WO2000044719A3 - 1,2-dioxetanes, preparation and use thereof for the dosing of thiols and acetylcholinesterase - Google Patents

1,2-dioxetanes, preparation and use thereof for the dosing of thiols and acetylcholinesterase Download PDF

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Publication number
WO2000044719A3
WO2000044719A3 PCT/FR2000/000183 FR0000183W WO0044719A3 WO 2000044719 A3 WO2000044719 A3 WO 2000044719A3 FR 0000183 W FR0000183 W FR 0000183W WO 0044719 A3 WO0044719 A3 WO 0044719A3
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WO
WIPO (PCT)
Prior art keywords
group
dioxetanes
acetylcholinesterase
thiols
dosing
Prior art date
Application number
PCT/FR2000/000183
Other languages
French (fr)
Other versions
WO2000044719A2 (en
Inventor
Jacques Grassi
Stephane Sabelle
Pierre-Yves Renard
Original Assignee
Commissariat Energie Atomique
Jacques Grassi
Stephane Sabelle
Pierre-Yves Renard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique, Jacques Grassi, Stephane Sabelle, Pierre-Yves Renard filed Critical Commissariat Energie Atomique
Publication of WO2000044719A2 publication Critical patent/WO2000044719A2/en
Publication of WO2000044719A3 publication Critical patent/WO2000044719A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to 1,2-dioxetanes of formula (I) wherein R1 represents a hydrogen atom or an organic group such as a methoxy or ethoxy; R2 is an optionally substituted divalent aromatic group, for example a phenylene group; R3 is an ortho or para-S substituted polyaromatic group or phenyl, for example a dinitrophenyl group; and R?4 and R5¿ are alkyl or aryl groups or preferably form together a polycycloalkyl group that is linked to the dioxetane cylce by means of a spiranic union, for example an adamantyl group. The 1-2 dioxetane compounds can be used to dose thiols and acetylcholinesterase.
PCT/FR2000/000183 1999-01-28 2000-01-27 1,2-dioxetanes, preparation and use thereof for the dosing of thiols and acetylcholinesterase WO2000044719A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9900949A FR2789075B1 (en) 1999-01-28 1999-01-28 1,2-DIOXETANE COMPOUNDS, THEIR PREPARATION AND THEIR USE FOR DETERMINING THIOLS AND ACETYLCHOLINESTERASE
FR99/00949 1999-01-28

Publications (2)

Publication Number Publication Date
WO2000044719A2 WO2000044719A2 (en) 2000-08-03
WO2000044719A3 true WO2000044719A3 (en) 2002-10-03

Family

ID=9541318

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/000183 WO2000044719A2 (en) 1999-01-28 2000-01-27 1,2-dioxetanes, preparation and use thereof for the dosing of thiols and acetylcholinesterase

Country Status (2)

Country Link
FR (1) FR2789075B1 (en)
WO (1) WO2000044719A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2886292B1 (en) * 2005-05-27 2009-10-16 Quidd Soc Par Actions Simplifiee BIOMARKER WITH LUMINESCENT TRANSMISSION
CA3118540A1 (en) * 2018-11-07 2020-05-14 University Of Houston System Non-enzymatic glow assays

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0671395A1 (en) * 1994-03-11 1995-09-13 Masakatsu Matsumoto 1,2-Dioxetane derivatives, intermediates for syntheses thereof and methods of producing the intermediates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0671395A1 (en) * 1994-03-11 1995-09-13 Masakatsu Matsumoto 1,2-Dioxetane derivatives, intermediates for syntheses thereof and methods of producing the intermediates

Also Published As

Publication number Publication date
FR2789075B1 (en) 2001-03-02
WO2000044719A2 (en) 2000-08-03
FR2789075A1 (en) 2000-08-04

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