WO2000053244A1 - Seringue a deux compartiments - Google Patents

Seringue a deux compartiments Download PDF

Info

Publication number
WO2000053244A1
WO2000053244A1 PCT/GB2000/000169 GB0000169W WO0053244A1 WO 2000053244 A1 WO2000053244 A1 WO 2000053244A1 GB 0000169 W GB0000169 W GB 0000169W WO 0053244 A1 WO0053244 A1 WO 0053244A1
Authority
WO
WIPO (PCT)
Prior art keywords
plunger
syringe
barrel
seal
chamber
Prior art date
Application number
PCT/GB2000/000169
Other languages
English (en)
Inventor
Christopher John Clarke
John Targell
Alastair Douglas Wright
Original Assignee
Nmt Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nmt Group Plc filed Critical Nmt Group Plc
Priority to AU30660/00A priority Critical patent/AU3066000A/en
Publication of WO2000053244A1 publication Critical patent/WO2000053244A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing

Definitions

  • a syringe comprising a barrel having a forward end adapted to be fitted with a needle assembly, a plunger slidable within the barrel and having a plunger seal at its forward end, an annular chamber defined between the plunger and a wall surrounding the plunger, and means for establishing communication between the interior of the barrel and the annular chamber around the outer periphery of the plunger seal when the plunger is retracted.
  • the slots may extend through the barrel end giving the portion a castellated form. There may be a top seal between the rear end of the chamber and the plunger.
  • retraction of the plunger is effective to create a reduced pressure zone in the forward section of the barrel to assist transfer of one of the components to be admixed from the annular chamber to the barrel section forwardly of the plunger seal.
  • the pressure responsive one-way valve may for instance comprise a generally U-shaped seal arranged with the mouth of the seal open towards the forward direction of plunger travel and with the radially outer limb of the U-shaped seal bearing slidably against the inner wall surface of the barrel.
  • the syringe comprises a barrel 10 having a forward end 11 adapted to be fitted with a needle assembly (not shown) and preferably one such as that described in our European Patent No. 0 776 225 (the disclosure of which is incorporated herein by this reference) providing for automatic retraction of the needle into the body of the syringe at completion of administration of the injection.
  • the syringe further comprises a hollow plunger 12 which has a seal 13 at its forward end and is slidable axially within the barrel 10 between a forward position as shown in Figure 1 and a retracted position as shown in Figures 2 and 3.
  • the fully retracted position may be defined by a stop (not shown).
  • annular chamber 14 of enlarged cross-sectional area is defined between the plunger 12 and a cylindrical wall 15 surrounding the plunger 12.
  • a top seal 16 is provided between the rear end of the wall 15 and the plunger 12.
  • the wall 15 also surrounds a rearmost annular portion 17 of the barrel 10 with which the plunger seal 13 remains engaged when the plunger is fully retracted.
  • the annular portion 17 is of castellated form having circumferentially spaced axially extending slots 18.
  • the interior of the barrel 10 and annular chamber 14 define separate compartments which are pre-filled with the dry drug pellet 20 and liquid solvent or other diluent 21 respectively.
  • the pre-filled syringe is supplied with the plunger 12 substantially depressed into the barrel 10 as shown in Figure 1.
  • the plunger 12 is withdrawn as shown in Figure 2 to evacuate the interior of the barrel forwardly of the plunger and bring the seal 13 into register with the portion 17 thus providing communication via the slots 18 around the outer periphery of the seal 12 between the annular chamber 14 and that section of the barrel disposed forwardly of the plunger.
  • the solvent 21 is drawn into the barrel 10 through the slots 18 aided by the vacuum within the barrel.
  • the syringe of Figures 1 to 3 may be provided with a needle retraction mechanism for projecting the needle after use into the interior of the plunger.
  • the forward end of the plunger may be appropriately adapted, inboard of the seal 13, so as to be broken away in response to operation of the needle retraction mechanism to allow the needle to be projected into the interior of the plunger in the manner described for example in European Patent No. 0 776 225.
  • the plunger is shown in its initially depressed condition from which it must be retracted in order to transfer liquid from the section 48 to the section 46.
  • a second seal 47 fixed with respect to the barrel, is provided between the plunger and the barrel at the rear end of the barrel.
  • the seal 44 comprises a flexibly deformable cup-type washer and is of generally U-shaped configuration in cross-section with the mouth of the U opening in the forward direction of plunger travel.
  • the seal has two limbs 50, 52, one being attached to the plunger 42 and the other being arranged to bear against the inner periphery of the barrel 40.
  • the sealing afforded by seal 44 is fully effective and serves to isolate the forward section of the barrel from the rearward section.
  • plunger retraction i.e. movement to the right as viewed in Figure 4
  • the pressure in the rearward section 48 increases while the pressure in the forward section 46 decreases.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne une seringue dont le corps présente une extrémité avant conçue pour être assemblée avec un ensemble aiguille, un piston pouvant coulisser dans le corps et pourvu d'un obturateur sur son extrémité avant, enfin une chambre annulaire définie par le piston et une paroi entourant le piston. L'intérieur du corps et la chambre annulaire peuvent être préremplis de deux composants qui doivent être mélangés avant d'être administrés. La rétraction du piston permet d'établir une communication entre l'intérieur du corps et la chambre annulaire, de sorte que les composants préremplis puissent se mélanger à l'intérieur du corps. Dans une variante, seule la chambre annulaire est préremplie d'un médicament destiné à être administré, le médicament étant transféré à un endroit situé devant le joint de piston en réponse à la réaction du piston, de sorte que ce médicament est prêt à être administré par pression sur le piston.
PCT/GB2000/000169 1999-03-09 2000-01-14 Seringue a deux compartiments WO2000053244A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU30660/00A AU3066000A (en) 1999-03-09 2000-01-14 Two compartment syringe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9905258.1 1999-03-09
GBGB9905258.1A GB9905258D0 (en) 1999-03-09 1999-03-09 Syringe for use with hypodermic needle

Publications (1)

Publication Number Publication Date
WO2000053244A1 true WO2000053244A1 (fr) 2000-09-14

Family

ID=10849166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/000169 WO2000053244A1 (fr) 1999-03-09 2000-01-14 Seringue a deux compartiments

Country Status (3)

Country Link
AU (1) AU3066000A (fr)
GB (1) GB9905258D0 (fr)
WO (1) WO2000053244A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743194B2 (en) 2002-03-28 2004-06-01 Igal Sharon Multi-compartment syringe
WO2010144021A1 (fr) * 2009-06-11 2010-12-16 Jan Svensson Piston et contenant muni d'un tel piston
US9526846B2 (en) 2009-08-19 2016-12-27 Safety Syringes, Inc. Patient-contact activated needle stick safety device
CN114025814A (zh) * 2019-05-03 2022-02-08 康尔福盛303公司 多腔室注射器

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2082128A5 (en) * 1970-03-04 1971-12-10 Idees Syringe - for preserving and injecting medicaments
DE2514412A1 (de) * 1975-04-02 1976-10-14 Wimmer Pharma Gummi Gmbh Trennkolben fuer injektionsspritzen
US4464173A (en) * 1982-12-08 1984-08-07 Tartaglia John A Medical syringe
US4874381A (en) * 1988-02-16 1989-10-17 Arzheimittel Gmbh Apotheker Vetter & Co. Ravensburg Hypodermic syringe
EP0776225A1 (fr) 1994-08-18 1997-06-04 NMT Group PLC Mecanismes de rappel d'aiguille
US5779668A (en) * 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2082128A5 (en) * 1970-03-04 1971-12-10 Idees Syringe - for preserving and injecting medicaments
DE2514412A1 (de) * 1975-04-02 1976-10-14 Wimmer Pharma Gummi Gmbh Trennkolben fuer injektionsspritzen
US4464173A (en) * 1982-12-08 1984-08-07 Tartaglia John A Medical syringe
US4874381A (en) * 1988-02-16 1989-10-17 Arzheimittel Gmbh Apotheker Vetter & Co. Ravensburg Hypodermic syringe
EP0776225A1 (fr) 1994-08-18 1997-06-04 NMT Group PLC Mecanismes de rappel d'aiguille
US5782804A (en) * 1994-08-18 1998-07-21 Nmt Group Plc Needle retraction mechanisms
US5779668A (en) * 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743194B2 (en) 2002-03-28 2004-06-01 Igal Sharon Multi-compartment syringe
WO2010144021A1 (fr) * 2009-06-11 2010-12-16 Jan Svensson Piston et contenant muni d'un tel piston
CN102481416A (zh) * 2009-06-11 2012-05-30 英特拉德拉格医疗系统公司 活塞和带有这种活塞的容器
US9526846B2 (en) 2009-08-19 2016-12-27 Safety Syringes, Inc. Patient-contact activated needle stick safety device
US10314985B2 (en) 2009-08-19 2019-06-11 Safety Syringes, Inc. Patient-contact activated needle stick safety device
US11400234B2 (en) 2009-08-19 2022-08-02 Safety Syringes, Inc. Patient-contact activated needle stick safety device
CN114025814A (zh) * 2019-05-03 2022-02-08 康尔福盛303公司 多腔室注射器
CN114025814B (zh) * 2019-05-03 2024-04-19 康尔福盛303公司 多腔室注射器

Also Published As

Publication number Publication date
AU3066000A (en) 2000-09-28
GB9905258D0 (en) 1999-04-28

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