WO2000022101A3 - Enzymes as a power source for nanofabricated devices - Google Patents

Enzymes as a power source for nanofabricated devices Download PDF

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Publication number
WO2000022101A3
WO2000022101A3 PCT/US1999/023636 US9923636W WO0022101A3 WO 2000022101 A3 WO2000022101 A3 WO 2000022101A3 US 9923636 W US9923636 W US 9923636W WO 0022101 A3 WO0022101 A3 WO 0022101A3
Authority
WO
WIPO (PCT)
Prior art keywords
atpase
nems
nanomechanical
devices
integration
Prior art date
Application number
PCT/US1999/023636
Other languages
French (fr)
Other versions
WO2000022101A2 (en
Inventor
Carlo D Montemagno
Original Assignee
Cornell Res Foundation Inc
Carlo D Montemagno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Res Foundation Inc, Carlo D Montemagno filed Critical Cornell Res Foundation Inc
Priority to EP99951914A priority Critical patent/EP1144601A3/en
Priority to AU64252/99A priority patent/AU6425299A/en
Publication of WO2000022101A2 publication Critical patent/WO2000022101A2/en
Publication of WO2000022101A3 publication Critical patent/WO2000022101A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02N—ELECTRIC MACHINES NOT OTHERWISE PROVIDED FOR
    • H02N11/00—Generators or motors not provided for elsewhere; Alleged perpetua mobilia obtained by electric or magnetic means
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02S—GENERATION OF ELECTRIC POWER BY CONVERSION OF INFRARED RADIATION, VISIBLE LIGHT OR ULTRAVIOLET LIGHT, e.g. USING PHOTOVOLTAIC [PV] MODULES
    • H02S99/00—Subject matter not provided for in other groups of this subclass
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
    • H10K85/00—Organic materials used in the body or electrodes of devices covered by this subclass
    • H10K85/761—Biomolecules or bio-macromolecules, e.g. proteins, chlorophyl, lipids or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E10/00—Energy generation through renewable energy sources
    • Y02E10/50—Photovoltaic [PV] energy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

A nanoscale engineered system includes the integration of at least one F1-ATPase molecular motor with a nano-electro-mechanical system (NEMS). The resultant functional hybrid organic/inorganic nanomechanical system provides the ability to move nanotechnology into medical and physiologic applications. The ability to accurately and precisely position and orient individual proteins on a substrate is presented. Motive power for the nanomechanical systems disclosed is provided through the genetic expression and integration of at least one F1-ATPase molecular motor, which utilizes ATP as a chemical energy source. In addition, the device is capable of being fuelled with light energy. The NEMS device can be controlled by an 'on/off' switch genetically engineered into the F1-ATPase. The NEMS consists of one or more silicon based mechanical devices capable of operating in liquid environments and performing a variety of functions. The F1-ATPase motors are used to pump fluids and open and close valves in microfluidic devices, as well as provide mechanical drives and motive power for nanomechanical devices.
PCT/US1999/023636 1998-10-13 1999-10-13 Enzymes as a power source for nanofabricated devices WO2000022101A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99951914A EP1144601A3 (en) 1998-10-13 1999-10-13 Enzymes as a power source for nanofabricated devices
AU64252/99A AU6425299A (en) 1998-10-13 1999-10-13 Enzymes as a power source for nanofabricated devices

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10406298P 1998-10-13 1998-10-13
US60/104,062 1998-10-13
US12658699P 1999-03-26 1999-03-26
US60/126,586 1999-03-26
US15298399P 1999-09-09 1999-09-09
US60/152,983 1999-09-09

Publications (2)

Publication Number Publication Date
WO2000022101A2 WO2000022101A2 (en) 2000-04-20
WO2000022101A3 true WO2000022101A3 (en) 2001-12-13

Family

ID=27379650

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/023636 WO2000022101A2 (en) 1998-10-13 1999-10-13 Enzymes as a power source for nanofabricated devices

Country Status (3)

Country Link
EP (1) EP1144601A3 (en)
AU (1) AU6425299A (en)
WO (1) WO2000022101A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7974123B2 (en) 2001-03-12 2011-07-05 Yeda Research And Development Co. Ltd. Method using a synthetic molecular spring device in a system for dynamically controlling a system property and a corresponding system thereof
WO2002073062A2 (en) 2001-03-12 2002-09-19 Yeda Research Development Co. Ltd. Synthetic molecular spring device
US7014823B2 (en) 2002-10-18 2006-03-21 Florida State University Research Foundation, Inc. Biomolecular-based actuator
US7516759B2 (en) 2003-02-24 2009-04-14 The Penn State Research Foundation Autonomous moving microstructures
WO2005016533A2 (en) * 2003-08-14 2005-02-24 Arizona Board Of Regents Method and apparatus for nanomotors in microfluidic devices
US10015931B2 (en) 2012-12-28 2018-07-10 Elwha Llc Production of electricity from plants
US10017392B2 (en) 2012-12-28 2018-07-10 Elwha Llc Articles and methods for administering CO2 into plants
US10015971B2 (en) 2012-12-28 2018-07-10 Elwha Llc Articles and methods for administering CO2 into plants
WO2014105563A1 (en) * 2012-12-28 2014-07-03 Allen Paul G Articles and methods for administering co2 into plants
GB201502866D0 (en) * 2015-02-20 2015-04-08 Drexler Kim E Molecular motor
CN107855536B (en) * 2017-11-13 2020-03-31 哈尔滨工业大学（威海） Method for forming high-strength reliable connection between metal and organic matter by using copper nano material

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0488995A (en) * 1990-07-31 1992-03-23 Oki Electric Ind Co Ltd Atp synthesizing device
JPH08196284A (en) * 1995-01-19 1996-08-06 Canon Inc Enzymatic reaction element and production thereof, enzyme reactor and method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0488995A (en) * 1990-07-31 1992-03-23 Oki Electric Ind Co Ltd Atp synthesizing device
JPH08196284A (en) * 1995-01-19 1996-08-06 Canon Inc Enzymatic reaction element and production thereof, enzyme reactor and method thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
C. MONTEMAGNO ET AL.: "Constructiong biological motor powered nanomechanical devices", SIXTH FORESIGHT CONFERENCE ON MOLECULAR NANOTECHNOLOGY, 12 November 1998 (1998-11-12) - 15 November 1998 (1998-11-15), pages 1 - 9, XP002947428, Retrieved from the Internet <URL:http://www.foresight.org/Conferences/MNT6/Papers/Montemagno/index.html> [retrieved on 20000201] *
HELLINGA H W ET AL: "CONSTRUCTION OF NEW LIGAND BINDING SITES IN PROTEINS OF KNOWN STRUCTURE. II. GRAFTING OF A BURIED TRANSITION METAL BINDING SITE INTO ESCHERICHIA COLI THIOREDOXIN", JOURNAL OF MOLECULAR BIOLOGY,GB,LONDON, vol. 222, 1991, pages 787 - 803, XP002914683, ISSN: 0022-2836 *
JUNGE W ET AL: "ATP synthase: an electrochemical transducer with rotatory mechanics", TIBS TRENDS IN BIOCHEMICAL SCIENCES,EN,ELSEVIER PUBLICATION, CAMBRIDGE, vol. 22, no. 11, 1 November 1997 (1997-11-01), pages 420 - 423, XP004094963, ISSN: 0968-0004 *
NOJI H ET AL.: "DIRECT OBSERVATION OF THE ROTATION OF F1- ATPASE [SEE COMMENTS]", NATURE (1997 MAR 20) 386 (6622) 299-302, XP002129537 *
PATENT ABSTRACTS OF JAPAN vol. 016, no. 310 (C - 0960) 8 July 1992 (1992-07-08) *
PATENT ABSTRACTS OF JAPAN vol. 1996, no. 12 26 December 1996 (1996-12-26) *
T ET AL: "Reversible oriented immobilization of histidine-tagged proteins on gold surfaces using a chelator thioalkane", SUPRAMOLECULAR SCIENCE,GB,OXFORD, vol. 2, no. 3/04, 1 January 1995 (1995-01-01), pages 155 - 160, XP002082734, ISSN: 0958-5677 *
THOMAS N ET AL: "THE PHYSICS OF BIOLOGICAL MOLECULAR MOTORS", JOURNAL OF PHYSICS D. APPLIED PHYSICS,GB,IOP PUBLISHING, BRISTOL, vol. 31, no. 3, 7 February 1998 (1998-02-07), pages 253 - 266, XP000766997, ISSN: 0022-3727 *

Also Published As

Publication number Publication date
EP1144601A3 (en) 2002-05-02
EP1144601A2 (en) 2001-10-17
AU6425299A (en) 2000-05-01
WO2000022101A2 (en) 2000-04-20

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