WO2000034465A3 - HEAT SHOCK GENES AND PROTEINS FROM NEISSERIA MENINGITIDIS, CANDIDA GLABRATA AND $i(ASPERGILLUS FUMIGATUS) - Google Patents

HEAT SHOCK GENES AND PROTEINS FROM NEISSERIA MENINGITIDIS, CANDIDA GLABRATA AND $i(ASPERGILLUS FUMIGATUS)

Info

Publication number
WO2000034465A3
WO2000034465A3 PCT/CA1999/001152 CA9901152W WO0034465A3 WO 2000034465 A3 WO2000034465 A3 WO 2000034465A3 CA 9901152 W CA9901152 W CA 9901152W WO 0034465 A3 WO0034465 A3 WO 0034465A3
Authority
WO
WIPO (PCT)
Prior art keywords
heat shock
neisseria meningitidis
aspergillus fumigatus
proteins
candida glabrata
Prior art date
Application number
PCT/CA1999/001152
Other languages
French (fr)
Other versions
WO2000034465A2 (en
Inventor
Jan Wisniewski
Original Assignee
Stressgen Biotechnologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stressgen Biotechnologies Corp filed Critical Stressgen Biotechnologies Corp
Priority to CA002352608A priority Critical patent/CA2352608A1/en
Priority to AU15408/00A priority patent/AU1540800A/en
Priority to EP99957790A priority patent/EP1137770A2/en
Publication of WO2000034465A2 publication Critical patent/WO2000034465A2/en
Publication of WO2000034465A3 publication Critical patent/WO2000034465A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56961—Plant cells or fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/22—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Neisseriaceae (F), e.g. Acinetobacter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
    • G01N2333/38—Assays involving biological materials from specific organisms or of a specific nature from fungi from Aspergillus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
    • G01N2333/39—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts
    • G01N2333/40—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts from Candida
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods and compositions comprising isolated nucleic acid molecules specific to Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus heat shock proteins (Hsps), as well as vector constructs and isolated polypeptides specific to the same are provided. Such compositions and methods are useful for the diagnosis of infections by these organisms and for generating an immune response to the organisms.
PCT/CA1999/001152 1998-12-08 1999-12-01 HEAT SHOCK GENES AND PROTEINS FROM NEISSERIA MENINGITIDIS, CANDIDA GLABRATA AND $i(ASPERGILLUS FUMIGATUS) WO2000034465A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002352608A CA2352608A1 (en) 1998-12-08 1999-12-01 Heat shock genes and proteins from neisseria meningitidis, candida glabrata and aspergillus fumigatus
AU15408/00A AU1540800A (en) 1998-12-08 1999-12-01 Heat shock genes and proteins from (neisseria meningitidis), (candida glabrata) and (aspergillus fumigatus)
EP99957790A EP1137770A2 (en) 1998-12-08 1999-12-01 Heat shock genes and proteins from neisseria meningitidis, candida glabrata and aspergillus fumigatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/207,388 US6497880B1 (en) 1998-12-08 1998-12-08 Heat shock genes and proteins from Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus
US09/207,388 1998-12-08

Publications (2)

Publication Number Publication Date
WO2000034465A2 WO2000034465A2 (en) 2000-06-15
WO2000034465A3 true WO2000034465A3 (en) 2000-10-26

Family

ID=22770344

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/001152 WO2000034465A2 (en) 1998-12-08 1999-12-01 HEAT SHOCK GENES AND PROTEINS FROM NEISSERIA MENINGITIDIS, CANDIDA GLABRATA AND $i(ASPERGILLUS FUMIGATUS)

Country Status (5)

Country Link
US (3) US6497880B1 (en)
EP (1) EP1137770A2 (en)
AU (1) AU1540800A (en)
CA (1) CA2352608A1 (en)
WO (1) WO2000034465A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7279459B2 (en) * 2001-01-04 2007-10-09 Vascular Biogenics Ltd. Methods employing and compositions containing plaque associated molecules for prevention and treatment of atherosclerosis
US20050226890A1 (en) * 1999-08-12 2005-10-13 Cohen David I Tat-based vaccine compositions and methods of making and using same
ATE326236T1 (en) * 2000-06-26 2006-06-15 Stressgen Biotechnologies Corp HPV-E7 FOR THE TREATMENT OF HUMAN PAPILLOMAVIRUS
US20080044435A1 (en) * 2004-03-16 2008-02-21 Cohen David I Tat-Based Tolerogen Compositions and Methods of Making and Using Same
US6916626B1 (en) * 2001-04-25 2005-07-12 Rockeby Biomed Ltd. Detection of Candida
US20040259226A1 (en) * 2003-05-30 2004-12-23 Robey W. Wade Monitoring for and detecting microbes used in bioterrorism
US20040101860A1 (en) * 2002-11-27 2004-05-27 Jones Alison M. Predicting animal performance
US20040185446A1 (en) * 2003-03-18 2004-09-23 Jones Alison M. Cpn60 targets for quantification of microbial species
US20040185434A1 (en) * 2003-03-21 2004-09-23 Robey W. Wade Detecting microbial contamination in animal by-products
US20040241662A1 (en) * 2003-05-30 2004-12-02 Robey W. Wade Detecting microbial contamination in grain and related products
US20060241288A1 (en) * 2003-06-10 2006-10-26 Ace Biosciences A/S Extracellular aspergillus polypeptides
WO2005090968A1 (en) * 2004-03-16 2005-09-29 Inist Inc. Tat-based immunomodulatory compositions and methods of their discovery and use
US7622121B2 (en) * 2005-09-21 2009-11-24 New York University Heat shock proteins from Mycobacterium leprae and uses thereof
US20090099040A1 (en) * 2007-10-15 2009-04-16 Sigma Aldrich Company Degenerate oligonucleotides and their uses
MX352246B (en) 2009-03-18 2017-10-25 Instituto Potosino De Investig Cientifica Y Tecnologica A C In vitro method for detecting candida glabrata, diagnosis kit and use thereof.
CN102405057B (en) 2009-03-23 2016-05-25 那尼尔科斯治疗公司 By immunostimulating Hiv Tat derivative polypeptides treatment cancer
CA2926221A1 (en) 2013-10-04 2015-04-09 Pin Pharma, Inc. Immunostimulatory hiv tat derivative polypeptides for use in cancer treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996036707A1 (en) * 1995-05-16 1996-11-21 Universita' Degli Studi Di Roma 'la Sapienza' CANDIDA HEAT SHOCK PROTEIN, cDNA AND USES THEREOF
JPH10108678A (en) * 1996-10-07 1998-04-28 Kurita Water Ind Ltd Heat shock promoter, stress-sensing gene and detection of stress

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US471A (en) * 1837-11-20 Mode of
US4600225A (en) * 1983-12-23 1986-07-15 Interlock Technologies Corporation Tubular connection having a parallel chevron thread
GB8404280D0 (en) 1984-02-17 1984-03-21 Stanford J L Biological preparations
IL71683A0 (en) 1984-04-27 1984-09-30 Yeda Res & Dev Pharmaceutical compositions for treating arthritis type diseases comprising fractions obtained from mycobacteria
US4906742A (en) 1986-07-31 1990-03-06 Whitehead Institute For Biomedical Research Encoding antigens of M. Leprae
NL8701163A (en) 1986-09-09 1988-04-05 Nederlanden Staat USE OF A PEPTIDE FOR THE PREPARATION OF PREPARATIONS FOR LIGHTING, TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASES, IN PARTICULAR ARTHRITIC CONDITIONS, COMPOUNDS RELATED TO THIS PEPTIDE, AND PHARMACEUTICAL AND DIAGNOSTIC PREPARATORY.
AU1548388A (en) 1987-02-02 1988-08-24 Whitehead Institute For Biomedical Research Mycobacterium tuberculosis genes and encoding protein antigens
US4952395A (en) 1987-02-26 1990-08-28 Scripps Clinic And Research Foundation Mycobacterial recombinants and peptides
US5504005A (en) 1987-03-02 1996-04-02 Albert Einstein College Of Medicine Of Yeshiva University Recombinant mycobacterial vaccine
NL8703107A (en) 1987-12-22 1989-07-17 Nederlanden Staat POLYPEPTIDES AND DERIVATIVES THEREOF, AND THEIR USE THEREOF IN PHARMACEUTICAL AND DIAGNOSTIC PREPARATIONS.
WO1989012455A1 (en) 1988-06-15 1989-12-28 Whitehead Institute For Biomedical Research Stress proteins and uses therefor
US5232833A (en) 1988-09-14 1993-08-03 Stressgen Biotechnologies Corporation Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants
US5114844A (en) 1989-03-14 1992-05-19 Yeda Research And Development Co., Ltd. Diagnosis and treatment of insulin dependent diabetes mellitus
AU5848090A (en) 1989-06-19 1991-01-08 Whitehead Institute For Biomedical Research Vector-mediated genomic insertion and expression of dna in bcg
GB8919321D0 (en) 1989-08-25 1989-10-11 Univ London Treatment of chronic inflammatory conditions
GB9007194D0 (en) 1990-03-30 1990-05-30 Wellcome Found Live vaccines
GB9024320D0 (en) 1990-11-08 1990-12-19 Univ London Treatment of uveitis
AU660430B2 (en) 1990-11-08 1995-06-29 Stanford Rook Limited Mycobacterium as adjuvant for antigens
GB2251186A (en) 1990-12-04 1992-07-01 Randall Neal Gatz Polypeptide for use in treatment of autoimmune disease
IT1262896B (en) 1992-03-06 1996-07-22 CONJUGATE COMPOUNDS FORMED FROM HEAT SHOCK PROTEIN (HSP) AND OLIGO-POLY-SACCHARIDES, THEIR USE FOR THE PRODUCTION OF VACCINES.
IL102687A (en) 1992-07-30 1997-06-10 Yeda Res & Dev Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
JPH08510756A (en) 1993-06-04 1996-11-12 ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ Stress proteins and their use
US5961979A (en) 1994-03-16 1999-10-05 Mount Sinai School Of Medicine Of The City University Of New York Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens
GB9419979D0 (en) 1994-10-04 1994-11-16 Medeva Holdings Bv Vaccine compositions
US5708160A (en) 1995-04-26 1998-01-13 The National Research Council HSP-60 genomic locus and primers for species identification
CZ394297A3 (en) 1995-06-07 1998-04-15 Biochem Vaccines Inc. Thermal shock streptococcus proteins of the hsp70 group
WO1997006828A1 (en) 1995-08-18 1997-02-27 Sloan-Kettering Institute For Cancer Research Method for treatment of cancer and infectious diseases and compositions useful in same
WO1997026910A2 (en) 1996-01-27 1997-07-31 Max-Delbrück-Centrum für Molekulare Medizin Tumour vaccine for immunotherapy of malignant tumours
US6174001B1 (en) * 1998-03-19 2001-01-16 Hydril Company Two-step, low torque wedge thread for tubular connector
US6254146B1 (en) * 1999-04-23 2001-07-03 John Gandy Corporation Thread form with multifacited flanks
ITRM20020234A1 (en) * 2002-04-30 2003-10-30 Tenaris Connections Bv THREADED JOINT FOR PIPES.
US6832789B2 (en) * 2002-11-01 2004-12-21 Torquelock Corporation Threaded pipe connection with cylindrical metal-to-metal, high pressure containment seal

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996036707A1 (en) * 1995-05-16 1996-11-21 Universita' Degli Studi Di Roma 'la Sapienza' CANDIDA HEAT SHOCK PROTEIN, cDNA AND USES THEREOF
JPH10108678A (en) * 1996-10-07 1998-04-28 Kurita Water Ind Ltd Heat shock promoter, stress-sensing gene and detection of stress

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BHATTACHARYYA T ET AL: "Cloning and subcellular localization of human mitochondrial hsp70.", JOURNAL OF BIOLOGICAL CHEMISTRY, (1995 JAN 27) 270 (4) 1705-10., XP002136598 *
DATABASE EMBL 13 October 1997 (1997-10-13), TALBI ET AL.: "Construction and characterization of a DnaK mutant of Ralstonia eutropha strain CH34", XP002136591 *
PANNEKOEK ET AL.: "Construction of recombinant neisserial HSP60 proteins and mapping of antigenic domains", MOLECULAR MICROBIOLOGY, vol. 15, no. 2, 1995, pages 277 - 285, XP000886440 *

Also Published As

Publication number Publication date
US6497880B1 (en) 2002-12-24
AU1540800A (en) 2000-06-26
WO2000034465A2 (en) 2000-06-15
US20030099664A1 (en) 2003-05-29
EP1137770A2 (en) 2001-10-04
US20070122434A1 (en) 2007-05-31
CA2352608A1 (en) 2000-06-15

Similar Documents

Publication Publication Date Title
WO2000034465A3 (en) HEAT SHOCK GENES AND PROTEINS FROM NEISSERIA MENINGITIDIS, CANDIDA GLABRATA AND $i(ASPERGILLUS FUMIGATUS)
AU3246300A (en) Polypeptides having galactose oxidase activity and nucleic acids encoding same
CA2294516A1 (en) Ikk-.beta. proteins, nucleic acids and methods
WO1999057280A3 (en) Neisseria meningitidis antigens and compositions
WO2001029222A3 (en) Polypeptides having phospholipase b activity and nucleic acids encoding same
CA2339791A1 (en) Methods and compositions for cloning nucleic acid molecules
WO2003033651A3 (en) Compositions and methods for promoting nematode resistance in plants
EP1808180A3 (en) Modified GP 100 and uses thereof
WO1999032617A3 (en) Expression cloning in filamentous fungi
WO2001034635A3 (en) Methods and compositions for peptide synthesis
CA2034504A1 (en) Fungal stress proteins
WO2002002783A3 (en) Expression vectors
WO2003089598A3 (en) Polypeptides having xyloglucanase activity and nucleic acids encoding same
WO1997003192A3 (en) Chromosome 1 gene and gene products related to alzheimer's disease
CA2170515A1 (en) Nucleotide sequences for novel protein tyrosine phosphatases
SI1675956T1 (en) Minimal dna sequence acting as a chromatin insulator and its use in protein expression
TW200512292A (en) Fungal immunomodulatory protein (FIP) prepared by microorganisms and uses thereof
CA2301044A1 (en) Antimicrobial peptide and dna construct and expression system thereof
AU2003287115A1 (en) Fluorescent proteins from copepoda species and methods for using same
WO2001040313A3 (en) Feline immunoregulatory proteins, nucleic acid molecules, and uses thereof
WO2001046225A3 (en) Chlamydia antigens and corresponding dna fragments and uses thereof
WO2004108749A3 (en) Binding peptides: methods for their generation and use
Mistiniene et al. Oligomeric assembly and ligand binding of the members of protein family YER057c/YIL051c/YJGF
WO2001066752A3 (en) Reproduction-specific genes
WO2003035892A3 (en) Novel methods for introducing molecules into cells and vectors and compositions for use in such methods

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref document number: 2000 15408

Country of ref document: AU

Kind code of ref document: A

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1999957790

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2352608

Country of ref document: CA

Kind code of ref document: A

Ref document number: 2352608

WWP Wipo information: published in national office

Ref document number: 1999957790

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642