WO1999064861A3 - Method of identifying antidepressant compounds - Google Patents

Method of identifying antidepressant compounds Download PDF

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Publication number
WO1999064861A3
WO1999064861A3 PCT/GB1999/001859 GB9901859W WO9964861A3 WO 1999064861 A3 WO1999064861 A3 WO 1999064861A3 GB 9901859 W GB9901859 W GB 9901859W WO 9964861 A3 WO9964861 A3 WO 9964861A3
Authority
WO
WIPO (PCT)
Prior art keywords
transport
compound
identifying
alpha
protein
Prior art date
Application number
PCT/GB1999/001859
Other languages
French (fr)
Other versions
WO1999064861A2 (en
Inventor
Saad Al-Damluji
Original Assignee
Univ London
Saad Al Damluji
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ London, Saad Al Damluji filed Critical Univ London
Priority to AU42829/99A priority Critical patent/AU4282999A/en
Publication of WO1999064861A2 publication Critical patent/WO1999064861A2/en
Publication of WO1999064861A3 publication Critical patent/WO1999064861A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

There is disclosed a method of identifying compounds having antidepressant activity which method comprises: a) contacting a cell expressing an alpha-1b-adrenergic receptor and transport-P protein with said compound to be tested; and b) prior to or after step a) contacting said compound with a cell expressing an alpha-1b-adrenergic receptor but not transport-P protein; and c) selecting a compound which preferentially binds transport P. Compounds identified using the method of the invention are also provided in addition to pharmaceutical compositions containing them and their use in treating depression.
PCT/GB1999/001859 1998-06-11 1999-06-11 Method of identifying antidepressant compounds WO1999064861A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU42829/99A AU4282999A (en) 1998-06-11 1999-06-11 Method of identifying antidepressant compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9812624.6 1998-06-11
GBGB9812624.6A GB9812624D0 (en) 1998-06-11 1998-06-11 Method of identifying antidepressant compounds

Publications (2)

Publication Number Publication Date
WO1999064861A2 WO1999064861A2 (en) 1999-12-16
WO1999064861A3 true WO1999064861A3 (en) 2000-06-29

Family

ID=10833600

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/001859 WO1999064861A2 (en) 1998-06-11 1999-06-11 Method of identifying antidepressant compounds

Country Status (3)

Country Link
AU (1) AU4282999A (en)
GB (1) GB9812624D0 (en)
WO (1) WO1999064861A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2817117B1 (en) * 2000-11-24 2005-11-04 Commissariat Energie Atomique TRANSGENIC OR RECOMBINANT NON-HUMAN MAMMALS AND USES THEREOF IN THE SCREENING OF MEDICAMENTS USEFUL IN PSYCHOACTIVE DISORDERS
CN106383193A (en) * 2016-11-22 2017-02-08 无锡艾科瑞思产品设计与研究有限公司 Detection method for phenylethanolamine in pork
US20230265045A1 (en) * 2020-06-29 2023-08-24 Gilgamesh Pharmaceuticals, Inc. Phenalkylamines and methods of treating mood disorders
CN115400109A (en) * 2022-09-29 2022-11-29 首都医科大学附属北京安定医院 Application of tyramine and derivatives thereof in preparation of drugs for treating depression

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000280A (en) * 1974-08-14 1976-12-28 Astra Lakemedel Aktiebolag Pharmaceutical compositions containing an amphetamine derivative for the alleviation of anxiety or treatment of depression
WO1994008040A1 (en) * 1992-09-25 1994-04-14 Synaptic Pharmaceutical Corporation Dna encoding human alpha 1 adrenergic receptors and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000280A (en) * 1974-08-14 1976-12-28 Astra Lakemedel Aktiebolag Pharmaceutical compositions containing an amphetamine derivative for the alleviation of anxiety or treatment of depression
WO1994008040A1 (en) * 1992-09-25 1994-04-14 Synaptic Pharmaceutical Corporation Dna encoding human alpha 1 adrenergic receptors and uses thereof

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
AL-DAMLUJI S, KOPIN IJ: "Binding and competitive inhibition of amine uptake at postsynaptic neurones (transport-P) by tricyclic antidepressants", BRITISH JOURNAL OF PHARMACOLOGY, vol. 117, no. 5, March 1996 (1996-03-01), pages 811 - 816, XP000863509 *
AL-DAMLUJI S, KOPIN IJ: "Functional properties of the uptake of amines in immortalised peptidergic neurones (transport-P)", BRITISH JOURNAL OF PHARMACOLOGY, vol. 117, no. 1, January 1996 (1996-01-01), pages 111 - 118, XP000863501 *
AL-DAMLUJI S, KOPIN IJ: "Structural properties of phenylethylamine derivatives which inhibit transport-P in peptidergic neurones", BRITISH JOURNAL OF PHARMACOLOGY, vol. 124, no. 4, June 1998 (1998-06-01), pages 693 - 702, XP000863479 *
AL-DAMLUJI S, KRSMANOVIC LZ, CATT KJ: "High-affinity uptake of noradrenaline in postsynaptic neurones", BRITISH JOURNAL OF PHARMACOLOGY, vol. 109, no. 2, June 1993 (1993-06-01), pages 299 - 307, XP000863500 *
AL-DAMLUJI S, PORTER D, KRSMANOVIC LZ, KNUTSON JR, KOPIN IJ: "Visual detection of transport-P in peptidergic neurones", BRITISH JOURNAL OF PHARMACOLOGY, vol. 120, no. 5, March 1997 (1997-03-01), pages 876 - 882, XP000863504 *
COTECCHIA S. ET AL.: "MOLECULAR CLONING AND EXPRESSION OF THE CDNA FOR THE HAMSTER ALPHA 1-ADRENERGIC RECEPTOR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 85, no. 19, October 1988 (1988-10-01), pages 7159 - 7163, XP002135236 *
GAO B. ET AL.: "ISOLATION AND CHARACTERIZATION OF THE GENE ENCODING THE RAT ALPHA1B ADRENERGIC RECEPTOR", GENE, vol. 131, no. 2, 15 September 1993 (1993-09-15), pages 243 - 247, XP000645085, ISSN: 0378-1119 *
HANCOCK A A: "alpha(1) adrenoceptor subtypes: A synopsis of their pharmacology and molecular biology", DRUG DEVELOPMENT RESEARCH, vol. 39, no. 1, September 1996 (1996-09-01), pages 54 - 107, XP000863474 *
RAMARAO C. S. ET AL.: "GENOMIC ORGANIZATION AND EXPRESSION OF THE HUMAN ALPHA 1B-ADRENERGIC RECEPTOR", JOURNAL OF BIOLOGICAL CHEMISTRY (1992 OCT 25) 267 (30) 21936-45, XP002135235 *
S WHITE, S AL-DAMLUJI: "Molecular Cloning of alpha-1 Adrenergic Receptor cDNA from GnRH Neurones", JOURNAL OF ENDOCRINOLOGY (VOL. 152 SUPPLEMENT, ABSTRACT P150), vol. 152, 1997, XP000863507 *
VOIGT M. M. ET AL.: "SEQUENCE OF A RAT BRAIN CDNA ENCODING AN ALPHA-1B ADRENERGIC RECEPTOR", NUCLEIC ACIDS RESEARCH, vol. 18, no. 4, February 1990 (1990-02-01), pages 1053, XP002135237 *

Also Published As

Publication number Publication date
WO1999064861A2 (en) 1999-12-16
AU4282999A (en) 1999-12-30
GB9812624D0 (en) 1998-08-12

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