WO2000009037A1 - Dispositifs et procedes d'apport de substances - Google Patents
Dispositifs et procedes d'apport de substances Download PDFInfo
- Publication number
- WO2000009037A1 WO2000009037A1 PCT/NZ1999/000126 NZ9900126W WO0009037A1 WO 2000009037 A1 WO2000009037 A1 WO 2000009037A1 NZ 9900126 W NZ9900126 W NZ 9900126W WO 0009037 A1 WO0009037 A1 WO 0009037A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formulation
- gas
- electrodes
- outlet
- precursor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Definitions
- the present invention relates to dispensing apparatus for dispensing an agent or its precursor(s), methods of use thereof and related means, methods and applications.
- an active agent or its precursor(s) there are many instances where it is desired to activate or allow the activation of the release of an active agent or its precursor(s) whether as a single dose, a continuous dose or as a pulsile dose.
- Instances include microprocessor control active delivery of agents as might be used to release a medicament into a body cavity such as, for example, disclosed in PCT/NZ98/00011.
- Such active delivery device in addition to microprocessor or other logic means capable of empowering the release) utilise a reservoir or barrel having a membrane or piston that separates the formulation of the active agent or its precursor(s) from a gas generating arrangement, eg; a hydrogel and its electrodes.
- a gas generating arrangement eg; a hydrogel and its electrodes.
- Such constructions are expensive to manufacture and have the prospect of occasional failure in the case of a piston arrangement owing to jamming.
- DISCLOSURE OF THE INVENTION The present invention is directed to providing dispensing apparatus which lends itself to an easier manufacturing procedure (as will be described hereinafter in more detail) and therefore it is an object of the present invention to provide such apparatus and related means, methods and procedures.
- the present invention consists in dispensing apparatus for dispensing an agent or its precursor(s), said apparatus comprising or including a formulation (complex or simple) of the agent or its precursor(s), the formulation having an electrolyte character, a pair of electrodes disposed and enabled or enablable by electrolysis of at least part of the formulation to generate at least one gas, and housing means with at least one outlet (whether closed or not) housing at least part (preferably all) of said formulation and at least part of at least one (preferably both) of said electrodes, wherein enablement of the electrodes by the provision of an electric potential thereto generates by electrolysis gas(es) which
- the formulation is plug like in character [or is of a kind where the interface of the gas generating electrode(s) to the formulation offers to the gas(es) so generated at such electrode(s) less resistance to gas travel than the formulation itself] (for example, of a consistency less conducive to gas passage there-through, such as might be the case with a suitably viscous liquid, a suitable gel, a suitable solid, or the like, irrespective of orientation of the apparatus) migrates along at least one electrode away from said outlet so as to gas pressurise a movement of the formulation at least towards said outlet.
- the formulation whilst having an electrolyte character is in the form of a gel or solid but one in which preferably said agent or its precursor (for example, a bio-precursor) does not provide the majority or any of the electrolyte character of the formulation. In other forms however it may.
- the outlet may include a disruptible seal or closure capable of being opened by movement of the formulation and/or gas pressure.
- the formulation is expressed at least partly out of said outlet.
- the outlet is closed by a rupturible seal.
- the formula is preferably liquid or, if solid or a gel, is conduited or provided with electrodes such that gas pressure directly (rather than the formula) ruptures the seal.
- the present invention consists in dispensing apparatus for dispensing an agent or its precursor(s), said apparatus comprising or including a formulation (complex or simple) of the agent or its precursor(s), the formulation having an electrolyte character, a pair of electrodes disposed and enabled or enablable to generate at least one gas by electrolysis of at least part of the formulation, means enabling and/or to enable the pair of electrodes by the provision of an electric potential across the electrodes, and housing means with at least one outlet (whether closed or not) housing at least part (preferably all) of said formulation and at least part of at least one (preferably both) of said electrodes, wherein enablement of the electrodes by the provision of an electric potential thereto generates by electrolysis gas(es), and wherein the formulation is of a kind where the interface of the gas generating electrode(s) to the formulation offers to the gas(es) so generated at such electrode(s) less resistance to gas travel than the formulation itself] and wherein at least a substantial amount of any gas(es) generated at the
- the formulation whilst having an electrolyte character is in the form of a gel or solid but one in which preferably said agent or its precursor (for example, a bio-precursor) does not provide the majority or any of the electrolyte character of the formulation. In other forms however it may.
- the outlet may include a disruptible seal or closure capable of being opened by movement of the formulation and/or gas pressure.
- the formulation is expressed at least partly out of said outlet.
- the present invention consists in dispensing apparatus for dispensing an agent or its precursor(s), said apparatus comprising or including a formulation (complex or simple) of the agent or its precursor(s), the formulation having an electrolyte character, a pair of electrodes disposed and enabled or enablable to generate at least one gas by electrolysis of at least part of the formulation, means enabling and/or to enable the pair of electrodes by the provision of an electric potential across the electrodes, and housing means with at least one outlet (whether closed or not) housing at least part (preferably all) of said formulation and at least part of at least one (preferably both) of said electrodes, wherein enablement of the electrodes by the provision of an electric potential thereto generates by electrolysis gas(es), and wherein the formulation is of a consistency less conducive to gas passage therethrough than a low viscosity liquid (such as might be the case with a suitably viscous liquid, a suitable gel, a suitable solid, or the like, irrespective of orientation of the apparatus) whereby any combination of the
- the formulation whilst having an electrolyte character is in the form of a gel or solid but one in which preferably said agent or its precursor (for example, a bio-precursor) does not provide the majority or any of the electrolyte character of the formulation. In other forms however it may.
- the outlet may include a disruptible seal or closure capable of being opened by movement of the formulation and/or gas pressure.
- the formulation is expressed at least partly out of said outlet.
- the invention consists in dispensing apparatus for dispensing an agent or its precursor(s), said apparatus comprising or including a formulation (complex or simple) of the agent or its precursor(s), the formulation having an electrolyte character, a pair of electrodes disposed and enabled or enablable to generate at least one gas by electrolysis of at least part of the formulation, means enabling and/or to enable the pair of electrodes by the provision of an electric potential across the electrodes, and housing means with at least one outlet (whether closed or not) housing at least part (preferably all) of said formulation and at least part of at least one (preferably both) of said electrodes, wherein enablement of the electrodes by the provision of an electric potential thereto generates by electrolysis gas(es) which issues (or issue) from the formulation and has the effect of opening said outlet which in the absence of the pressure of such gas(es) would remain closed and thus confine the formulation in said housing means.
- the arrangement is an option (A), (E) or (F) as disclosed hereafter by reference to Figure 1.
- the outlet is closed by a rupturible seal.
- the invention is a dispensing device for a formulation containing an active material in solution or suspension and an electrolytic media of electrolytes or polyvalent polymers which preferably (although not essentially) have a standard reduction potential more positive than the standard reduction potential of the active material and which can at least in part be expressed from a delivery reservoir under the action of at least one gas generated on the provision of an electric potential across electrodes in contact with said formulation.
- the formulation may be liquid, gel or solid.
- the present invention consists in dispensing apparatus substantially as hereinbefore described when used to deliver the formulation into an environment whether it be a body of a mammal or not.
- the present invention consists in a method of delivery of an agent or its precursor(s) which comprises disposing dispensing apparatus in accordance with the present invention in a position from which the agent or its precursor(s) can be effectively released and thereafter allowing the dispensing apparatus to dispense the formulation.
- said dispensing is under the control of a timer and/or microprocessor.
- a timer and/or microprocessor Preferably by movement of the formulation there is a total or partial expulsion.
- Such movement(s) may be such as to provide instant, continuous or pulsile release.
- said device includes its own logic and power circuits for the electrodes.
- the invention consists in the foregoing and also envisages constructions of which the following gives examples. DETAILED DESCRIPTION OF THE INVENTION
- Figure 1 in each instance (A) to (F) shows a barrel or reservoir having an outlet in each case at the upper end.
- the formulation is protected within the barrel by a rupturible seal 1 which in the case of (A) maintains the liquid formulation 2 within the barrel 3 around the electrodes 4.
- the option (A) is that which has been hitherto defined as option (a) on page 2 hereof in the sense that gas issuing at one or other of the electrodes will pressurise the sealed chamber and ultimately rupture the seal 1 thereby allowing delivery of the liquid formulation from the outlet initially sealed by seal 1.
- Preferred forms of the present invention are as disclosed by reference to (B), (C), (D), (E) and (F) where a gel or solid (or indeed even a heavily viscous liquid) is depicted having a capability in each instance of being expressed progressively (where continuously or in a pulsile manner) from the respective barrel upon generation of a gas about at least one of the electrodes which will migrate along the electrode in preference to general migration through the formulation to thereby achieve a pressurisation having the net effect as if the gas issues solely at the zone 5.
- the length of the electrodes depicted in option (B) will mean that substantially all of the formulation 6 is expressed from the barrel.
- the option shown in (D) shows how the delivery reservoir or barrel need not be a true barrel, ie; it can be divergent.
- the divergent form shown as (D) has the effect, despite the longer electrodes shown for (D), of allowing gas migration around the formulation (if it is shape retaining) after a certain stage of movement of the formulation out of the optionally sealed opening.
- Option (E) and (F) show options where gas may issue above and below the formulation to first rupture seal 1 and to release gas above the formulation 6 prior to thereafter having some of the gas produced providing a net force urging formulation to the outlet.
- the outlet may be such that the plug does not simply emerge but rather extrudes (eg; as in option (F)). Therefore there is no mandatory requirement for the outlet to be axially aligned with the axis of a barrel.
- the empowerment of the electrodes could be by any of their means mentioned in the aforementioned PCT Application No. PCT/NZ98/00011 or related prior art.
- Electrolyte solution e.g. NaCl 5%w/v.
- Polyionic polymer solution e.g. Na dextran sulphate 10%w/v.
- Gelled polyionic polymer that maintains its physical shape once expelled into an environment below the gelling point of the gel, e.g. agarose 3.5%w/v and
- Timed delivery of a therapeutic agent to the rumen of a ruminant animal e.g. anthelmintics (of which ivomectin is an example) and antibiotics (of which monensin is an example).
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Electrolytic Production Of Metals (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0103901A GB2361711A (en) | 1998-08-14 | 1999-08-11 | Material delivery devices and methods |
AU54531/99A AU5453199A (en) | 1998-08-14 | 1999-08-11 | Material delivery devices and methods |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ33139198A NZ331391A (en) | 1998-08-14 | 1998-08-14 | Dispensing apparatus comprising a formulation, a pair of electrodes and a housing means for agent and electrodes |
NZ331391 | 1998-08-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000009037A1 true WO2000009037A1 (fr) | 2000-02-24 |
Family
ID=19926882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NZ1999/000126 WO2000009037A1 (fr) | 1998-08-14 | 1999-08-11 | Dispositifs et procedes d'apport de substances |
Country Status (4)
Country | Link |
---|---|
AU (1) | AU5453199A (fr) |
GB (1) | GB2361711A (fr) |
NZ (1) | NZ331391A (fr) |
WO (1) | WO2000009037A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002062415A1 (fr) | 2001-02-09 | 2002-08-15 | Interag | Dispositifs a memoire de forme pour cavites corporelles |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991000753A1 (fr) * | 1989-07-12 | 1991-01-24 | Apcis | Dispositif de delivrance d'un principe actif pharmacologique par pompage electrolytique |
WO1993007920A1 (fr) * | 1991-10-24 | 1993-04-29 | Insutech, Incorporated | Dispositif de perfusion utilisant la pression d'un gaz par electrolyse en hydrogels |
DE4342849A1 (de) * | 1993-12-10 | 1995-06-14 | Rainer Dr Habil Hintsche | Anordnung und Verfahren zur Mikrodosierung |
WO1998033452A1 (fr) * | 1997-02-03 | 1998-08-06 | Dec International Nz Limited | Dispositif de delivrance active et procedes correspondants |
WO1999007346A1 (fr) * | 1997-08-07 | 1999-02-18 | Microlin, L.C. | Dispositif implantable servant a administrer un agent de traitement propulse par un gaz |
-
1998
- 1998-08-14 NZ NZ33139198A patent/NZ331391A/en unknown
-
1999
- 1999-08-11 AU AU54531/99A patent/AU5453199A/en not_active Abandoned
- 1999-08-11 GB GB0103901A patent/GB2361711A/en not_active Withdrawn
- 1999-08-11 WO PCT/NZ1999/000126 patent/WO2000009037A1/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991000753A1 (fr) * | 1989-07-12 | 1991-01-24 | Apcis | Dispositif de delivrance d'un principe actif pharmacologique par pompage electrolytique |
WO1993007920A1 (fr) * | 1991-10-24 | 1993-04-29 | Insutech, Incorporated | Dispositif de perfusion utilisant la pression d'un gaz par electrolyse en hydrogels |
DE4342849A1 (de) * | 1993-12-10 | 1995-06-14 | Rainer Dr Habil Hintsche | Anordnung und Verfahren zur Mikrodosierung |
WO1998033452A1 (fr) * | 1997-02-03 | 1998-08-06 | Dec International Nz Limited | Dispositif de delivrance active et procedes correspondants |
WO1999007346A1 (fr) * | 1997-08-07 | 1999-02-18 | Microlin, L.C. | Dispositif implantable servant a administrer un agent de traitement propulse par un gaz |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002062415A1 (fr) | 2001-02-09 | 2002-08-15 | Interag | Dispositifs a memoire de forme pour cavites corporelles |
Also Published As
Publication number | Publication date |
---|---|
AU5453199A (en) | 2000-03-06 |
NZ331391A (en) | 2000-12-22 |
GB2361711A (en) | 2001-10-31 |
GB0103901D0 (en) | 2001-04-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5496360A (en) | Implantable cardiac electrode with rate controlled drug delivery | |
US4054138A (en) | Implants for acting on living beings | |
US4416659A (en) | Sustained release capsule for ruminants | |
US3760805A (en) | Osmotic dispenser with collapsible supply container | |
AU6742100A (en) | Multiple material dispensing | |
AU2011325975B2 (en) | Intravaginal devices for controlled delivery of lubricants | |
US6352524B1 (en) | Active delivery device with reduced passive delivery | |
US4863422A (en) | Swab applicator for generation of heated medicament | |
WO1992007619A1 (fr) | Electrode iontophoretique d'apport de medicament et procede pour son hydratation | |
US6450991B1 (en) | Delivery devices and their use | |
JPH0832622B2 (ja) | 薬剤投与デバイス | |
RU2535781C2 (ru) | Поршень для пустотелого предмета медицинского назначения и пустотелый предмет медицинского назначения | |
US4180073A (en) | Device for delivering drug to biological environment | |
US6884239B2 (en) | Ingestible device for the release of substances at distinct locations in alimentary canal | |
WO2013064745A1 (fr) | Système d'administration vaginale osmotiquement actif | |
WO2000009037A1 (fr) | Dispositifs et procedes d'apport de substances | |
US4776836A (en) | Swab applicator for generation of heated medicament | |
KR0137261B1 (ko) | 소수성 부하물을 함유하는 지효성 전달 장치 | |
PT89554B (pt) | Dispositivo para administracao de medicamentos ao rumen de animais | |
US11090260B2 (en) | Single-dose dual-compartment drug delivery system | |
CN1519040A (zh) | 一种消化道微型药物释放装置 | |
PT94049A (pt) | Dispositivo intra-ruminal para administracao de um agente activo a ruminantes | |
CA1079636A (fr) | Implants dynamiques et methodes d'implantation | |
AU755686B2 (en) | Active delivery device with reduced passive delivery | |
CN2605867Y (zh) | 一种刺破式消化道微型药物释放装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 54531/99 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref country code: GB Ref document number: 200103901 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09744972 Country of ref document: US |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase |