WO2000050596A3 - 14273 receptor, a novel g-protein coupled receptor - Google Patents

14273 receptor, a novel g-protein coupled receptor Download PDF

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Publication number
WO2000050596A3
WO2000050596A3 PCT/US2000/005068 US0005068W WO0050596A3 WO 2000050596 A3 WO2000050596 A3 WO 2000050596A3 US 0005068 W US0005068 W US 0005068W WO 0050596 A3 WO0050596 A3 WO 0050596A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
polynucleotides
invention further
relates
receptor polypeptides
Prior art date
Application number
PCT/US2000/005068
Other languages
French (fr)
Other versions
WO2000050596A2 (en
WO2000050596A9 (en
Inventor
Maria Alexandra Glucksmann
Fong-Ying Tsai
Original Assignee
Millenium Pharmaceuticals Inc
Maria Alexandra Glucksmann
Tsai Fong Ying
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/261,599 external-priority patent/US6395877B1/en
Application filed by Millenium Pharmaceuticals Inc, Maria Alexandra Glucksmann, Tsai Fong Ying filed Critical Millenium Pharmaceuticals Inc
Priority to CA002363794A priority Critical patent/CA2363794A1/en
Priority to AU36088/00A priority patent/AU3608800A/en
Priority to EP00914739A priority patent/EP1157109A2/en
Priority to JP2000601160A priority patent/JP2002536997A/en
Publication of WO2000050596A2 publication Critical patent/WO2000050596A2/en
Publication of WO2000050596A3 publication Critical patent/WO2000050596A3/en
Publication of WO2000050596A9 publication Critical patent/WO2000050596A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders, specifically, cardiovascular diseases, including congestive heart failure. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.
PCT/US2000/005068 1999-02-26 2000-02-28 14273 receptor, a novel g-protein coupled receptor WO2000050596A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002363794A CA2363794A1 (en) 1999-02-26 2000-02-28 14273 receptor, a novel g-protein coupled receptor
AU36088/00A AU3608800A (en) 1999-02-26 2000-02-28 14273 receptor, a novel g-protein coupled receptor
EP00914739A EP1157109A2 (en) 1999-02-26 2000-02-28 14273 receptor, a g-protein coupled receptor
JP2000601160A JP2002536997A (en) 1999-02-26 2000-02-28 Novel G protein-coupled receptor 14273 receptor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/261,599 US6395877B1 (en) 1998-06-30 1999-02-26 14273 receptor, a novel G-protein coupled receptor
US09/456,455 US6448005B1 (en) 1998-06-30 1999-12-08 14723 Receptor, a novel G-protein coupled receptor
US09/261,599 1999-12-08
US09/456,455 1999-12-08

Publications (3)

Publication Number Publication Date
WO2000050596A2 WO2000050596A2 (en) 2000-08-31
WO2000050596A3 true WO2000050596A3 (en) 2000-12-21
WO2000050596A9 WO2000050596A9 (en) 2002-06-20

Family

ID=26948710

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/005068 WO2000050596A2 (en) 1999-02-26 2000-02-28 14273 receptor, a novel g-protein coupled receptor

Country Status (6)

Country Link
US (2) US6448005B1 (en)
EP (1) EP1157109A2 (en)
JP (1) JP2002536997A (en)
AU (1) AU3608800A (en)
CA (1) CA2363794A1 (en)
WO (1) WO2000050596A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4728599A (en) * 1998-06-30 2000-01-17 Millennium Pharmaceuticals, Inc. 14273 receptor, a g-protein coupled receptor
US20020151705A1 (en) * 1999-10-05 2002-10-17 Smith Kelli E. DNA encoding orphan SNORF49 receptor
US7115375B2 (en) 2000-11-14 2006-10-03 Bristol-Myers Squibb Methods of diagnosing renal tumors by determining the expression level of RNA encoding the HGPRBMY18 polypeptide
AU2002258428A1 (en) * 2001-02-26 2002-09-12 Millennium Pharmaceuticals, Inc. Methods for the treatment of metabolic disorders, including obesity and diabetes
WO2003106694A2 (en) * 2002-06-13 2003-12-24 New England Medical Center Hospitals, Inc. Rapid methods for assessing therapeutic activity using animals expressing constitutively active g protein-coupled receptors
JP4574177B2 (en) * 2003-01-17 2010-11-04 武田薬品工業株式会社 New screening method
US20080160033A1 (en) * 2003-01-17 2008-07-03 Takeda Pharmaceutical Company Limited Novel Screening Method
US20080004227A1 (en) * 2004-03-01 2008-01-03 Pharmafrontier Co., Ltd Pharmaceutical Composition for Lowering Blood Sugar Level
EP1932920A4 (en) * 2005-09-02 2009-04-08 Eisai R&D Man Co Ltd Method for screening of substance effective on disease using gpr120 and phospholipase
CA2837477C (en) * 2005-10-14 2016-06-21 Aethon, Inc. Robotic ordering and delivery apparatuses, systems and methods
JP5420400B2 (en) 2007-04-26 2014-02-19 国立大学法人京都大学 G protein-coupled receptor agonist

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014331A1 (en) * 1994-11-07 1996-05-17 Merck & Co., Inc. Modified neuropeptide y receptors
WO1999033982A2 (en) * 1997-12-23 1999-07-08 Chiron Corporation Human genes and gene expression products i
WO1999038972A2 (en) * 1998-01-28 1999-08-05 Chiron Corporation Human genes and gene expression products ii
WO2000000611A2 (en) * 1998-06-30 2000-01-06 Millennium Pharmaceuticals, Inc. 14273 receptor, a g-protein coupled receptor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756460A (en) 1991-03-06 1998-05-26 Garvan Institute Of Medical Research Human galanin, CDNA clones encoding human galanin and a method of producing human galanin
US5576296A (en) 1991-05-15 1996-11-19 Aktiebolaget Astra Galanin antagonist
US5789223A (en) * 1995-05-26 1998-08-04 Smithkline Beecham Corporation Human galactokinase gene
US6329197B2 (en) 1996-10-09 2001-12-11 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR3 receptors and uses thereof
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014331A1 (en) * 1994-11-07 1996-05-17 Merck & Co., Inc. Modified neuropeptide y receptors
WO1999033982A2 (en) * 1997-12-23 1999-07-08 Chiron Corporation Human genes and gene expression products i
WO1999038972A2 (en) * 1998-01-28 1999-08-05 Chiron Corporation Human genes and gene expression products ii
WO2000000611A2 (en) * 1998-06-30 2000-01-06 Millennium Pharmaceuticals, Inc. 14273 receptor, a g-protein coupled receptor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHATELAIN P. ET AL.: "Cardiac ischaemia: possibilities for future drug therapy", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 9, 1 September 1997 (1997-09-01), pages 687 - 707, XP004094066, ISSN: 0223-5234 *
LEE N. H. ET AL.: "MOLECULAR BIOLOGY OF G-PROTEIN-COUPLED RECEPTORS", DRUG NEWS AND PERSPECTIVES, vol. 6, no. 7, 1 September 1993 (1993-09-01), pages 488 - 497, XP000677175, ISSN: 0214-0934 *
MARRA M. ET AL.: "The WashU-HHMI mouse EST project.", EMBL DATABASE ACCESSION NUMBER AA030752, 23 August 1996 (1996-08-23), XP002125905 *
MARRA M. ET AL.: "The WashU-HHMI mouse EST project.", EMBL DATABASE ACCESSION NUMBER AA413234, 5 May 1997 (1997-05-05), XP002125904 *
MARRA M. ET AL.: "The WashU-HHMI mouse EST project.", EMBL DATABASE ACCESSION NUMBER AA647793, 5 November 1997 (1997-11-05), XP002125906 *

Also Published As

Publication number Publication date
AU3608800A (en) 2000-09-14
CA2363794A1 (en) 2000-08-31
US20030073168A1 (en) 2003-04-17
WO2000050596A2 (en) 2000-08-31
WO2000050596A9 (en) 2002-06-20
US6448005B1 (en) 2002-09-10
EP1157109A2 (en) 2001-11-28
JP2002536997A (en) 2002-11-05

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