IL139683A0 - Composition for the induction of a tumour-specific immune response, methods for its production and use of the composition for the treatment of neoplasia - Google Patents
Composition for the induction of a tumour-specific immune response, methods for its production and use of the composition for the treatment of neoplasiaInfo
- Publication number
- IL139683A0 IL139683A0 IL13968399A IL13968399A IL139683A0 IL 139683 A0 IL139683 A0 IL 139683A0 IL 13968399 A IL13968399 A IL 13968399A IL 13968399 A IL13968399 A IL 13968399A IL 139683 A0 IL139683 A0 IL 139683A0
- Authority
- IL
- Israel
- Prior art keywords
- composition
- production
- tumor
- neoplasia
- tumour
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
A composition (I) comprising a phage or functionally equivalent fragment expressing at least one tumor-specific and/or tumor-associated antigen as a fusion protein, with a phage coat protein or derivative on its surface, is new. An Independent claim is also included for a method for the production of (I), comprising: (1) extraction of DNA from an individual tumor cell, so that the gene encoding the tumor-specific antigen can be amplified; (2) cloning, after digestion of the gene in a vector system with restriction enzymes and gel electrophoresis; and (3) expression of the gene as a phage fusion protein.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19821925A DE19821925A1 (en) | 1998-05-15 | 1998-05-15 | Bacteriophage expression system for production of composition for induction of tumor specific responses |
| EP9903353 | 1999-05-14 | ||
| PCT/EP1999/003380 WO1999059624A2 (en) | 1998-05-15 | 1999-05-17 | Composition for inducing a tumor-specific immune response, method for the production and utilization of said composition in the treatment of neoplasia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL139683A0 true IL139683A0 (en) | 2002-02-10 |
Family
ID=7867943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13968399A IL139683A0 (en) | 1998-05-15 | 1999-05-17 | Composition for the induction of a tumour-specific immune response, methods for its production and use of the composition for the treatment of neoplasia |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP1214942A3 (en) |
| AT (1) | ATE222772T1 (en) |
| AU (1) | AU764390B2 (en) |
| CA (1) | CA2328057A1 (en) |
| DE (2) | DE19821925A1 (en) |
| DK (1) | DK1077720T3 (en) |
| ES (1) | ES2181444T3 (en) |
| IL (1) | IL139683A0 (en) |
| WO (1) | WO1999059624A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003293958A1 (en) * | 2002-12-23 | 2004-07-22 | Apalexo Biotechnologie Gmbh | Purification of recombinant filamental bacteriophages by means of affinity chromatography to increase the immunogenicity and efficacy of phagic vaccines |
| CN114907472A (en) * | 2022-04-07 | 2022-08-16 | 武汉爱博泰克生物科技有限公司 | Method for accurately copying antibody and application |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219192A (en) * | 1986-02-07 | 1991-10-25 | Oncogen | Peptides related to p97 melanoma-associated peptide, recombinant virus and vaccines |
| US5262177A (en) * | 1986-02-07 | 1993-11-16 | Oncogen | Recombinant viruses encoding the human melanoma-associated antigen |
| GB9022190D0 (en) * | 1990-10-12 | 1990-11-28 | Perham Richard N | Immunogenic material |
| US5674486A (en) * | 1991-06-25 | 1997-10-07 | San Diego Regional Cancer Center | Cancer immunotherapy with carrier cells |
| US5759535A (en) * | 1994-05-13 | 1998-06-02 | Research Corporation Technologies, Inc. | Immunotherapeutic strategies for the treatment of cancer |
-
1998
- 1998-05-15 DE DE19821925A patent/DE19821925A1/en not_active Ceased
-
1999
- 1999-05-17 DE DE59902472T patent/DE59902472D1/en not_active Expired - Fee Related
- 1999-05-17 AT AT99924991T patent/ATE222772T1/en not_active IP Right Cessation
- 1999-05-17 DK DK99924991T patent/DK1077720T3/en active
- 1999-05-17 CA CA002328057A patent/CA2328057A1/en not_active Abandoned
- 1999-05-17 EP EP02003333A patent/EP1214942A3/en not_active Withdrawn
- 1999-05-17 ES ES99924991T patent/ES2181444T3/en not_active Expired - Lifetime
- 1999-05-17 EP EP99924991A patent/EP1077720B1/en not_active Expired - Lifetime
- 1999-05-17 IL IL13968399A patent/IL139683A0/en unknown
- 1999-05-17 WO PCT/EP1999/003380 patent/WO1999059624A2/en active IP Right Grant
- 1999-05-17 AU AU41442/99A patent/AU764390B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1214942A3 (en) | 2002-10-02 |
| EP1077720A2 (en) | 2001-02-28 |
| ATE222772T1 (en) | 2002-09-15 |
| EP1214942A2 (en) | 2002-06-19 |
| ES2181444T3 (en) | 2003-02-16 |
| EP1077720B1 (en) | 2002-08-28 |
| DE19821925A1 (en) | 1999-11-18 |
| AU764390B2 (en) | 2003-08-14 |
| WO1999059624A2 (en) | 1999-11-25 |
| DK1077720T3 (en) | 2004-03-22 |
| WO1999059624A3 (en) | 2000-01-27 |
| CA2328057A1 (en) | 1999-11-25 |
| DE59902472D1 (en) | 2002-10-02 |
| AU4144299A (en) | 1999-12-06 |
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