WO1999061145A1 - Procede et dispositif servant a preparer une matrice de produit encapsulee - Google Patents

Procede et dispositif servant a preparer une matrice de produit encapsulee Download PDF

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Publication number
WO1999061145A1
WO1999061145A1 PCT/US1999/010949 US9910949W WO9961145A1 WO 1999061145 A1 WO1999061145 A1 WO 1999061145A1 US 9910949 W US9910949 W US 9910949W WO 9961145 A1 WO9961145 A1 WO 9961145A1
Authority
WO
WIPO (PCT)
Prior art keywords
particles
product
matrix
free
ejecting
Prior art date
Application number
PCT/US1999/010949
Other languages
English (en)
Inventor
Subraman R. Cherukuri
Supapong Siris
Original Assignee
Fuisz International Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IE980395A external-priority patent/IE980395A1/en
Application filed by Fuisz International Ltd. filed Critical Fuisz International Ltd.
Priority to CA002362633A priority Critical patent/CA2362633A1/fr
Priority to AU40840/99A priority patent/AU4084099A/en
Priority to JP2000550592A priority patent/JP2002516171A/ja
Priority to EP99924314A priority patent/EP1085940A1/fr
Publication of WO1999061145A1 publication Critical patent/WO1999061145A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/18—Chewing gum characterised by shape, structure or physical form, e.g. aerated products
    • A23G4/20—Composite products, e.g. centre-filled, multi-layer, laminated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

Definitions

  • the present invention relates generally to a process and apparatus for forming a feedstock product matrix. More particularly, the present invention is directed to an improved method and apparatus for forming an encapsulated product matrix. The invention further relates to equipment and a process for forming an encapsulated product matrix utilizing two or more encapsulating materials, as well as combining two or more products in the encapsulated matrix.
  • particulate feedstock material is formed as an intermediate product for use in further processing.
  • the particles may be formed by various techniques.
  • One technique is to spray dry eject product particles from a spray nozzle.
  • This technique employs a spray nozzle supported within a tower.
  • the spray nozzle converts liquid emulsions to dry powder at elevated temperatures.
  • Conventional heated liquid emulsion is transported to the spray nozzle where it is ejected therefrom as a dry powder into a freeflow feedstream. As the heated dry powder falls in a free-flow condition, it cools and solidifies into particles.
  • the particles may then be used for further processing in conventional material handling applications for the formation of food stuffs and pharmaceutical products.
  • One technique to provide an encapsulated product matrix is to form the encapsulated product in an extrusion process.
  • An encapsulant such as fat is typically processed in an extruder under controlled heat and pressure.
  • the fat is liquefied or molten and forced through extrusion dies to form round bead or sphere-like particles.
  • Additives may be introduced into the fat during the extrusion process so that the small formed beads include the additive encapsulated within the fat.
  • the present invention provides a method for forming a product matrix.
  • the method includes the delivery of a substantially solid additive into a free-flow condition.
  • the substantially solid matrix additive is encapsulated during the free-flow condition with a matrix encapsulant which is also supplied to the free-flow condition.
  • the encapsulated additive may also be cooled during the free-flow condition to form the product matrix.
  • the present invention further provides an apparatus for forming an encapsulated product matrix.
  • the apparatus includes a delivery device that places a product additive into a feedstream of substantially solid particles.
  • a product encapsulant is also delivered into the feedstream of the substantially solid particles to encapsulate the particles.
  • a cooling device may also be employed for cooling the encapsulated solid particles in the feedstream if desired.
  • a processing tower or other containment environment which has a sufficient free-flow volume is employed.
  • the processing tower accommodates a delivery device at one end thereof so as to eject, deliver or otherwise place the product additive into a free-flow condition within the free-floe containment volume.
  • An encapsulant delivery device ejects, or otherwise delivers the product encapsulant into the free-flow stream so as to encapsulate the individual particles therein.
  • the encapsulated particles remain in a free-flow condition for a sufficient amount of time to form the product matrix.
  • the processing tower apparatus may be modified to include additional entry ports for inclusion of double, or even triple or more, the quantity of material to be encapsulated.
  • the product additive delivery device for delivering particles of the product additive into the free-flow condition can be located towards either end of the free-flow containment environment or tower. The equipment will therefore permit differing types of material to encapsulate or to be encapsulated to separately enter the apparatus.
  • the invention provides an encapsulated product matrix in which both the types of material to be encapsulated and the encapsulating materials themselves can be optimized according to whatever requirements are necessary in the final product without the need to utilize additional apparatus or to stop and clean the instant inventive apparatus.
  • Figure 1 is schematic representation of the product encapsulating apparatus of the present invention.
  • Figure 2 is a schematic representation of an encapsulant extruder used in accordance with the present invention.
  • Figure 3 is a detailed schematic representation of an ejection nozzle of the extruder of Figure 2.
  • Figure 4 is a further embodiment of the apparatus shown in Figure 1.
  • Figure 5 is still another embodiment of the apparatus shown in Figure 1.
  • the present invention is directed to method and apparatus for forming an encapsulated feedstock product matrix.
  • the resultant product matrix is preferably in the form of tiny particles in the shape of beads or spheres, though variations thereof are certainly within the scope of the invention.
  • Each of the sphere-like particles includes particles of a matrix additive (material to be encapsulated) which are enrobed with spheres or tiny masses of an encapsulating material.
  • the product additives may include flavors, fibers, colorings, sugars and other additives useful in the manufacture of food-stuffs, and especially confectionery products such as gums, candies, lozenges and mints, etc and combinations thereof.
  • actives i.e. those materials which are intended to produce a biological, chemical or pharmacological, etc. response once ingested.
  • drugs, vitamins, minerals, nutraceutcials and other dietary supplement material are within the scope of materials to be encapsulated.
  • actives with undesirable organoleptic qualities such as bitter taste or offensive odor.
  • the encapsulating material or materials may include a dissimilar material such as an oleaginous material like various fats or oils and including vegetable oils, soy bean oil, cannola oil, corn oil, cocoa butter, sunflower oil, animal fats, tallows, lards, fish oils, crustation oils, and mixtures thereof. Also useful are medium chain triglycerides, and other substances with fatty moieties. Materials with emulsifying capabilities are also highly desirable. Particularly preferred may be natural and synthetic flavor oils, including without limitation, such oils as a spearmint, peppermint, menthol, wintergreen, cinnamon and citrus oils.
  • This encapsulating material can also have incorporated thereinto other additives such as bioaffecting agents, dyes, fragrances, crystallization modifiers, surfactants, control agents, sweeteners, flavors and mixtures thereof.
  • additional additives which are directly introduced into the oleaginous material, are typically of the type which may be subjected to fairly high temperature environments without degradation of product qualities.
  • the encapsulating material in fact be substantially or wholly a proteinaceous substance or carbohydrate-based.
  • the term "oleaginous" is intended to cover all such materials.
  • the present invention permits the incorporation of certain other additives of the type described above which would be subject to product degradation if combined with oleaginous material in a conventional high-heat extrusion process.
  • the present invention is directed to the incorporation of certain product additives into extruded oleaginous spheres without degradation of the beneficial attributes of the additive.
  • a product encapsulating apparatus 10 of the present invention is shown.
  • Encapsulating apparatus 10 includes a free flow containment device 12.
  • the free flow containment device is preferably a tower apparatus 12, but those skilled in the art will recognize that any device which can contain, suspend, fluidize and/or separate the additives and encapsulating material may be utilized.
  • the preferred tower 12 is generally an elongate enclosure container having cylindrical side wall 14 in communication with a lower frustro-conical end wall 16.
  • Frustro-conical end wall 16 has a lower open end 18 which is in communication with a collection hopper 20.
  • encapsulating apparatus 10 includes a source 28 of product additive to be encapsulated.
  • This source 28 can include any device capable of delivering material into the tower 12.
  • the delivery source 28 may be a supply ejector, or a spinning head apparatus, such as that described in U.S.
  • the product source 28 is a spray dry device.
  • Dry spray device 28 includes a dry spray nozzle 30 supported within the interior 26 of tower 12 adjacent the upper end 22 thereof using any means known in the art.
  • Dry spray nozzle 30 is in communication with a product conduit 32 for delivering liquid or semi-liquid product (in one embodiment liquid product emulsion) to the spray nozzle 30.
  • the conduit 32 may be formed of an insulated pipe which delivers the liquid material from a location where the liquid material is prepared (not shown) to the spray nozzle 30 within interior 26 of tower 12.
  • Dry spray apparatus 28 can be of conventional construction and is desirably used to dry out excess moisture in the liquid product and convert the liquid product to a dry powder at relatively high temperatures. Those skilled in the art will discover that the product does not have to be dry upon entering the tower via conduit 32, however (the material may be wet and subsequently be either partially or wholly dried upon exposure to the air or other gaseous medium inside the tower 12, or in some instances may even remain in a liquid or semi-liquid state upon entering the interior of the tower). Dry spray apparatus 28 may be operational under electrical power and may heat the emulsion by gas, steam or electrical energy.
  • the emulsion which is delivered by conduit 32 includes an emulsion of a product additive as above-described.
  • the dry spray nozzle 30 operates in a conventional fashion to convert the liquid product to a dried power and spray eject solid powered particles 31 into a feedstream of such particles in a free-flow condition.
  • the dried particles 31 drop under the influence of gravity through the tower interior 26 in such free-flow condition.
  • the additive material contain a "drying" material recognized by those skilled in the art.
  • cellulosic material may be utilized to imbibe and absorb excess moisture which might otherwise contaminate the product additive. In this way, any drying action of the dry spray apparatus 28 may be augmented or even replaced.
  • Encapsulating apparatus 10 of the present invention further includes an encapsulation extruding device 40.
  • Extruding device 40 delivers an extruded liquid or semi-liquid encapsulating material, preferably oleaginous material such as one or more fats or oils, to an extrusion nozzle 42 which is supported within the interior 26 of tower 12 adjacent the lower end 23 thereof.
  • the encapsulating material is at an elevated temperature.
  • the extruder serves to eject extruded oleaginous beads or spheres 41 into the interior 26 of tower 12. Formation of such fat or oil spheres with extruding device 40 may be accomplished preferably in accordance with a method and apparatus disclosed in commonly assigned U.S. Patent No.
  • the process and apparatus disclosed therein forms a shear-form matrix by raising the temperature of the oleaginous material to a point where the material undergoes internal flow upon application of a fluid shear force, but at a temperature typically below the melting point of the material.
  • the material is advanced and ejected while in this internal flow condition and subjected to a disruptive fluid shear force to form multiple parts or masses which have a sphere or bead-like configuration.
  • the multiple masses are cooled substantially immediately after contact with the disruptive shear force and are ejected into a feedstream into a free-flow condition and solidified.
  • the disruptive force is applied to the oleaginous material abruptly over a short period of time so that the duration of the disruptive force can be considered instantaneous.
  • the oleaginous material can be subjected to a stream of fluid, gas or liquid impacting the material at a velocity which creates the flash disruptive shear force.
  • the preferred fluid is air.
  • other types of fluids may be used to create the fluid shear force.
  • air is ejected against the material as a continuous high velocity jet. The pat of the material is abruptly disrupted into discrete continuous masses or spheres due to the shear acting on the material while it has internal flow.
  • shear is provided to the extruded encapsulating material 40a while in the internal flow condition by directing a stream of high velocity air against the coherent stream exiting the nozzle 42.
  • the high velocity air can be provided by air stream 43 which can pass through a filter and pressure/flow regulator 44 to an in-line heater 45 and a thermo-couple 46 to control the temperature of the air.
  • the in-line heater 45 can be used to raise the temperature of the air to enhance the free-flow feature of the sheared masses separated from the feedstock stream.
  • the air is heated to a temperature of about 75 to 90°C. Those skilled in the art will appreciate that this temperature will vary, depending upon the particular material to be extruded. Any pre-extrusion additives can be introduced with a static mixer 47.
  • the stream of air is directed against the extruded encapsulant exterior by the nozzle 42 to provide discontinuities in the encapsulant and basically transform the morphology of the original encapsulant to a new morphology achieved by free-flow solidification as discontinuous masses such as spheres or beads.
  • air stream 43 is seen as being in fluid communication with annular channel 50 which surrounds the internal nozzle device 52.
  • Extruded encapsulant material 40a is shown being fed to the nozzle device 52 and exiting as a coherent feedstream 54 where it is subjected to high-velocity air stream 56 which is created by the combination of tortuous path exits provided by air cap 58 and retaining ring 59.
  • the coherent feedstream is formed of beads of spheres 41 of encapsulating material.
  • such spheres 41 are preferably ejected upwardly in a free-flow condition.
  • the spheres 41 may be ejected sideways or even downwards from nozzle 42, should such conditions optimize the formation of encapsulated product additive matrices according to the needs of the person skilled in the art.
  • the shear force When air is used to create the shear force, it is applied in a two-fluid nozzle at a pressure of from about 1.5 to about 20 atmospheres. Preferably, the pressure is applied at about 4 - 6 atmospheres.
  • the temperature of the air used to create the shear force should preferably be controlled to a temperature at least about 0.1°C about the temperature of the feedstock being ejected for every atmosphere of pressure.
  • the extruding device 40 is arranged with respect to tower 12 such that the nozzle 42 is positioned below the dry spray nozzle 30. Thus, the extrusion nozzle 42 is positioned within the feedstream of the ejected solid particles 31 in free-flow condition.
  • the extruding device 40 is arranged so that the extrusion nozzle 42 is directed preferably upwardly so as to eject spheres 41 directly into the gravity fed free-flow feedstream of particles 31 ejected from dry spray nozzle 30.
  • the nozzle 42 will be directed at about 90 degrees upwards (as shown in Figure 1), with variations thereof of less than about +/- 45 degrees, more preferably +/- 25 degrees, and even more preferably about +/- 10 degrees or even less. Further optimization is attainable according to the particular needs of the skilled technician.
  • the extruding nozzle 42 may also be positioned at a desirable spaced apart location with respect to nozzle 30.
  • tower 12 provides multiple entry ports 60 along the length of cylindrical side wall 14.
  • the location of the extruding nozzle 42 with respect to the dry spray nozzle 30 may be adjusted depending upon the type(s) of material(s) being processed.
  • the position of the extruding nozzle 42 may be varied to control the contact between particles 31 in the free-flow and the ejected spheres 41. Factors such as time of free-flow, temperature and the like are considered when positioning nozzle 42 of extruding device 40 with respect to nozzle 30 of dry spray device 28.
  • the multiple entry ports 60 can accommodate more than one extruding nozzle 42 at a time. Two or more extruding nozzles may therefore be positioned within the tower 12 at spatially optimal locations (horizontally (x), vertically (y) and laterally(z)) according to the needs of the skilled artisan.
  • the fat spheres 41 are ejected so as to come into contact with the dry spray particles 31 in the free-flow condition, the fat spheres are caused to encapsulate the dry spray particles so as to form an encapsulated product matrix 61 of product particles encapsulated with fat spheres.
  • the encapsulated product matrix continues in a free-flow condition under gravity through the lower end 23 of tower 12 and into the frustro-conical wall 16 which funnels the encapsulated product matrix to opening 18 for collection within a hopper 20.
  • the encapsulated product matrix 61 is preferably subjected to a stream of gaseous fluid so as to solidify the encapsulated product matrix 61.
  • the gaseous fluid is preferably air, but may also comprise any other substantially inert gas.
  • the gaseous fluid is an air stream.
  • the gaseous fluid may be heated or cooled, or may also be at room temperature, depending upon the type of drying and free-fall conditions required within the tower 12.
  • An air flow pattern may also be utilized to recirculate the encapsulated particles to another part of the tower 12 or to a location outside the tower.
  • a preferred embodiment is set forth in Figure 1.
  • Cold air stream 65 is introduced into the interior 26 of tower 12 through an air entry port 66 through the frustro-conical wall 16.
  • the entry port 66 is desirably located near the bottom of the tower 12, but it is also within the scope of the invention to optimize location at or near the midpoint or even the top of the tower to take full advantage of fluid dynamics.
  • the air is generated by an air generating device 67 which maintains a cool dry air stream through the entry port.
  • the air stream is preferably supplied within a temperature range of between about 5° to 10°C and a relatively dry humidity, preferably that of about 25% relative humidity or less, more preferably about 10% relative humidity or less, and even more desirably about 5% or less. In this way, there is less water and consequently less microbial activity in the encapsulated product matrix 61.
  • the matrix particles 61 fall through the frustro-conical wall 16 to the lower open end 18.
  • the air pattern heretofore described can optimize the free-fall conditions of the encapsulated matrices through creation of positive or negative pressure flows, or merely through assistance of the natural forces of gravity.
  • the encapsulated particles are collected within collection hopper 20 for further processing.
  • the encapsulated matrix material may be in solid form, but may also be in semi-solid form, and is preferably in the shape of tiny spheres, beads or solloids.
  • Encapsulating apparatus 10 is shown with optional additional entry ports 70.
  • these entry ports allow for introduction of additional particles 31 via components 28 and 32.
  • the various levels of entry of the additional ports 70 shown in Figure 1, as well as their respective orientations, may be adjusted by the skilled artisan to account for variations in the physical properties of the material 31 itself, e.g. weight, density, thickness, etc.
  • the entry ports 70 may also be utilized to admit material 31 to the apparatus 10 from another source 28a, 30a and 32a shown in Figure 4. In this way, double or even triple the amount of material may be added to the apparatus 10 at the same time, or two or more separate and distinct materials may be added for encapsulation.
  • the materials 31 may be added simultaneously or in sequence.
  • the various heights of the additional entry ports 70 may be utilized so that one material is encapsulated first, and a second material (which is introduced at a lower or higher level) is next encapsulated. This procedure may be especially relevant when the materials to be encapsulated are particularly reactive with one another.
  • the oleaginous material encapsulates both materials during free fall, and at the same time, can keep them physically apart from one another. It is within the skilled artisan's judgment to decide how many additional entry ports 70 to utilize, as well as their relative locations. It is also possible to adjust the direction of the nozzle(s) 30.
  • one or more could be directed upwards (as shown in the Figures), but one or more could also be directed sideways or downwards as well, to thereby operate in the most efficient way with respect to one another.
  • the skilled artisan may be further able to regulate and maximize optimal conditions for encapsulation according to his or her needs.
  • a still further aspect of the invention is set forth in Figure 5.
  • two or more distinct oleaginous encapsulating materials be added at the same time via additional components 40a and 42a shown in Figure 5, for example. It is further possible to add one type of oleaginous encapsulating material through one entry port 70, and a second (or third, etc.) oleaginous encapsulating material thereafter through another entry port, whether simultaneously or in succession. As heretofore described as well, one or more of the nozzles 42 may be directed upwards, while at the same time one or more may be directed sideways or even downwards as well. It is further within the scope of the invention that the embodiments shown in Figures 4 and 5 be utilized in conjunction with one another. Optimization of the particular embodiments is possible, depending upon the type and quantity of material(s) to be encapsulated, as well as the type and quantity of encapsulating material to be utilized.
  • Additional entry ports 70 may also be utilized to adjust the relative positions of the components 30 and 42 with respect to one another. When one or more of the entry ports 70 is not in use, it may simply be covered.
  • the encapsulated material as a result of the novel process is a matrix in which there is intimate mixing of dissimilar ingredients such as sugars and oils. It is also possible to attain increased loading of the additives which are encapsulated compared to other processes known in the art such as standard spray drying and spray congealing techniques.
  • a further advantage of the invention is enhanced product uniformity; there is often considerably less variance in content within the same batch and even after several batches of processed material. Enhanced dispersion of the encapsulated product matrix in further media such as, for example, standard chewing gum bases is also attainable.
  • the drying process of the invention is furthermore unique in that the encapsulated product also exhibits a lowered water activity and microbial activity as compared to other encapsulations available today. In addition, the encapsulated product matrix exhibits excellent taste-masking in certain embodiments and improved taste in others.
  • the tower 12 may be replaced with a sideways T- shaped tube in which air is circulated via the two stems of the "T” and both additive material and encapsulating material enter via the main portion of the "T” and are brought together by the action of the air flow.
  • a tube-within-a-tube design permits air circulation and introduction of material into the interior tube. Upon mixing under the force of the circulating air, the encapsulated product matrices exit into the exterior tube for collection.
  • the device set forth in Figure 1 was utilized to form an encapsulated product matrix.
  • a peppermint/spearmint flavor combination and sucrose mixture was encapsulated using peppermint oil (an oleaginous material).
  • the resultant product matrix was a substantial quantity of large spheres that were dry to the touch. When sampled, the spheres revealed an intense mint taste. Little of the mint sensation could be detected, however, with the nostrils, indicating that the peppermint/spearmint flavors were well encapsulated and preserved within the matrix.
  • the product matrix spheres were then combined with gum base in a traditional manner, along with other chewing gum additives. The final chewing gum product provided a sweet minty chewing sensation, which due to the encapsulated product matrix throughout the gum base, was intense and long-lasting for over 30 minutes.
  • Example 2 For this example, a bitter tasting medicament (ibuprofen) was successfully encapsulated using spearmint oil. When combined into a confectionery base having a soft and chewy consistency, the resultant product yielded a delivery system in which medicine could be palatably administered without off-taste, thereby substantially increasing patient compliance.
  • ibuprofen a bitter tasting medicament
  • the resultant product yielded a delivery system in which medicine could be palatably administered without off-taste, thereby substantially increasing patient compliance.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Confectionery (AREA)
  • Glanulating (AREA)

Abstract

Procédé et dispositif servant à préparer une matrice encapsulée contenant une charge de produit. On éjecte par pulvérisation un additif de matrice de produit solide à l'état coulant. On encapsule cet additif de matrice dans son état coulant au moyen d'un agent d'encapsulation de matrice. L'additif encapsulé se solidifie dans son état coulant, ce qui permet d'obtenir la matrice de produit.
PCT/US1999/010949 1998-05-22 1999-05-19 Procede et dispositif servant a preparer une matrice de produit encapsulee WO1999061145A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002362633A CA2362633A1 (fr) 1998-05-22 1999-05-19 Procede et dispositif servant a preparer une matrice de produit encapsulee
AU40840/99A AU4084099A (en) 1998-05-22 1999-05-19 Method and apparatus for forming an encapsulated product matrix
JP2000550592A JP2002516171A (ja) 1998-05-22 1999-05-19 封入された製品マトリックスを形成するための方法及び装置
EP99924314A EP1085940A1 (fr) 1998-05-22 1999-05-19 Procede et dispositif servant a preparer une matrice de produit encapsulee

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IE980395 1998-05-22
IE980395A IE980395A1 (en) 1998-05-22 1998-05-22 Method and appartus for forming and encapsulated product matrix
US09/309,224 1999-05-10
US09/309,224 US6224939B1 (en) 1998-05-22 1999-05-10 Method and apparatus for forming an encapsulated product matrix

Publications (1)

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WO1999061145A1 true WO1999061145A1 (fr) 1999-12-02

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PCT/US1999/010949 WO1999061145A1 (fr) 1998-05-22 1999-05-19 Procede et dispositif servant a preparer une matrice de produit encapsulee

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EP (1) EP1085940A1 (fr)
JP (1) JP2002516171A (fr)
AU (1) AU4084099A (fr)
CA (1) CA2362633A1 (fr)
WO (1) WO1999061145A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9157054B2 (en) 2007-11-14 2015-10-13 The University Of Queensland Device and method for preparing microparticles
EP3300724A1 (fr) 2016-09-30 2018-04-04 Erber Aktiengesellschaft Particule contenant au moins une substance volatile et procédé pour sa préparation
EP3545763A1 (fr) 2018-03-29 2019-10-02 Erber Aktiengesellschaft Particule contenant au moins une substance volatile, procédé de préparation associé, aliment ou additif alimentaire les contenant et utilisation
TWI686251B (zh) * 2018-11-30 2020-03-01 財團法人金屬工業研究發展中心 微粉成型裝置

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5712630B2 (ja) * 2011-01-20 2015-05-07 トヨタ自動車株式会社 流動層装置

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FR2628014A1 (fr) * 1988-03-07 1989-09-08 Total France Procede et dispositif pour enrober des particules solides d'un film continu d'une matiere protectrice
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US9157054B2 (en) 2007-11-14 2015-10-13 The University Of Queensland Device and method for preparing microparticles
EP3300724A1 (fr) 2016-09-30 2018-04-04 Erber Aktiengesellschaft Particule contenant au moins une substance volatile et procédé pour sa préparation
WO2018059732A1 (fr) 2016-09-30 2018-04-05 Erber Aktiengesellschaft Particule contenant au moins une substance volatile et son procédé de préparation
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AU4084099A (en) 1999-12-13
CA2362633A1 (fr) 1999-12-02
EP1085940A1 (fr) 2001-03-28

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