WO2000004141A3 - Use of nucleic acid molecules as antiviral agents - Google Patents
Use of nucleic acid molecules as antiviral agents Download PDFInfo
- Publication number
- WO2000004141A3 WO2000004141A3 PCT/US1999/016253 US9916253W WO0004141A3 WO 2000004141 A3 WO2000004141 A3 WO 2000004141A3 US 9916253 W US9916253 W US 9916253W WO 0004141 A3 WO0004141 A3 WO 0004141A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acid
- acid molecules
- antiviral agents
- viral polymerase
- inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/332—Abasic residue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU53169/99A AU5316999A (en) | 1998-07-20 | 1999-07-15 | Use of nucleic acid molecules as antiviral agents |
CA002334161A CA2334161A1 (en) | 1998-07-20 | 1999-07-15 | Use of nucleic acid molecules as antiviral agents |
EP99938756A EP1098969A2 (en) | 1998-07-20 | 1999-07-15 | Use of nucleic acid molecules as antiviral agents |
JP2000560239A JP2002520051A (en) | 1998-07-20 | 1999-07-15 | Use of nucleic acid molecules as antiviral agents |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9348998P | 1998-07-20 | 1998-07-20 | |
US17951698A | 1998-10-26 | 1998-10-26 | |
US60/093,489 | 1998-10-26 | ||
US09/179,516 | 1998-10-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000004141A2 WO2000004141A2 (en) | 2000-01-27 |
WO2000004141A3 true WO2000004141A3 (en) | 2000-04-27 |
Family
ID=26787599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/016253 WO2000004141A2 (en) | 1998-07-20 | 1999-07-15 | Use of nucleic acid molecules as antiviral agents |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1098969A2 (en) |
JP (1) | JP2002520051A (en) |
AU (1) | AU5316999A (en) |
CA (1) | CA2334161A1 (en) |
WO (1) | WO2000004141A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7294457B2 (en) * | 2001-08-07 | 2007-11-13 | Boehringer Ingelheim (Canada) Ltd. | Direct binding assay for identifying inhibitors of HCV polymerase |
US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
ES2322602T3 (en) | 2004-02-24 | 2009-06-23 | Japan Tobacco, Inc. | CONDENSED HETEROTETHYCLIC COMPOUNDS AND ITS USE AS AN HCV POLYMERASE INHIBITOR. |
US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
US8017612B2 (en) | 2006-04-18 | 2011-09-13 | Japan Tobacco Inc. | Piperazine compound and use thereof as a HCV polymerase inhibitor |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997010328A2 (en) * | 1995-07-13 | 1997-03-20 | Ribozyme Pharmaceuticals, Inc. | Compositions and method for modulation of gene expression in plants |
WO1997026270A2 (en) * | 1996-01-16 | 1997-07-24 | Ribozyme Pharmaceuticals, Inc. | Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules |
WO1998003668A1 (en) * | 1996-07-22 | 1998-01-29 | Zeneca Limited | Virus resistance in plants |
WO1999049031A1 (en) * | 1998-03-26 | 1999-09-30 | Advanced Research And Technology Institute, Inc. | Use of nucleic acid molecules as antiviral agents |
-
1999
- 1999-07-15 CA CA002334161A patent/CA2334161A1/en not_active Abandoned
- 1999-07-15 AU AU53169/99A patent/AU5316999A/en not_active Abandoned
- 1999-07-15 EP EP99938756A patent/EP1098969A2/en not_active Withdrawn
- 1999-07-15 JP JP2000560239A patent/JP2002520051A/en active Pending
- 1999-07-15 WO PCT/US1999/016253 patent/WO2000004141A2/en not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997010328A2 (en) * | 1995-07-13 | 1997-03-20 | Ribozyme Pharmaceuticals, Inc. | Compositions and method for modulation of gene expression in plants |
WO1997026270A2 (en) * | 1996-01-16 | 1997-07-24 | Ribozyme Pharmaceuticals, Inc. | Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules |
WO1998003668A1 (en) * | 1996-07-22 | 1998-01-29 | Zeneca Limited | Virus resistance in plants |
WO1999049031A1 (en) * | 1998-03-26 | 1999-09-30 | Advanced Research And Technology Institute, Inc. | Use of nucleic acid molecules as antiviral agents |
Non-Patent Citations (6)
Title |
---|
ADKINS S ET AL: "Minimal templates directing accurate initiation of subgenomic RNA synthesis in vitro by the brome mosaic virus RNA-dependent RNA polymerase.", RNA, (1997 JUN) 3 (6) 634-47., XP002110077 * |
ADKINS S ET AL: "Subgenomic RNA promoters dictate the mode of recognition by bromoviral RNA-dependent RNA polymerases.", VIROLOGY, (1998 DEC 5) 252 (1) 1-8., XP002110079 * |
HUNTLEY C C ET AL: "MINUS SENSE TRANSCRIPTS OF BROME MOSAIC VIRUS RNA-3 INTERCISTRONIC REGION INTERFERE WITH VIRAL REPLICATION", VIROLOGY, vol. 192, 1993, pages 290 - 297, XP002047298, ISSN: 0042-6822 * |
SIEGEL, R. ET AL.: "Moieties in an RNA promoter specifically recognized by a viral RNA-dependent RNA polymerase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 95, September 1998 (1998-09-01), pages 11613 - 11618, XP002110078, ISSN: 0027-8424 * |
SIEGEL, R. ET AL.: "Sequence-specific recognition of a subgenomic RNA promoter by a viral RNA polymerase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 94, October 1997 (1997-10-01), pages 11238 - 11243, XP002110076, ISSN: 0027-8424 * |
ZACCOMER B ET AL: "TRANSGENIC PLANTS THAT EXPRESS GENES INCLUDING THE 3' UNTRANSLATED REGION OF THE TURNIP YELLOW MOSAIC VIRUS (TYMV) GENOME ARE PARTIALLY PROTECTED AGAINST TYMV INFECTION", GENE, vol. 136, 1 January 1993 (1993-01-01), pages 87 - 94, XP002047299, ISSN: 0378-1119 * |
Also Published As
Publication number | Publication date |
---|---|
WO2000004141A2 (en) | 2000-01-27 |
CA2334161A1 (en) | 2000-01-27 |
EP1098969A2 (en) | 2001-05-16 |
JP2002520051A (en) | 2002-07-09 |
AU5316999A (en) | 2000-02-07 |
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