WO2000025820A1 - Composes et procedes destines a l'immunisation genetique - Google Patents

Composes et procedes destines a l'immunisation genetique Download PDF

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Publication number
WO2000025820A1
WO2000025820A1 PCT/US1999/025979 US9925979W WO0025820A1 WO 2000025820 A1 WO2000025820 A1 WO 2000025820A1 US 9925979 W US9925979 W US 9925979W WO 0025820 A1 WO0025820 A1 WO 0025820A1
Authority
WO
WIPO (PCT)
Prior art keywords
dna
promoter
immune response
mammal
virus
Prior art date
Application number
PCT/US1999/025979
Other languages
English (en)
Inventor
John Gebhard
Barbara A. Araneo
Original Assignee
Pharmadigm, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmadigm, Inc. filed Critical Pharmadigm, Inc.
Priority to AU16061/00A priority Critical patent/AU1606100A/en
Publication of WO2000025820A1 publication Critical patent/WO2000025820A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

L'invention concerne des composés et des procédés destinés à l'immunisation génétique, par exemple, d'un patient âgé. Les composés et procédés de la présente invention permettent une immunisation efficace des patients âgés, qui constituent une catégorie de la population normalement réfractaire à l'immunisation, et assurent, en comparaison aux techniques et compositions existantes, une immunisation plus efficace des patients qui ne font pas partie de cette catégorie. L'invention concerne aussi des composés et des procédés de criblage permettant d'identifier les antigènes capables de déclencher une réponse immunitaire.
PCT/US1999/025979 1998-11-04 1999-11-03 Composes et procedes destines a l'immunisation genetique WO2000025820A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16061/00A AU1606100A (en) 1998-11-04 1999-11-03 Compounds and methods for genetic immunization

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18667198A 1998-11-04 1998-11-04
US09/186,671 1998-11-04

Publications (1)

Publication Number Publication Date
WO2000025820A1 true WO2000025820A1 (fr) 2000-05-11

Family

ID=22685846

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/025979 WO2000025820A1 (fr) 1998-11-04 1999-11-03 Composes et procedes destines a l'immunisation genetique

Country Status (2)

Country Link
AU (1) AU1606100A (fr)
WO (1) WO2000025820A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593972A (en) * 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5620896A (en) * 1992-03-23 1997-04-15 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
US5665383A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of immunostimulating agents for in vivo delivery
US5795872A (en) * 1995-09-19 1998-08-18 Pharmadigm, Inc. DNA construct for immunization
US5958895A (en) * 1996-10-23 1999-09-28 American Home Products Corporation DNA vaccines for herpes simplex virus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620896A (en) * 1992-03-23 1997-04-15 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
US5593972A (en) * 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5665383A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of immunostimulating agents for in vivo delivery
US5795872A (en) * 1995-09-19 1998-08-18 Pharmadigm, Inc. DNA construct for immunization
US5958895A (en) * 1996-10-23 1999-09-28 American Home Products Corporation DNA vaccines for herpes simplex virus

Also Published As

Publication number Publication date
AU1606100A (en) 2000-05-22

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