WO2000053738A3 - Methods and compositions for regulating memory consolidation - Google Patents

Methods and compositions for regulating memory consolidation Download PDF

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Publication number
WO2000053738A3
WO2000053738A3 PCT/US2000/006526 US0006526W WO0053738A3 WO 2000053738 A3 WO2000053738 A3 WO 2000053738A3 US 0006526 W US0006526 W US 0006526W WO 0053738 A3 WO0053738 A3 WO 0053738A3
Authority
WO
WIPO (PCT)
Prior art keywords
memory consolidation
methods
compositions
mammal
consolidation
Prior art date
Application number
PCT/US2000/006526
Other languages
French (fr)
Other versions
WO2000053738A8 (en
WO2000053738A2 (en
Inventor
Cristina M Alberini
Mark F Bear
Leon N Cooper
Stephen M Taubenfeld
Kjesten A Wiig
Original Assignee
Univ Brown Res Found
Cristina M Alberini
Mark F Bear
Leon N Cooper
Stephen M Taubenfeld
Kjesten A Wiig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brown Res Found, Cristina M Alberini, Mark F Bear, Leon N Cooper, Stephen M Taubenfeld, Kjesten A Wiig filed Critical Univ Brown Res Found
Priority to IL14528900A priority Critical patent/IL145289A0/en
Priority to EP00913904A priority patent/EP1161525A2/en
Priority to AU35264/00A priority patent/AU3526400A/en
Priority to CA002366429A priority patent/CA2366429A1/en
Priority to JP2000603360A priority patent/JP2002541440A/en
Publication of WO2000053738A2 publication Critical patent/WO2000053738A2/en
Publication of WO2000053738A3 publication Critical patent/WO2000053738A3/en
Publication of WO2000053738A8 publication Critical patent/WO2000053738A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides methods for identifying genes involved in memory consolidation, and for identifying agents which effect memory consolidation in a mammal. These methods preferably use (1) non-human mammals which have been manipulated to create at least partial disruption of fornix-mediated afferant signalling to the hippocampus, said disruption affecting memory consolidation or (2) non-lesioned mammals which have been subjected to a learning and memory test to provide a learned behavior in the mammal.
PCT/US2000/006526 1999-03-12 2000-03-13 Methods and compositions for regulating memory consolidation WO2000053738A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IL14528900A IL145289A0 (en) 1999-03-12 2000-03-13 Method and compositions for regulating memory consolidation
EP00913904A EP1161525A2 (en) 1999-03-12 2000-03-13 Methods and compositions for regulating memory consolidation
AU35264/00A AU3526400A (en) 1999-03-12 2000-03-13 Methods and compositions for regulating memory consolidation
CA002366429A CA2366429A1 (en) 1999-03-12 2000-03-13 Methods and compositions for regulating memory consolidation
JP2000603360A JP2002541440A (en) 1999-03-12 2000-03-13 Methods and compositions for regulating memory consolidation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12430199P 1999-03-12 1999-03-12
US60/124,301 1999-03-12

Publications (3)

Publication Number Publication Date
WO2000053738A2 WO2000053738A2 (en) 2000-09-14
WO2000053738A3 true WO2000053738A3 (en) 2001-01-11
WO2000053738A8 WO2000053738A8 (en) 2001-04-05

Family

ID=22414034

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006526 WO2000053738A2 (en) 1999-03-12 2000-03-13 Methods and compositions for regulating memory consolidation

Country Status (6)

Country Link
EP (1) EP1161525A2 (en)
JP (1) JP2002541440A (en)
AU (1) AU3526400A (en)
CA (1) CA2366429A1 (en)
IL (1) IL145289A0 (en)
WO (1) WO2000053738A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2173369A2 (en) * 2003-08-08 2010-04-14 DSM IP Assets B.V. Novel method for screening brain-active compounds
KR20110049801A (en) * 2008-07-18 2011-05-12 다트 뉴로사이언시즈, 엘엘씨 Methods and systems for evaluating memory agents
JP6448922B2 (en) * 2014-06-09 2019-01-09 国立研究開発法人産業技術総合研究所 Encapsulated stroke model animal using non-human primate and method for producing the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2228263A (en) * 1989-02-17 1990-08-22 Tanabe Seiyaku Co Test animal and method of preparation; conjugate for use in said preparation and method of testing the pharmaceutic effect of a compound using said test animal

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2228263A (en) * 1989-02-17 1990-08-22 Tanabe Seiyaku Co Test animal and method of preparation; conjugate for use in said preparation and method of testing the pharmaceutic effect of a compound using said test animal

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALBERINI CM.: "Genes to remember.", J EXP BIOL., vol. 202, no. pt 21, November 1999 (1999-11-01), pages 2887 - 2891, XP000923350 *
DE CASTRO J. & HALL T.W.: "Fornix lesions : effects on active and passive avoidance behavior", PHYSIOLOGICAL PSYCHOLOGY, vol. 3, no. 3, 1975, pages 201 - 204, XP000934333 *
GUZOWSKI, J.F. & MCGAUGH, J.L.: "Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 94, March 1997 (1997-03-01), NATIONAL ACADEMY OF SCIENCE. WASHINGTON., US, pages 2693 - 2698, XP000934313, ISSN: 0027-8424 *
SILVA AJ, KOGAN JH, FRANKLAND PW, KIDA S.: "CREB and memory.", ANNU REV NEUROSCI., vol. 21, 1998, pages 127 - 148, XP000900517 *
SNELL R.S.: "Clinical neuroanatomy for medical students", 1980, LITTLE, BROWN AND COMPANY, BOSTON, XP002145578 *
TAUBENFELD SM, WIIG KA, BEAR MF, ALBERINI CM.: "A molecular correlate of memory and amnesia in the hippocampus.", NAT NEUROSCI., vol. 2, no. 4, April 1999 (1999-04-01), pages 309 - 310, XP000900406 *

Also Published As

Publication number Publication date
JP2002541440A (en) 2002-12-03
WO2000053738A8 (en) 2001-04-05
WO2000053738A2 (en) 2000-09-14
CA2366429A1 (en) 2000-09-14
EP1161525A2 (en) 2001-12-12
AU3526400A (en) 2000-09-28
IL145289A0 (en) 2002-06-30

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