WO2000034317A3 - Method for reducing immunogenicity of proteins - Google Patents

Method for reducing immunogenicity of proteins Download PDF

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Publication number
WO2000034317A3
WO2000034317A3 PCT/GB1999/004119 GB9904119W WO0034317A3 WO 2000034317 A3 WO2000034317 A3 WO 2000034317A3 GB 9904119 W GB9904119 W GB 9904119W WO 0034317 A3 WO0034317 A3 WO 0034317A3
Authority
WO
WIPO (PCT)
Prior art keywords
epitopes
proteins
humans
self
reducing immunogenicity
Prior art date
Application number
PCT/GB1999/004119
Other languages
French (fr)
Other versions
WO2000034317A2 (en
Inventor
Francis Joseph Carr
Fiona Suzanne Adair
Anita Anne Hamilton
Graham Carter
Original Assignee
Biovation Ltd
Francis Joseph Carr
Fiona Suzanne Adair
Anita Anne Hamilton
Graham Carter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9826925.1A external-priority patent/GB9826925D0/en
Priority claimed from GBGB9902139.6A external-priority patent/GB9902139D0/en
Application filed by Biovation Ltd, Francis Joseph Carr, Fiona Suzanne Adair, Anita Anne Hamilton, Graham Carter filed Critical Biovation Ltd
Priority to JP2000586759A priority Critical patent/JP2002534959A/en
Priority to AU16676/00A priority patent/AU776910B2/en
Priority to DE69934967T priority patent/DE69934967T2/en
Priority to CA002342967A priority patent/CA2342967A1/en
Priority to EP99959535A priority patent/EP1051432B1/en
Publication of WO2000034317A2 publication Critical patent/WO2000034317A2/en
Publication of WO2000034317A3 publication Critical patent/WO2000034317A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

It is known that proteins, or parts of them, may be rendered non- or less immunogenic to humans or other species by identifying one or more potential T cell epitopes and eliminating them by amino acid modification. Conventionally, certain epitopes may be retained in a protein sequence if the peptides constituting such epitopes are present in endogenous human protein, since they would be recognised as 'self'. However, it has now been found that even self epitopes may give rise to immune reactions. The invention provides for their elimination, for example by recombinant DNA technology, to render them more useful for administration to humans, for example for therapeutic or diagnostic purposes.
PCT/GB1999/004119 1998-12-08 1999-12-08 Method for reducing immunogenicity of proteins WO2000034317A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2000586759A JP2002534959A (en) 1998-12-08 1999-12-08 Methods for modifying immunogenic proteins
AU16676/00A AU776910B2 (en) 1998-12-08 1999-12-08 Modifying protein immunogenicity
DE69934967T DE69934967T2 (en) 1998-12-08 1999-12-08 METHOD FOR REDUCING IMMUNOGENICITY OF PROTEINS
CA002342967A CA2342967A1 (en) 1998-12-08 1999-12-08 Modifying protein immunogenicity
EP99959535A EP1051432B1 (en) 1998-12-08 1999-12-08 Method for reducing immunogenicity of proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9826925.1A GB9826925D0 (en) 1998-12-08 1998-12-08 Therapeutic non-homologous proteins
GBGB9902139.6A GB9902139D0 (en) 1999-02-02 1999-02-02 Therapeutic non-autologous proteins
GB9826925.1 1999-02-02
GB9902139.6 1999-02-02

Publications (2)

Publication Number Publication Date
WO2000034317A2 WO2000034317A2 (en) 2000-06-15
WO2000034317A3 true WO2000034317A3 (en) 2000-08-17

Family

ID=26314799

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/004119 WO2000034317A2 (en) 1998-12-08 1999-12-08 Method for reducing immunogenicity of proteins

Country Status (9)

Country Link
EP (1) EP1051432B1 (en)
JP (1) JP2002534959A (en)
CN (1) CN1202128C (en)
AT (1) ATE352559T1 (en)
AU (1) AU776910B2 (en)
CA (1) CA2342967A1 (en)
DE (1) DE69934967T2 (en)
ES (1) ES2278463T3 (en)
WO (1) WO2000034317A2 (en)

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US9399680B2 (en) 2007-12-05 2016-07-26 Chugai Seiyaku Kabushiki Kaisha Nucleic acids encoding anti-NR10 antibodies

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