WO2001004354A3 - Use of ras inhibitors of inhibiting muscle atrophy - Google Patents

Use of ras inhibitors of inhibiting muscle atrophy Download PDF

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Publication number
WO2001004354A3
WO2001004354A3 PCT/US2000/017173 US0017173W WO0104354A3 WO 2001004354 A3 WO2001004354 A3 WO 2001004354A3 US 0017173 W US0017173 W US 0017173W WO 0104354 A3 WO0104354 A3 WO 0104354A3
Authority
WO
WIPO (PCT)
Prior art keywords
muscle atrophy
inhibiting
ras inhibitors
inhibiting muscle
provides
Prior art date
Application number
PCT/US2000/017173
Other languages
French (fr)
Other versions
WO2001004354A2 (en
Inventor
David J Glass
Christian Rommel
George D Yancopoulos
Original Assignee
Regeneron Pharma
David J Glass
Christian Rommel
George D Yancopoulos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, David J Glass, Christian Rommel, George D Yancopoulos filed Critical Regeneron Pharma
Priority to JP2001509553A priority Critical patent/JP2003504351A/en
Priority to EP00941641A priority patent/EP1192281A2/en
Priority to CA002378982A priority patent/CA2378982A1/en
Priority to AU56323/00A priority patent/AU5632300A/en
Publication of WO2001004354A2 publication Critical patent/WO2001004354A2/en
Publication of WO2001004354A3 publication Critical patent/WO2001004354A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061—Muscle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides a method for inhibiting atrophy in muscle cells. It further provides a method for inhibiting skeletal muscle atrophy or causing skeletal muscle hypertrophy in vertebrate animals. It also provides a method of identifying agents, genes and gene products that may be used to reduce proteolysis or increase protein synthesis in muscle cells.
PCT/US2000/017173 1999-07-07 2000-06-22 Use of ras inhibitors of inhibiting muscle atrophy WO2001004354A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001509553A JP2003504351A (en) 1999-07-07 2000-06-22 How to inhibit muscle atrophy
EP00941641A EP1192281A2 (en) 1999-07-07 2000-06-22 Use of ras inhibitors for inhibiting muscle atrophy
CA002378982A CA2378982A1 (en) 1999-07-07 2000-06-22 Methods of inhibiting muscle atrophy
AU56323/00A AU5632300A (en) 1999-07-07 2000-06-22 Methods of inhibiting muscle atrophy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14285799P 1999-07-07 1999-07-07
US60/142,857 1999-07-07

Publications (2)

Publication Number Publication Date
WO2001004354A2 WO2001004354A2 (en) 2001-01-18
WO2001004354A3 true WO2001004354A3 (en) 2001-08-16

Family

ID=22501570

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/017173 WO2001004354A2 (en) 1999-07-07 2000-06-22 Use of ras inhibitors of inhibiting muscle atrophy

Country Status (5)

Country Link
EP (1) EP1192281A2 (en)
JP (1) JP2003504351A (en)
AU (1) AU5632300A (en)
CA (1) CA2378982A1 (en)
WO (1) WO2001004354A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004526776A (en) * 2001-04-25 2004-09-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Farnesyl protein transferase inhibitors for treating cachexia
EP1745144B1 (en) 2004-05-11 2010-12-01 Axiogenesis Ag Assay for drug discovery based on in vitro differentiated cells
US20110313027A1 (en) * 2008-08-13 2011-12-22 Zador Ernoe Methods and substances for stimulating muscle regeneration
WO2012087437A2 (en) * 2010-11-09 2012-06-28 Sarcotein Diagnostics Llc Bin1 expression as a marker of skeletal muscle mass and neurological conditions
US9846159B2 (en) 2011-09-30 2017-12-19 Sarcotein Diagnostics, Llc BIN1 expression as a marker of cancer
WO2015085097A1 (en) 2013-12-05 2015-06-11 The Broad Institute, Inc. Compositions and methods for identifying and treating cachexia or pre-cachexia
US10436800B2 (en) 2015-03-02 2019-10-08 Sarcotein Diagnostics, Llc 13+/17+ BIN1 expression as a marker of cardiac disorders
WO2017106196A1 (en) 2015-12-14 2017-06-22 The Broad Institute, Inc. Compositions and methods for treating cardiac dysfunction

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444047A (en) * 1994-06-16 1995-08-22 Dipasquale; Gene Treatment of arthritic and post-surgical orthopedic conditions with Insulin-like Growth Factor-I
WO1997045412A1 (en) * 1996-05-30 1997-12-04 Merck & Co., Inc. A method of treating cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444047A (en) * 1994-06-16 1995-08-22 Dipasquale; Gene Treatment of arthritic and post-surgical orthopedic conditions with Insulin-like Growth Factor-I
WO1997045412A1 (en) * 1996-05-30 1997-12-04 Merck & Co., Inc. A method of treating cancer

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BOWEN D C ET AL: "Regulation of MuSK expression in skeletal muscle during development and after injury.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 22, no. 1-3, 1996, 26th Annual Meeting of the Society for Neuroscience;Washington, D.C., USA; November 16-21, 1996, pages 1476, XP000986706, ISSN: 0190-5295 *
COLEMAN M E ET AL: "MYOGENIC VECTOR EXPRESSION OF INSULIN-LIKE GROWTH FACTOR I SIMULATES MUSCLE CELL DIFFERENTIATION AND MYOFIBER HYPERTROPHY IN TRANSGENIC MICE", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 270, no. 20, 19 May 1995 (1995-05-19), pages 12109 - 12116, XP000611917, ISSN: 0021-9258 *
COOLICAN SHARON A ET AL: "The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 10, 1997, pages 6653 - 6662, XP002161387, ISSN: 0021-9258 *
DUDLEY DAVID T ET AL: "A synthetic inhibitor of the mitogen-activated protein kinase cascade.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 92, no. 17, 1995, 1995, pages 7686 - 7689, XP002161388, ISSN: 0027-8424 *
ROMMEL CHRISTIAN ET AL: "Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.", SCIENCE (WASHINGTON D C), vol. 286, no. 5445, 26 November 1999 (1999-11-26), pages 1738 - 1741, XP002161386, ISSN: 0036-8075 *
SAMUEL D S ET AL: "Raf-1 activation stimulates proliferation and inhibits IGF-stimulated differentiation in L6A1 myoblasts.", HORMONE AND METABOLIC RESEARCH, vol. 31, no. 2-3, February 1999 (1999-02-01), pages 55 - 64, XP000986726, ISSN: 0018-5043 *

Also Published As

Publication number Publication date
EP1192281A2 (en) 2002-04-03
AU5632300A (en) 2001-01-30
CA2378982A1 (en) 2001-01-18
WO2001004354A2 (en) 2001-01-18
JP2003504351A (en) 2003-02-04

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