WO2000045799A3 - Utilisation d'acides isoxazolcarboxyliques substitues et de leurs derives, et nouvelles substances - Google Patents
Utilisation d'acides isoxazolcarboxyliques substitues et de leurs derives, et nouvelles substances Download PDFInfo
- Publication number
- WO2000045799A3 WO2000045799A3 PCT/EP2000/000517 EP0000517W WO0045799A3 WO 2000045799 A3 WO2000045799 A3 WO 2000045799A3 EP 0000517 W EP0000517 W EP 0000517W WO 0045799 A3 WO0045799 A3 WO 0045799A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- derivatives
- carboxylic acids
- novel substances
- substituted isoxazol
- isoxazol carboxylic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU21100/00A AU2110000A (en) | 1999-02-04 | 2000-01-24 | Use of substituted isoxazol carboxylic acids and derivatives and novel substances |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19904389.2 | 1999-02-04 | ||
DE19904389A DE19904389A1 (de) | 1999-02-04 | 1999-02-04 | Verwendung von substituierten Isoxazolcarbonsäuren und Derivate und neue Stoffe |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000045799A2 WO2000045799A2 (fr) | 2000-08-10 |
WO2000045799A3 true WO2000045799A3 (fr) | 2002-01-24 |
Family
ID=7896332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/000517 WO2000045799A2 (fr) | 1999-02-04 | 2000-01-24 | Utilisation d'acides isoxazolcarboxyliques substitues et de leurs derives, et nouvelles substances |
Country Status (5)
Country | Link |
---|---|
AR (1) | AR022469A1 (fr) |
AU (1) | AU2110000A (fr) |
DE (1) | DE19904389A1 (fr) |
GT (1) | GT200000011A (fr) |
WO (1) | WO2000045799A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8884034B2 (en) | 2009-07-08 | 2014-11-11 | Dermira (Canada), Inc. | TOFA analogs useful in treating dermatological disorders or conditions |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6320998A (en) | 1997-02-21 | 1998-09-09 | Bristol-Myers Squibb Company | Benzoic acid derivatives and related compounds as antiarrhythmic agents |
MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
PL374536A1 (en) | 2002-08-23 | 2005-10-31 | Rigel Pharmaceuticals, Inc. | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
WO2004099164A1 (fr) | 2003-05-02 | 2004-11-18 | Rigel Pharmaceuticals, Inc. | Diphenyl isoxazoles, pyrazoles et oxadiazoles substitues, destines au traitement d'une infection par le vhc |
US7326790B2 (en) | 2003-05-02 | 2008-02-05 | Rigel Pharmaceuticals, Inc. | Diphenylisoxazole compounds and hydro isomers thereof |
US7220745B2 (en) | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
WO2005049065A2 (fr) | 2003-11-19 | 2005-06-02 | Rigel Pharmaceuticals, Inc. | Combinaisons efficaces d'un point de vue synergique de composes dihaloacetamide et d'interferon ou de ribavirine contre les infections par le virus de l'hepatite c (vhc) |
US7514434B2 (en) | 2004-02-23 | 2009-04-07 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof |
WO2006044682A1 (fr) * | 2004-10-13 | 2006-04-27 | Ptc Therapeutics, Inc. | Composés permettant de supprimer les effets des mutations non-sens, et méthodes d’emploi desdits composés |
JP2008540425A (ja) | 2005-05-02 | 2008-11-20 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 代謝可能部分を含む複素環式抗ウイルス性化合物およびその使用 |
BRPI0612028A2 (pt) * | 2005-06-08 | 2010-10-13 | Novartis Ag | oxadiazóis ou isodiazóis policìclicos e uso dos mesmos como ligantes de receptor s1p |
GB0601744D0 (en) * | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
JP5253401B2 (ja) | 2006-09-07 | 2013-07-31 | アクテリオン ファーマシューティカルズ リミテッド | 免疫調節薬としてのピリジン−4−イル誘導体 |
NZ576059A (en) * | 2006-09-08 | 2012-03-30 | Actelion Pharmaceuticals Ltd | Pyridin-3-yl derivatives as immunomodulating agents |
US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
NZ580454A (en) | 2007-03-16 | 2011-05-27 | Actelion Pharmaceuticals Ltd | Amino- pyridine derivatives as s1p1 /edg1 receptor agonists |
JP5718053B2 (ja) | 2007-08-27 | 2015-05-13 | ヘリコン・セラピューティクス・インコーポレーテッド | 治療用イソオキサゾール化合物 |
CA2707671C (fr) | 2007-12-07 | 2016-02-02 | Abbott Gmbh & Co. Kg | Derives d'oxindole a double substitution en positions 5 et 6 et leur utilisation pour traiter des maladies liees a la vasopressine |
WO2010009775A1 (fr) | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Dérivés d'oxindole à substitution carbamate et utilisation de ceux-ci pour traiter des maladies dépendant de la vasopressine |
RU2484090C2 (ru) | 2007-12-07 | 2013-06-10 | Эбботт Гмбх Унд Ко.Кг | 5-галогензамещенные производные оксиндола и их применение для лечения вазопрессинзависимых заболеваний |
CA2707667C (fr) | 2007-12-07 | 2016-02-23 | Abbott Gmbh & Co. Kg | Derives oxindoliques substitues par amidomethyle et leur utilisation dans le traitement de maladies vasopressine-dependantes |
WO2010138600A2 (fr) | 2009-05-29 | 2010-12-02 | Abbott Laboratories | Compositions pharmaceutiques utilisées dans le traitement de la douleur |
DK2454255T3 (da) | 2009-07-16 | 2013-12-16 | Actelion Pharmaceuticals Ltd | Pyridin-4-ylderivater som s1p1/edg1-agonister |
MY163185A (en) | 2011-01-19 | 2017-08-15 | Idorsia Pharmaceuticals Ltd | 2-methoxy-pyridin-4-yl derivatives |
CN102329277B (zh) * | 2011-10-24 | 2013-08-07 | 海南霞迪药业有限公司 | 一种制备帕瑞昔布的方法 |
HUE047646T2 (hu) | 2015-05-20 | 2020-05-28 | Idorsia Pharmaceuticals Ltd | Az (S)-3-{4-[5-(2-ciklopentil-6-metoxi-piridin-4-il)-[1,2,4]oxadiazol-3-il]-2-etil-6-metil-fenoxi} -propán-1,2-diol vegyület kristályformája |
CN116535399B (zh) * | 2022-01-25 | 2024-02-27 | 中国药科大学 | 3-羟基-5-(异噁唑-5-基)吡啶甲酰甘氨酸类化合物、制法、药物组合物和应用 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB149877A (en) * | 1919-11-22 | 1920-08-26 | Arthur William Wells | Improvements in and in connection with safety razors |
EP0015140A1 (fr) * | 1979-02-22 | 1980-09-03 | Monsanto Company | Préparation thermolytique d'acides 2-(3-aryl-isoxazol-5-yl) benzoiques, de leurs sels et d'halogénures à partir de 3'-(aryl)-spiro(isobenzofuran-1(3H),5'(4'H)isoxazol)-3-ones |
WO1993019062A1 (fr) * | 1992-03-24 | 1993-09-30 | Warner-Lambert Company | Derives de tetrahydropyridine isoxazoline |
DE4314966A1 (de) * | 1993-05-06 | 1994-11-10 | Fahlberg List Pharma Gmbh | 2-Hydroxyphenylsubstituierte Isoxazole, ihre Verwendung als pharmazeutische Wirkstoffe und sie enthaltende Arzneimittel |
WO1997019039A1 (fr) * | 1995-11-17 | 1997-05-29 | Novartis Ag | Synthese en phase solide de composes heterocycliques et d'une banque combinatoire de composes |
EP0838543A1 (fr) * | 1996-09-30 | 1998-04-29 | Lindauer Dornier Gesellschaft M.B.H | Métier à tisser avec dispositifs pour recevoir et guider des bielles de commande de cadres |
WO1998057923A1 (fr) * | 1997-06-18 | 1998-12-23 | Fujisawa Pharmaceutical Co., Ltd. | Nouveau procede de preparation |
-
1999
- 1999-02-04 DE DE19904389A patent/DE19904389A1/de not_active Withdrawn
-
2000
- 2000-01-24 WO PCT/EP2000/000517 patent/WO2000045799A2/fr active Application Filing
- 2000-01-24 AU AU21100/00A patent/AU2110000A/en not_active Abandoned
- 2000-02-01 AR ARP000100427A patent/AR022469A1/es unknown
- 2000-02-03 GT GT200000011A patent/GT200000011A/es unknown
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB149877A (en) * | 1919-11-22 | 1920-08-26 | Arthur William Wells | Improvements in and in connection with safety razors |
EP0015140A1 (fr) * | 1979-02-22 | 1980-09-03 | Monsanto Company | Préparation thermolytique d'acides 2-(3-aryl-isoxazol-5-yl) benzoiques, de leurs sels et d'halogénures à partir de 3'-(aryl)-spiro(isobenzofuran-1(3H),5'(4'H)isoxazol)-3-ones |
WO1993019062A1 (fr) * | 1992-03-24 | 1993-09-30 | Warner-Lambert Company | Derives de tetrahydropyridine isoxazoline |
DE4314966A1 (de) * | 1993-05-06 | 1994-11-10 | Fahlberg List Pharma Gmbh | 2-Hydroxyphenylsubstituierte Isoxazole, ihre Verwendung als pharmazeutische Wirkstoffe und sie enthaltende Arzneimittel |
WO1997019039A1 (fr) * | 1995-11-17 | 1997-05-29 | Novartis Ag | Synthese en phase solide de composes heterocycliques et d'une banque combinatoire de composes |
EP0838543A1 (fr) * | 1996-09-30 | 1998-04-29 | Lindauer Dornier Gesellschaft M.B.H | Métier à tisser avec dispositifs pour recevoir et guider des bielles de commande de cadres |
WO1998057923A1 (fr) * | 1997-06-18 | 1998-12-23 | Fujisawa Pharmaceutical Co., Ltd. | Nouveau procede de preparation |
EP0994101A1 (fr) * | 1997-06-18 | 2000-04-19 | Fujisawa Pharmaceutical Co., Ltd. | Nouveau procede de preparation |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8884034B2 (en) | 2009-07-08 | 2014-11-11 | Dermira (Canada), Inc. | TOFA analogs useful in treating dermatological disorders or conditions |
US9434718B2 (en) | 2009-07-08 | 2016-09-06 | Dermira (Canada), Inc. | TOFA analogs useful in treating dermatological disorders or conditions |
Also Published As
Publication number | Publication date |
---|---|
DE19904389A1 (de) | 2000-08-10 |
AU2110000A (en) | 2000-08-25 |
WO2000045799A2 (fr) | 2000-08-10 |
AR022469A1 (es) | 2002-09-04 |
GT200000011A (es) | 2001-07-27 |
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