WO1999058136A1 - Use of shark liver oil for local treatment of skin diseases of domestic animals - Google Patents
Use of shark liver oil for local treatment of skin diseases of domestic animals Download PDFInfo
- Publication number
- WO1999058136A1 WO1999058136A1 PCT/SE1999/000820 SE9900820W WO9958136A1 WO 1999058136 A1 WO1999058136 A1 WO 1999058136A1 SE 9900820 W SE9900820 W SE 9900820W WO 9958136 A1 WO9958136 A1 WO 9958136A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- liver oil
- preparation
- treatment
- shark liver
- sore
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
Definitions
- the present invention relates to the use of shark liver oil comprising alkyl glycerols for the preparation of a drug for the local treatment of skin diseases of domestic ammals e.g. horses, cattle, sheep, dogs and cats as well as a method of treatment of skin diseases of domestic animals.
- skin diseases e.g. horses, cattle, sheep, dogs and cats
- diseases are for example summer sore, sarcoids, such as Equine sarcoids, favus and scurf of different origin, greasy heels, mud fever, rain scalds, saddle sore, girth galls, and ringworm.
- shark liver oil extracted e.g. from Greenland shark and from the so called Seamouse, Chimera monstr osa, was used within the traditional medicine for a variety of therapeutic purposes, such as combating weakness and irritation of the respiratory and digestive organs, gland diseases, bee stings and wound healing, etc.
- Crude shark liver oil contains squalene, etherlipids (alkyl glycerols) and triglycerides.
- the composition of the oil varies widely from one shark species to another. In some species the oil contains as much as 90% squalene, while the ether lipids or the triglycerides dominate in other.
- alkylglycerols more specifically batyl alcohol, chimyl alcohol and selachyl alcohol, in the treatment of inflammatory diseases in warm-blooded ammals is disclosed.
- Summer sore is a skin disease affecting domestic animals, mainly horses, associated with itching and involving loss of hair with ⁇ inning, ulcerous skin.
- the background to summer sore is not entirely clear but it is believed to be associated with sun shine and heat, but may also depend on allergic reactions to insect bites. It is usually treated in that the horse is covered with a horse-cloth and stabled, the latter especially by night. Treatment with cortisone preparation which alleviates the pain has also been suggested.
- Other alternatives are treatment with some homeopathic preparations e.g. one named Okozon added to the fodder of the animal or an oil called "PROB oil" comprising root extracts, herbs, oils and char coal.
- PROB oil an oil
- Equine sarcoids are fibroblastic skin tumours and papillomas, attributed to viruses such as retro- and papillom viruses.
- viruses such as retro- and papillom viruses.
- the tumours do not spread in the body but might spread locally in the skin and cause considerable inconveniences.
- the lesions are notoriously difficult to treat due to infiltrative growth, with multiple lesions resulting in high rates of recurrence.
- One way of treatment has been by surgery or laser surgery, other freezing, immunotherapy, radiation treatment, hyperthermia, bri ⁇ hing with etching substances or injection with cytotoxic drugs directly into the tumour.
- Dermatophilus congolensis causing dermatophilosis penetrates into the skin when it is softened due to wet surroundings or cracked under dusty and dry conditions and makes the skin scurfy.
- the treatment available hitherto has been to remove the scurf, cut the hair, shampoo the affected 3
- Ringworm is the name of a group of fungal diseases of the skin of man and domestic animal marked by the formation of ring-shaped pigmented patches covered with vesicles and scales and caused by dermatophytes.
- ring-shaped pigmented patches covered with vesicles and scales and caused by dermatophytes.
- the problem to be solved by the present invention is to provide a preparation which in a simple and effective way by local application cure the diseases mentioned above.
- the above presented problem is solved by the present invention which relates to the use of shark liver oil for the preparation of a drug for the local treatment of skin diseases of domestic animals such as e.g. horses, cattle, sheep, dogs and cats etc.
- the shark liver oil used for the preparation of the drug is crude or refined shark liver oil comprising alkyl glycerols in an amount of up to 100 % and used in a concentration of from 1 to 100 %.
- Other ingredients that may be added to the shark liver oil to enhance the penetration of the active compound into the skin, to preserve it and to make it convenient to handle, are selected from acidifying agents, emollients, emulsifying agents, surfactants, preservatives, viscosity controlling agents, anti-oxidants, solvents, etc.
- the skin diseases which may be treated with the drug according to the invention are e.g. summer sore, sarcoids such as Equine sarcoids, favus and scurf of different origin such as those emerging with infections by Dermatophilus, e.g. dermatophilosis, greasy heels, mud fever, rain scalds, saddle sores, girth galls, and ringworm.
- sarcoids such as Equine sarcoids, favus and scurf of different origin
- Dermatophilus e.g. dermatophilosis, greasy heels, mud fever, rain scalds, saddle sores, girth galls, and ringworm.
- the preparation according to the invention alleviates the itch of summer sore and gives a clear improvement after a treatment period of 2 to 5 days and eventually, completely healed after continuous treatment during at least one week.
- a suitable treatment frequency of summer sore is by local application of the preparation to the affected area 2 to 3 times per week during at least one week.
- Sarcoids were treated by the local application of the preparation according to the invention on the skin of the animal once daily and when a clear improvement was noticed the preparation was applied twice a week.
- Substances included in the preparation are e.g., acidifying agents, emollients, emulsifying agents, surfactants, preservatives, viscosity controlling agents, anti-oxidants, solvents, etc.
- An agent suitable as emulsifier, emollient and surfactant is e.g. Tefose 2561 comprising PEG-6 stearate (50-72%), Ceteth-20 (10-24.9%), Glyceryl stearate (5-9.9%), and Steareth-20 (5-9.9%), included in amounts of up to 30 %
- preservatives and acidifiers are all substances accepted of the man skilled in the art for veterinary medicine treatment. Suitable examples are sorbic acid, lactic acid, salicylic acid, or other ⁇ -hydroxy acids, each in amounts of up to 10 %.
- anti-oxidants e. g. ascorbyl palmitate
- suitable anti-oxidants e. g. ascorbyl palmitate
- anti-oxidants acceptable within the art of veterinary medicine and known to the man skilled may be used.
- the amounts included are decided according to stability test results in line with established practise.
- the preparation can be in any form suitable for topical application such as an ointment, a cream, a milk, a lotion, a liquid emulsion, a spray, an aerosol or a powder.
- the preparation may be applied to the skin in any suitable way such as by rubbing, spraying, the application of liquid impregnated patches, drenched plasters, etc. 5
- the water phase (B) is heated under stirring to 75 °C and slowly added to the oil phase under stirring. The mixture is cooled to 20°C.
- the preparation is a sprayable lotion prepared in accordance with Example 1.
- a drenched patch or plaster should be applied comprising substantially neat shark liver oil, which however has to be stabilised.
- composition of the additives included in the preparation are as follows:
- Ecomer oil is shark liver oil, the active substance and emollient.
- CITHOROL 2621 is a polyglyceryl-3-di-isostearate an emulsifying agent.
- Bentone gel consists of stearalkonium hectorite, a viscosity controlling agent, caprylic/capric triglyceride, an emollient, and propylene carbonate, a solvent.
- ROXAN A comprises (dl- ⁇ -tocopherol 5%, ascorbyl palmitate 25% and lechitine 70%) and act as stabiliser.
- TEFOSE 2561 consists of PEG-6 stearate (50-70.2%) an emulsifying agent; Ceteth-20 (10- 24.9%) an emulsifying agent and surfactant; Glyceryl sterate (5-9.9%) an emulsifying agent and Steareth 20 (5-9.9%) an emulsifying agent, and surfactant.
- Ascorbyl palmitate is an ami oxidant.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Marine Sciences & Fisheries (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99928301A EP1077710A1 (en) | 1998-05-14 | 1999-05-12 | Use of shark liver oil for local treatment of skin diseases of domestic animals |
AU45398/99A AU4539899A (en) | 1998-05-14 | 1999-05-12 | Use of shark liver oil for local treatment of skin diseases of domestic animals |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9801700-7 | 1998-05-14 | ||
SE9801700A SE9801700D0 (en) | 1998-05-14 | 1998-05-14 | New use |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999058136A1 true WO1999058136A1 (en) | 1999-11-18 |
Family
ID=20411314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1999/000820 WO1999058136A1 (en) | 1998-05-14 | 1999-05-12 | Use of shark liver oil for local treatment of skin diseases of domestic animals |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1077710A1 (en) |
AU (1) | AU4539899A (en) |
SE (1) | SE9801700D0 (en) |
WO (1) | WO1999058136A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001093825A1 (en) * | 2000-06-09 | 2001-12-13 | Air Liquide Sante (International) | Storage-stable compositions of glycerol monoalkyl ethers |
EP1552827A1 (en) * | 2002-06-19 | 2005-07-13 | Maruha Corporation | Oral preventive/therapeutic agent for skin damage containing diacylglyceryl ether |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4447418A (en) * | 1981-03-06 | 1984-05-08 | Maddoux Lilla A | Animal medicine |
EP0321428A2 (en) * | 1987-12-17 | 1989-06-21 | Hälsoprodukter Lars Kärnerud Ab | Use of glycerol ethers in dermatological diseases |
US5554361A (en) * | 1994-01-21 | 1996-09-10 | Dixon; Gary W. | Processed product for skin and hair treatment |
-
1998
- 1998-05-14 SE SE9801700A patent/SE9801700D0/en unknown
-
1999
- 1999-05-12 AU AU45398/99A patent/AU4539899A/en not_active Abandoned
- 1999-05-12 EP EP99928301A patent/EP1077710A1/en not_active Withdrawn
- 1999-05-12 WO PCT/SE1999/000820 patent/WO1999058136A1/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4447418A (en) * | 1981-03-06 | 1984-05-08 | Maddoux Lilla A | Animal medicine |
EP0321428A2 (en) * | 1987-12-17 | 1989-06-21 | Hälsoprodukter Lars Kärnerud Ab | Use of glycerol ethers in dermatological diseases |
US5554361A (en) * | 1994-01-21 | 1996-09-10 | Dixon; Gary W. | Processed product for skin and hair treatment |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001093825A1 (en) * | 2000-06-09 | 2001-12-13 | Air Liquide Sante (International) | Storage-stable compositions of glycerol monoalkyl ethers |
EP1806123A2 (en) * | 2000-06-09 | 2007-07-11 | Air Liquide Santé (International) | Storage-stable compositions of glycerol monoalkyl ethers |
EP1806123A3 (en) * | 2000-06-09 | 2008-03-12 | Air Liquide Santé (International) | Storage-stable compositions of glycerol monoalkyl ethers |
EP2279778A1 (en) * | 2000-06-09 | 2011-02-02 | Air Liquide Santé (International) | Storage-stable compositions of glycerol monoalkyl ethers |
EP1552827A1 (en) * | 2002-06-19 | 2005-07-13 | Maruha Corporation | Oral preventive/therapeutic agent for skin damage containing diacylglyceryl ether |
EP1552827A4 (en) * | 2002-06-19 | 2006-08-30 | Maruha Corp | Oral preventive/therapeutic agent for skin damage containing diacylglyceryl ether |
US7906557B2 (en) | 2002-06-19 | 2011-03-15 | Maruha Nichiro Seafoods, Inc. | Oral preventive/therapeutic agent for skin damage containing diacylglyceryl ether |
Also Published As
Publication number | Publication date |
---|---|
AU4539899A (en) | 1999-11-29 |
SE9801700D0 (en) | 1998-05-14 |
EP1077710A1 (en) | 2001-02-28 |
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