WO1999066875A3 - Kombinationspräparat von antiinfektiös wirkenden verbindungen, die den 2-c-methylerythrose-4-stoffwechselweg hemmen, und hemmern des fettstoffwechsels - Google Patents

Kombinationspräparat von antiinfektiös wirkenden verbindungen, die den 2-c-methylerythrose-4-stoffwechselweg hemmen, und hemmern des fettstoffwechsels Download PDF

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Publication number
WO1999066875A3
WO1999066875A3 PCT/EP1999/004360 EP9904360W WO9966875A3 WO 1999066875 A3 WO1999066875 A3 WO 1999066875A3 EP 9904360 W EP9904360 W EP 9904360W WO 9966875 A3 WO9966875 A3 WO 9966875A3
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WO
WIPO (PCT)
Prior art keywords
combined preparation
methylerythrose
lipid metabolism
metabolic pathway
inhibitors
Prior art date
Application number
PCT/EP1999/004360
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English (en)
French (fr)
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WO1999066875A2 (de
Inventor
Hassan Jomaa
Original Assignee
Hassan Jomaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19828097A external-priority patent/DE19828097A1/de
Application filed by Hassan Jomaa filed Critical Hassan Jomaa
Priority to EP99929309A priority Critical patent/EP1100510A2/de
Priority to PL99345513A priority patent/PL345513A1/xx
Priority to AU46155/99A priority patent/AU752714B2/en
Priority to IL13996599A priority patent/IL139965A0/xx
Priority to JP2000555562A priority patent/JP2002518418A/ja
Priority to CA002334645A priority patent/CA2334645A1/en
Priority to SK1961-2000A priority patent/SK19612000A3/sk
Publication of WO1999066875A2 publication Critical patent/WO1999066875A2/de
Publication of WO1999066875A3 publication Critical patent/WO1999066875A3/de

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)

Abstract

Kombinationspräparat, enthaltend als Wirkstoffe mindestens eine antiinfektiös wirkende Verbindung, die den 2-C-Methylerythrose-4-Stoffwechselweg hemmt, und mindestens einen Fettstoffwechselhemmer. Das Kombinationspräparat wird bei infektiösen Prozessen eingesetzt, insbesondere Infektionen bei Mensch und Tier und als Herbizid bei Pflanzen. Es zeigt sich, daß die Resistenzbildung bei dem Kombinationspräparat gegenüber den Einzelpräparaten stark reduziert ist.
PCT/EP1999/004360 1998-06-24 1999-06-23 Kombinationspräparat von antiinfektiös wirkenden verbindungen, die den 2-c-methylerythrose-4-stoffwechselweg hemmen, und hemmern des fettstoffwechsels WO1999066875A2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP99929309A EP1100510A2 (de) 1998-06-24 1999-06-23 Kombinationspräparat von antiinfektiös wirkenden verbindungen, die den 2-c-methylerythrose-4-stoffwechselweg hemmen, und hemmern des fettstoffwechsels
PL99345513A PL345513A1 (en) 1998-06-24 1999-06-23 Combined preparation of anti-infectiously active compounds which inhibit the 2-c-methylerythrose-4 metabolic pathway, and inhibitors of lipid metabolism
AU46155/99A AU752714B2 (en) 1998-06-24 1999-06-23 Combined preparation of anti-infectiously active compounds which inhibit the 2-C-methylerythrose-4 metabolic pathway, and inhibitors of lipid metabolism
IL13996599A IL139965A0 (en) 1998-06-24 1999-06-23 Combined preparation of anti-infectiously active compounds which inhibit the 2-c-methylerythrose-4 metabolic pathway and inhibitors of lipid metabolism
JP2000555562A JP2002518418A (ja) 1998-06-24 1999-06-23 ２−ｃ−メチルエリトロース−４代謝経路を阻害する抗感染活性化合物と脂質代謝の阻害剤の複合調製物
CA002334645A CA2334645A1 (en) 1998-06-24 1999-06-23 Combined preparation of anti-infectiously active compounds which inhibit the 2-c-methylerythrose-4 metabolic pathway, and inhibitors of lipid metabolism
SK1961-2000A SK19612000A3 (sk) 1998-06-24 1999-06-23 Kombinovaný prípravok antiinfekčne pôsobiacich zlúčenín, ktoré inhibujú metabolickú dráhu 2-c-metylerytrózy-4 a inhibítorov metabolizmu lipidov

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19828097A DE19828097A1 (de) 1998-06-24 1998-06-24 Kombinationspräparat von Aminohydrocarbylphosphonsäurederivaten und Hemmern des Fettstoffwechsels
DE19828097.1 1998-06-24
DE19843279 1998-09-22
DE19843279.8 1998-09-22

Publications (2)

Publication Number Publication Date
WO1999066875A2 WO1999066875A2 (de) 1999-12-29
WO1999066875A3 true WO1999066875A3 (de) 2000-09-14

Family

ID=26047010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/004360 WO1999066875A2 (de) 1998-06-24 1999-06-23 Kombinationspräparat von antiinfektiös wirkenden verbindungen, die den 2-c-methylerythrose-4-stoffwechselweg hemmen, und hemmern des fettstoffwechsels

Country Status (10)

Country Link
EP (1) EP1100510A2 (de)
JP (1) JP2002518418A (de)
CN (1) CN1348374A (de)
AU (1) AU752714B2 (de)
CA (1) CA2334645A1 (de)
IL (1) IL139965A0 (de)
PL (1) PL345513A1 (de)
SK (1) SK19612000A3 (de)
TR (1) TR200003783T2 (de)
WO (1) WO1999066875A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2175025A1 (de) 1998-04-14 2010-04-14 Kyowa Hakko Bio Co., Ltd. Verfahren zur Herstellung von Isoprenoidverbindungen durch Mikroorganismen
PE20161328A1 (es) * 2014-02-23 2016-12-17 Fmc Corp Uso de compuestos 3-isoxalidinonas como herbicidas selectivos

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330529A (en) * 1978-02-15 1982-05-18 Fujisawa Pharmaceutical Co., Ltd. Antibacterial composition
JPS6064991A (ja) * 1983-09-17 1985-04-13 Fujisawa Pharmaceut Co Ltd セファレキシン・ホスミドマイシン塩およびその製造法
EP0256785A2 (de) * 1986-08-11 1988-02-24 Fujisawa Pharmaceutical Co., Ltd. Herbizides Mittel
EP0513760A2 (de) * 1991-05-13 1992-11-19 E.R. SQUIBB & SONS, INC. Verwendung von Biphosphonat-Squalensynthetaseinhibitoren in pharmazeutischen Zusammensetzungen zur Senkung des Cholesterinspiegels
EP0537008A1 (de) * 1991-10-11 1993-04-14 E.R. SQUIBB & SONS, INC. Verwendung von Biphosphonaten zur Herstellung eines Arzneimittels zur Blockierung neoplastischer Zelltransformationen die durch Ras-Oncogene verursacht werden

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330529A (en) * 1978-02-15 1982-05-18 Fujisawa Pharmaceutical Co., Ltd. Antibacterial composition
JPS6064991A (ja) * 1983-09-17 1985-04-13 Fujisawa Pharmaceut Co Ltd セファレキシン・ホスミドマイシン塩およびその製造法
EP0256785A2 (de) * 1986-08-11 1988-02-24 Fujisawa Pharmaceutical Co., Ltd. Herbizides Mittel
EP0513760A2 (de) * 1991-05-13 1992-11-19 E.R. SQUIBB & SONS, INC. Verwendung von Biphosphonat-Squalensynthetaseinhibitoren in pharmazeutischen Zusammensetzungen zur Senkung des Cholesterinspiegels
EP0537008A1 (de) * 1991-10-11 1993-04-14 E.R. SQUIBB & SONS, INC. Verwendung von Biphosphonaten zur Herstellung eines Arzneimittels zur Blockierung neoplastischer Zelltransformationen die durch Ras-Oncogene verursacht werden

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 198521, Derwent World Patents Index; Class B02, AN 1985-126148, XP002130218 *
YOKOTA, YOSHIKO ET AL: "In vitro synergism of FR-31564, a new phosphonic acid antibiotic", J. ANTIBIOT. (1981), 34(7), 876-83, 1981, XP000867644 *

Also Published As

Publication number Publication date
EP1100510A2 (de) 2001-05-23
TR200003783T2 (tr) 2001-06-21
SK19612000A3 (sk) 2001-08-06
CA2334645A1 (en) 1999-12-29
CN1348374A (zh) 2002-05-08
AU752714B2 (en) 2002-09-26
AU4615599A (en) 2000-01-10
IL139965A0 (en) 2002-02-10
PL345513A1 (en) 2001-12-17
JP2002518418A (ja) 2002-06-25
WO1999066875A2 (de) 1999-12-29

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