WO2001002568A3 - Human genes and gene expression products - Google Patents

Human genes and gene expression products Download PDF

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Publication number
WO2001002568A3
WO2001002568A3 PCT/US2000/018374 US0018374W WO0102568A3 WO 2001002568 A3 WO2001002568 A3 WO 2001002568A3 US 0018374 W US0018374 W US 0018374W WO 0102568 A3 WO0102568 A3 WO 0102568A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
expression products
human genes
cancer cells
polynucleotides
Prior art date
Application number
PCT/US2000/018374
Other languages
French (fr)
Other versions
WO2001002568A2 (en
Inventor
Lewis T Williams
Jaime Escobedo
Michael A Innis
Pablo Dominguez Garcia
Julie Klinger
Altaf Kassam
Christoph Reinhard
Filippo Randazzo
Guilia C Kennedy
David Pot
George Lamson
Radoje Drmanac
Radomir Crkenjakov
Snezana Drmanac
Mark Dickson
Ivan Labat
Dena Leshkowitiz
David Kita
Veronica Garcia
Lee William Jones
Birgit Strache-Crain
Original Assignee
Chiron Corp
Hyseq Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp, Hyseq Inc filed Critical Chiron Corp
Priority to AU60693/00A priority Critical patent/AU6069300A/en
Priority to EP00947021A priority patent/EP1194549A2/en
Priority to JP2001508340A priority patent/JP2003518920A/en
Publication of WO2001002568A2 publication Critical patent/WO2001002568A2/en
Publication of WO2001002568A3 publication Critical patent/WO2001002568A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides novel polynucleotides. The invention further provides novel members of protein families, and polynucleotides that are differentially expressed in cancer cells relative to normal cells, and in metastatic cancer cells relative to normal cells or non-metastatic cancer cells.
PCT/US2000/018374 1999-07-02 2000-06-30 Human genes and gene expression products WO2001002568A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU60693/00A AU6069300A (en) 1999-07-02 2000-06-30 Novel human genes and gene expression products
EP00947021A EP1194549A2 (en) 1999-07-02 2000-06-30 Human genes and gene expression products
JP2001508340A JP2003518920A (en) 1999-07-02 2000-06-30 New human genes and gene expression products

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14231099P 1999-07-02 1999-07-02
US14231199P 1999-07-02 1999-07-02
US60/142,311 1999-07-02
US60/142,310 1999-07-02

Publications (2)

Publication Number Publication Date
WO2001002568A2 WO2001002568A2 (en) 2001-01-11
WO2001002568A3 true WO2001002568A3 (en) 2001-08-30

Family

ID=26839967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/018374 WO2001002568A2 (en) 1999-07-02 2000-06-30 Human genes and gene expression products

Country Status (4)

Country Link
EP (1) EP1194549A2 (en)
JP (1) JP2003518920A (en)
AU (1) AU6069300A (en)
WO (1) WO2001002568A2 (en)

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US20030170864A1 (en) 2000-05-30 2003-09-11 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US8101349B2 (en) 1997-12-23 2012-01-24 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells and their methods of use II
US6462187B1 (en) 2000-06-15 2002-10-08 Millennium Pharmaceuticals, Inc. 22109, a novel human thioredoxin family member and uses thereof
CA2503475A1 (en) * 1998-12-01 2000-06-08 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
ATE318303T1 (en) * 1999-02-12 2006-03-15 Genentech Inc GENE AMPLIFIED IN TUMORS AND RELATED MATERIALS AND METHODS
US6759508B2 (en) 2000-09-01 2004-07-06 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6951738B2 (en) 1999-07-16 2005-10-04 Human Genome Sciences, Inc. Human tumor necrosis factor receptors TR13 and TR14
KR100543857B1 (en) * 1999-09-01 2006-01-23 제넨테크, 인크. Promotion or Inhibition of Angiogenesis and Cardiovascularization
AU4018201A (en) * 1999-09-23 2001-04-24 Incyte Genomics, Inc. Molecules for diagnostics and therapeutics
US7029895B2 (en) 1999-09-27 2006-04-18 Millennium Pharmaceuticals, Inc. 27411, a novel human PGP synthase
FR2800388A1 (en) * 1999-10-29 2001-05-04 Pf Medicament CLONING, EXPRESSION AND CHARACTERIZATION OF A GENE EXPRESSED IN TUMOR CELLS AND INVOLVED IN REGULATION OF THE IMMUNE RESPONSE
EP1690872A3 (en) * 1999-12-01 2006-08-23 Genentech, Inc. Composition and methods for the diagnosis of tumours
US20020156238A1 (en) * 1999-12-09 2002-10-24 Peyman John A. Novel polypeptides and polynucleotides encoding same
MXPA02006027A (en) * 1999-12-16 2002-12-05 Amgen Inc TNFR OPGminus;LIKE MOLECULES AND USES THEREOF.
WO2001062921A2 (en) * 2000-02-22 2001-08-30 Lexicon Genetics Incorporated Novel human regulatory protein and polynucleotides encoding the same
WO2001062929A2 (en) * 2000-02-25 2001-08-30 Curagen Corporation Sodium/solute symporter-like protein and nucleic acids encoding same
US6413757B1 (en) 2000-02-28 2002-07-02 Millennium Pharmaceuticals, Inc. 25312, a novel human agmatinase-like homolog
AU2001249078A1 (en) 2000-02-28 2001-09-12 Millenium Pharmaceuticals, Inc. 27411, a novel human pgp synthase
EP1276875A2 (en) 2000-03-07 2003-01-22 Millennium Pharmaceuticals, Inc. 16835, a human phospholipase c and uses thereof
WO2001066753A2 (en) * 2000-03-09 2001-09-13 Chiron Corporation Human genes and gene expression products
US6511834B1 (en) 2000-03-24 2003-01-28 Millennium Pharmaceuticals, Inc. 32142,21481,25964,21686, novel human dehydrogenase molecules and uses therefor
US6627423B2 (en) 2000-03-24 2003-09-30 Millennium Pharmaceuticals, Inc. 21481, a novel dehydrogenase molecule and uses therefor
US6500657B1 (en) * 2000-03-31 2002-12-31 Millennium Pharmaceuticals, Inc. 33167, a novel human hydrolase and uses therefor
US20060058516A1 (en) * 2000-04-10 2006-03-16 Burkhard Scharm Novel serine-threonine kinase
AU6531101A (en) * 2000-06-02 2001-12-17 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
ES2281437T3 (en) 2000-08-22 2007-10-01 Agensys, Inc. NUCLEIC ACID AND CORRESPONDING PROTEIN DENOMINATED 158P1D7 USEFUL FOR THE TREATMENT AND DETECTION OF BLADDER CANCER AND OTHER CANCERES.
US7358353B2 (en) 2000-08-22 2008-04-15 Agensys, Inc. Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
US20040072185A1 (en) * 2000-09-15 2004-04-15 Patrizia Paterlini-Brechot Cellular genes involved in oncogenesis, products of said genes and their diagnostic and therapeutic uses
FR2814176A1 (en) * 2000-09-15 2002-03-22 Inst Nat Sante Rech Med New nucleic acid implicated in oncogenesis, useful for diagnosis and treatment of cancer, also related polypeptides and antibodies
DE60140559D1 (en) * 2000-10-05 2009-12-31 Millenium Pharmaceuticals Inc 32144, A HUMAN FATTY ACID HYDROLASE AND ITS USES
US7208267B2 (en) 2000-11-22 2007-04-24 Diadexus, Inc. Compositions and methods relating to breast specific genes and proteins
US20030027253A1 (en) 2000-11-28 2003-02-06 Presnell Scott R. Cytokine receptor zcytor19
EP1284289A4 (en) * 2000-12-21 2004-03-31 Genox Research Inc Method of examining allergic disease
US20060063230A1 (en) 2000-12-27 2006-03-23 Roman Naworth Sulfatases and methods of use thereof
US7601825B2 (en) 2001-03-05 2009-10-13 Agensys, Inc. Nucleic acid and corresponding protein entitled 121P1F1 useful in treatment and detection of cancer
US6924358B2 (en) 2001-03-05 2005-08-02 Agensys, Inc. 121P1F1: a tissue specific protein highly expressed in various cancers
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
EP1573024A4 (en) 2001-04-10 2007-08-29 Agensys Inc Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US7157558B2 (en) 2001-06-01 2007-01-02 Genentech, Inc. Polypeptide encoded by a polynucleotide overexpresses in tumors
EP2325335A3 (en) * 2001-09-14 2012-01-25 Clinical Genomics Pty. Ltd Nucleic acid markers for use in determining predisposition to neoplasm and/or adenoma
US6787327B2 (en) 2001-10-05 2004-09-07 Kelk Graduate Of Applied Life Sciences Methods for determining tyrosine-DNA phosphodiesterase activity
US7033787B2 (en) * 2001-12-21 2006-04-25 Ludwig Institute For Cancer Research Isolated cytokine receptor LICR-2
EP1497415B1 (en) 2002-04-19 2010-12-29 ZymoGenetics, L.L.C. Methods for detection or modulation of the interaction of a cytokine receptor with its ligand
US7026467B2 (en) * 2002-07-19 2006-04-11 Arizona Board Of Regents, Acting For And On Behalf Of, Northern Arizona University High resolution typing system for pathogenic Mycobaterium tuberculosum
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
DK2331136T3 (en) 2008-09-26 2018-03-05 Oncomed Pharm Inc FRIZZLED BINDING AGENTS AND APPLICATIONS THEREOF
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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO1997040151A2 (en) * 1996-04-19 1997-10-30 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them

Non-Patent Citations (2)

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Title
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Also Published As

Publication number Publication date
JP2003518920A (en) 2003-06-17
WO2001002568A2 (en) 2001-01-11
EP1194549A2 (en) 2002-04-10
AU6069300A (en) 2001-01-22

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