WO1999067430A3 - Analytische substrate und antioxidative mittel - Google Patents

Analytische substrate und antioxidative mittel Download PDF

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Publication number
WO1999067430A3
WO1999067430A3 PCT/DE1999/001834 DE9901834W WO9967430A3 WO 1999067430 A3 WO1999067430 A3 WO 1999067430A3 DE 9901834 W DE9901834 W DE 9901834W WO 9967430 A3 WO9967430 A3 WO 9967430A3
Authority
WO
WIPO (PCT)
Prior art keywords
analytic substrates
substrates
agents
coor5
cox
Prior art date
Application number
PCT/DE1999/001834
Other languages
English (en)
French (fr)
Other versions
WO1999067430A2 (de
Inventor
Michael Stoeter
Gerd Koenig
Herbert Polligkeit
Original Assignee
Isis Pharma Gmbh
Michael Stoeter
Gerd Koenig
Herbert Polligkeit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1998130006 external-priority patent/DE19830006A1/de
Priority claimed from DE1998127981 external-priority patent/DE19827981A1/de
Priority claimed from DE1998129908 external-priority patent/DE19829908A1/de
Application filed by Isis Pharma Gmbh, Michael Stoeter, Gerd Koenig, Herbert Polligkeit filed Critical Isis Pharma Gmbh
Priority to AU55031/99A priority Critical patent/AU5503199A/en
Priority to EP99941378A priority patent/EP1087926A2/de
Publication of WO1999067430A2 publication Critical patent/WO1999067430A2/de
Publication of WO1999067430A3 publication Critical patent/WO1999067430A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/12—Eight-membered rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/06—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase

Abstract

Die Erfindung beschreibt neue analytische Substrate der allgemeinen Formel (I), worein R1; R2 und R3 gleich oder voneinander verschieden R4, CH2-ONO2, CH2-OR5, CH2-X, COOR5, COX, CH2-COOR5, oder CH¿2?-COX, wobei jedoch mindestens einer der Substituenten R1 bis R3 gleich R4 ist, R4:CHO, R:5 H oder ein geradkettiger oder verzweigter C1-bis C6-Alkylrest und X ein Halogen sind, welche insbesondere bei biochemischen und pharmakologischen Untersuchungen oder als Arzneimittel Verwendung finden können.
PCT/DE1999/001834 1998-06-24 1999-06-24 Analytische substrate und antioxidative mittel WO1999067430A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU55031/99A AU5503199A (en) 1998-06-24 1999-06-24 Analytic substrates and antioxidative agents
EP99941378A EP1087926A2 (de) 1998-06-24 1999-06-24 Analytische substrate und antioxidative mittel

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19830006.9 1998-06-24
DE1998130006 DE19830006A1 (de) 1998-06-24 1998-06-24 Pentaerythritolderivate und Intermediate zu deren Herstellung
DE19827981.7 1998-06-24
DE1998127981 DE19827981A1 (de) 1998-06-24 1998-06-24 Analytische Substrate
DE19829908.7 1998-07-06
DE1998129908 DE19829908A1 (de) 1998-07-06 1998-07-06 Antioxidative Mittel

Publications (2)

Publication Number Publication Date
WO1999067430A2 WO1999067430A2 (de) 1999-12-29
WO1999067430A3 true WO1999067430A3 (de) 2000-05-04

Family

ID=27218471

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/001834 WO1999067430A2 (de) 1998-06-24 1999-06-24 Analytische substrate und antioxidative mittel

Country Status (3)

Country Link
EP (1) EP1087926A2 (de)
AU (1) AU5503199A (de)
WO (1) WO1999067430A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19950483A1 (de) * 1999-10-19 2001-05-10 Isis Pharma Gmbh Verfahren zur Herstellung von 3-Nitryloxy-2,2-bis(nitryloxymethyl)-propanal

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2275586A (en) * 1938-03-25 1942-03-10 Gen Aniline & Film Corp Tri (hydroxy methyl) acetaldehyde and a process of making it
GB1040139A (en) * 1962-06-07 1966-08-24 Nitrochemie Gmbh A method of partially nitrating polyhydric alcohols
GB1132317A (en) * 1966-04-06 1968-10-30 Warner Lambert Pharmaceutical Therapeutic compositions
WO1995026725A1 (de) * 1994-03-30 1995-10-12 Isis Pharma Gmbh Pharmazeutische zubereitingen und arzneistoffe zur prävention und behandlung endothelialer dysfunktion
WO1998015521A1 (de) * 1996-10-10 1998-04-16 Isis Pharma Gmbh Neue derivate des pentaerythrits, deren herstellung und verwendung sowie intermediate zur synthese derselben
WO1999018930A2 (de) * 1997-10-16 1999-04-22 Isis Pharma Gmbh Pharmazeutische zubereitungen

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2275586A (en) * 1938-03-25 1942-03-10 Gen Aniline & Film Corp Tri (hydroxy methyl) acetaldehyde and a process of making it
GB1040139A (en) * 1962-06-07 1966-08-24 Nitrochemie Gmbh A method of partially nitrating polyhydric alcohols
GB1132317A (en) * 1966-04-06 1968-10-30 Warner Lambert Pharmaceutical Therapeutic compositions
WO1995026725A1 (de) * 1994-03-30 1995-10-12 Isis Pharma Gmbh Pharmazeutische zubereitingen und arzneistoffe zur prävention und behandlung endothelialer dysfunktion
WO1998015521A1 (de) * 1996-10-10 1998-04-16 Isis Pharma Gmbh Neue derivate des pentaerythrits, deren herstellung und verwendung sowie intermediate zur synthese derselben
WO1999018930A2 (de) * 1997-10-16 1999-04-22 Isis Pharma Gmbh Pharmazeutische zubereitungen

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BINKS, PETER R. ET AL: "Degradation of pentaerythritol tetranitrate by Enterobacter cloacae PB2", APPL. ENVIRON. MICROBIOL. (1996), 62(4), 1214-19, XP002129418 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KEMP, TERENCE J. ET AL: "Mechanism of the thermal degradation of prepolymeric poly(3-nitratomethyl-3-methyloxetane)", XP002129419, retrieved from STN Database accession no. 129:345075 HCA *
DIETZ G.: "[ Pentaerythrityl tetranitrate (PETN) does not lead to nitrate tolerance]. PETN FUHRT NICHT ZU NITRATTOLERANZ.", PHARMAZEUTISCHE ZEITUNG, (19 FEB 1998) 143/8 (46)., XP000870330 *
FINK, BRUNO ET AL: "Unexpected, tolerance-devoid vasomotor and platelet actions of pentaerythritol tetranitrate", J. CARDIOVASC. PHARMACOL. (1997), 30(6), 831-836, XP000870325 *
KOJDA G ET AL: "Effects of nonintermittent treatment of rabbits with pentaerythritol tetranitrate on vascular reactivity and superoxide production.", EUROPEAN JOURNAL OF PHARMACOLOGY, (1998 AUG 14) 355 (1) 23-31., XP000870146 *
KOJDA G ET AL: "In vivo effects of pentaerythrityl -tetranitrate and isosorbide-5-mononitrate on the development of atherosclerosis and endothelial dysfunction in cholesterol-fed rabbits.", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, (1995 MAY) 25 (5) 763-73., XP000874083 *
POLYMER (1998), VOLUME DATE 1999, 40(1), 65-93 *

Also Published As

Publication number Publication date
EP1087926A2 (de) 2001-04-04
WO1999067430A2 (de) 1999-12-29
AU5503199A (en) 2000-01-10

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