WO2000030704A1 - Dispositif d'injection multidose par jet ameliore sans aiguille - Google Patents

Dispositif d'injection multidose par jet ameliore sans aiguille Download PDF

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Publication number
WO2000030704A1
WO2000030704A1 PCT/US1999/027856 US9927856W WO0030704A1 WO 2000030704 A1 WO2000030704 A1 WO 2000030704A1 US 9927856 W US9927856 W US 9927856W WO 0030704 A1 WO0030704 A1 WO 0030704A1
Authority
WO
WIPO (PCT)
Prior art keywords
cylinder
plunger
piston
valve
nozzle
Prior art date
Application number
PCT/US1999/027856
Other languages
English (en)
Inventor
Marc R. Pickrell
Jerry R. Pickrell
Original Assignee
Pickrell Marc R
Pickrell Jerry R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pickrell Marc R, Pickrell Jerry R filed Critical Pickrell Marc R
Priority to AU17442/00A priority Critical patent/AU1744200A/en
Publication of WO2000030704A1 publication Critical patent/WO2000030704A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/204—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically connected to external reservoirs for multiple refilling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum

Definitions

  • the present invention relates to an improved multi-dose device used to inject injectable material (nominally a liquid) into the hypoderma of animals or humans without the use of a hypodermic needle by a procedure known as “needleless hypodermic jet injection.
  • injectable material includes liquids, medicaments, inoculants, powders and substances which contain suspended solid particles.
  • animal as used in this specification includes a mammal, a human, a bird and a reptile and the term “propellant” as used in this specification includes the term “gas, " "air” and all substances commonly associated therewith, and all combinations thereof, unless the context indicates otherwise.
  • skin as used in this specification includes the term “hide. "
  • Pneumatically-operated injection devices were created as an alternative to needle injection devices to ameliorate some of the shortcomings noted above.
  • the pneumatically-operated device discharges injectable material from a reservoir through a port as a jet by a piston moved along the reservoir by subjecting it to a force created by the sudden release of a propellant under pressure.
  • Propellant has been supplied to needleless injection devices to eject injectable material by various means, ranging from the use of small gas capsules which are punctured at the time of delivery to larger portable or stationary sources of compressed propellant for larger mass- dose models.
  • an improved multi-dose jet injection device intended for connection to a propellant- dispensing device which regulates a compressed propellant supply derived from an external, separate source.
  • a device in accordance with the invention referenced herein is intended to be particularly and uniquely well-suited for the single or mass-inoculation of animals.
  • the device in accordance with the invention may be connected to any source of compressed propellant having a suitable fitting for connection, but it is primarily intended for attachment to any compressed propellant supply with a suitable outlet pressure regulator to supply the compressed propellant at a regulated, constant mass flow and at an acceptable pressure. This flow and pressure may be adjusted or changed by the external air pressure regulator between the times when an injection is being administered.
  • the use of a nipple with a greater or lesser hole diameter will, in concert with the air pressure regulator, adjust the medicament outflow pressure upwards or downwards in relationship to the size of the hole, resulting in a greater or lesser skin penetration.
  • the propulsion force for the device in accordance with the invention may also be an electromagnetic or mechanical means.
  • the control of propulsion forces existing within the device in accordance with the invention, in lieu of or in combination with a mechanical means may also be a pneumatic or electromagnetic means.
  • a device for multi-dose injection of injectable material into the body of an animal comprising a pneumatically and/or electro agnetically-operated needleless jet injector means for injecting injectable material through the skin of an animal into the hypoderma with a semiautomatic adjustable injection force and a control means for manually adjusting the injection dosage.
  • FIG. 1 is an external view of the left side (from the operator's perspective) of the device in accordance with the invention.
  • the operator can then slide the tube 2 lengthwise of the body 7 to align a selected one of the four circumferential segments of the channel with the index pin. The operator then turns the tube 2 so that the index pin enters the selected circumferential segment and tightens the clamping nut 4.
  • a nozzle 1 is screwed onto the forward end of the tube 2. Between the nozzle and the forward end of the tube 2 there is a nozzle check valve composed of a ball 34 and a spring 38. The nozzle check valve allows fluid to pass out of the interior space of the tube 2 through the nozzle but does not permit reverse flow.
  • a plunger 3 is fitted slidably in the tube 2.
  • a medicament chamber is defined between the plunger 3 and the forward end of the tube 2.
  • the plunger is attached to a hollow shaft 6 which is in turn attached at its rear end to a piston 15C.
  • the piston 15C is fitted slidably in the cylindrical body 7.
  • a compression spring 8 effective between the nose piece 5 and the piston 15C urges the piston rearwards .
  • a trigger latch 20 (not shown in detail) engages the actuator shaft 19 and prevents movement of the shaft 19 towards the rear of the injector.
  • the trigger latch 20 releases the actuator shaft 19 and allows the shaft to move rearwards against the spring-loaded control button 23.
  • the chambers forward of the piston 15A, 15B and 15C are vented by holes 26 in the wall of the cylindrical body 7. All three pistons 15A, 15B and 15C are forced forwards, and the force applied to the pistons is transmitted to the plunger 3, which is driven forwards. A high pressure is thereby generated in the medicament chamber and medicament is expelled from the medicament chamber at high pressure through the nozzle 1.
  • the medicament be expelled from the nozzle as a rapidly spreading spray rather than as a narrow jet. It has been observed in tests of the pattern in which liquid is expelled from the nozzle into the ambient air towards a target that is spaced from the nozzle that the liquid is in fact expelled as a rapidly spreading spray rather than as a narrow jet. It is believed that this desirable characteristic is caused or aided by the fact that the medicament must flow past the ball 34 and spring 38, which impart turbulence to the flow of medicament and ensure that the flow of medicament is non-laminar.

Abstract

Cette invention se rapporte à un dispositif d'injection multidose par jet amélioré sans aiguille, qui comprend un réservoir, lequel reçoit un agent propulseur sous pression projeté via une valve (21) vers trois ensembles à pistons (15A-15C) et cylindres agissant en coopération. Lorsque l'agent propulseur est projeté vers les pistons (15A-15C), ceux-ci se déplacent de façon à éjecter la substance injectable du réservoir contenu dans le dispositif sous la forme d'un jet à travers une buse (1) placée contre la peau du receveur, jusque dans l'hypoderme.
PCT/US1999/027856 1998-11-24 1999-11-23 Dispositif d'injection multidose par jet ameliore sans aiguille WO2000030704A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU17442/00A AU1744200A (en) 1998-11-24 1999-11-23 Improved multi-dose non-needle jet injection device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10986798P 1998-11-24 1998-11-24
US60/109,867 1998-11-24

Publications (1)

Publication Number Publication Date
WO2000030704A1 true WO2000030704A1 (fr) 2000-06-02

Family

ID=22329982

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027856 WO2000030704A1 (fr) 1998-11-24 1999-11-23 Dispositif d'injection multidose par jet ameliore sans aiguille

Country Status (2)

Country Link
AU (1) AU1744200A (fr)
WO (1) WO2000030704A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068296A2 (fr) * 2002-02-12 2003-08-21 Medical International Technology (Mit) Inc. Injecteur sans aiguille
CN109331297A (zh) * 2018-09-27 2019-02-15 欧罗巴科技发展（深圳）有限公司 一种电子式射流注射器
WO2021236092A1 (fr) * 2020-05-22 2021-11-25 Pulse Needlefree Systems, Inc. Dispositif d'injection et composants correspondants
DE102020134181A1 (de) 2020-12-18 2022-06-23 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
CN117379643A (zh) * 2023-11-17 2024-01-12 青岛力腾医药科技有限公司 一种去氧胆酸注射液注射装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342310A (en) * 1980-07-08 1982-08-03 Istvan Lindmayer Hydro-pneumatic jet injector
US5503627A (en) * 1989-11-09 1996-04-02 Bioject, Inc. Ampule for needleless injection
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342310A (en) * 1980-07-08 1982-08-03 Istvan Lindmayer Hydro-pneumatic jet injector
US5503627A (en) * 1989-11-09 1996-04-02 Bioject, Inc. Ampule for needleless injection
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068296A2 (fr) * 2002-02-12 2003-08-21 Medical International Technology (Mit) Inc. Injecteur sans aiguille
WO2003068296A3 (fr) * 2002-02-12 2003-10-16 Medical Internat Technology Mi Injecteur sans aiguille
CN109331297A (zh) * 2018-09-27 2019-02-15 欧罗巴科技发展（深圳）有限公司 一种电子式射流注射器
WO2021236092A1 (fr) * 2020-05-22 2021-11-25 Pulse Needlefree Systems, Inc. Dispositif d'injection et composants correspondants
EP4153277A4 (fr) * 2020-05-22 2024-02-28 Pulse Needlefree Systems Inc Dispositif d'injection et composants correspondants
DE102020134181A1 (de) 2020-12-18 2022-06-23 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids
CN117379643A (zh) * 2023-11-17 2024-01-12 青岛力腾医药科技有限公司 一种去氧胆酸注射液注射装置

Also Published As

Publication number Publication date
AU1744200A (en) 2000-06-13

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