WO2000009526A3 - Methode de localisation nucleaire de dpc4 (smad4) - Google Patents

Methode de localisation nucleaire de dpc4 (smad4) Download PDF

Info

Publication number
WO2000009526A3
WO2000009526A3 PCT/US1999/018540 US9918540W WO0009526A3 WO 2000009526 A3 WO2000009526 A3 WO 2000009526A3 US 9918540 W US9918540 W US 9918540W WO 0009526 A3 WO0009526 A3 WO 0009526A3
Authority
WO
WIPO (PCT)
Prior art keywords
dpc4
nuclear localization
smad4
prognostically
polynucleotide
Prior art date
Application number
PCT/US1999/018540
Other languages
English (en)
Other versions
WO2000009526A2 (fr
Inventor
Scott E Kern
Jia Le Dai
Original Assignee
Univ Johns Hopkins Med
Scott E Kern
Jia Le Dai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med, Scott E Kern, Jia Le Dai filed Critical Univ Johns Hopkins Med
Priority to AU55630/99A priority Critical patent/AU5563099A/en
Publication of WO2000009526A2 publication Critical patent/WO2000009526A2/fr
Publication of WO2000009526A3 publication Critical patent/WO2000009526A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des méthodes et compositions de localisation nucléaire de séquences polynucléotidiques et polypeptidiques codant un nouveau gène suppresseur de tumeurs, le Dpc4. L'invention concerne également une méthode de traitement d'un trouble de prolifération cellulaire associé à Dpc4. Dpc4 est un marqueur pouvant s'utiliser pour un diagnostic, un pronostic ou une thérapie des troubles associés à Dpc4.
PCT/US1999/018540 1998-08-14 1999-08-13 Methode de localisation nucleaire de dpc4 (smad4) WO2000009526A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU55630/99A AU5563099A (en) 1998-08-14 1999-08-13 Method for dpc4 (smad4) nuclear localization

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9662898P 1998-08-14 1998-08-14
US60/096,628 1998-08-14

Publications (2)

Publication Number Publication Date
WO2000009526A2 WO2000009526A2 (fr) 2000-02-24
WO2000009526A3 true WO2000009526A3 (fr) 2000-06-02

Family

ID=22258299

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/018540 WO2000009526A2 (fr) 1998-08-14 1999-08-13 Methode de localisation nucleaire de dpc4 (smad4)

Country Status (2)

Country Link
AU (1) AU5563099A (fr)
WO (1) WO2000009526A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2605166A1 (fr) 2005-04-15 2006-10-26 Tgen Methodes, composes et compositions a activite anticancereuse selective relative au genotype
US20210322314A1 (en) * 2018-07-24 2021-10-21 Avinash Seth Use Of Liposomes To Deliver A Protein And A Gene Encoding The Protein To A Live Cell

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712097A (en) * 1996-01-19 1998-01-27 The Johns Hopkins University School Of Medicine Tumor suppressor gene, DPC4

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712097A (en) * 1996-01-19 1998-01-27 The Johns Hopkins University School Of Medicine Tumor suppressor gene, DPC4

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DE CAESTECKER ET AL.: "Characterization of functional domains within Smad4/DPC4", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 21, May 1997 (1997-05-01), pages 13690 - 13696, XP002923112 *
DE WINTER ET AL.: "DPC4 (SMAD4) mediates transforming growth factor beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumor cells", ONCOGENE, vol. 14, no. 16, April 1997 (1997-04-01), pages 1891 - 1899, XP002923115 *
DENNIER ET AL.: "Direct binding of SMAD3 and SMAD4 to critical TGFbeta elements in the promoter of human plasminogen activator inhibitor-type 1 gene", THE EMBO JOURNAL, vol. 17, no. 11, June 1998 (1998-06-01), pages 3091 - 3100, XP002923000 *
FENG ET AL.: "The tumor suppressor Smad4/DPC-4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGFbeta induced transcriptional activation", GENES AND DEVELOPMENT, vol. 12, July 1998 (1998-07-01), pages 2153 - 2163, XP002923111 *
LIU ET AL.: "Dual role of the smad4/dpc4 tumor suppressor in the TGFbeta inducible transcriptional complexes", GENES AND DEVELOPMENT, vol. 11, 1997, pages 3157 - 3167, XP002923114 *
SHI ET AL.: "A structural basis for mutational inactivation of the tumor suppressor SMAD4", NATURE, vol. 388, 3 July 1997 (1997-07-03), pages 87 - 93, XP002923116 *
YINGLING ET AL.: "Tumor suppressor Smad4 is a transforming growth factor beta inducible DNA binding protein", MOLECULAR AND CELLULAR BIOLOGY, vol. 17, no. 12, December 1997 (1997-12-01), pages 7019 - 7028, XP002923113 *

Also Published As

Publication number Publication date
WO2000009526A2 (fr) 2000-02-24
AU5563099A (en) 2000-03-06

Similar Documents

Publication Publication Date Title
NZ298554A (en) A tumour suppressor gene (Hypermethylated in Cancer) HIC-1 and its use
SI0917571T1 (en) Agouti-related gene
EP1953229A3 (fr) Gênes régulés du cancer du sein et du colôn métastatiques
AU641568B2 (en) Polypeptide,DNA fragment encoding the same and process for producing the same, and enzyme inhibition process, drug composition and methods of treating using the same
IL62553A0 (en) Vectors comprising dna sequences and methods for producing recombinant dna molecules and cloning vectors
WO2000073348A3 (fr) Procedes et compositions visant a inhiber la proliferation des cellules cancereuses
WO2000037638A3 (fr) Methodes permettant d'inhiber la croissance de cellules neoplasiques
RU2001104349A (ru) Композиции и способы для терапии и диагностики рака предстательной железы
IE810451L (en) Tumour localization with labeled antibodies
AU4230985A (en) Coked and calcium ferrite- bonded iron ore pellets
WO2000009526A3 (fr) Methode de localisation nucleaire de dpc4 (smad4)
UA32602C2 (uk) Спосіб отримання губчатого заліза та установка для здійснення цього способу
EP0110791A3 (en) Peptides containing an immunogenic site of the poliovirus, and dna's containing nucleotide fragments encoding for these peptides
WO2000032778A3 (fr) Methodes et compositions permettant d'inhiber la croissance de cellules neoplasiques
WO1987007472A3 (fr) Sequence d'adn codant le mas oncogene, polypeptides codes a partir de ce dernier, et diagnostic et autres methodes fondees sur celui-ci
HK1118861A1 (en) Genes differentially expressed in breast cancer
EP0112012A3 (fr) Molécules recombinantes d'ADN
DE3371724D1 (en) Magnetic iron carbon nitride based material, and preparation and application as magnetic recording material
EP0904279A4 (fr) Dpc4, nouveau gene suppresseur de tumeur
EP1282641A4 (fr) Proteine suppressive du cancer du col de l'uterus chez la femme, polynucleotide codant pour elle, cellule transformee par le polynucleotide et methode de suppression de la proliferation de cellules cancereuses utilisant le vecteur d'expression
WO1998042830A3 (fr) Nouvelles compositions de genes noey2 et leurs utilisations
NZ502270A (en) Derivatives of mammalian secretory peptide-9 for treating cancer and may be used in conjunction with cytokines
CA2118373A1 (fr) Methode d'inversion du phenotype de cellules transformees par le facteur de transcription irf-i
WO2001029218A3 (fr) Proteines de matrice nucleaire, sequences polynucleotidiques codant ces proteines et utilisation de ces proteines
IL139683A0 (en) Composition for the induction of a tumour-specific immune response, methods for its production and use of the composition for the treatment of neoplasia

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase