WO2000030475A1 - Aliments contenant des substances nourrissantes pour les cheveux - Google Patents

Aliments contenant des substances nourrissantes pour les cheveux Download PDF

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Publication number
WO2000030475A1
WO2000030475A1 PCT/JP1999/006550 JP9906550W WO0030475A1 WO 2000030475 A1 WO2000030475 A1 WO 2000030475A1 JP 9906550 W JP9906550 W JP 9906550W WO 0030475 A1 WO0030475 A1 WO 0030475A1
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WO
WIPO (PCT)
Prior art keywords
hair
white
crow
food
necked
Prior art date
Application number
PCT/JP1999/006550
Other languages
English (en)
Japanese (ja)
Inventor
Chunyu Cao
Original Assignee
Wakamoto Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wakamoto Pharmaceutical Co., Ltd. filed Critical Wakamoto Pharmaceutical Co., Ltd.
Priority to AU14087/00A priority Critical patent/AU1408700A/en
Publication of WO2000030475A1 publication Critical patent/WO2000030475A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

Definitions

  • the present invention relates to a hair-growing food characterized by containing Baishou u as an active ingredient.
  • Hair has a hair cycle.
  • they are anagen, involution and telogen.
  • the hair matrix and hair papilla unite to form a hair bulb, and hair matrix cells use amino acids, minerals, vitamins, and other nutrients in the blood to stimulate hair while undergoing active cell division. Generate and grow.
  • the hair matrix and the hair matrix head separate, and the hair regrowth ceases.
  • the follicle and the papilla are completely separated, the follicle becomes smaller, and the follicle has moved to the vicinity of the pilus muscle. In this state, the hair has not stopped coming out and has stopped, and this state generally lasts several months.
  • the hair enters the anagen phase again through the hair growth preparation stage, and new hair is generated. As the new hair grows, the old hair depilates so as to be pushed out.
  • Alopecia can be roughly classified into premature alopecia, senile alopecia and alopecia areata. If classified by cause, androgenetic alopecia, seborrheic alopecia, stressful alopecia, diffuse alopecia, malnutrition type alopecia, dermatosis, hair loss due to underlying diseases such as endocrine disorders, postpartum hair loss, scarring hair loss, radiation Hair loss by drugs such as anticancer drugs, toxins, boiling water, acid, Hair loss due to external causes such as lukari, trauma, mold, and bacterial hair loss are classified. In many cases, hair loss is caused by a combination of multiple causes.
  • Hair loss is a serious problem for many people, and research into hair restorers has been active. Even now, there is a search for even better hair restorers. Numerous natural and synthetic compounds with a hair-growth effect are known.
  • Examples of natural-derived hair restorers include Mycal Flower Extract, Sempuri Extract Extract, Cordyceps Extract, Entrance Extract, Bitter Ginseng Extract, Rose Mariex Extract, Tamasaki Kippura Wisteria Extract, Pepper tincture, Carrot extract, duke extract, white medicinal extract, cashew extract, brassicae extract, castor oil, hinokitiol, / 5-glycyrrhizic acid, monoammonium glycyrrhizinate, neo-canal, cepharanthin and the like are known.
  • Synthetic hair restorers include carpronium chloride, minoxidil, dialkyl monoamine derivatives, ethinyl estradiol, getyl stil vestellol, estradioyl benzoate, hydrocortisone, resorcinol, allantoin, diphenhydramine hydrochloride, mononitro Guaiacol, pendus decanoic acid glyceride and the like are known.
  • vitamins such as benzyl nicotinate, vitamin E and its derivatives, pantothenyl ether ether, D-pantothenyl alcohol, pyridoxine hydrochloride, calcium pantothenate, vitamin A, vitamin B6, vitamin F and vitamin H are also formulated in the hair restorer. ing.
  • amino acids such as serine, calcium aspartate, and methionine
  • flavors such as menthol
  • anti-inflammatory agents such as salicylic acid
  • solvents such as isopropylmethylphenol, isopropylmethylether, dibutylhydroxytoluene, ester acetate, and ethanol.
  • hair-growth components are used to expand capillaries and promote blood circulation, activate hair cells, Activating vesicles, anti-androgen effect, suppressing sebaceous gland activity, removing sebum, nourishment, strengthening skin, activating skin metabolism, moisturizing, preventing dandruff, sterilizing, preventing gray hair, anti-inflammatory, and other favorable effects on hair growth
  • multiple components are selected and blended to give a favorable feeling of use.
  • All of these hair restorers are used topically on the hair and are not topically effective for eating.
  • An object of the present invention is to provide an effective and safe food having a hair-restoring action, that is, a hair-restoring food, which does not depend on conventional external use.
  • the present invention is a food for hair growth, characterized by containing white crows as an active ingredient.
  • Figure 1 is a schematic diagram of the search hair cycle. BEST MODE FOR CARRYING OUT THE INVENTION
  • the white crow used in the present invention is a plant widely distributed in China such as Hebei, Henan, Shandong, Shanxi, Liaoning, Jiangsu and Jilin. It is also cultivated in Shandong and Jiangsu provinces.
  • the original plant belongs to the genus Ascelepiadaceae, and it has a variety of types such as ear-leaf cow skin (Cynanchun auriculatum Royle ex Wight), bisan mountain cow skin (Cynanchum wilforan (Maxim.) Hemsl), and cypress leaf cow skin (Cynanchum bungei Decne).
  • the rhizomes of the white necked crow have been edible in the private sector for more than 100 years.
  • the breed of Bai Jiang Wu in Jiangsu Province is considered to be the ear-leaf cow skin because of its botanical characteristics.
  • Nakaanashi (2nd volume, People's Health Publishing Company, p.335, 1979) has the pharmacology of the white-necked crow rhizome. Action and toxicity are described. That is, the pharmacological action has a cardiotonic effect, but the toxicity is that when mice were orally administered a suspension of the original plant powder at 15 g / kg and a decoction solution at 30 g / kg, abnormal appearance and behavior of animals and abnormalities were observed. It is stated that no deaths occurred.
  • Embodiments of the present invention are basically foods, but in addition to general foods, forms included in the concept of so-called functional foods, health foods, foods for specified health use, dietary supplements, special nutritional foods, etc. Is also included.
  • Shiraneck crow is originally a rhizome, and the product obtained by processing and refining the rhizome part is, for example, in the form of purified powder, powder, flake, chip, paste, liquid, etc. It is marketed mainly as health food and natural food in China.
  • Product examples include, for example, Guo Baekju Wheat Flour (Yancheng Jinyu Health Foods Co., Ltd.), Guo Baekju Wang Fragment (Yancheng Jinju Health Foods Co., Ltd.), Jingwu Jing (Jiangsu Binhai Jingwu Product) Factory), Shuwu Nutrition Mouth Liquid (Jiangsu Binhai Jingwu Product Factory), Shuwo Fast Soybean Milk Powder (Jiangsu Binhai Jingwu Product Factory), Whole Drain (Purified Shuwu Powder; Jiangsu Binhai Jingwu Product) Exhibition).
  • these products can be used as they are.
  • Hakuju crow is one of the natural food ingredients. Therefore, various processings used in food engineering are possible. For example, various operations such as heating, crushing, extraction, freeze-drying, drying, and extrusion can be added.
  • processed products processed by adding various known chemical operations can be used as one embodiment of the present invention.
  • a single solvent such as water, ethanol, hydrated ethanol, methanol, hydrated methanol, ethyl acetate, acetone, or ether, or a mixed solvent thereof, and then removing the solvent as necessary, processed products
  • water suspension Suspended liquids are processed with a cationic or anionic ion-exchange resin to remove processed metal ions and other processed products.
  • one of the main components of the rhizome of Shirakubi-kara is starch, so it is possible to make it into a new food form by processing with o-amylase, branching enzyme, and glucoamylase.
  • the white rhinoceros rhizome is basically one of the food ingredients.
  • White rhinoceros rhizomes may be peeled, eaten raw, or raw with skin. They may be eaten in chips. Generally, powdered products are heated and dissolved in water to make porridge and used for food.
  • other food ingredients sweeteners, colorings, seasonings, odorants, sour preservatives, pastes,
  • the form of food prepared by cooking them and the like can also be one of the embodiments of the present invention.
  • these additives for example, what is known as a food additive can be used according to the food additive use standard.
  • One of the embodiments of the present invention is to use various natural products and synthetic products known to have a hair-growth effect within the range of edible use in Shiraneck crow or processed products thereof. Can be.
  • various vitamins and various amino acids are mixed and used. be able to.
  • the white-necked crow or its processed product may be added to other foods (eg, rice porridge, udon, buckwheat, kamaboko, or other paste products).
  • other foods eg, rice porridge, udon, buckwheat, kamaboko, or other paste products.
  • Example 1 Peel the white necked rhizome, rinse with water and grind. Add cold water to paint. Collect the precipitate by centrifugation. This operation is repeated two or three times, and the obtained precipitate is dried to obtain a white powder.
  • Example 1 Peel the white necked rhizome, rinse with water and grind. Add cold water to paint. Collect the precipitate by centrifugation. This operation is repeated two or three times, and the obtained precipitate is dried to obtain a white powder.
  • Sugar-necked flour (10-50 g) is suspended in a small amount of cold water, and boiling water is added to the mixture while stirring.
  • Purified white bean flour (12 g) was suspended in 12 ml of 20% aqueous ethanol.
  • a 0.3 ml suspension was orally administered to rats (Long Evans, Oss, 5 weeks old, 5 animals per group) three times a day. Seven days after the start of administration, the hair on the rat head was cut with a clipper in a size of 2 ⁇ 5 cm. Thereafter, 0.3 ml of the suspension was orally administered once a day three times.
  • 20% aqueous ethanol was orally administered daily at 0.3 ml three times a day.
  • the cut hairs of all the rats were completed after 25 days, whereas in the control group, the cut hairs of all the rats were recovered. It took 30-34 days to get together.
  • Purified white-necked crow flour (7.2 kg) was suspended in 14.4 liters of water overnight. Rabbits (oss, 2.5-3.0 kg, 4 birds per group) were orally administered 3 times a day once per day. Sixty days after the start of the administration, the hair at the center of the inner side of the rabbit ear was shaved to a size of 2.5 ⁇ 2.5 cm. Thereafter, 3 ml of the suspension was orally administered once a day three times a day. As a control group (four birds), water was orally administered daily, 12 ml at a time, 1 time, 3 times. Over 30 days after shaving, the shaved area was observed for hair growth. As a result, the group to which the purified white-necked flour suspension was administered showed significant growth as compared to the control group. Test example 3
  • mice were administered a white-necked crow mixed diet (10% white-necked bird) in which 10% of the aged white-necked crow pieces were mixed with a normal solid feed CRF-1 (Oriental Yeast Co., Ltd.). Also, C The group fed RF-1 was the control group.
  • mice Male C3H strain SPF mice (4 weeks old at the time of arrival) were divided into a 10% white-necked crow group and a CRF-1 group (control group). They were bred at F-1. Pentobarbital sodium (Nembutal: Dainippon Pharmaceutical) was intraperitoneally administered (30 mg / kg) to mice bred on a mixed diet for 4 weeks, and under anesthesia, the animals were roughly shaved using an electric clipper (Natsume Seisakusho, blade No. 40).
  • the L value of the shaved part was measured using a colorimeter (Color-Reader-CR-13: Minoru). The measurement was performed at five points around the center of the shaved part, and the average value was taken as the L value of the solid shaved part.
  • the hair score (1-10) of each individual was expressed as the sum of the area (1-5) and the growth state (1-5).
  • Formalin-fixed mouse skin was cut out so that the hair root tissues at the telogen and anagen sites were crossed, respectively, embedded in paraffin according to a conventional method, and hematoxylin and eosin stained specimens were prepared. The following searches were performed .
  • the hair cycle was classified according to the following criteria.
  • Fig. 1 shows a schematic diagram of the search hair cycle.
  • the following sites estimated to correspond to the maximum diameter of hair follicles were measured by the following image processing method.
  • a digital camera RD-175 (Minol Yu Co., Ltd.) can be used for each unit. , And photographed any number of places and converted them into digital images.
  • the cross section of the hair follicle was extracted using the Photoshop software (Adobe Systems Incorporated) for the corresponding hair follicle. Thereafter, the extracted image was measured for the short diameter using the image analysis software Sion Image (National Institutes of Health), and the diameter was measured.
  • the L value and the score are shown as the average soil standard error, and the follicle diameter is shown as the average soil standard deviation.
  • the statistical significance of each group is tested by the Student's test if the variance is equal by the F-test, and the Aspin-Welch test is performed if the variances are not equal. There was.
  • L value On the 14th day after shaving, the L values of the control group and the 10% white crow group were 53.7 ⁇ 0.2 and 41.5 ⁇ 1.1, respectively. ) L value decreased significantly.
  • the follicle diameters of the control group and the 10% white neck crow group were 58.2 ⁇ 4.0 and 65.7 ⁇ 4.1, respectively, and the 10% white neck crow group was significantly ( ⁇ ⁇ 0.01) increased hair follicle diameter.
  • the present invention is useful for people suffering from hair loss and thinning hair, because the superior hair growth effect can be obtained by eating Shiraneck Karasu as compared with a hair growth agent when topically used externally according to the conventional technology. is there.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne des aliments contenant des substances nourrissantes pour les cheveux, qui comprennent comme principe actif du rhizome de Baishouwu. Ils présentent un effet nourrissant sur les cheveux, à la fois sûr et excellent.
PCT/JP1999/006550 1998-11-26 1999-11-25 Aliments contenant des substances nourrissantes pour les cheveux WO2000030475A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU14087/00A AU1408700A (en) 1998-11-26 1999-11-25 Hair-nourishing foods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10/335240 1998-11-26
JP33524098 1998-11-26

Publications (1)

Publication Number Publication Date
WO2000030475A1 true WO2000030475A1 (fr) 2000-06-02

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Application Number Title Priority Date Filing Date
PCT/JP1999/006550 WO2000030475A1 (fr) 1998-11-26 1999-11-25 Aliments contenant des substances nourrissantes pour les cheveux

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AU (1) AU1408700A (fr)
WO (1) WO2000030475A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010504568A (ja) * 2006-08-25 2010-02-12 レストレーション ロボティクス，インク． 毛包単位を分類するシステム及び方法
CN109182152A (zh) * 2018-11-15 2019-01-11 重庆农笑农业发展有限公司 用于提高冬虫夏草菌丝体活性成分的培养基

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61178924A (ja) * 1985-02-04 1986-08-11 Kesaichi Shibata 養毛効果を有する健康食品
JPH07132064A (ja) * 1993-11-13 1995-05-23 Sunstar Inc 育毛養毛用食品
JPH09252746A (ja) * 1996-03-22 1997-09-30 Nippon Kankyo Yakuhin Kk 栄養補助食品

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61178924A (ja) * 1985-02-04 1986-08-11 Kesaichi Shibata 養毛効果を有する健康食品
JPH07132064A (ja) * 1993-11-13 1995-05-23 Sunstar Inc 育毛養毛用食品
JPH09252746A (ja) * 1996-03-22 1997-09-30 Nippon Kankyo Yakuhin Kk 栄養補助食品

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010504568A (ja) * 2006-08-25 2010-02-12 レストレーション ロボティクス，インク． 毛包単位を分類するシステム及び方法
JP4847586B2 (ja) * 2006-08-25 2011-12-28 レストレーション ロボティクス，インク． 毛包単位を分類するシステム及び方法
CN109182152A (zh) * 2018-11-15 2019-01-11 重庆农笑农业发展有限公司 用于提高冬虫夏草菌丝体活性成分的培养基
CN109182152B (zh) * 2018-11-15 2020-10-30 锬酃藏虫草生物科技(深圳)有限公司 用于提高冬虫夏草菌丝体活性成分的培养基

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