WO2001036465A3 - Human zven proteins - Google Patents

Human zven proteins Download PDF

Info

Publication number
WO2001036465A3
WO2001036465A3 PCT/US2000/031278 US0031278W WO0136465A3 WO 2001036465 A3 WO2001036465 A3 WO 2001036465A3 US 0031278 W US0031278 W US 0031278W WO 0136465 A3 WO0136465 A3 WO 0136465A3
Authority
WO
WIPO (PCT)
Prior art keywords
human
proteins
human zven
zven proteins
zvenl
Prior art date
Application number
PCT/US2000/031278
Other languages
French (fr)
Other versions
WO2001036465A2 (en
Inventor
Paul O Sheppard
Paul D Bishop
Theodore E Whitmore
Penny P Thompson
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to CA002392128A priority Critical patent/CA2392128A1/en
Priority to JP2001538954A priority patent/JP2003515322A/en
Priority to AU16082/01A priority patent/AU1608201A/en
Priority to EP00978641A priority patent/EP1230362A2/en
Publication of WO2001036465A2 publication Critical patent/WO2001036465A2/en
Publication of WO2001036465A3 publication Critical patent/WO2001036465A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

The present invention provides two members of a new family of human proteins, designated as 'Zven.' The Zvenl gene, which resides in human chromosome 3p21.1 - 3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
PCT/US2000/031278 1999-11-16 2000-11-14 Human zven proteins WO2001036465A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002392128A CA2392128A1 (en) 1999-11-16 2000-11-14 Human zven proteins
JP2001538954A JP2003515322A (en) 1999-11-16 2000-11-14 Human Zven protein
AU16082/01A AU1608201A (en) 1999-11-16 2000-11-14 Human zven proteins
EP00978641A EP1230362A2 (en) 1999-11-16 2000-11-14 Human zven proteins

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US44216499A 1999-11-16 1999-11-16
US09/442,164 1999-11-16
US51187900A 2000-02-25 2000-02-25
US09/511,879 2000-02-25
US55220300A 2000-04-19 2000-04-19
US09/552,203 2000-04-19
US21033200P 2000-06-07 2000-06-07
US60/210,332 2000-06-07

Publications (2)

Publication Number Publication Date
WO2001036465A2 WO2001036465A2 (en) 2001-05-25
WO2001036465A3 true WO2001036465A3 (en) 2001-11-22

Family

ID=27498801

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/031278 WO2001036465A2 (en) 1999-11-16 2000-11-14 Human zven proteins

Country Status (4)

Country Link
EP (1) EP1230362A2 (en)
AU (1) AU1608201A (en)
CA (1) CA2392128A1 (en)
WO (1) WO2001036465A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000073454A1 (en) * 1999-06-02 2000-12-07 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20020132253A1 (en) 1997-06-16 2002-09-19 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7264801B2 (en) 1998-08-11 2007-09-04 Genentech, Inc. EG-VEGF nucleic acids and polypeptides and method of use
US20020172678A1 (en) * 2000-06-23 2002-11-21 Napoleone Ferrara EG-VEGF nucleic acids and polypeptides and methods of use
US6485938B1 (en) 1999-11-16 2002-11-26 Zymogenetics, Inc. Nucleic acid molecules that encodes human Zven1
DE60128916T2 (en) * 2000-07-18 2007-09-20 Takeda Pharmaceutical Co. Ltd. NEW, PHYSIOLOGICALLY ACTIVE PEPTIDE AND ITS USE
EP1506971A1 (en) * 2000-11-03 2005-02-16 The Regents of the University of California Prokineticin polypeptides, related compositions and methods
CA2427800A1 (en) * 2000-11-03 2002-05-10 The Regents Of The University Of California Prokineticin polypeptides, related compositions and methods
US20040048314A1 (en) * 2001-02-02 2004-03-11 Tetsuya Ohtaki Novel physiologically active peptide and use thereof
WO2003020892A2 (en) * 2001-08-29 2003-03-13 Genentech, Inc. Bv8 NUCLEIC ACIDS AND POLYPEPTIDES WITH MITOGENIC ACTIVITY
EP1572099A4 (en) 2002-10-04 2007-01-03 Univ California Screening and therapeutic methods relating to neurogenesis
JP2006514683A (en) * 2002-10-07 2006-05-11 ザイモジェネティクス，インコーポレイティド Use of human ZVEN antagonists
EP1551440A4 (en) * 2002-10-07 2009-07-15 Zymogenetics Inc Uses of human zven proteins and polynucleotides
JP2006515989A (en) * 2002-10-07 2006-06-15 ザイモジェネティクス，インコーポレイティド Use of human ZVEN proteins and polynucleotides
MXPA05009743A (en) 2003-03-12 2006-03-09 Genentech Inc Use of bv8 and/or eg-vegf to promote hematopoiesis.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006550A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN PROSTATE
WO1999063088A2 (en) * 1998-06-02 1999-12-09 Genentech, Inc. Membrane-bound proteins and nucleic acids encoding the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006550A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN PROSTATE
WO1999063088A2 (en) * 1998-06-02 1999-12-09 Genentech, Inc. Membrane-bound proteins and nucleic acids encoding the same

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 14 December 1999 (1999-12-14), WECHSELBERGER C ET AL: "Mus musculus Bv8 variant 3 precursor (Bv8) mRNA, complete cds.", XP002173443 *
DATABASE EMBL 2 October 2000 (2000-10-02), JILEK A ET AL: "Homo sapiens Bv8 protein (BV8) mRNA, partial cds.", XP002173444 *
DATABASE EMBL 5 May 2001 (2001-05-05), LI M ET AL: "Homo sapiens prokineticin 1 precursor (PROK1) mRNA, complete cds.", XP002173446 *
DATABASE EMBL 5 May 2001 (2001-05-05), LI M ET AL: "Homo sapiens prokineticin 2 precursor (PROK2) mRNA, complete cds.", XP002173445 *
FEDI PAOLO ET AL: "Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 27, 2 July 1999 (1999-07-02), pages 19465 - 19472, XP002173440, ISSN: 0021-9258 *
HSIEH JEN-CHIH ET AL: "A new secreted protein that binds to Wnt proteins and inhibits their activities.", NATURE (LONDON), vol. 398, no. 6726, 1 April 1999 (1999-04-01), pages 431 - 436, XP002173441, ISSN: 0028-0836 *
JILEK A ET AL: "Murine Bv8 gene maps near a synteny breakpoint of mouse chromosome 6 and human 3p21.", GENE (AMSTERDAM), vol. 256, no. 1-2, 3 October 2000 (2000-10-03), pages 189 - 195, XP004238404, ISSN: 0378-1119 *
LI M ET AL: "Identification of two prokineticin cDNAs: Recombinant proteins potently contract gastrointestinal smooth muscle.", MOLECULAR PHARMACOLOGY, vol. 59, no. 4, April 2001 (2001-04-01), pages 692 - 698, XP001010437, ISSN: 0026-895X *
WECHSELBERGER CHRISTIAN ET AL: "The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes.", FEBS LETTERS, vol. 462, no. 1-2, 26 November 1999 (1999-11-26), pages 177 - 181, XP002173442, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
AU1608201A (en) 2001-05-30
CA2392128A1 (en) 2001-05-21
EP1230362A2 (en) 2002-08-14
WO2001036465A2 (en) 2001-05-25

Similar Documents

Publication Publication Date Title
WO2001036465A3 (en) Human zven proteins
AU2002216273A1 (en) Proteins, genes and their use for diagnosis and treatment of kidney response
AU3364099A (en) Diagnosis of disease state using mrna profiles in peripheral leukocytes
AU2003225160A1 (en) "biosensor for dialysis therapy"
AU3997300A (en) Gene sequence variations with utility in determining the treatment of disease
AU7748200A (en) Hypoxia-related human genes, proteins, and uses thereof
AU2002303261A1 (en) Gene brcc2 and diagnostic and therapeutic uses thereof
AU2002326813A1 (en) Diagnosis and treatment of vascular disease
AU6425800A (en) Agents for the diagnosis, prognosis and treatment of malignant diseases
AU2067501A (en) Human oxidoreductase proteins
GB2395903B (en) Dickkopf 5 gene, protein and antibodies: a role in the treatment and diagnosis of insulin-resistant states
AU2002341880A1 (en) Diagnosis and treatment of vascular disease
AU7508100A (en) Human seizure related proteins
AU2001232053A1 (en) System for the extracorporeal treatment of blood
AU2002341604A1 (en) Diagnosis and treatment of vascular disease
AU2001237543A1 (en) Proteins, genes and their use for diagnosis and treatment of schizophrenia
AU2002306600A1 (en) Sperm protein 17 for the diagnosis and treatment of cancer
AU2001240820A1 (en) Proteins, genes and their use for diagnosis and treatment of vascular dementia
WO1998046747A3 (en) Genes in the non-recombining region of the y chromosome
AU3064800A (en) The therapeutic use of r-warfarin as anticoagulant
AU5876899A (en) Polymorphisms in the human alpha4 integrin subunit gene, suitable for diagnosis and treatment of integrin ligand mediated diseases
AU2352301A (en) Gene expression in corneal diseases
AU2002364757A1 (en) Peptides for the production of preparations for the diagnosis and therapy of autoimmun diseases
AU2002319591A1 (en) Diagnosis and treatment of vascular disease
AU5876399A (en) Polymorphisms in the human beta1 integrin subunit gene, suitable for diagnosis and treatment of integrin ligand mediated diseases

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2392128

Country of ref document: CA

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 538954

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2000978641

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000978641

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642