WO1999056793A1 - Procede pour nettoyer un equipement medical avec des micro-ondes - Google Patents

Procede pour nettoyer un equipement medical avec des micro-ondes Download PDF

Info

Publication number
WO1999056793A1
WO1999056793A1 PCT/US1999/009353 US9909353W WO9956793A1 WO 1999056793 A1 WO1999056793 A1 WO 1999056793A1 US 9909353 W US9909353 W US 9909353W WO 9956793 A1 WO9956793 A1 WO 9956793A1
Authority
WO
WIPO (PCT)
Prior art keywords
peroxide
medical equipment
treating composition
mixtures
composition
Prior art date
Application number
PCT/US1999/009353
Other languages
English (en)
Inventor
Allan Scott Goldstein
Howard David Hutton
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to AU37723/99A priority Critical patent/AU3772399A/en
Priority to EP99920158A priority patent/EP1076570A1/fr
Priority to US09/674,475 priority patent/US6521178B1/en
Priority to CA002331019A priority patent/CA2331019A1/fr
Priority to JP2000546817A priority patent/JP2002513641A/ja
Publication of WO1999056793A1 publication Critical patent/WO1999056793A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/12—Microwaves

Definitions

  • the invention generally relates to the field of cleaning compositions. More specifically, the invention relates to a method for cleaning, sanitizing and/or otherwise removing stains, odors, particulate matter and microbes from medical equipment surfaces by contacting the equipment with a cleaning composition and subjecting the equipment to microwaves.
  • the composition is a liquid, gel, foam, or trigger-spray detergent composition. This method provides a convenient way in which medical equipment such that which is used in surgical operations can be sanitized on-site, for example at the hospital, in the operating room, or at a doctor's office.
  • the detergent composition comprises water, surfactant, and optionally, a bleaching agent such as a peroxide in a liquid or gel formulation.
  • equipment such as mirrors that are not particularly used to penetrate tissue, but nevertheless are contacted with tissue and the like when used during surgical operations or other medical procedures will therefore require disinfecting and/or sterilization prior to use on the next patient.
  • certain equipment such as scalpels, sealers, burs, and forceps, must be sterilized prior to re-use so as to prevent the transmission of disease from patient to patient.
  • the invention provides a method by which medical equipment, such as surgical scalpels, can be sanitized using detergent or treating composition containing a surfactant and a solvent such as water.
  • the method involves placing used medical equipment in a non-metal container and contacting it with the treating composition, and subjecting both the equipment and composition to microwaves.
  • the composition foams during microwaving and/or immerses the equipment such that microwave arcing is avoided, and such that the medical equipment is sanitized, preferably to the point of sterilization.
  • a method of sanitizing medical equipment containing microbes comprises the 3
  • a medical equipment sanitizing product comprises a treating composition containing a surfactant and a solvent which generates heat under microwave radiation.
  • the product further includes instructions for using of the treating composition comprising the steps of: (a) contacting the medical equipment
  • the method of the invention essentially includes the steps of contacting microbe-containing medical equipment with a treating composition and subjecting both the composition and equipment to microwaves.
  • the treating composition essentially includes the steps of contacting microbe-containing medical equipment with a treating composition and subjecting both the composition and equipment to microwaves.
  • the treating composition essentially includes the steps of contacting microbe-containing medical equipment with a treating composition and subjecting both the composition and equipment to microwaves.
  • composition contains a solvent which generates heat upon exposure to microwaves and is generally responsible for killing the microbes on the medical equipment.
  • the treating composition preferably also contains a surfactant which aides in the sanitization of the equipment.
  • sanitizing amount it is meant an amount of microbe
  • microbes means any material that has been damaged or destroyed.
  • fection means removal of at least about 90% of the microbes
  • sterilization means removal of at least about 99.9% of the microbes.
  • microbes means any material that has been damaged or destroyed.
  • spore e.g., B. sutilis or C. sporogenes
  • yeast e.g., C. albicans
  • anaerobes e.g., P. gingivalis
  • proteins/bugs e.g., plaque
  • gram (+) e.g., S. mutans
  • gram (-) e.g., E. col ⁇
  • fungi A. meger
  • the treating composition is preferably a detergent composition which
  • ком ⁇ онент 120 contains a surfactant, solvent, and optionally, also contains a bleaching agent.
  • the surfactant is present in an amount of from about 0.01% to about 50%, more preferably from about 1% to about 10%, and most preferably from about 2% to about 5% by weight.
  • the treating composition further comprises an ingredient selected from the group consisting of
  • the treating composition can be in a variety of forms including a liquid, gel or granules.
  • the medical equipment is preferably placed in a non-metal container into
  • the treating composition can be dispensed. It is important for the medical equipment to be totally immersed in the treating composition, or at least partially immersed such that the composition will be able to foam and substantially immerse the equipment with liquid and foam such that arcing does not occur during microwaving.
  • a variety of containers can be used to help provide a place for the
  • a "boat-shaped" container having a false or grated bottom much like a broiling pan can be used such that the treating composition is placed in the false bottom and the equipment on top of the grating.
  • the treating composition foams up from the grating so as to immerse the medical equipment to
  • the treating or detergent composition and dental equipment are subjected to
  • an "effective amount of time” is from about 30 seconds to about 5 minutes, preferably from about 30 seconds to about 3 minutes, and most preferably from about 1 minute to 2 minutes. During this 5
  • the medical equipment 150 delivers the treating composition to substantially all exposed surfaces of the equipment.
  • the medical equipment can be rinsed with fresh solvent once it is removed from the microwave and allowed to dry.
  • the drying time can be enhanced by placing the sanitized medical equipment into a conventional oven. Thereafter, the sanitized medical equipment is stored in a sanitary fashion (e.g.
  • Preferred aspects of the treating composition described herein include having the bleaching agent selected from the group consisting of diacyl peroxide, a source of hydrogen peroxide and bleach activator, a source of hydrogen peroxide, a chlorine
  • Another highly preferred treating composition is a gel or liquid detergent composition comprising by weight: (a) from about 0.1% to about 60% of said bleaching agent which is selected from the group consisting of: i) diacyl peroxide having the general formula:
  • R and Rl can be the same or different; ii) a source of hydrogen peroxide; iii) a source of hydrogen peroxide and a bleach activator; iv) a chlorine bleach; and v) mixtures thereof; (b) from 0% to about 95% of a solvent; (c) from 0.01% to about 50% of a surfactant; and (d) from 0% to about 7% of a thickener.
  • Another highly preferred treating composition is a gel detergent composition comprising by weight:
  • R and Rl can be the same or different; (b) from 0.01% to about 50% of a surfactant; and (c) from 0% to about 7% of a thickener; the composition having a neat pH of from about 3 to about 10; and such that said diacyl peroxide remains
  • Microwaves - By microwaving herein is meant exposing said surface treated with said compositions to microwave electromagnetic radiation. This is by any conventional means such as by placing the surface in a typical microwave such as used in homes and microwaving the surface for a sufficient time. Microwaves have
  • composition of the present invention preferably contain diacyl peroxide of the general formula:
  • R and Rl can be the same or different and are hydrocarbyls, preferably no
  • more than one is a hydrocarbyl chain of longer than ten carbon atoms, more preferably at least one has an aromatic nucleus.
  • diacyl peroxides are selected from the group consisting dibenzoyl peroxide, dianisoyl peroxide, benzoyl gluaryl peroxide, benzoyl succinyl peroxide, di-(2-methybenzoyl) peroxide, diphthaloyl peroxide, dinaphthoyl peroxide,
  • dibenzoyl peroxide substituted dinaphthoyl peroxide, and mixtures thereof, more preferably dibenzoyl peroxide, dicumyl peroxide, diphthaloyl peroxides and mixtures thereof.
  • a particularly preferred diacyl peroxide is dibenzoyl peroxide.
  • compositions of the present invention may comprise a source of oxygen bleach, preferably a source of hydrogen peroxide with
  • the source of hydrogen peroxide is typically any common hydrogen-peroxide releasing salt, such as sodium perborate or sodium percarbonate. Hydrogen peroxide sources are illustrated in detail in Kirk Othmer Review on Bleaching and include the various forms of sodium perborate and sodium percarbonate and modified forms. An "effective amount" of a source of hydrogen
  • peroxide is any amount capable of measurably improving stain removal (especially of tea and tomato stains) from the soiled surface compared to a hydrogen peroxide source-free composition when the soiled surface is washed by the consumer.
  • the preferred source of hydrogen peroxide used herein can be any convenient source, including hydrogen peroxide itself.
  • perborate e.g., sodium
  • 210 perborate any hydrate but preferably the mono- or tetra-hydrate
  • sodium carbonate peroxyhydrate or equivalent percarbonate salts sodium pyrophosphate peroxy- hydrate, urea peroxyhydrate, or sodium peroxide
  • sodium perborate monohydrate and sodium percarbonate are particularly preferred. Mixtures of any convenient hydrogen peroxide sources can also be used.
  • Another source of hydrogen peroxide is enzymes. Examples include
  • Lipoxidase glucose oxidase, peroxidase, alcohol oxidases, and mixtures thereof.
  • Bleach Activators Numerous conventional bleach activators are known. See for example activators referenced hereinabove in the background as well as U.S. Patent 4,915,854, issued April 10, 1990 to Mao et al, and U.S. Patent 4,412,934.
  • Nonanoyloxybenzenesulfonate (NOBS) or acyl lactam activators may be used, and mixtures thereof with TAED can also be used. See also U.S. 4,634,551 for other 7
  • amido-derived bleach activators of the formulae: R 1 N(R 5 )C(O)R C(O)L or RlC(O)N(R 5 )R2c(O)L wherein Rl is an alkyl group containing from about 6 to about 12 carbon atoms, R 2
  • bleach activators of the above formulae include (6-octanamidocaproyl)oxybenzenesulfonate, (6-nonanamidocaproyl)- oxybenzenesulfonate, (6-decanamidocaproyl)oxybenzenesulfonate, and mixtures
  • bleach activators comprises the benzoxazin-type activators disclosed by Hodge et al in U.S. Patent 4,966,723, issued October 30, 1990.
  • Still another class of bleach activators includes acyl lactam activators such as octanoyl caprolactam, 3,5,5-trimethylhexanoyl caprolactam, nonanoyl caprolactam, decanoyl caprolactam, undecenoyl caprolactam,
  • compositions can optionally comprise aryl benzoates, such as phenyl benzoate, and acety triethyl citrate.
  • compositions can also comprise quaternary substituted bleach activators (QSBA).
  • QSBA's herein typically have the formula E-[Z] n -C(O)-L, wherein group E is referred to as the "head”, group Z is referred to as the "spacer” (n is 0 or 1, i.e., this group may be present or absent, though its presence is generally preferred) and L is referred to as
  • L is a leaving group, the pKa of the corresponding carbon acid (HL) of which can lie in the general range from about 5 to about 30, more preferably, from
  • Preferred QSBA's herein are water-soluble but have a tendency to partition to a definite extent into surfactant micelles, especially into micelles of nonionic surfactants.
  • Z is a poly(methylene) or oligo(methylene) moiety, i.e., the spacer is aliphatic, and the quaternary moiety is E.
  • U.S. 4,818,426 issued Apr. 4., 1989 discloses another class of QSBA's suitable for use herein.
  • These compounds are quaternary ammonium carbonate esters wherein, with reference to the above formula, the moiety Z is attached to E via a carbon atom
  • Chlorine Bleach Any chlorine bleach typically known in the art is suitable for use herein.
  • Preferred chlorine bleaches for use herein include sodium hypochlorite, lithium hypochlorite, calcium hyposhlorite, chlorinated trisodium phosphates, and mixtures thereof. For more about chlorine bleaches see Surfactant
  • Ingredients - Detersive ingredients or adjuncts optionally included in the instant compositions can include one or more materials for assisting or enhancing cleaning performance, treatment of the surface to be cleaned, or designed to improve the aesthetics or ease of manufacture of the compositions.
  • Other adjuncts which can be
  • compositions of the invention at their conventional art- established levels, generally from 0% to about 20% of the composition, preferably at from about 0.1% to about 10%, include one or more processing aids, color speckles, dyes, fillers, bleach-compatible enzymes, germicides, alkalinity sources, hydrotropes, stabilizers, perfumes, solubilizing agents, carriers.
  • processing aids color speckles, dyes, fillers, bleach-compatible enzymes, germicides, alkalinity sources, hydrotropes, stabilizers, perfumes, solubilizing agents, carriers.
  • Exemplary germicides suitable for use include triclosan, triclocarbon, hydrogen peroxide and other oxygen bleaches, para-chloro-meta-xylenol, iodine/iodophors, selected alcohols, chlorohexidine, phenols, phospholipids, thymol,
  • quaternary surfactants may also show antimicrobial action and may be included as an adjunct germicide.
  • additional ingredients such as water-soluble silicates (useful to provide alkalinity and assist in controlling corrosion), dispersant
  • bleach-improving materials such as bleach catalysts may be added.
  • the solvent of the present invention is of the type in which the diacyl peroxide will dissolve.
  • the preferred solvents are selected based upon the solubility parameter value of the diacyl peroxide employed.
  • the solubility parameter value of a compound is available from literature sources such as Polymer Handbook. Values obtained by experiments are preferred. If the solubility parameter value is
  • the value can be calculated by using any of the methods described by Robert F. Fedor's article "A Method of Estimating Both the Solubility Parameters & Molar Volumes of Liquids", Polymer Engineering & Science, February, 1974, Vol 14, No. 2. Once the solubility parameter value is obtained of the diacyl peroxide, solvents are selected having a solubility parameter
  • Said solvent is preferably selected from the group consisting of N-alkyl pyrrolidones, such as N-ethyl pyrrolidone, diacetone alcohol, long chain (greater than C6) alkyl ethers, cyclic alkyl ketones, and mixtures thereof. Amines, ethers and short chain (less than C ) primary and secondary alcohols are preferably not present.
  • the presence of these compounds may introduce stability problems.
  • the amount of amine, ether, or primary or secondary alcohol be limited to no more than about 5%, preferably no more than about 3%, by weight of the composition.
  • Nonlimiting examples of surfactants useful herein include the conventional C ⁇ 1 -C ⁇ 8 alkyl benzene sulfonates ("LAS") and primary, branched- chain and random CI Q-C20 alkyl sulfates ("AS"), the Ci o-Cjg secondary (2,3) alkyl sulfates of the formula CH3(CH2) x (CHOSO -M + ) CH 3 and CH 3 (CH2) y (CHOS ⁇ 3-M + ) CH2CH3 where x and (y + 1) are integers of at least about 7,
  • M is a water-solubilizing cation, especially sodium, unsaturated sulfates such as oleyl sulfate, the C1 Q-CI g alkyl alkoxy sulfates ("AE X S"; especially EO 1-7 ethoxy sulfates), C1 Q-CI g alkyl alkoxy carboxylates (especially the EO 1-5 ethoxycarboxylates), the C ⁇ Q-CI 8 glycerol ethers, the C1 - C ⁇ $ alkyl polyglycosides and their corresponding sulfated polyglycosides, and C j 2"
  • AE X S especially EO 1-7 ethoxy sulfates
  • C1 Q-CI g alkyl alkoxy carboxylates especially the EO 1-5 ethoxycarboxylates
  • C ⁇ Q-CI 8 glycerol ethers the C1 - C ⁇ $ alkyl polyglycoside
  • the conventional nonionic and amphoteric surfactants such as the Cl2"Cl8 alkyl ethoxylates ("AE") including the so-called narrow peaked alkyl 10
  • ethoxylates and C6-C12 alkyl phenol alkoxylates especially ethoxylates and mixed ethoxy/propoxy
  • C12-C18 betaines and sulfobetaines especially ethoxylates and mixed ethoxy/propoxy
  • the Cio-C] 8 N-alkyl polyhydroxy fatty acid amides can also be used. Typical examples include the C12-C18 N- methylglucamides. See WO 9,206,154. Other sugar-derived surfactants include the N-alkoxy polyhydroxy fatty acid amides, such as CJ O-CI S N-(3-methoxypropyl) glucamide. The N-propyl through N-hexyl C12-C18 glucamides can be used for low
  • C10-C20 conventional soaps may also be used. If high sudsing is desired, the branched-chain C ⁇ 0-C16 soaps may be used. Mixtures of anionic and nonionic surfactants are especially useful. Other conventional useful surfactants are listed in standard texts.
  • anionic surfactants are used herein. Without being limited by
  • anionic surfactants maximizes both cleaning performance and removal of residual bleach from the surface being treated.
  • surfactants suitable for use herein are those selected from the group consisting of alkyl ether sulfate, long chain (greater than about C7) alkyl ethoxylate, linear alkyl benzene sulfonate (LAS), alkyl (ether)
  • Thickeners - Thickeners for use herein can be selected from clay, polycarboxylates, such as Polygel®, gums, carboxymethyl cellulose, polyacrylates, and mixtures thereof.
  • the preferred clay type herein has a double-layer structure.
  • the clay may be naturally occurring, e.g., Bentonites, or artificially made, e.g.,
  • Laponite® is supplied by Southern Clay Products, Inc. See The
  • Bleach catalysts may additionally incorporate a catalyst or accelerator to further improve bleaching or starchy soil
  • compositions will comprise from about 0.0001% to about 0.1% by weight of bleach catalyst.
  • Typical bleach catalysts comprise a transition-metal complex, for example one wherein the metal coordinating ligands are quite resistant to labilization and which does not deposit metal oxides or hydroxides to any appreciable extent under
  • catalyst compounds often have features of naturally occurring compounds such as enzymes but are principally provided synthetically.
  • Highly preferred accelerators include, for example, the cobalt 3+ catalysts, especially ⁇ Co(NH3)5 ⁇ 2+or equivalents thereof with various alternate donor ligands.
  • Such complexes include those formerly disclosed for use in laundry 1 1
  • the active species thereof is believed to be ⁇ Co(NH3)5(OOH) ⁇ 2 + and is disclosed in J. Chem. Soc. Faraday Trans., 1994, Vol. 90, 1105-1114.
  • Alternate catalysts or accelerators are the noncobalt transition metal complexes disclosed in this reference, especially those based on Mo(VI), Ti(IV), W(VI), V(V) and Cr(VI) although alternate oxidation states and metals may also be used.
  • Such catalysts include manganese-based catalysts disclosed in U.S. Pat. 5,246,621, U.S. 5,244,594; U.S. 5,194,416; U.S.
  • metal-based bleach catalysts include those disclosed in U.S. Pat. 4,430,243 and U.S. Pat. 5,114,611.
  • the use of manganese with various complex ligands to enhance bleaching is also reported in the following United States Patents: 4,728,455; 5,284,944; 5,246,612; 5,256,779; 5,280,117; 5,274,147; 5,153,161; and 5,227,084.
  • Transition metals may be precomplexed or complexed in-situ with suitable donor ligands selected in function of the choice of metal, its oxidation state and the denticity of the ligands.
  • suitable transition metals in said transition-metal-containing bleach catalysts include iron, cobalt, ruthenium, rhodium, iridium, and copper.
  • Builders - Detergent builders can optionally be included in the compositions herein to assist in controlling mineral hardness. Inorganic as well as organic builders can be used. Builders are typically used in fabric laundering compositions to assist in the removal of particulate soils.
  • the level of builder can vary widely depending upon the end use of the composition and its desired physical form. When present, the compositions will typically comprise at least about 1% builder. Liquid formulations typically comprise from about 5% to about 50%, more typically about 5% to about 30%, by weight, of detergent builder. Lower or higher levels of builder, however, are not meant to be excluded. 12
  • Inorganic or P-containing detergent builders include, but are not limited to, the alkali metal, ammonium and alkanolammonium salts of polyphosphates (exemplified by the tripolyphosphates, pyrophosphates, and glassy polymeric meta- phosphates), phosphonates, phytic acid, silicates, carbonates (including bicarbonates
  • silicate builders are the alkali metal silicates, particularly those having a SiO2:Na2O ratio in the range 1.6:1 to 3.2:1 and layered silicates, such as the layered sodium silicates described in U.S. Patent 4,664,839, issued May 12, 1987 to H. P. Rieck. NaSKS-6 is the trademark for a crystalline layered silicate marketed
  • NaSKS-6 415 by Hoechst (commonly abbreviated herein as "SKS-6").
  • NaSKS-6 can be prepared by methods such as those described in German DE-A-3,417,649 and DE-A- 3,742,043.
  • Other layered silicates such as those having the general formula NaMSi x ⁇ 2 ⁇ + ⁇ -yH2 ⁇ wherein M is sodium or hydrogen, x is a number from 1.9 to 4, preferably 2, and y is a number from 0 to 20 can be used herein.
  • M sodium or hydrogen
  • x is a number from 1.9 to 4
  • y is a number from 0 to 20
  • 420 layered silicates from Hoechst include NaSKS-5, NaSKS-7 and NaSKS-11 , as the alpha, beta and gamma forms.
  • carbonate builders are the alkaline earth and alkali metal carbonates as disclosed in German Patent Application No. 2,321,001 published on November 15, 1973.
  • Aluminosilicate builders may be useful in the present invention.
  • Aluminosilicate builders include those having the empirical formula:
  • M z (zAlO 2 )y]-xH O wherein z and y are integers of at least 6, the molar ratio of z to y is in the range from 1.0 to about 0.5, and x is an integer from about 15 to about 264.
  • aluminosilicate ion exchange materials are commercially available.
  • a method for producing aluminosilicate ion exchange materials is disclosed in U.S. Patent 3,985,669, Krummel, et al, issued October 12, 1976.
  • Preferred synthetic crystalline aluminosilicate ion exchange materials useful herein are available under the designations Zeolite A, Zeolite P (B), Zeolite MAP and Zeolite X.
  • the crystalline aluminosilicate ion exchange material has the formula:
  • the aluminosilicate has a particle size of about 0.1-10 microns in diameter.
  • Organic detergent builders suitable for the purposes of the present invention include, but are not restricted to, a wide variety of polycarboxylate compounds. As 13
  • polycarboxylate refers to compounds having a plurality of carboxylate groups, preferably at least 3 carboxylates.
  • Polycarboxylate builder can generally be
  • alkali metals such as sodium, potassium, and lithium, or alkanolammonium salts are preferred.
  • polycarboxylate builders include a variety of categories of useful materials.
  • One important category of polycarboxylate builders encompasses
  • ether polycarboxylates including oxydisuccinate, as disclosed in Berg, U.S. Patent 3,128,287, issued April 7, 1964, and Lamberti et al, U.S. Patent 3,635,830, issued January 18, 1972. See also "TMS/TDS" builders of U.S. Patent 4,663,071, issued to Bush et al, on May 5, 1987.
  • Suitable ether polycarboxylates also include cyclic compounds, particularly alicyclic compounds, such as those described in U.S.
  • detergency builders include the ether hydroxypolycarboxylates, copolymers of maleic anhydride with ethylene or vinyl methyl ether, 1, 3, 5- trihydroxy benzene-2, 4, 6-trisulphonic acid, and carboxymethyloxysuccinic acid, the various alkali metal, ammonium and substituted ammonium salts of polyacetic acids
  • 460 such as ethylenediamine tetraacetic acid and nitrilotriacetic acid, as well as polycarboxylates such as mellitic acid, succinic acid, oxydisuccinic acid, polymaleic acid, benzene 1,3,5-tricarboxylic acid, carboxymethyloxysuccinic acid, and soluble salts thereof.
  • polycarboxylates such as mellitic acid, succinic acid, oxydisuccinic acid, polymaleic acid, benzene 1,3,5-tricarboxylic acid, carboxymethyloxysuccinic acid, and soluble salts thereof.
  • Citrate builders e.g., citric acid and soluble salts thereof (particularly sodium
  • 465 salt are polycarboxylate builders of importance for liquid detergent formulations due to their availability from renewable resources and their biodegradability. Oxydisuccinates are also especially useful in such compositions and combinations.
  • compositions of the present invention are the 3,3- dicarboxy-4-oxa-l,6-hexanedioates and the related compounds disclosed in U.S.
  • Laurylsuccinates are the preferred builders of this group, and are described in European Patent Application 86200690.5/0,200,263, published November 5, 1986.
  • Fatty acids e.g., C12-C18 monocarboxylic acids
  • tripolyphosphates sodium pyrophosphate and sodium orthophosphate can be used.
  • Phosphonate builders such as ethane- l-hydroxy-l,l-diphosphonate and other known phosphonates (see, for example, U.S. Patents 3,159,581; 3,213,030; 3,422,021; 3,400,148 and 3,422,137) can also be used.
  • Enzymes - Suitable enzymes include proteases, amylases, Upases, cellulases,
  • peroxidases and mixtures thereof of any suitable origin, such as vegetable, animal, bacterial, fungal and yeast origin. Preferred selections are influenced by factors such as pH-activity and or stability optima, thermostability, and stability to active bleach, detergents, builders and the like. In this respect bacterial or fungal enzymes are preferred, such as bacterial amylases and proteases, and fungal cellulases.
  • Enzymes are normally incorporated into detergent or detergent additive compositions at levels sufficient to provide a "cleaning-effective amount".
  • cleaning effective amount refers to any amount capable of producing a cleaning, stain removal, soil removal, whitening, deodorizing, or freshness improving effect on surfaces such as dishware and the like. In practical terms for current commercial
  • compositions herein may comprise from 0.001% to 5%, preferably 0.01%-1% by weight of a commercial enzyme preparation.
  • Protease enzymes are usually present in such commercial preparations at levels sufficient to provide from 0.005 to 0.1 Anson units (AU) of activity per gram of composition.
  • proteases 500 GB 1,243,784 to Novo.
  • suitable proteases include ALCALASE® and
  • Enzymatic detergents comprising protease, one or more other enzymes, and a reversible protease inhibitor are described in WO 9203529 A to Novo.
  • Other preferred proteases include those of WO 9510591 A to Procter & Gamble .
  • a protease having decreased adsorption and increased hydrolysis is available as described in WO 9507791 to Procter & Gamble.
  • Amylases suitable herein, especially for, but not limited to automatic dishwashing purposes include, for example, ⁇ -amylases described in GB 1,296,839 to Novo; RAPIDASE®, International Bio-Synthetics, Inc. and TERMAMYL®,
  • amylases include (a) an amylase according to the hereinbefore incorporated WO 9402597, Novo, Feb. 3, 1994.
  • Other amylases include variants having additional modification in the
  • 520 immediate parent as described in WO 9510603 A and are available from the assignee, Novo, as DURAMYL®.
  • Other particularly preferred oxidative stability enhanced amylase include those described in WO 9418314 to Genencor International and WO 9402597 to Novo.
  • Cellulases usable herein include those disclosed in U.S. 4,435,307,
  • Suitable lipase enzymes for detergent usage include those produced by microorganisms of the Pseudomonas group, such as Pseudomonas stutzeri ATCC
  • Upases include Amano-CES, Upases ex Chromobacter viscosum, e.g. Chromobacter viscosum var. lipolyticum NRRLB 3673 from Toyo Jozo Co., Tagata, Japan; Chromobacter viscosum Upases from U.S. Biochemical Corp., U.S.A. and Disoynth
  • Cutinase enzymes suitable for use herein are described in WO 8809367 A to
  • Peroxidase enzymes may be used in combination with oxygen sources, e.g., percarbonate, perborate, hydrogen peroxide, etc., for "solution bleaching" or prevention of transfer of dyes or pigments removed from surfaces during the wash to
  • oxygen sources e.g., percarbonate, perborate, hydrogen peroxide, etc.
  • peroxidases include horseradish peroxidase, ligninase, and haloperoxidases such as chloro- or bromo-peroxidase.
  • Peroxidase-containing detergent compositions are disclosed in WO 89099813 A, October 19, 1989 to Novo and WO 8909813 A to Novo.
  • Enzyme Stabilizing System - Enzyme-containing including but not limited to, liquid compositions, herein may comprise from about 0.001% to about 10%, preferably from about 0.005% to about 8%, most preferably from about 0.01% to
  • Such stabilizing systems can, for example, comprise calcium ion, boric acid, propylene glycol, short chain carboxylic acids, boronic acids, and mixtures thereof, and are designed to address different stabilization problems depending on the type and physical form of the detergent composition. See Severson, U.S. 4,537,706 for a review of Borate
  • Stabilizing systems may further comprise from 0 to about 10%, preferably from about 0.01% to about 6% by weight, of chlorine bleach scavengers, added to prevent chlorine bleach species present in many water supplies from attacking and inactivating the enzymes, especially under alkaline conditions.
  • Suitable chlorine bleach scavengers added to prevent chlorine bleach species present in many water supplies from attacking and inactivating the enzymes, especially under alkaline conditions.
  • 575 scavenger anions are widely known and readily available, and, if used, can be salts containing ammonium cations with sulfite, bisulfite, thiosulfite, thiosulfate, iodide, etc.
  • Antioxidants such as carbamate, ascorbate, etc., organic amines such as ethylenediaminetetracetic acid (EDTA) or alkali metal salt thereof, monoethanolamine (MEA), and mixtures thereof can likewise be used.
  • EDTA ethylenediaminetetracetic acid
  • MEA monoethanolamine
  • conventional scavengers such as bisulfate, nitrate, chloride, sources of hydrogen peroxide such as sodium perborate tetrahydrate, sodium perborate monohydrate and sodium percarbonate, as well as phosphate, condensed phosphate, acetate, benzoate, citrate, formate, lactate, malate, tartrate, salicylate, etc., and mixtures thereof can be used if desired.
  • compositions may optionally contain as corrosion inhibitors and/or anti-tarnish aids one or more material care agents such as silicates.
  • material care agents are preferred especially in countries where electroplated nickel silver and sterling silver are common in domestic flatware, or when aluminium protection is a concern and the composition is low in silicate. 17
  • Material care agents include bismuth salts, transition metal salts such as those of manganese, certain types of paraffin, triazoles, pyrazoles, thiols, mercaptans, aluminium fatty acid salts, and mixtures thereof and are preferably incorporated at low levels, e.g., from about 0.01% to about 5% of the composition.
  • a preferred paraffin oil is a predominantly branched aliphatic hydrocarbon comprising from
  • compositions herein may also optionally
  • Such chelating agents can be selected from the group consisting of amino carboxylates, amino phosphonates, polyfunctionally-substituted aromatic chelating agents and mixtures therein, all as hereinafter defined.
  • Amino carboxylates useful as optional chelating agents include
  • 610 ethylenediaminetetracetates, N-hydroxyethylethylenediaminetriacetates, nitrilo- triacetates, ethylenediamine tetraproprionates, triethylenetetra-amine-hexacetates, diethylenetriaminepentaacetates, and ethanoldiglycines, alkali metal, ammonium, and substituted ammonium salts therein and mixtures therein.
  • compositions herein See U.S. Patent 3,812,044, issued May 21, 1974, to Connor et al.
  • Preferred compounds of this type in acid form are dihydroxydisulfobenzenes such as l,2-dihydroxy-3,5-disulfobenzene.
  • a preferred biodegradable chelator for use herein is ethylenediamine disuccinate ("EDDS"), especially the [S,S] isomer as described in U.S. Patent 4,704,233, November 3, 1987, to Hartman and Perkins.
  • EDDS ethylenediamine disuccinate
  • these chelating agents will generally comprise from about 0.1 % to about 10% by weight of the detergent compositions herein. More preferably, if utilized, the chelating agents will comprise from about 0.1% to about 3.0% by weight of such compositions.
  • Polymeric Dispersing Agents can be any suitable dispersing agent.
  • Polymeric dispersing agents can be any suitable dispersing agents.
  • compositions herein advantageously be utilized at levels from about 0.1% to about 7%, by weight, in the compositions herein, especially in the presence of zeolite and/or layered silicate 18
  • Suitable polymeric dispersing agents include polymeric polycarboxylates and polyethylene glycols, although others known in the art can also be used. It is believed, though it is not intended to be limited by theory, that polymeric dispersing
  • 630 agents enhance overall detergent builder performance, when used in combination with other builders (including lower molecular weight polycarboxylates) by crystal growth inhibition, particulate soil release peptization, and anti-redeposition.
  • the instructions 635 forms of advertising associated with the sale or use of the product.
  • the instructions may be included in any manner typically used by consumer product manufacturing or supply companies. Examples include providing instructions on a label attached to the container holding the medical equipment; on a sheet either attached to the container or accompanying it when purchased; or in advertisements, demonstrations,
  • the instructions will include a description of the use of the treating composition and microbe-containing medical equipment in connection with microwaving.
  • the instructions may additionally include information
  • Process - Methods for producing diacyl peroxide particles for use in the compositions herein wherein an abrasive particle is desired may include any particle making process commonly known in the art, including shear mixing.
  • the diacyl particles for use herein can range in size from sub-micron (0.1) to about 100 microns. A preferred range is from about 1 to about 20 microns.
  • Another process for making the diacyl particles for use herein can range in size from sub-micron (0.1) to about 100 microns. A preferred range is from about 1 to about 20 microns. Another process for making
  • dispersion of small homogeneous particles ranging in size of from about 1 to about 20 microns.
  • commercially available diacyl peroxide raw material particles can be used which have particle sizes on the order of 800 microns or more, although these are not preferred. 19
  • compositions are prepared for use as a treating composition.
  • Each of the compositions are dispensed into "boat-shaped" containers, after which microbe-containing medical equipment is immersed in the compositions.
  • the container containing the medical equipment and composition is then placed into a
  • 680 conventional household microwave and operated at the highest setting for the noted times, respectively.
  • ⁇ Acyl Peroxides selected from dibenzoyl peroxide, dianisoyl peroxide, benzoyl
  • diphthaloyl peroxide diphthaloyl peroxide, dinaphthoyl peroxide, substituted dinaphthoyl peroxide, and mixtures thereof.
  • the percent microbe removal 690 is determined by standard techniques (ASTM). As can be seen in this Example, all of the compositions A, B and C unexpectedly remove a sanitizing amount of microbes from the medical equipment in inexpensive and timely manner.

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Detergent Compositions (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

Selon cette invention, on stérilise un équipement médical tel que les scalpels chirurgicaux au moyen d'un détergent ou d'une composition de traitement contenant un surfactant et un solvant tel que l'eau. Le procédé consiste à mettre l'équipement médical utilisé en contact avec la composition de traitement et à soumettre l'équipement et la composition à l'action des micro-ondes. Lors du traitement aux micro-ondes, la composition mousse et/ou immerge l'équipement, ce qui permet d'éviter la formation d'étincelles sous l'effet des micro-ondes et de nettoyer l'équipement médical.
PCT/US1999/009353 1998-05-01 1999-04-30 Procede pour nettoyer un equipement medical avec des micro-ondes WO1999056793A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU37723/99A AU3772399A (en) 1998-05-01 1999-04-30 Method for sanitizing medical equipment using microwaves
EP99920158A EP1076570A1 (fr) 1998-05-01 1999-04-30 Procede pour nettoyer un equipement medical avec des micro-ondes
US09/674,475 US6521178B1 (en) 1999-04-30 1999-04-30 Method for sanitizing medical equipment using microwaves
CA002331019A CA2331019A1 (fr) 1998-05-01 1999-04-30 Procede pour nettoyer un equipement medical avec des micro-ondes
JP2000546817A JP2002513641A (ja) 1998-05-01 1999-04-30 マイクロ波を用いた医療用器材の衛生化方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8377398P 1998-05-01 1998-05-01
US60/083,773 1998-05-01

Publications (1)

Publication Number Publication Date
WO1999056793A1 true WO1999056793A1 (fr) 1999-11-11

Family

ID=22180607

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/009353 WO1999056793A1 (fr) 1998-05-01 1999-04-30 Procede pour nettoyer un equipement medical avec des micro-ondes

Country Status (6)

Country Link
EP (1) EP1076570A1 (fr)
JP (1) JP2002513641A (fr)
AR (1) AR013037A1 (fr)
AU (1) AU3772399A (fr)
CA (1) CA2331019A1 (fr)
WO (1) WO1999056793A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19957924A1 (de) * 1999-12-01 2001-06-07 Robert Nusko Verfahren und Behältnisse zur Sterilisation von Gegenständen
EP1390161A1 (fr) * 2001-05-01 2004-02-25 The Procter & Gamble Company Composition de blanchiment sous forme de liquide stable ou de gel, contenant des particules de peroxyde de diacyle
US6939836B2 (en) * 2000-09-01 2005-09-06 Novapharm Research (Australia) Pty Ltd Surfactant system
WO2019112443A1 (fr) 2017-12-06 2019-06-13 Plastservice As Procédé de désinfection de dispositifs en plastique
EP3720511A4 (fr) * 2017-12-06 2021-11-24 Plastservice AS Procédé de désinfection de dispositifs en plastique

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4606183B2 (ja) * 2005-01-25 2011-01-05 ニッポウ興産株式会社 医療廃棄物の加熱殺菌装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543111A (en) * 1990-07-06 1996-08-06 Iit Research Institute Method and apparatus for rendering medical materials safe
WO1998003624A2 (fr) * 1996-07-24 1998-01-29 The Procter & Gamble Company Compositions de detergence en gel ou liquides pouvant etre vaporisees et contenant un agent de blanchiment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO728797A0 (en) * 1997-06-11 1997-07-03 Containers Pty Ltd Preferential heating of materials by use of non-ionising electromagnetic radiation
HUP0003196A2 (hu) * 1997-07-21 2001-02-28 The Procter & Gamble Co. Eljárás tárgyak fertőtlenítésére mosószerkészítményekkel
EP1032636A1 (fr) * 1997-11-14 2000-09-06 The Procter & Gamble Company Procede de nettoyage mettant en oeuvre des micro-ondes et une composition de blanchiment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543111A (en) * 1990-07-06 1996-08-06 Iit Research Institute Method and apparatus for rendering medical materials safe
WO1998003624A2 (fr) * 1996-07-24 1998-01-29 The Procter & Gamble Company Compositions de detergence en gel ou liquides pouvant etre vaporisees et contenant un agent de blanchiment

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19957924A1 (de) * 1999-12-01 2001-06-07 Robert Nusko Verfahren und Behältnisse zur Sterilisation von Gegenständen
US6939836B2 (en) * 2000-09-01 2005-09-06 Novapharm Research (Australia) Pty Ltd Surfactant system
EP1390161A1 (fr) * 2001-05-01 2004-02-25 The Procter & Gamble Company Composition de blanchiment sous forme de liquide stable ou de gel, contenant des particules de peroxyde de diacyle
EP1390161A4 (fr) * 2001-05-01 2005-12-28 Procter & Gamble Composition de blanchiment sous forme de liquide stable ou de gel, contenant des particules de peroxyde de diacyle
WO2019112443A1 (fr) 2017-12-06 2019-06-13 Plastservice As Procédé de désinfection de dispositifs en plastique
EP3720511A4 (fr) * 2017-12-06 2021-11-24 Plastservice AS Procédé de désinfection de dispositifs en plastique

Also Published As

Publication number Publication date
JP2002513641A (ja) 2002-05-14
AR013037A1 (es) 2000-11-22
CA2331019A1 (fr) 1999-11-11
EP1076570A1 (fr) 2001-02-21
AU3772399A (en) 1999-11-23

Similar Documents

Publication Publication Date Title
US6306219B1 (en) Method for stain removal on hard surfaces with detergent compositions containing bleach
US6521178B1 (en) Method for sanitizing medical equipment using microwaves
US6322748B1 (en) Method for activation of bleaches
US6287346B1 (en) Method for stain removal on fabric with detergent compositions containing bleach
EP1250938A2 (fr) Absorption des odeurs et désodorisation
WO1999025802A1 (fr) Procede de nettoyage mettant en oeuvre des micro-ondes et une composition de blanchiment
US6440920B1 (en) Sprayable, liquid or gel detergent compositions containing bleach
AU2021219053A1 (en) Antimicrobial compositions containing peroxyphthalic acid and/or salt thereof
US20190071621A1 (en) Process for removal of biofilm
US6423265B1 (en) Method for sanitizing dental equipment using microwaves
EP1076570A1 (fr) Procede pour nettoyer un equipement medical avec des micro-ondes
AU2004319251A1 (en) Decontamination system
AU8406898A (en) Method for sanitization of substrates with detergent compositions
US20030220214A1 (en) Method of cleaning using gel detergent compositions containing acyl peroxide
WO2010030255A1 (fr) Processus de stérilisation de produits textiles
CA3068287A1 (fr) Desinfectant sporicide
MXPA00004626A (en) Method for cleaning using microwaves and a bleaching composition
JPH10295785A (ja) 細菌芽胞の殺菌方法
CN1094749A (zh) 一种兼具消毒、杀菌作用的洗涤剂
JPS6344505A (ja) 殺菌防カビ剤
JP2007082900A (ja) 消毒又は滅菌方法
MXPA00000791A (en) Method for sanitization of substrates with detergent compositions

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AM AT AT AU AZ BA BB BG BR BY CA CH CN CU CZ CZ DE DE DK DK EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2331019

Country of ref document: CA

Ref country code: JP

Ref document number: 2000 546817

Kind code of ref document: A

Format of ref document f/p: F

NENP Non-entry into the national phase

Ref country code: KR

WWE Wipo information: entry into national phase

Ref document number: 09674475

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 1999920158

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999920158

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1999920158

Country of ref document: EP