WO2000021569A3 - Makromolekulare wirkstoffkonjugate und verfahren zu ihrer herstellung - Google Patents

Makromolekulare wirkstoffkonjugate und verfahren zu ihrer herstellung Download PDF

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Publication number
WO2000021569A3
WO2000021569A3 PCT/DE1999/003338 DE9903338W WO0021569A3 WO 2000021569 A3 WO2000021569 A3 WO 2000021569A3 DE 9903338 W DE9903338 W DE 9903338W WO 0021569 A3 WO0021569 A3 WO 0021569A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
active substance
conjugates
relates
macromolecular active
Prior art date
Application number
PCT/DE1999/003338
Other languages
English (en)
French (fr)
Other versions
WO2000021569A2 (de
Inventor
Hannsjoerg Sinn
Hans-Hermann Schrenk
Eva Frei
Andrea Breuer
Martina Weigand
Original Assignee
Deutsches Krebsforsch
Hannsjoerg Sinn
Schrenk Hans Hermann
Eva Frei
Andrea Breuer
Martina Weigand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Hannsjoerg Sinn, Schrenk Hans Hermann, Eva Frei, Andrea Breuer, Martina Weigand filed Critical Deutsches Krebsforsch
Priority to AU17682/00A priority Critical patent/AU1768200A/en
Priority to EP99960791A priority patent/EP1121154A2/de
Publication of WO2000021569A2 publication Critical patent/WO2000021569A2/de
Publication of WO2000021569A3 publication Critical patent/WO2000021569A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Die Erfindung betrifft Konjugate aus planaren aromatischen polycyclischen Verbindungen und einem nicht als körperfremd angesehenen Protein, Verfahren zur Herstellung derartiger Konjugate sowie deren Verwendung zur Unterscheidung von krankhaften bzw. erkrankten Geweben und deren Verwendung zum Nachweis bzw. Therapie von Tumoren oder entzündlichen Prozessen.
PCT/DE1999/003338 1998-10-14 1999-10-14 Makromolekulare wirkstoffkonjugate und verfahren zu ihrer herstellung WO2000021569A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU17682/00A AU1768200A (en) 1998-10-14 1999-10-14 Macromolecular active substance conjugates and a method for the production thereof
EP99960791A EP1121154A2 (de) 1998-10-14 1999-10-14 Makromolekulare wirkstoffkonjugate und verfahren zu ihrer herstellung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19847362.1 1998-10-14
DE19847362A DE19847362A1 (de) 1998-10-14 1998-10-14 Makromolekulare Wirkstoffkonjugate und Verfahren zu ihrer Herstellung

Publications (2)

Publication Number Publication Date
WO2000021569A2 WO2000021569A2 (de) 2000-04-20
WO2000021569A3 true WO2000021569A3 (de) 2000-08-24

Family

ID=7884446

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/003338 WO2000021569A2 (de) 1998-10-14 1999-10-14 Makromolekulare wirkstoffkonjugate und verfahren zu ihrer herstellung

Country Status (4)

Country Link
EP (1) EP1121154A2 (de)
AU (1) AU1768200A (de)
DE (1) DE19847362A1 (de)
WO (1) WO2000021569A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104744510B (zh) * 2013-12-25 2016-08-17 广西师范大学 茜素氨基膦酸酯衍生物及其合成方法和应用
DE102016125666A1 (de) 2016-12-23 2018-06-28 Michael Denck HSA-Galenik

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991007989A1 (en) * 1989-11-28 1991-06-13 Universite Laval A method of inactivating human immunodeficiency virus
WO1996025956A2 (de) * 1995-02-21 1996-08-29 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Konjugat zur individuellen dosierung von arzneimitteln
WO1996032133A2 (de) * 1995-04-13 1996-10-17 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Konjugat zur behandlung von entzündungs-, infektions- und/oder hauterkrankungen
WO1997026920A2 (de) * 1996-01-23 1997-07-31 Deutsches Krebsforschungszentrum Konjugat zur unterscheidung von krankhaftem und gesundem gewebe
WO1999005521A2 (de) * 1997-07-23 1999-02-04 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Konjugat zur unterscheidung von krankhaftem und gesundem gewebe

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4122210C2 (de) * 1991-07-04 1999-04-01 Deutsches Krebsforsch Konjugate aus tumoraktiver Verbindung und Serumalbumin sowie Verfahren zu deren Herstellung und ihre Verwendung

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991007989A1 (en) * 1989-11-28 1991-06-13 Universite Laval A method of inactivating human immunodeficiency virus
WO1996025956A2 (de) * 1995-02-21 1996-08-29 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Konjugat zur individuellen dosierung von arzneimitteln
WO1996032133A2 (de) * 1995-04-13 1996-10-17 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Konjugat zur behandlung von entzündungs-, infektions- und/oder hauterkrankungen
WO1997026920A2 (de) * 1996-01-23 1997-07-31 Deutsches Krebsforschungszentrum Konjugat zur unterscheidung von krankhaftem und gesundem gewebe
WO1999005521A2 (de) * 1997-07-23 1999-02-04 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Konjugat zur unterscheidung von krankhaftem und gesundem gewebe

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KOZLOVA, G. G. ET AL: "Luminescence of acridine dyes in various biological systems and solvents", XP002136856, retrieved from STN Database accession no. 107:24794 *
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; JOUSSEN A.M. ET AL: "Photothrombosis of corneal neovascularization with photosensitizers coupled to macromolecules.", XP002136855, retrieved from STN Database accession no. 1999012282 *
KRATZ, FELIX ET AL: "Preparation, characterization and in vitro efficacy of albumin conjugates of doxorubicin", BIOL. PHARM. BULL. (1998), 21(1), 56-61, XP000738275 *
KRATZ, FELIX ET AL: "Transferrin Conjugates of Doxorubicin: Synthesis, Characterization, Cellular Uptake, and in Vitro Efficacy", J. PHARM. SCI. (1998), 87(3), 338-346, XP000736343 *
LASERS AND LIGHT IN OPHTHALMOLOGY, (1998) 8/4 (211-219). *
ZH. PRIKL. SPEKTROSK. (1986), 45(4), 591-6 *

Also Published As

Publication number Publication date
AU1768200A (en) 2000-05-01
EP1121154A2 (de) 2001-08-08
WO2000021569A2 (de) 2000-04-20
DE19847362A1 (de) 2000-04-20

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