WO2000025768A8 - Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives - Google Patents

Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives

Info

Publication number
WO2000025768A8
WO2000025768A8 PCT/US1999/025331 US9925331W WO0025768A8 WO 2000025768 A8 WO2000025768 A8 WO 2000025768A8 US 9925331 W US9925331 W US 9925331W WO 0025768 A8 WO0025768 A8 WO 0025768A8
Authority
WO
WIPO (PCT)
Prior art keywords
combinatorial libraries
thiadiazole
oxadiazole
triazole derivatives
compounds
Prior art date
Application number
PCT/US1999/025331
Other languages
English (en)
Other versions
WO2000025768A1 (fr
Inventor
R Normand Hebert
Amy L Hannah
Original Assignee
Trega Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trega Biosciences Inc filed Critical Trega Biosciences Inc
Priority to EP99971314A priority Critical patent/EP1126833A4/fr
Priority to AU14555/00A priority patent/AU1455500A/en
Publication of WO2000025768A1 publication Critical patent/WO2000025768A1/fr
Publication of WO2000025768A8 publication Critical patent/WO2000025768A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention se rapporte à de nouveaux composés représentés par la formule (I), dans laquelle X1, X2, X3, X4, T, U et V sont définis dans la description. Cette invention se rapporte également à des bibliothèques combinatoires contenant ces composés.
PCT/US1999/025331 1998-10-29 1999-10-28 Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives WO2000025768A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99971314A EP1126833A4 (fr) 1998-10-29 1999-10-28 Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives
AU14555/00A AU1455500A (en) 1998-10-29 1999-10-28 Oxadiazole, thiadiazole and triazole derivatives and combinatorial libraries thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18322298A 1998-10-29 1998-10-29
US09/183,222 1998-10-29

Publications (2)

Publication Number Publication Date
WO2000025768A1 WO2000025768A1 (fr) 2000-05-11
WO2000025768A8 true WO2000025768A8 (fr) 2000-08-24

Family

ID=22671958

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/025331 WO2000025768A1 (fr) 1998-10-29 1999-10-28 Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives

Country Status (3)

Country Link
EP (1) EP1126833A4 (fr)
AU (1) AU1455500A (fr)
WO (1) WO2000025768A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9278962B2 (en) 2011-04-22 2016-03-08 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001002375A1 (fr) * 1999-07-01 2001-01-11 Chemrx Advanced Technologies, Inc. Synthese d'oxadiazoles
US20020002171A1 (en) * 2000-01-28 2002-01-03 Chalquest Richard R. Materials and methods for killing nematodes and nematode eggs
US6683191B2 (en) * 2000-06-05 2004-01-27 Ortho-Mcneil Pharmaceuticals, Inc. Method for synthesis of substituted azole libraries
US6951948B2 (en) 2000-06-05 2005-10-04 Ortho-Mcneil Pharmaceutical, Inc. Method for synthesis of substituted azole libraries
US6482829B2 (en) * 2000-06-08 2002-11-19 Hoffmann-La Roche Inc. Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
SI3345895T1 (sl) 2003-04-11 2020-03-31 Ptc Therapeutics, Inc. Spojina 1,2,4-oksadiazol benzojske kisline in njena uporaba za supresijo nesmiselne in zdravljenje bolezni
ES2568769T3 (es) 2003-07-30 2016-05-04 Xenon Pharmaceuticals Inc. Derivados de piperazina y su uso como agentes terapéuticos
GB0325956D0 (en) * 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
CA2547198A1 (fr) 2003-12-17 2005-06-30 Merck & Co., Inc. Carboxylates propanoiques 3,4-disusbstitues utilises en tant qu'agonistes du recepteur s1p (edg)
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
BRPI0515478A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seu uso como mediadores de estearoil-coa-desaturase
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
TW200626154A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
TW200626155A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
WO2006034279A1 (fr) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Derives heterocycliques et leur utilisation comme agents therapeutiques
AU2005329423A1 (en) 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
EP2387995A1 (fr) 2006-03-30 2011-11-23 PTC Therapeutics, Inc. Procédés pour la production d'une protéine fonctionnelle à partir d'ADN ayant une mutation non-sens et traitement de troubles associés
WO2008013622A2 (fr) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Amides azocycliques fongicides
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
BRPI0719122A2 (pt) 2006-08-24 2013-12-10 Novartis Ag Compostos orgânicos
NZ577111A (en) 2006-12-15 2012-05-25 Abbott Lab Novel oxadiazole compounds
WO2010108187A2 (fr) 2009-03-20 2010-09-23 Brandeis University Composés et procédés pour traiter les infections microbiennes gastro-intestinales mammaliennes
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
WO2014028931A2 (fr) 2012-08-17 2014-02-20 Brandeis University Composés et procédés de traitement d'infections microbiennes gastro-intestinales de mammifère
CA2942147C (fr) 2014-03-06 2022-12-13 Ptc Therapeutics, Inc. Compositions pharmaceutiques et sels d'un acide benzoique 1,2,4-oxadiazole
AR106530A1 (es) 2015-10-30 2018-01-24 Ptc Therapeutics Inc Métodos para tratar epilepsia
CN112010828B (zh) * 2020-09-27 2023-01-31 中国医科大学 Cdk7小分子抑制剂的化合物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8801289D0 (en) * 1988-01-21 1988-02-17 Shell Int Research Oxadiazole compounds their preparation & their use as pesticides
US5242890A (en) * 1988-07-07 1993-09-07 Korea Research Institute Of Chemical Technology 1,2,4-oxadiazole derivative, useful as selective herbicide
US5366987A (en) * 1991-08-22 1994-11-22 Warner-Lambert Company Isoxazolyl-substituted alkyl amide ACAT inhibitors
DE69633003T2 (de) * 1995-01-27 2005-08-18 Novo Nordisk A/S Verbindungen mit wachstumshormon-freisetzenden eigenschaften
AU722883B2 (en) * 1995-10-18 2000-08-10 Merck & Co., Inc. Cyclopentyl tachykinin receptor antagonists
EA199800353A1 (ru) * 1995-10-30 1998-12-24 Смитклайн Бичам Корпорейшн Ингибиторы протеаз
AU6320998A (en) * 1997-02-21 1998-09-09 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9278962B2 (en) 2011-04-22 2016-03-08 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use

Also Published As

Publication number Publication date
EP1126833A4 (fr) 2004-09-08
AU1455500A (en) 2000-05-22
WO2000025768A1 (fr) 2000-05-11
EP1126833A2 (fr) 2001-08-29

Similar Documents

Publication Publication Date Title
WO2000025768A8 (fr) Derives oxadiazole, thiadiazole et triazole et bibliotheques combinatoires contenant ces derives
CA2274464A1 (fr) Cetobenzamides s'utilisant comme inhibiteurs de la calpaine
CA2268954A1 (fr) Oxadiazoles, procedes permettant de les preparer et leur utilisation comme medicaments
ZA200007222B (en) Glycopeptide derivatives and pharmaceutical compositions containing the same.
EP1019389A4 (fr) Derives d'epothilone
CA2276455A1 (fr) Phthalazinones
EP1283039A4 (fr) Inhibiteurs de la -secretase
AU1924699A (en) Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses
CA2390649A1 (fr) Composes de 5-aryl-1h-1,2,4-triazole en tant qu'inhibiteurs de cyclooxygenase-2 et compositions pharmaceutiques les contenant
WO2001029055A3 (fr) Nouveaux oligosaccharides, leur preparation et les compositions pharmaceutiques les contenant
WO2000053583A8 (fr) Inhibiteurs de la tyrosine phosphatase
WO1999011606A3 (fr) Inhibiteurs de la proteine tyrosine phosphatase
AU1457299A (en) Novel signal transduction inhibitors, compositions containing them
WO2001023392A8 (fr) Derives de benzimidazole tetracycliques et bibliotheques combinatoires
CA2037975A1 (fr) Analogues du 5-hydroxy-2,3-dihydrobenzofurane comme inhibiteurs de la biosynthese des leucotrienes
WO2002079753A3 (fr) Derives de 2-aminobenzoxazole et leurs bibliotheques combinatoires
WO2002016340A8 (fr) Aminoalkoxybenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant
CA2317604A1 (fr) Inhibiteurs de metalloproteases matricielles
MXPA04004802A (es) Derivados del 1,2,4-triazol que contienen un grupo sulfamato como inhibidores de aromatasa.
WO1997008190A3 (fr) Composes
GR3023427T3 (en) Heteroarylmethylbenzols aromatase inhibitors
WO2002008227A3 (fr) Derives d'hydantoine bicycliques et bibliotheques combinatoires de ces derniers
WO1999048851A3 (fr) Procedes de preparation d'intermediaires
WO2000040589A3 (fr) Nouveaux derives de la classe des oleandomycines
WO2002016338A8 (fr) Aminoalkenylbenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant

Legal Events

Date Code Title Description
ENP Entry into the national phase in:

Ref country code: AU

Ref document number: 2000 14555

Kind code of ref document: A

Format of ref document f/p: F

AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA JP KR NO NZ

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: C1

Designated state(s): AU CA JP KR NO NZ

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

WR Later publication of a revised version of an international search report
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 1999971314

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999971314

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1999971314

Country of ref document: EP