WO2000010554A3 - Procedes et compositions employant le vigabatrin s(+) optiquement pur - Google Patents

Procedes et compositions employant le vigabatrin s(+) optiquement pur Download PDF

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Publication number
WO2000010554A3
WO2000010554A3 PCT/US1999/019346 US9919346W WO0010554A3 WO 2000010554 A3 WO2000010554 A3 WO 2000010554A3 US 9919346 W US9919346 W US 9919346W WO 0010554 A3 WO0010554 A3 WO 0010554A3
Authority
WO
WIPO (PCT)
Prior art keywords
vigabatrin
methods
optically pure
compositions employing
employing optically
Prior art date
Application number
PCT/US1999/019346
Other languages
English (en)
Other versions
WO2000010554A2 (fr
Inventor
Paul D Rubin
Timothy J Barberich
William E Yelle
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Priority to JP2000565876A priority Critical patent/JP2003520189A/ja
Priority to CA002341400A priority patent/CA2341400A1/fr
Priority to AU57844/99A priority patent/AU5784499A/en
Priority to EP99945177A priority patent/EP1107748A2/fr
Publication of WO2000010554A2 publication Critical patent/WO2000010554A2/fr
Publication of WO2000010554A3 publication Critical patent/WO2000010554A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des procédés et compositions pour la prévention, le traitement et/ou la gestion des symptômes de neuropathie périphérique et d'affections connexes, de narcomanie ou d'alcoolisme ou leurs symptômes, ou des symptômes associés au sevrage alcoolique ou au sevrage de drogue, utilisant du vigabatrin S(+) optiquement pur, ou un sel de celui-ci pharmaceutiquement acceptable.
PCT/US1999/019346 1998-08-25 1999-08-24 Procedes et compositions employant le vigabatrin s(+) optiquement pur WO2000010554A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000565876A JP2003520189A (ja) 1998-08-25 1999-08-24 光学的に純粋なｓ（＋）ビガバトリンを用いる方法および組成物
CA002341400A CA2341400A1 (fr) 1998-08-25 1999-08-24 Procedes et compositions employant le vigabatrin s(+) optiquement pur
AU57844/99A AU5784499A (en) 1998-08-25 1999-08-24 Methods and compositions employing optically pure s(+) vigabatrin
EP99945177A EP1107748A2 (fr) 1998-08-25 1999-08-24 Procedes et compositions employant le vigabatrin s(+) optiquement pur

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9778698P 1998-08-25 1998-08-25
US60/097,786 1998-08-25
US11445698P 1998-12-30 1998-12-30
US60/114,456 1998-12-30

Publications (2)

Publication Number Publication Date
WO2000010554A2 WO2000010554A2 (fr) 2000-03-02
WO2000010554A3 true WO2000010554A3 (fr) 2000-11-30

Family

ID=26793638

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/019346 WO2000010554A2 (fr) 1998-08-25 1999-08-24 Procedes et compositions employant le vigabatrin s(+) optiquement pur

Country Status (5)

Country Link
EP (1) EP1107748A2 (fr)
JP (1) JP2003520189A (fr)
AU (1) AU5784499A (fr)
CA (1) CA2341400A1 (fr)
WO (1) WO2000010554A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100179214A1 (en) 2006-05-19 2010-07-15 Somaxon Pharmaceuticals, Inc. Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
US20100179215A1 (en) 2006-05-19 2010-07-15 Somaxon Pharmaceuticals, Inc. Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
US20080058408A1 (en) 2006-05-19 2008-03-06 Rogowski Roberta L Low-dose doxepin for treatment of sleep disorders in elderly patients
JP2009537553A (ja) 2006-05-19 2009-10-29 ソマクソン ファーマシューティカルズ インコーポレイテッド 睡眠改善のための低用量ドキセピンの使用法
WO2008011150A1 (fr) 2006-07-20 2008-01-24 Somaxon Pharmaceuticals, Inc. Méthodes destinées à améliorer la pharmacocinétique de la doxépine
WO2008052139A2 (fr) 2006-10-25 2008-05-02 Somaxon Pharmaceuticals, Inc. Doxepine à dose ultrafaible, et ses procédés d'utilisation pour traiter des troubles du sommeil
US20110077200A1 (en) 2006-12-06 2011-03-31 Somaxon Pharmaceuticals, Inc. Combination therapy using low-dose doxepin for the improvement of sleep
US20090074862A1 (en) 2007-04-13 2009-03-19 Luigi Schioppi Low-dose doxepin formulations and methods of making and using the same
CA3016851A1 (fr) * 2016-03-10 2017-09-14 Orphelia Pharma Formes galeniques solides de vigabatrine
CN110869003A (zh) * 2019-01-28 2020-03-06 上海奥科达生物医药科技有限公司 一种不含防腐剂的固体剂型氨己烯酸药物组合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595697A (en) * 1984-03-28 1986-06-17 Merrell Dow Pharmaceuticals Inc. Treatment of seizure disorders and pharmaceutical compositions useful therein
US4621145A (en) * 1982-12-30 1986-11-04 Merrell Dow Pharmaceuticals Inc. Process for preparing 5-vinyl-2-pyrrolidinone and intermediates therefor
EP0509180A1 (fr) * 1991-04-18 1992-10-21 Merrell Dow Pharmaceuticals Inc. Utilisation d'inhibiteurs de la GABA-T pour le traitement de la schizophrenie et l'intoxication de la phencyclidine
WO2000007583A2 (fr) * 1998-08-05 2000-02-17 Brookhaven Science Associates Traitement de l'accoutumance et comportement lie a l'accoutumance

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4621145A (en) * 1982-12-30 1986-11-04 Merrell Dow Pharmaceuticals Inc. Process for preparing 5-vinyl-2-pyrrolidinone and intermediates therefor
US4595697A (en) * 1984-03-28 1986-06-17 Merrell Dow Pharmaceuticals Inc. Treatment of seizure disorders and pharmaceutical compositions useful therein
EP0509180A1 (fr) * 1991-04-18 1992-10-21 Merrell Dow Pharmaceuticals Inc. Utilisation d'inhibiteurs de la GABA-T pour le traitement de la schizophrenie et l'intoxication de la phencyclidine
WO2000007583A2 (fr) * 1998-08-05 2000-02-17 Brookhaven Science Associates Traitement de l'accoutumance et comportement lie a l'accoutumance

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ALVES N D: "Behavioral-pharmacological study of a possible analgesic effect of vigabatrin (gamma-vinil-GABA) in experimental chronic neuropathic pain", ARQUIVOS DE NEURO-PSIQUIATRIA, (MAR 1998) VOL. 56, NO. 1, PP. 150-150. PUBLISHER: ASSOC ARQUIVOS DE NEURO- PSIQUIATRIA, C/O DR OSWALDO LANGE, CAIXA POSTAL 8877, 01065-970 SAO PAULO SP, BRAZIL. ISSN: 0004-282X., vol. 56, no. 1, March 1998 (1998-03-01), UNIV FED CEARA, TESE MESTRADO, FORTALEZA, CEARA, BRAZIL, pages 150, XP000905078 *
BENNETT GJ, XIE JK: "A peripheral mononeuropathy in rats produces disorders of pain sensation like those seen in man", PAIN, vol. 33, 1988, pages 87 - 107, XP000905585 *
BUCKETT W R: "THE INFLUENCE OF A GABA TRANSAMINASE INHIBITOR, GAMMA-VINYL GABA, ON VOLUNTARY MORPHINE CONSUMPTION IN THE RAT", PSYCHOPHARMACOLOGY,DE,SPRINGER VERLAG, BERLIN, vol. 75, no. 2, 1981, pages 214 - 216, XP000856589, ISSN: 0033-3158 *
DEWEY S L ET AL: "A PHARMACOLOGIC STRATEGY FOR THE TREATMENT OF NICOTINE ADDICTION", SYNAPSE,GB,WILEY AND SONS, CHICHESTER, vol. 31, no. 1, January 1999 (1999-01-01), pages 76 - 86, XP000856613, ISSN: 0887-4476 *
GRAM L. ET AL: "Experimental studies of the influence of vigabatrin on the GABA system.", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, (1989) 27/SUPPL. 1 (13S-17S)., XP000905099 *
MORGAN ET AL: "Effects of pharmacologic increases in brain GABA levels on cocaine-induced changes in extracellular dopamine", SYNAPSE,GB,WILEY AND SONS, CHICHESTER, vol. 18, no. 1, January 1998 (1998-01-01), pages 60 - 65, XP002127041, ISSN: 0887-4476 *
SASTRE-GARAU P; THOMAS P; BEAUSSART M; GOUDEMAND M: "Manic attack induced by a vigabatrin-clomipramine association.", ENCEPHALE, vol. 19, no. 4, 1993, pages 351 - 352, XP000911788 *
SHERIF FATHI M; TAWATI AHMED M; AHMED SALEEM S; SHARIF SULEIMAN I: "Basic aspects of GABA-transmission in alcoholism, with particular reference to GABA-transaminase.", EUROPEAN NEUROPSYCHOPHARMACOLOGY, vol. 7, no. 1, 1997, pages 1 - 7, XP000911797 *
STUPPAECK C H ET AL: "THE IRREVERSIBLE GAMMA-AMINOBUTYRATE TRANSAMINASE INHIBITOR VIGABATRIN IN THE TREATMENT OF THE ALCOHOL WITHDRAWAL SYNDROME", ALCOHOL AND ALCOHOLISM. SUPPLEMENT,GB,PERGAMON, OXFORD, vol. 31, no. 1, January 1996 (1996-01-01), pages 109 - 111, XP000856593, ISSN: 1358-6173 *
WEGELIUS K ET AL: "GAMMA-VINYL GABA DECREASES VOLUNTARY ALCOHOL CONSUMPTION IN ALCOHOL-PREFERRING AA RATS", PHARMACOLOGY AND TOXICOLOGY,DK,MUNKSGAARD INTERNATIONAL PUBLISHERS, COPENHAGEN,, vol. 73, no. 3, September 1993 (1993-09-01), pages 150 - 152, XP000856621, ISSN: 0901-9928 *

Also Published As

Publication number Publication date
WO2000010554A2 (fr) 2000-03-02
JP2003520189A (ja) 2003-07-02
EP1107748A2 (fr) 2001-06-20
AU5784499A (en) 2000-03-14
CA2341400A1 (fr) 2000-03-02

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