WO1999058656A3 - Sustained dna delivery from structural matrices - Google Patents

Sustained dna delivery from structural matrices Download PDF

Info

Publication number
WO1999058656A3
WO1999058656A3 PCT/US1999/010330 US9910330W WO9958656A3 WO 1999058656 A3 WO1999058656 A3 WO 1999058656A3 US 9910330 W US9910330 W US 9910330W WO 9958656 A3 WO9958656 A3 WO 9958656A3
Authority
WO
WIPO (PCT)
Prior art keywords
dna
structural matrices
dna delivery
transfection
matrices
Prior art date
Application number
PCT/US1999/010330
Other languages
French (fr)
Other versions
WO1999058656A2 (en
Inventor
Lonnie D Shea
Jeffrey Bonadio
David J Mooney
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Priority to AU38986/99A priority Critical patent/AU3898699A/en
Publication of WO1999058656A2 publication Critical patent/WO1999058656A2/en
Publication of WO1999058656A3 publication Critical patent/WO1999058656A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Disclosed are particular 3-dimensional structural matrices containing DNA and their use in the prolonged release of DNA in various biological environments. The DNA-matrix materials are created such that they maintain a defined space, allowing cellular migration, transfection and proliferation to occur in a controlled manner. Such DNA-containing structural matrices are thus particularly useful in in vivo cell transfection and gene expression in the context of gene therapy.
PCT/US1999/010330 1998-05-13 1999-05-12 Sustained dna delivery from structural matrices WO1999058656A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU38986/99A AU3898699A (en) 1998-05-13 1999-05-12 Sustained dna delivery from structural matrices

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8530598P 1998-05-13 1998-05-13
US60/085,305 1998-05-13
US10905498P 1998-11-19 1998-11-19
US60/109,054 1998-11-19

Publications (2)

Publication Number Publication Date
WO1999058656A2 WO1999058656A2 (en) 1999-11-18
WO1999058656A3 true WO1999058656A3 (en) 2000-01-06

Family

ID=26772546

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/010330 WO1999058656A2 (en) 1998-05-13 1999-05-12 Sustained dna delivery from structural matrices

Country Status (2)

Country Link
AU (1) AU3898699A (en)
WO (1) WO1999058656A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889635B2 (en) 2008-09-30 2014-11-18 The Regents Of The University Of Michigan Dendrimer conjugates
US8912323B2 (en) 2009-10-30 2014-12-16 The Regents Of The University Of Michigan Multifunctional small molecules
US8945508B2 (en) 2009-10-13 2015-02-03 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
US9017644B2 (en) 2008-11-07 2015-04-28 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767928B1 (en) 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
AU4173000A (en) 1999-03-19 2000-10-09 Regents Of The University Of Michigan, The Mineralization and cellular patterning on biomaterial surfaces
AU1622801A (en) * 1999-11-18 2001-05-30 Regents Of The University Of Michigan, The Sustained drug delivery from structural matrices
WO2001040272A2 (en) * 1999-12-01 2001-06-07 Selective Genetics, Inc. In situ bioreactors and methods of use thereof
WO2001076457A2 (en) * 2000-04-11 2001-10-18 Cogent Neuroscience, Inc. Compositions and methods for diagnosing and treating conditions, disorders, or diseases involving cell death
US20040120979A1 (en) * 2000-06-02 2004-06-24 Roessler Blake J. Delivery systems comprising biocompatible and bioerodable membranes
US20040048260A1 (en) * 2002-09-10 2004-03-11 Fu-Hsiung Chang Transfection of nucleic acid
US8753309B2 (en) 2011-06-24 2014-06-17 The Invention Science Fund I, Llc Device, system, and method including micro-patterned cell treatment array
US9402911B2 (en) 2011-12-08 2016-08-02 The Regents Of The University Of Michigan Multifunctional small molecules
GB201612625D0 (en) * 2016-07-21 2016-09-07 Univ Leeds Innovations Ltd Matrices
US11904006B2 (en) 2019-12-11 2024-02-20 University Of Iowa Research Foundation Poly(diaminosulfide) particle-based vaccine
WO2023192378A1 (en) * 2022-03-29 2023-10-05 President And Fellows Of Harvard College Scaffolds for modifying immune cells and the uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994023738A1 (en) * 1993-04-19 1994-10-27 Medisorb Technologies International L.P. Encapsulation of nucleic acids with conjugates that facilitate and target cellular uptake and gene expression
WO1995022611A2 (en) * 1994-02-18 1995-08-24 The Regents Of The University Of Michigan Methods and compositions for stimulating bone cells
WO1997038729A1 (en) * 1996-04-12 1997-10-23 The Regents Of The University Of Michigan In vivo gene transfer methods for wound healing
WO1997044070A1 (en) * 1996-05-22 1997-11-27 Ben-Gurion University Of The Negev Polysaccharide sponges for cell culture and transplantation
WO1998001160A2 (en) * 1996-07-10 1998-01-15 Danbiosyst Uk Limited Compositions suitable for delivery of genes to epithelial cells
WO1998012228A1 (en) * 1996-09-19 1998-03-26 The Regents Of The University Of Michigan Polymers containing polysaccharides such as alginates or modified alginates
WO1998044027A1 (en) * 1997-03-31 1998-10-08 The Regents Of The University Of Michigan Open pore biodegradable matrices

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994023738A1 (en) * 1993-04-19 1994-10-27 Medisorb Technologies International L.P. Encapsulation of nucleic acids with conjugates that facilitate and target cellular uptake and gene expression
WO1995022611A2 (en) * 1994-02-18 1995-08-24 The Regents Of The University Of Michigan Methods and compositions for stimulating bone cells
WO1997038729A1 (en) * 1996-04-12 1997-10-23 The Regents Of The University Of Michigan In vivo gene transfer methods for wound healing
WO1997044070A1 (en) * 1996-05-22 1997-11-27 Ben-Gurion University Of The Negev Polysaccharide sponges for cell culture and transplantation
WO1998001160A2 (en) * 1996-07-10 1998-01-15 Danbiosyst Uk Limited Compositions suitable for delivery of genes to epithelial cells
WO1998012228A1 (en) * 1996-09-19 1998-03-26 The Regents Of The University Of Michigan Polymers containing polysaccharides such as alginates or modified alginates
WO1998044027A1 (en) * 1997-03-31 1998-10-08 The Regents Of The University Of Michigan Open pore biodegradable matrices

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FANG J. ET AL.: "Stimulation of new bone formation by direct transfer of osteogenic plasmid genes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 93, no. 12, 1996, WASHINGTON US, pages 5753 - 5758, XP002121280 *
KAUFMANN P.M. ET AL.: "Highly porous polymer matrices as a three-dimensional culture system for hepatocytes", CELL TRANSPLANT, vol. 6, no. 5, September 1997 (1997-09-01), pages 463 - 468, XP002121279 *
LABHASETWAR V. ET AL.: "Gene-based therapies for resethenosis", ADVANCED DRUG DELIVERY REVIEWS, vol. 24, no. 1, 1997, pages 109 - 120, XP002121281 *
LEWIS K. ET AL.: "Biodegradable poly(L-lactic acid) matrices for the sustained delivery of antisense oligonucelotides", JOURNAL OF CONTROLLED RELEASE, vol. 37, no. 1-2, 1995, pages 173 - 183, XP000535916 *
SHEA L.D.: "DNA delivery from polymer matrices for tissue engineering", NATURE BIOTHECNOLOGY, vol. 17, no. 6, 1999, pages 551 - 554, XP002121278 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889635B2 (en) 2008-09-30 2014-11-18 The Regents Of The University Of Michigan Dendrimer conjugates
US8980907B2 (en) 2008-09-30 2015-03-17 The Regents Of The University Of Michigan Dendrimer conjugates
US9017644B2 (en) 2008-11-07 2015-04-28 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
US8945508B2 (en) 2009-10-13 2015-02-03 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
US8912323B2 (en) 2009-10-30 2014-12-16 The Regents Of The University Of Michigan Multifunctional small molecules

Also Published As

Publication number Publication date
WO1999058656A2 (en) 1999-11-18
AU3898699A (en) 1999-11-29

Similar Documents

Publication Publication Date Title
WO1999058656A3 (en) Sustained dna delivery from structural matrices
AU4882296A (en) DNA molecules, preparation and use in gene therapy
ATE163046T1 (en) GENETIC MODIFICATION OF ENDOTHELIAL CELLS
WO2001002568A3 (en) Human genes and gene expression products
AU1265097A (en) Nucleic acid constructs for the cell cycle-regulated expression of genes, cells containing such constructs and their use for preparing drugs
AU4526193A (en) Binding competent oligomers containing 2', 5' linkages
CA2184345A1 (en) Coordinate in vivo gene expression
AU1606897A (en) Thymidine kinase variants, corresponding nucleic acid sequences and their use in gene therapy
AU5788096A (en) Plasmid for delivery of nucleic acids to cells and methods of use
AU2095599A (en) Human genes and gene expression products i
WO2001035932A3 (en) Sustained drug delivery from structural matrices
WO2003093449A3 (en) Methods for delivery of nucleic acids
AU4266597A (en) Use of a non-mammalian dna virus to express an exogenous gene in a mammalian cell
WO1998034952A3 (en) Il-2 gene expression and delivery systems and uses
AU4089899A (en) Stable envelope proteins for retroviral, viral and liposome vectors and use in gene and drug therapy
ZA961161B (en) Medicinal combination for transfecting and expressing exogenous genes in vivo
WO1995034669A3 (en) Retroviral gene therapy vectors and therapeutic methods based thereon
AU2092700A (en) Novel potassium channels and genes encoding these potassium channels
EP1020529A3 (en) Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
EP1007717B8 (en) Methods and compositions for cancer therapies using genes encoding interferon-beta
AU3584993A (en) Methods and compositions for neutralizing intracellular nucleic acid-binding protein biological activity in a cell, including methods and compositions useful to regulate gene function
EP0763205A4 (en) Nucleic acid sequences controlling lung cell-specific gene expression
AU2153401A (en) Gene expression in biological conditions
AU3556800A (en) Expression of dna or proteins in (c. elegans)
AU6346898A (en) Gene therapy using bone marrow transplants transfected with therapeutic genes under the control of tissue-specific promoters

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase

Ref country code: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase