WO2000037918A3 - A method and an apparatus for cutting of tissue blocks - Google Patents

A method and an apparatus for cutting of tissue blocks Download PDF

Info

Publication number
WO2000037918A3
WO2000037918A3 PCT/DK1999/000720 DK9900720W WO0037918A3 WO 2000037918 A3 WO2000037918 A3 WO 2000037918A3 DK 9900720 W DK9900720 W DK 9900720W WO 0037918 A3 WO0037918 A3 WO 0037918A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
embedding
sectioning
irregular
orientation
Prior art date
Application number
PCT/DK1999/000720
Other languages
French (fr)
Other versions
WO2000037918A2 (en
Inventor
Jens Christian Hedem Soerensen
Finn Geneser
Ulrik Kjaergaard Soerensen
Graziano Cancian
Carsten Reides Bjarkam
Original Assignee
Histotech Aps
Jens Christian Hedem Soerensen
Finn Geneser
Ulrik Kjaergaard Soerensen
Graziano Cancian
Carsten Reides Bjarkam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Histotech Aps, Jens Christian Hedem Soerensen, Finn Geneser, Ulrik Kjaergaard Soerensen, Graziano Cancian, Carsten Reides Bjarkam filed Critical Histotech Aps
Priority to KR1020017007792A priority Critical patent/KR20010099854A/en
Priority to EP99960950A priority patent/EP1149275A2/en
Priority to CA002353876A priority patent/CA2353876A1/en
Priority to JP2000589928A priority patent/JP2002533670A/en
Priority to AU17734/00A priority patent/AU1773400A/en
Publication of WO2000037918A2 publication Critical patent/WO2000037918A2/en
Publication of WO2000037918A3 publication Critical patent/WO2000037918A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to a tissue embedding procedure and an apparatus for sectioning of irregular tissue blocks in slabs with section planes in the same orientation as any scanning plane used in CT, MRI or PET scanning. Using an embedding apparatus the tissue block is embedded into an algino plastic polymer with defined regular outer surfaces adapted to the sectioning apparatus. The embedding procedure allows tissue and organs with irregular surfaces such as e.g. brain and kidney to be cut in a reproducible fashion and in any orientation. The machine consists of an array of long razor blades in a frame that can be lowered through the action of crank. The razor blade frame is set into vibration by a pneumatic vibrator. The alginate tissue block is kept in place by vacuum produced by a pressurised air flow valve.
PCT/DK1999/000720 1998-12-21 1999-12-20 A method and an apparatus for cutting of tissue blocks WO2000037918A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1020017007792A KR20010099854A (en) 1998-12-21 1999-12-20 A method and an apparatus for cutting of tissue blocks
EP99960950A EP1149275A2 (en) 1998-12-21 1999-12-20 A method and an apparatus for cutting of tissue blocks
CA002353876A CA2353876A1 (en) 1998-12-21 1999-12-20 A method and an apparatus for cutting of tissue blocks
JP2000589928A JP2002533670A (en) 1998-12-21 1999-12-20 Method and apparatus for cutting tissue mass
AU17734/00A AU1773400A (en) 1998-12-21 1999-12-20 A method and an apparatus for cutting of tissue blocks

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199801699 1998-12-21
DKPA199801699 1998-12-21

Publications (2)

Publication Number Publication Date
WO2000037918A2 WO2000037918A2 (en) 2000-06-29
WO2000037918A3 true WO2000037918A3 (en) 2001-03-08

Family

ID=8107314

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1999/000720 WO2000037918A2 (en) 1998-12-21 1999-12-20 A method and an apparatus for cutting of tissue blocks

Country Status (6)

Country Link
EP (1) EP1149275A2 (en)
JP (1) JP2002533670A (en)
KR (1) KR20010099854A (en)
AU (1) AU1773400A (en)
CA (1) CA2353876A1 (en)
WO (1) WO2000037918A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1330636A1 (en) * 2000-11-03 2003-07-30 Histotech Aps A device and a method for sectioning of tissue blocks
DE10311061A1 (en) * 2003-03-13 2004-09-30 Cell Center Cologne Gmbh Apparatus to cut a tissue sample into thin slices, for analysis, has a casting frame to embed the sample in a cast block, to be advanced to a lateral cutting blade to cut slices in a selected thickness
US8122804B2 (en) 2006-11-01 2012-02-28 Kurume University Slicing guide device for preparing texture slices, texture slices preparing device, and method for preparing texture slices
JP4510908B2 (en) 2008-05-30 2010-07-28 周 市原 Extract slice assist device and extract slice assist set
JP5316161B2 (en) * 2009-03-27 2013-10-16 ソニー株式会社 Observation device
US8854042B2 (en) 2010-08-05 2014-10-07 Life Services, LLC Method and coils for human whole-body imaging at 7 T
JP5335852B2 (en) 2011-04-27 2013-11-06 周 市原 Extracted slice auxiliary tool and auxiliary device
JP5881006B2 (en) * 2011-12-27 2016-03-09 東芝Ｉｔコントロールシステム株式会社 Tomography equipment
DE102012214476B4 (en) * 2012-08-14 2014-06-18 Leica Microsystems Cms Gmbh Apparatus and method for producing a plurality of sample cuts in the form of a cut stack
JP6256968B2 (en) * 2013-05-20 2018-01-10 国立研究開発法人量子科学技術研究開発機構 Fixed position display kit and position display fixing method
US10191128B2 (en) 2014-02-12 2019-01-29 Life Services, LLC Device and method for loops-over-loops MRI coils
US10281534B2 (en) 2014-03-20 2019-05-07 Life Services, LLC Tissue-slice MRI coil and rotation mechanism
US10288711B1 (en) 2015-04-30 2019-05-14 Life Services, LLC Device and method for simultaneous TX/RX in strongly coupled MRI coil loops
WO2017009800A1 (en) 2015-07-16 2017-01-19 Ecole Polytechnique Federale De Lausanne (Epfl) Device for high- throughput sample slicing and characterization
US10827948B1 (en) 2015-11-25 2020-11-10 Life Services, LLC Method and apparatus for multi-part close fitting head coil
US10324146B2 (en) 2016-01-12 2019-06-18 Life Services, LLC Method and apparatus for multi-part body coil
CN108318310A (en) * 2018-05-14 2018-07-24 上海交通大学医学院附属第九人民医院 A kind of lower device for the parallel irregular biological tissue of cutting of laser scanning guiding
JP7195339B2 (en) * 2018-12-17 2022-12-23 ヤマハ発動機株式会社 Biological sample slicer
KR102576409B1 (en) 2021-01-18 2023-09-08 충남대학교병원 Method for preparing cell-section using alginate bead
KR102526386B1 (en) 2021-03-19 2023-05-02 충남대학교병원 Method for cell block production using alginate-PVA composite beads
CN113172671A (en) * 2021-04-25 2021-07-27 吉林大学 Pathology department is with section device

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0245969A2 (en) * 1986-04-16 1987-11-19 Cambridge Instrument Company plc Methods of and apparatus for preparing tissue specimens
US5282404A (en) * 1990-11-09 1994-02-01 The Government Of The United States Of America As Represented By The Secretary Of The Dept. Of Health & Human Services Microtome with micro-plane and electric contact reference
DE4323483A1 (en) * 1992-08-20 1994-02-24 Anton Dr Kathrein Cryo-microtome device with rotary cutter - has cutting blades attached to high speed rotary shaft which extends parallel to surface of ice block in which samples are frozen
JPH07218398A (en) * 1994-01-31 1995-08-18 Seitai Kagaku Kenkyusho:Kk Method and instrument for preparation of sample of biological tissue
DE19743590A1 (en) * 1997-10-02 1999-05-06 Engel Brigitte Rapid sample preparation for analysis of objects being restored, especially wall paintings and wood sculptures
JPH11194076A (en) * 1997-12-27 1999-07-21 Murazumi Kogyo Kk Cassette clamp for microtome

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0245969A2 (en) * 1986-04-16 1987-11-19 Cambridge Instrument Company plc Methods of and apparatus for preparing tissue specimens
US5282404A (en) * 1990-11-09 1994-02-01 The Government Of The United States Of America As Represented By The Secretary Of The Dept. Of Health & Human Services Microtome with micro-plane and electric contact reference
DE4323483A1 (en) * 1992-08-20 1994-02-24 Anton Dr Kathrein Cryo-microtome device with rotary cutter - has cutting blades attached to high speed rotary shaft which extends parallel to surface of ice block in which samples are frozen
JPH07218398A (en) * 1994-01-31 1995-08-18 Seitai Kagaku Kenkyusho:Kk Method and instrument for preparation of sample of biological tissue
DE19743590A1 (en) * 1997-10-02 1999-05-06 Engel Brigitte Rapid sample preparation for analysis of objects being restored, especially wall paintings and wood sculptures
JPH11194076A (en) * 1997-12-27 1999-07-21 Murazumi Kogyo Kk Cassette clamp for microtome

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199542, Derwent World Patents Index; Class J04, AN 1995-323601, XP002900963 *
DATABASE WPI Section EI Week 199939, Derwent World Patents Index; Class S03, AN 1999-463078, XP002900964 *

Also Published As

Publication number Publication date
JP2002533670A (en) 2002-10-08
CA2353876A1 (en) 2000-06-29
KR20010099854A (en) 2001-11-09
WO2000037918A2 (en) 2000-06-29
EP1149275A2 (en) 2001-10-31
AU1773400A (en) 2000-07-12

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