WO1999060115A3 - Proteins and genes useful as tumor markers - Google Patents

Proteins and genes useful as tumor markers Download PDF

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Publication number
WO1999060115A3
WO1999060115A3 PCT/EP1999/003374 EP9903374W WO9960115A3 WO 1999060115 A3 WO1999060115 A3 WO 1999060115A3 EP 9903374 W EP9903374 W EP 9903374W WO 9960115 A3 WO9960115 A3 WO 9960115A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
tumor markers
genes useful
gene
concerns
Prior art date
Application number
PCT/EP1999/003374
Other languages
French (fr)
Other versions
WO1999060115A2 (en
Inventor
Leuven Fred Van
Original Assignee
Vlaams Interuniv Inst Biotech
Leuven Fred Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Interuniv Inst Biotech, Leuven Fred Van filed Critical Vlaams Interuniv Inst Biotech
Priority to AU43621/99A priority Critical patent/AU4362199A/en
Publication of WO1999060115A2 publication Critical patent/WO1999060115A2/en
Publication of WO1999060115A3 publication Critical patent/WO1999060115A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification

Abstract

The current invention concerns a human protein, its cDNA and its gene that is located on chromosome 19q12. The invention also concerns its mouse counterpart. The invention further relates to the use of monitoring the expression of said gene as tumor marker in general and especially as marker for Reed-Sternberg cells of Hodgkin's disease.
PCT/EP1999/003374 1998-05-18 1999-05-17 Proteins and genes useful as tumor markers WO1999060115A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU43621/99A AU4362199A (en) 1998-05-18 1999-05-17 Proteins and genes useful as tumor markers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201642 1998-05-18
EP98201642.0 1998-05-18

Publications (2)

Publication Number Publication Date
WO1999060115A2 WO1999060115A2 (en) 1999-11-25
WO1999060115A3 true WO1999060115A3 (en) 2000-03-23

Family

ID=8233734

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/003374 WO1999060115A2 (en) 1998-05-18 1999-05-17 Proteins and genes useful as tumor markers

Country Status (2)

Country Link
AU (1) AU4362199A (en)
WO (1) WO1999060115A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999038972A2 (en) * 1998-01-28 1999-08-05 Chiron Corporation Human genes and gene expression products ii
WO1999053045A1 (en) * 1998-04-09 1999-10-21 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999038972A2 (en) * 1998-01-28 1999-08-05 Chiron Corporation Human genes and gene expression products ii
WO1999053045A1 (en) * 1998-04-09 1999-10-21 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
CHAN W.C. AND DELABIE J.: "Single cell analysis of H/RS cells", ANNALS OF ONCOLOGY, vol. 7, no. Suppl. 4, 1996, pages S41 - S43, XP002095561 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002126924, Database accession no. AA430610 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002126925, Database accession no. AA119478 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002127711, Database accession no. AA384673 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002127712, Database accession no. H51991 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002127713, Database accession no. AA166771 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002127714, Database accession no. W38624 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002127715, Database accession no. AA031305 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002127716, Database accession no. AA756609 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002127717, Database accession no. AA617521 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002127718, Database accession no. AA185969 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002127719, Database accession no. C77012 *
DORJSUREN D. ET AL.: "RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by Hepatitis B virus X protein", MOLECULAR AND CELLULAR BIOLOGY, vol. 18, no. 12, December 1998 (1998-12-01), pages 7546 - 7555, XP002126923 *
VAN LEUVEN F. ET AL.: "Mannose-specific lectins bind alpha-2-macroglobulin and an unknown protein from human plasma", PROTEIN SCIENCE, vol. 2, no. 2, February 1993 (1993-02-01), pages 255 - 263, XP002095562 *
VAN LEUVEN F. ET AL.: "Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease", GENOMICS, vol. 54, no. 3, 15 December 1998 (1998-12-15), pages 511 - 520, XP002095560 *

Also Published As

Publication number Publication date
AU4362199A (en) 1999-12-06
WO1999060115A2 (en) 1999-11-25

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