WO2000031133A3 - Potassium channel interactors and uses therefor - Google Patents

Potassium channel interactors and uses therefor Download PDF

Info

Publication number
WO2000031133A3
WO2000031133A3 PCT/US1999/027428 US9927428W WO0031133A3 WO 2000031133 A3 WO2000031133 A3 WO 2000031133A3 US 9927428 W US9927428 W US 9927428W WO 0031133 A3 WO0031133 A3 WO 0031133A3
Authority
WO
WIPO (PCT)
Prior art keywords
pcip
nucleic acid
acid molecules
potassium channel
proteins
Prior art date
Application number
PCT/US1999/027428
Other languages
French (fr)
Other versions
WO2000031133A2 (en
Inventor
Kenneth Rhodes
Maria Betty
Huai-Ping Ling
Wenqian An
Original Assignee
Millennium Pharm Inc
American Home Prod
Kenneth Rhodes
Maria Betty
Ling Huai Ping
Wenqian An
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/298,731 external-priority patent/US6369197B1/en
Priority claimed from US09/350,874 external-priority patent/US20020019020A1/en
Priority claimed from US09/399,913 external-priority patent/US6361971B1/en
Priority claimed from US09/400,492 external-priority patent/US7115381B1/en
Priority to AU14797/00A priority Critical patent/AU775713B2/en
Priority to BR9915513-3A priority patent/BR9915513A/en
Priority to MXPA01004903A priority patent/MXPA01004903A/en
Priority to CA002351365A priority patent/CA2351365A1/en
Priority to KR1020017006388A priority patent/KR20010086407A/en
Priority to JP2000583959A priority patent/JP2002530104A/en
Application filed by Millennium Pharm Inc, American Home Prod, Kenneth Rhodes, Maria Betty, Ling Huai Ping, Wenqian An filed Critical Millennium Pharm Inc
Priority to EA200100566A priority patent/EA200100566A1/en
Priority to IL14314899A priority patent/IL143148A0/en
Priority to NZ512332A priority patent/NZ512332A/en
Priority to EP99972644A priority patent/EP1131349A2/en
Publication of WO2000031133A2 publication Critical patent/WO2000031133A2/en
Priority to US09/670,756 priority patent/US7078481B1/en
Publication of WO2000031133A3 publication Critical patent/WO2000031133A3/en
Priority to NO20012471A priority patent/NO20012471L/en
Priority to HK02107500.6A priority patent/HK1046914A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US1999/027428 1998-11-20 1999-11-19 Potassium channel interactors and uses therefor WO2000031133A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
EA200100566A EA200100566A1 (en) 1998-11-20 1999-11-19 Isolated nucleic acid molecules, isolated polypeptides AND METHOD FOR PRODUCTION THEREOF, METHOD FOR DETECTING THEM present in the sample (VARIANTS) host cell (VARIANTS) antibody kit (OPTIONS), a method of modulating activity of a polypeptide, IDENTIFICATION METHOD (VARIANTS) AND APPLICATION OF COMPOUNDS METHOD OF IDENTIFICATION OF THE SUBJECT (OPTIONS) AND METHOD OF TREATING THE SUBJECT WITH DAMAGE ASSOCIATED WITH POTASSIUM CHANNELS (OPTIONS)
IL14314899A IL143148A0 (en) 1998-11-20 1999-11-19 Potassium channel interactors and uses therefor
NZ512332A NZ512332A (en) 1998-11-20 1999-11-19 Potassium channel interactors and uses therefor
BR9915513-3A BR9915513A (en) 1998-11-20 1999-11-19 Potassium channel interactants and uses for such
EP99972644A EP1131349A2 (en) 1998-11-20 1999-11-19 Potassium channel interactors and uses therefor
MXPA01004903A MXPA01004903A (en) 1998-11-20 1999-11-19 Potassium channel interactors and uses therefor.
CA002351365A CA2351365A1 (en) 1998-11-20 1999-11-19 Potassium channel interactors and uses therefor
KR1020017006388A KR20010086407A (en) 1998-11-20 1999-11-19 Potassium channel interactors and uses therefor
JP2000583959A JP2002530104A (en) 1998-11-20 1999-11-19 Potassium channel interactors and uses thereof
AU14797/00A AU775713B2 (en) 1998-11-20 1999-11-19 Potassium channel interactors and uses therefor
US09/670,756 US7078481B1 (en) 1998-11-20 2000-09-27 Potassium channel interactors and uses therefor
NO20012471A NO20012471L (en) 1998-11-20 2001-05-18 Potassium channel interactors and uses thereof
HK02107500.6A HK1046914A1 (en) 1998-11-20 2002-10-16 Potassium channel interactors and uses therefor

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US10933398P 1998-11-20 1998-11-20
US60/109,333 1998-11-20
US11003398P 1998-11-25 1998-11-25
US60/110,033 1998-11-25
US11027798P 1998-11-30 1998-11-30
US60/110,277 1998-11-30
US09/298,731 1999-04-23
US09/298,731 US6369197B1 (en) 1998-11-20 1999-04-23 Potassium channel interactors and uses therefor
US09/350,874 1999-07-09
US09/350,614 1999-07-09
US09/350,874 US20020019020A1 (en) 1998-11-20 1999-07-09 Methods for treating cardiovascular disorders
US09/350,614 US6689581B1 (en) 1998-11-20 1999-07-09 Potassium channel interactors and uses therefor
US09/400,492 US7115381B1 (en) 1998-11-20 1999-09-21 Methods for treating cardiovascular disorders
US09/399,913 US6361971B1 (en) 1998-11-20 1999-09-21 Nucleic acid molecules encoding potassium channel interactors and uses therefor
US09/400,492 1999-09-21
US09/399,913 1999-09-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/400,492 Continuation-In-Part US7115381B1 (en) 1998-11-20 1999-09-21 Methods for treating cardiovascular disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/670,756 Continuation-In-Part US7078481B1 (en) 1998-11-20 2000-09-27 Potassium channel interactors and uses therefor

Publications (2)

Publication Number Publication Date
WO2000031133A2 WO2000031133A2 (en) 2000-06-02
WO2000031133A3 true WO2000031133A3 (en) 2000-10-05

Family

ID=27574798

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027428 WO2000031133A2 (en) 1998-11-20 1999-11-19 Potassium channel interactors and uses therefor

Country Status (12)

Country Link
EP (1) EP1131349A2 (en)
JP (1) JP2002530104A (en)
CN (1) CN1346368A (en)
AU (1) AU775713B2 (en)
BR (1) BR9915513A (en)
CA (1) CA2351365A1 (en)
CZ (1) CZ20011764A3 (en)
IL (1) IL143148A0 (en)
MX (1) MXPA01004903A (en)
NO (1) NO20012471L (en)
NZ (1) NZ512332A (en)
WO (1) WO2000031133A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369197B1 (en) 1998-11-20 2002-04-09 Millennium Pharmaceuticals, Inc. Potassium channel interactors and uses therefor
US7078481B1 (en) 1998-11-20 2006-07-18 Wyeth Potassium channel interactors and uses therefor
CN1498271A (en) * 2000-09-27 2004-05-19 ǧ��ҩƷ��˾ Potassium channel interactors protein and uses therefor
US9029080B2 (en) * 2008-11-06 2015-05-12 Basf Se Screening assay for insecticides
GB201906482D0 (en) * 2019-05-08 2019-06-19 Evox Therapeutics Ltd Exosome comprising stabilized RNA therapeutics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016185A2 (en) * 1996-10-17 1998-04-23 Nps Pharmaceuticals, Inc. Potassium channel blocking compounds and their use
WO1999049038A2 (en) * 1998-03-26 1999-09-30 Incyte Pharmaceuticals, Inc. Human calcium-binding proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016185A2 (en) * 1996-10-17 1998-04-23 Nps Pharmaceuticals, Inc. Potassium channel blocking compounds and their use
WO1999049038A2 (en) * 1998-03-26 1999-09-30 Incyte Pharmaceuticals, Inc. Human calcium-binding proteins

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BUXBAUM ET AL.: "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment", NATURE MEDICINE, vol. 10, October 1998 (1998-10-01), pages 1177 - 1181, XP002132975 *
CARRION ET AL.: "DREAM is a Ca2+-regulated transcriptional repressor", NATURE, vol. 398, 4 March 1999 (1999-03-04), pages 80 - 84, XP000700251 *
CASTAGNA ET AL.: "Molecular characteristics of mammalian and insect amino acid transporters: implications for amino acid homeostasis", THE JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 200, 1997, pages 269 - 286, XP002132978 *
DATABASE EMBL 1 July 1998 (1998-07-01), NCI-CGAP: "...Homo sapiens cDNA clone IMAGE:1659605 3' similar to SW:VIS3_RAT P35333 VISININ-LIKE PROTEIN", XP002133128 *
DATABASE EMBL 14 March 1998 (1998-03-14), BONALDO ET AL.: "Calcium-binding protein NCS-1", XP002133130 *
DATABASE EMBL 8 October 1998 (1998-10-08), HASHIMOTO ET AL.: "Mus musculus brain cDNA, clone MNCb-7005 : 5' end", XP002133129 *
LOMBARDI ET AL.: "Structure-activity relationships of the Kvbeta1 inactivation domain and its putative receptor probed using peptide analogs of voltage-gated potassium channel alpha- and beta-subunits", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 46, 13 November 1998 (1998-11-13), pages 30092 - 30096, XP002132979 *
VAN HILLE ET AL.: "Identification of two subunit A isoforms of the vacuolar H+-ATPase in human osteoclastoma", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 10, 1993, pages 7075 - 7080, XP002132977 *

Also Published As

Publication number Publication date
IL143148A0 (en) 2002-04-21
MXPA01004903A (en) 2003-03-10
CN1346368A (en) 2002-04-24
BR9915513A (en) 2002-02-05
NO20012471D0 (en) 2001-05-18
NO20012471L (en) 2001-07-18
EP1131349A2 (en) 2001-09-12
CZ20011764A3 (en) 2002-01-16
AU775713B2 (en) 2004-08-12
AU1479700A (en) 2000-06-13
JP2002530104A (en) 2002-09-17
CA2351365A1 (en) 2000-06-02
NZ512332A (en) 2004-02-27
WO2000031133A2 (en) 2000-06-02

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