WO1999055456A1 - Procede de synthese d'une pluralite de produits - Google Patents

Procede de synthese d'une pluralite de produits Download PDF

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Publication number
WO1999055456A1
WO1999055456A1 PCT/GB1999/001281 GB9901281W WO9955456A1 WO 1999055456 A1 WO1999055456 A1 WO 1999055456A1 GB 9901281 W GB9901281 W GB 9901281W WO 9955456 A1 WO9955456 A1 WO 9955456A1
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WO
WIPO (PCT)
Prior art keywords
articles
micro
article
reactor
synthesis
Prior art date
Application number
PCT/GB1999/001281
Other languages
English (en)
Inventor
Anthony Robert Corless
Original Assignee
Central Research Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Central Research Laboratories Limited filed Critical Central Research Laboratories Limited
Priority to CA002330124A priority Critical patent/CA2330124A1/fr
Priority to JP2000545643A priority patent/JP2002512878A/ja
Priority to AU37172/99A priority patent/AU746309B2/en
Priority to EP99919369A priority patent/EP1079919A1/fr
Priority to IL13908999A priority patent/IL139089A0/xx
Publication of WO1999055456A1 publication Critical patent/WO1999055456A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00295—Individual reactor vessels the reactor vessels having pervious side walls
    • B01J2219/00297—"Tea bags"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00461—Beads and reaction vessel together
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00461—Beads and reaction vessel together
    • B01J2219/00463—Directed sorting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00542—Alphanumeric characters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00565—Electromagnetic means
    • B01J2219/00567—Transponder chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Definitions

  • the present invention relates to a method of synthesizing a plurality of products using a process.
  • Combinatorial chemistry is a technique whereby very many different chemical compounds are produced by multiple chemical reactions.
  • a library of chemical compounds may be formed on solid phase supports.
  • the solid phase supports are commonly known as beads. Beads of the size approximately a tenth of a millimetre in diameter are typically used in such reactions. Molecules can be attached to the beads by way of chemical hooks.
  • beads in group 1 have a molecule of compound A attached to them
  • beads in group 2 have a molecule of compound B
  • beads in group 3 a molecule of compound C.
  • the 3 groups of beads are pooled, mixed up, and again split up into 3 groups.
  • Three more separate reactions are then carried out. This results in a combination of 3 reactions in the first stage of the process, and 3 reactions in the second stage, producing 9 different species of molecule. If the groups of beads are again pooled, mixed up, and split up into 3 further groups, 27 different compounds are generated.
  • the library of compounds created by the above steps is known as a 3 x 3 x 3 library.
  • Three individual (3 + 3 + 3) reactions have been carried out, and 27 (3 x 3 x 3) different compounds have been generated.
  • Other sizes of library may be created by varying the number of reaction stages, and by varying the number of groups of beads. Libraries containing many thousands of compounds, such as (50 x 50 x 50) or (20 x 20 x 20 x 20) are envisaged. 2 It is desirable to label each chemical compound of such a library. Until recently this has " been a very difficult task; typically additional sophisticated chemical processing stages have been undertaken to add a "chemical tag" to the bead. Such chemical tags have proved difficult to identify and, moreover, restrict the chemical processes which may be employed in the formation of desired compounds.
  • WO-A3-9712680 discloses methods of data storage and retrieval technology for use in molecular tracking and identification. Products for such tracking and identification are also described, along with assays, diagnostics and screening protocols that use the products.
  • UK Patent Application GB-A-2 306 484 discloses a method of labelling the beads by attaching a bar code to each bead to identify the particular reactions that the bead has undergone. A chemical compound of interest may be identified by reading the bar code attached to a bead.
  • the disadvantage of this method is that each bead must be labelled at each stage of the combinatorial process. This may be a time consuming, and therefore expensive, task.
  • Another method for forming libraries of compounds is to retain groups of beads in containers having porous walls. Chemical reagents are able to permeate the walls of the container and interact with the beads. Each container bears a unique tag, which may be used to identify the container and the reactions in which the container has taken part. Such containers are commonly known as micro-reactors. An advantage of using a micro-reactor in multiple chemical reactions is that large numbers of beads may be more conveniently processed by enclosing them in the micro-reactor.
  • MICROKANS are well known in combinatorial chemistry as a means of containing sets of beads as they pass through various stages of a combinatorial chemical process.
  • Iv ⁇ CROKANTM micro-reactors are designed to be loaded with solid phase resin beads. Chemical synthesis takes place in the micro-reactor by allowing reagents to flow through its outer mesh walls. By combining and dividing micro-reactors (rather than 3 individual solid phase resin beads) by a process known as "directed sorting", one discrete compound is synthesized in each reactor.
  • a miniature radio-frequency (RF) tag is contained within each micro-reactor.
  • the RF tag is a unique label that is used to identify the micro-reactor during sorting processes that occur between chemical synthesis steps.
  • the RF tag is encased in glass, and provides a unique ID for each micro-reactor and hence each compound. This unique ID allows each micro-reactor to be identified during the combinatorial "directed sorting" process.
  • MICROKANTM micro-reactors are expensive. This is limiting when synthesising libraries containing many thousands of compounds.
  • Another disadvantage is that the beads used within a MICROKANTM micro-reactor are not individually identified, or labelled. Hence, there is no easy way of sub-dividing a library of such beads and maintaining knowledge of the chemical compound attached to each individual bead.
  • An aim of the present invention is to provide a method of synthesizing a number of different chemical compounds which may easily be identified.
  • a method of synthesizing a plurality of products using a process including the steps of: 1) providing a plurality of articles on which the product is to be formed; 2) dividing the articles into a plurality of groups of articles and introducing each group of articles into respective micro- reactors; 3) subjecting the articles therein to a first synthesis step of the process; and 4) subjecting said articles to at least a second synthesis step of the process, characterised in that at least some of the articles are removed from at least one micro-reactor at the penultimate synthesis step and are labelled with an identifying code indicating the synthesis history which the articles in the micro-reactor have undergone.
  • the articles may be returned to the same or a different micro-reactor after they have been labelled, and the micro-reactor may be subjected to a final synthesis step of the 4 process. Alternatively, the articles may be retained so that the chemical compounds formed thereon (or attached thereto) may be analysed. The micro-reactors may then take part in a further synthesis step of the process.
  • the identifying code preferably also indicates the final synthesis step of the process to which the articles are to be subjected.
  • the process has at least 3 synthesis steps.
  • some of the articles are removed on completion of the second stage of the process.
  • These articles are then labelled with an identifying code.
  • the identifying code records the synthesis stages that the articles have undergone in stages 1 and 2, and also the synthesis steps that the articles will undergo in the final stage.
  • labelling of the articles occurs only once, that is, on completion of the second synthesis stage.
  • the process may be a combinatorial process.
  • the micro-reactors are grouped together and then divided into a plurality of groups before each synthesis step of the process, as in a conventional combinatorial process.
  • Some, or all of the articles may be marked with a code before the first step of the combinatorial process, i.e., before they have been introduced into the micro-reactor(s). These marked articles may be removed from the micro-reactor(s), and the code read, at the penultimate synthesis step. The articles may be returned to the micro-reactor(s) after this has occurred, or may be reserved for future use.
  • the micro-reactor may be a container having porous walls.
  • the container may, for example, resemble a tea bag.
  • the container may bear an identifying label, or tag.
  • the identifying code is applied to an article using a laser.
  • a "physical" tag is formed on the article. The use of such a tag does not restrict the chemical processes which may be employed in the formation of desired chemical compounds.
  • the identifying code includes an alphanumeric code.
  • the alphanumeric code enables both the chemical synthesis steps that an article has undergone while enclosed in 5 the micro-reactor, and a subsequent synthesis step, to be easily recorded. Thus the chemistry carried on the article may be identified.
  • an apparatus for labelling an article comprising a laser beam arranged to be directed onto the article so as to label the article, means for isolating an individual article, and means for directing the beam with respect to the surface of the article so as to form a label thereon.
  • the article may also be known as a bead.
  • beads labelled using this system are standard beads known in the field of combinatorial chemistry. However, non-standard beads or other solid phase supports may be used.
  • the beads may be formed from a highly cross-linked, lightly derivatised resin. This may be used for the laser marked beads, so that the label is retained throughout all the processing stages. A less cross-linked, highly derivatised resin may be used for the beads which are not labelled during the combinatorial process.
  • a product which is synthesized according to the aforedescribed method.
  • the product is preferably a chemical compound.
  • Figure 1 shows a diagrammatical cross-section through an embodiment of a micro- reactor
  • Figure 2 shows a diagrammatical representation of a first stage synthesis of a combinatorial process according to the invention.
  • Figure 3 shows a diagrammatical representation of a second stage synthesis of a combinatorial process according to the invention.
  • micro-reactor 24 comprises mesh walls which allow reagents to flow into (and from) micro- reactor 24 in order to interact with the beads 20.
  • Micro-reactor 24 contains a plurality of solid phase resin beads 20. Typically about 30 mg of resin beads 20 may be contained within micro-reactor 24.
  • Micro-reactor 24 bears a tag 22 used to identify the chemistries of the beads 20 contained therein.
  • Tag 22 may be a hand-written label, a bar code, an RF tag, or other identifying mark.
  • Each individual bead from a micro-reactor may be labelled using a laser system.
  • the label creates a record of the synthesis that the bead has undergone, and the next stage of synthesis to which the bead will be subjected.
  • the bead is then easily identifiable by reading the laser marked label.
  • the label may, for example, be an alphanumeric code, or any other identifier.
  • the library can be sub-divided in order to produce many sub-libraries. The micro-reactor is then available for re-use.
  • a typical sequence of events for labelling of the beads 20 is now described, by way of example only.
  • a 3 stage synthesis for example, a 3 x 3 x 3 library of 27 chemical compounds.
  • To form such a library on beads contained in micro-reactor 24 (or any other type of micro-reactor) would require 27 such micro-reactors and would be extremely expensive.
  • the first two stages of synthesis are carried out using 9 micro-reactors, producing a set of 3 x 3 compounds carried on the beads.
  • Stage 1 of the synthesis is illustrated by Figure 2, and stage 2 by Figure 3.
  • FIG. 2 shows reaction vessels 30, 32 and 34, each containing three micro-reactors.
  • Reaction vessel 30 contains micro-reactors 40, 41, and 42 in contact with reagent A.
  • Reaction vessel 32 contains micro-reactors 43, 44, and 45 in contact with reagent B.
  • Reaction vessel 34 contains micro-reactors 46, 47, and 48 in contact with reagent C.
  • the micro-reactors Prior to the second synthesis stage, the micro-reactors are pooled, and split up, as shown in Figure 3.
  • reaction vessel 30 contains micro-reactors 40, 43 and 46 in contact with reagent A
  • reaction vessel 32 contains micro-reactors 41, 44 and 47 in contact with 7 reagent B
  • reaction vessel 34 contains micro-reactors 42, 45 and 48 in contact with reagent C.
  • the beads contained in the micro-reactors have the chemistries shown in the Table below after two stages of synthesis.
  • a number of the beads are extracted from each of the 9 micro-reactors and labelled with a laser (not shown).
  • the laser marking indicates the processing that has been carried out in the micro-reactor, and the processing that is to be carried out in the next stage of the synthesis.
  • a bead from micro-reactor 40 may be marked 1 A 2 ⁇ 3 B .
  • This label indicates that the bead has undergone synthesis type A at the first stage, type A at the second stage (both while contained in micro- reactor 40), and is to undergo synthesis type B at the final stage - for example in a micro-reactor together with other beads such as 1 c 2 B 3 B .
  • This step is performed for all of the beads taking part in the third stage synthesis. Screening for compounds of interest attached to each bead then follows. 8 Variation may be made to the aforementioned embodiment without departing from the scope of the invention. For example, MicroTubeTM micro-reactors may be employed.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

On décrit un procédé qui permet de synthétiser une pluralité de produits à l'aide d'un processus. Le processus est un processus à étages multiples. Les produits formés par le processus sont reliés à des articles appelés billes (20). Le procédé comprend les étapes suivantes: on isole des billes individuelles (20) et on les marque avec un laser pour produire un code d'identification unique au niveau de l'avant-dernier étage du processus. Ce code permet d'enregistrer les voies de synthèse chimique suivies par chaque bille (20) et la synthèse chimique à laquelle doit être soumise chaque bille (20) à l'étage final du processus. Le produit peut ainsi être facilement identifié.
PCT/GB1999/001281 1998-04-25 1999-04-26 Procede de synthese d'une pluralite de produits WO1999055456A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002330124A CA2330124A1 (fr) 1998-04-25 1999-04-26 Procede de synthese d'une pluralite de produits
JP2000545643A JP2002512878A (ja) 1998-04-25 1999-04-26 複数の生成物を合成する方法
AU37172/99A AU746309B2 (en) 1998-04-25 1999-04-26 Method of synthesizing a plurality of products
EP99919369A EP1079919A1 (fr) 1998-04-25 1999-04-26 Procede de synthese d'une pluralite de produits
IL13908999A IL139089A0 (en) 1998-04-25 1999-04-26 Method of synthesizing a plurality of products

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9808783.6 1998-04-25
GBGB9808783.6A GB9808783D0 (en) 1998-04-25 1998-04-25 Labelling of small articles

Publications (1)

Publication Number Publication Date
WO1999055456A1 true WO1999055456A1 (fr) 1999-11-04

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ID=10830934

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/001281 WO1999055456A1 (fr) 1998-04-25 1999-04-26 Procede de synthese d'une pluralite de produits

Country Status (7)

Country Link
EP (1) EP1079919A1 (fr)
JP (1) JP2002512878A (fr)
AU (1) AU746309B2 (fr)
CA (1) CA2330124A1 (fr)
GB (1) GB9808783D0 (fr)
IL (1) IL139089A0 (fr)
WO (1) WO1999055456A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002083292A2 (fr) * 2001-04-18 2002-10-24 3 D Molecular Sciences Limited Banques chimiques fondees sur des particules codees

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631211A (en) * 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
WO1992009300A1 (fr) * 1990-11-21 1992-06-11 Iterex Pharmaceuticals Ltd. Partnership Synthese de melanges oligomeres multiples equimolaires, notamment de melanges d'oligopeptides
WO1996024061A1 (fr) * 1995-02-02 1996-08-08 Ontogen Corporation Procedes et dispositif de synthese de banques chimiques combinatoires marquees
WO1996036436A1 (fr) * 1995-04-25 1996-11-21 Irori Matrices programmables a distance et dotees de memoires, et leur utilisation
GB2306484A (en) * 1995-10-26 1997-05-07 Univ Hertfordshire Solid support particle marked with a machine-readable code for use in Combinatorial Chemistry Techniques
WO1997019958A1 (fr) * 1995-11-30 1997-06-05 Wlodek Mandecki Criblage des drogues a partir de bibliotheques chimiques combinatoires au moyen de transpondeurs
WO1998053093A1 (fr) * 1997-05-23 1998-11-26 Bioarray Solutions Llc Codage couleur et interrogation in-situ de composes chimiques couples a une matrice

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631211A (en) * 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
WO1992009300A1 (fr) * 1990-11-21 1992-06-11 Iterex Pharmaceuticals Ltd. Partnership Synthese de melanges oligomeres multiples equimolaires, notamment de melanges d'oligopeptides
WO1996024061A1 (fr) * 1995-02-02 1996-08-08 Ontogen Corporation Procedes et dispositif de synthese de banques chimiques combinatoires marquees
WO1996036436A1 (fr) * 1995-04-25 1996-11-21 Irori Matrices programmables a distance et dotees de memoires, et leur utilisation
GB2306484A (en) * 1995-10-26 1997-05-07 Univ Hertfordshire Solid support particle marked with a machine-readable code for use in Combinatorial Chemistry Techniques
WO1997019958A1 (fr) * 1995-11-30 1997-06-05 Wlodek Mandecki Criblage des drogues a partir de bibliotheques chimiques combinatoires au moyen de transpondeurs
WO1998053093A1 (fr) * 1997-05-23 1998-11-26 Bioarray Solutions Llc Codage couleur et interrogation in-situ de composes chimiques couples a une matrice

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002083292A2 (fr) * 2001-04-18 2002-10-24 3 D Molecular Sciences Limited Banques chimiques fondees sur des particules codees
WO2002083292A3 (fr) * 2001-04-18 2003-01-16 3 D Molecular Sciences Ltd Banques chimiques fondees sur des particules codees

Also Published As

Publication number Publication date
GB9808783D0 (en) 1998-06-24
JP2002512878A (ja) 2002-05-08
AU746309B2 (en) 2002-04-18
EP1079919A1 (fr) 2001-03-07
IL139089A0 (en) 2001-11-25
AU3717299A (en) 1999-11-16
CA2330124A1 (fr) 1999-11-04

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