WO2000029418A3 - Inhibitors of glycosidases and glycosyltransferases - Google Patents

Inhibitors of glycosidases and glycosyltransferases Download PDF

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Publication number
WO2000029418A3
WO2000029418A3 PCT/EP1999/008727 EP9908727W WO0029418A3 WO 2000029418 A3 WO2000029418 A3 WO 2000029418A3 EP 9908727 W EP9908727 W EP 9908727W WO 0029418 A3 WO0029418 A3 WO 0029418A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycosyltransferases
glycosidases
inhibitors
identification
preparation
Prior art date
Application number
PCT/EP1999/008727
Other languages
French (fr)
Other versions
WO2000029418A2 (en
Inventor
Chi-Huey Wong
Original Assignee
Novartis Ag
Novartis Erfind Verwalt Gmbh
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/326,902 external-priority patent/US6232450B1/en
Application filed by Novartis Ag, Novartis Erfind Verwalt Gmbh, Scripps Research Inst filed Critical Novartis Ag
Priority to AU12711/00A priority Critical patent/AU1271100A/en
Publication of WO2000029418A2 publication Critical patent/WO2000029418A2/en
Publication of WO2000029418A3 publication Critical patent/WO2000029418A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Inhibitors of glycosidases and glycosyltransferases, methods for their preparation and their identification are described.
PCT/EP1999/008727 1998-11-12 1999-11-12 Inhibitors of glycosidases and glycosyltransferases WO2000029418A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU12711/00A AU1271100A (en) 1998-11-12 1999-11-12 Inhibitors of glycosidases and glycosyltransferases

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US10797598P 1998-11-12 1998-11-12
US10801698P 1998-11-12 1998-11-12
US60/108,016 1998-11-12
US60/107,975 1998-11-12
US11862699P 1999-02-04 1999-02-04
US60/118,626 1999-02-04
US09/326,902 US6232450B1 (en) 1998-11-12 1999-06-07 Inhibition of human fucosyltransferases with N-linked Lewis-x and LacNAc analogs
US09/326,902 1999-06-07

Publications (2)

Publication Number Publication Date
WO2000029418A2 WO2000029418A2 (en) 2000-05-25
WO2000029418A3 true WO2000029418A3 (en) 2000-08-03

Family

ID=27493619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/008727 WO2000029418A2 (en) 1998-11-12 1999-11-12 Inhibitors of glycosidases and glycosyltransferases

Country Status (2)

Country Link
AU (1) AU1271100A (en)
WO (1) WO2000029418A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100172D0 (en) 2001-01-22 2001-01-22 Ulf Nilsson New inhibitors against galectins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
QIAO L ET AL: "Synergistic Inhibition of Human.alpha.-1,3-Fucosyltransferase V", J. AM. CHEM. SOC. (JACSAT,00027863);1996; VOL.118 (33); PP.7653-7662, Scripps Research Institute;Department of Chemistry; La Jolla; 92037; CA; USA (US), XP002127086 *
WISCHNAT R ET AL: "Chemoenzymic synthesis of iminocyclitol derivatives: a useful library strategy for the development of selective fucosyltransfer enzymes inhibitors", BIOORG. MED. CHEM. LETT. (BMCLE8,0960894X);1998; VOL.8 (23); PP.3353-3358, The Scripps Research Institute;Department of Chemistry and the Skaggs Institute for Chemical Biology; La Jolla; 92037; CA; USA (US), XP004143757 *
WISCHNAT R ET AL: "Synthesis of a New Class of N-Linked Lewis and LacNAc Analogs as Potential Inhibitors of Human Fucosyltransferases: A General Method for the Incorporation of an Iminocyclitol as a Transition-State Mimetic of the Donor Sugar to the Acceptor", J. ORG. CHEM. (JOCEAH,00223263);1998; VOL.63 (23); PP.8361-8365, The Scripps Research Institute;Department of Chemistry; La Jolla; 92037; CA; USA (US), XP002127087 *

Also Published As

Publication number Publication date
AU1271100A (en) 2000-06-05
WO2000029418A2 (en) 2000-05-25

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