerated and swirled as it travels through the swirl paths of second swirl structure 270. A swirling motion is imparted to the spray volume as it passes through the swirl paths of second swirl structure 270. The spray volume is then expelled from orifice 230 of nasal spray actuator 200.
  • the present invention provides a nasal spray actuator that includes a swirl pin with swirl structures at each end of the swirl pin. Since each of the swirl structures are similarly formed, it is not necessary to longitudinally orient the ends of the swirl pin before inserting the swirl pin into the actuator's chamber. Because of the relative sizes of the orifice of the pump stem and the chamber of the nasal spray actuator, the swirl structure positioned adjacent to the pump stem does not function to impart a swirling motion to the spray volume that is expelled from the pump stem. Rather, the swirl structure serves to assist in directing the spray volume into the plurality of pathways within the nasal spray actuator. Thus, because the swirl pin of the present invention has swirl structures at each of its ends, it provides for ease of assembly of the actuator. Additionally, because the swirl pin is constrained against being ejected from the distal end of the nasal spray actuator, the present invention provides for safety for the user of the nasal spray actuator.

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  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Devices For Medical Bathing And Washing (AREA)

Abstract

L'invention concerne un appareil et un procédé de distribution d'un spray médicamenteux. L'appareil peut comporter un corps (210) qui définit une chambre longitudinale (220) et un orifice de spray formant une partie intégrante. L'orifice de spray est placé à une extrémité distale (212) du corps (210) et est en communication avec la chambre (220). Un élément torsadé (250) comportant une première extrémité (254) et une seconde extrémité (256) est placé dans la chambre (220). La première extrémité (254) comporte une première structure torsadée (260) et la seconde extrémité (256) comporte une seconde structure torsadée (270).
PCT/US2000/006935 1999-03-17 2000-03-17 Appareil et procede de distribution d'un spray medicamenteux WO2000054887A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37517/00A AU3751700A (en) 1999-03-17 2000-03-17 Apparatus and method for dispensing a medicinal spray

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27128199A 1999-03-17 1999-03-17
US09/271,281 1999-03-17

Publications (1)

Publication Number Publication Date
WO2000054887A1 true WO2000054887A1 (fr) 2000-09-21

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ID=23034918

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006935 WO2000054887A1 (fr) 1999-03-17 2000-03-17 Appareil et procede de distribution d'un spray medicamenteux

Country Status (3)

Country Link
AU (1) AU3751700A (fr)
CO (1) CO5241299A1 (fr)
WO (1) WO2000054887A1 (fr)

Cited By (17)

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WO2005018812A2 (fr) 2003-08-08 2005-03-03 Valois Sas Tete de pulverisation de produit fluide
FR2904573A1 (fr) * 2006-08-04 2008-02-08 Rexam Dispensing Systems Sas Buse de pulverisation, organe de distribution comprenant une telle buse, distributeur comprenant un tel organe de distribution et utilisation d'une telle buse.
EP1916033A1 (fr) * 2005-07-06 2008-04-30 Mitani Valve Co., Ltd. Mécanisme d évacuation de contenu, produit de type aérosol et produit de type pompe dotés de ce mécanisme
US8757146B2 (en) 2008-02-07 2014-06-24 University Of Washington Through Its Center For Commercialization Circumferential aerosol device
US9550036B2 (en) 2011-03-03 2017-01-24 Impel Neuropharma Inc. Nasal drug delivery device
US9821126B2 (en) 2014-02-21 2017-11-21 Neogen Corporation Fluid atomizer, nozzle assembly and methods for assembling and utilizing the same
US9919117B2 (en) 2011-05-09 2018-03-20 Impel Neuropharma Inc. Nozzles for nasal drug delivery
US10537692B2 (en) 2013-04-28 2020-01-21 Impel Neuropharma, Inc. Medical unit dose container
EP2837426B1 (fr) * 2013-08-15 2020-06-24 Delavan Inc. Double chambre de tourbillonnement
US11185497B2 (en) 2018-01-05 2021-11-30 Impel Neuropharma, Inc. Intranasal delivery of dihydroergotamine by precision olfactory device
US11266799B2 (en) 2015-09-10 2022-03-08 Impel Neuropharma, Inc. In-line nasal delivery device
US11278492B2 (en) 2018-01-05 2022-03-22 Impel Neuropharma, Inc. Intranasal delivery of olanzapine by precision olfactory device
US11395887B2 (en) 2017-11-21 2022-07-26 Impel Pharmaceuticals Inc. Intranasal device with inlet interface
US11517548B2 (en) 2018-07-19 2022-12-06 Impel Pharmaceuticals Inc. Respiratory tract delivery of levodopa and DOPA decarboxylase inhibitor for treatment of Parkinson's Disease
US11571532B2 (en) 2017-11-21 2023-02-07 Impel Pharmaceuticals Inc. Intranasal device with dip tube
US11759585B2 (en) 2019-01-03 2023-09-19 Impel Pharmaceuticals Inc. Nasal drug delivery device with detachable nozzle
US11878109B2 (en) 2019-05-17 2024-01-23 Impel Pharmaceuticals Inc. Single-use nasal delivery device

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GB320567A (en) * 1928-12-14 1929-10-17 Gustav Schlick Improvements in or relating to nozzles
US1837339A (en) * 1928-04-23 1931-12-22 Schlick Gustav Atomizing nozzle
US3504893A (en) * 1966-08-20 1970-04-07 Lion Fat Oil Co Ltd Spray nozzle assembly
EP0412524A1 (fr) * 1989-08-11 1991-02-13 Toko Yakuhin Kogyo Kabushiki Kaisha Adaptateur de buse jetable pour conteneurs pulvérisants intranasaux
EP0499690A1 (fr) * 1991-02-21 1992-08-26 ELETTRO PLASTICA S.p.A. Dispensateur nasal pour atomiser des produits pharmaceutiques

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1837339A (en) * 1928-04-23 1931-12-22 Schlick Gustav Atomizing nozzle
GB320567A (en) * 1928-12-14 1929-10-17 Gustav Schlick Improvements in or relating to nozzles
US3504893A (en) * 1966-08-20 1970-04-07 Lion Fat Oil Co Ltd Spray nozzle assembly
EP0412524A1 (fr) * 1989-08-11 1991-02-13 Toko Yakuhin Kogyo Kabushiki Kaisha Adaptateur de buse jetable pour conteneurs pulvérisants intranasaux
EP0499690A1 (fr) * 1991-02-21 1992-08-26 ELETTRO PLASTICA S.p.A. Dispensateur nasal pour atomiser des produits pharmaceutiques

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018812A2 (fr) 2003-08-08 2005-03-03 Valois Sas Tete de pulverisation de produit fluide
EP1677916B1 (fr) * 2003-08-08 2012-04-11 Valois SAS Tete de pulverisation de produit fluide
EP1916033A1 (fr) * 2005-07-06 2008-04-30 Mitani Valve Co., Ltd. Mécanisme d évacuation de contenu, produit de type aérosol et produit de type pompe dotés de ce mécanisme
JPWO2007004314A1 (ja) * 2005-07-06 2009-01-22 株式会社三谷バルブ 内容物放出機構ならびにこれを備えたエアゾール式製品およびポンプ式製品
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JP4867036B2 (ja) * 2005-07-06 2012-02-01 株式会社三谷バルブ 内容物放出機構ならびにこれを備えたエアゾール式製品およびポンプ式製品
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