WO2002083292A2 - Banques chimiques fondees sur des particules codees - Google Patents

Banques chimiques fondees sur des particules codees Download PDF

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Publication number
WO2002083292A2
WO2002083292A2 PCT/GB2002/001788 GB0201788W WO02083292A2 WO 2002083292 A2 WO2002083292 A2 WO 2002083292A2 GB 0201788 W GB0201788 W GB 0201788W WO 02083292 A2 WO02083292 A2 WO 02083292A2
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library
chemical
code
holder
microparticle
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PCT/GB2002/001788
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English (en)
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WO2002083292A3 (fr
Inventor
Susan Louise Watson
Amit Kumar Som
Nigel Guy Skinner
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3 D Molecular Sciences Limited
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Publication of WO2002083292A2 publication Critical patent/WO2002083292A2/fr
Publication of WO2002083292A3 publication Critical patent/WO2002083292A3/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00461—Beads and reaction vessel together
    • B01J2219/00463—Directed sorting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00468—Beads by manipulation of individual beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00502—Particles of irregular geometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547—Bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00554—Physical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Abstract

La présente invention concerne une banque chimique et un procédé de création de cette banque chimique, ladite banque comprenant une pluralité de supports. Chaque support comporte un code de distinction lisible par une machine (code du support) et chaque support supportant une multiplicité de microparticules, chaque microparticule de chaque support individuel portant un code lisible par une machine (code de microparticule) et supportant un élément chimique ou une combinaison d'éléments chimiques de la banque qui est identique à l'élément chimique ou à la combinaison d'éléments chimiques supporté(e) par chaque autre microparticule du support individuel respectif, de sorte que chaque code de microparticule correspond géographiquement à un élément chimique unique ou à une combinaison unique d'éléments chimiques de la banque et que chaque code de support correspond géographiquement à un élément chimique unique ou à une combinaison unique d'éléments chimiques de la banque.
PCT/GB2002/001788 2001-04-18 2002-04-18 Banques chimiques fondees sur des particules codees WO2002083292A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0109545A GB0109545D0 (en) 2001-04-18 2001-04-18 Chemical libraries based on coded particles
GB0109545.4 2001-04-18

Publications (2)

Publication Number Publication Date
WO2002083292A2 true WO2002083292A2 (fr) 2002-10-24
WO2002083292A3 WO2002083292A3 (fr) 2003-01-16

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PCT/GB2002/001788 WO2002083292A2 (fr) 2001-04-18 2002-04-18 Banques chimiques fondees sur des particules codees

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GB (1) GB0109545D0 (fr)
WO (1) WO2002083292A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745092B2 (en) 2005-09-13 2010-06-29 Affymetrix, Inc. Multiple step printing methods for microbarcodes
US8119408B2 (en) * 2004-03-31 2012-02-21 Kabushiki Kaisha Toshiba Encoded carrier and a method of monitoring an encoded carrier
US8178278B2 (en) 2005-09-13 2012-05-15 Affymetrix, Inc. Miniaturized microparticles
US10481158B2 (en) 2015-06-01 2019-11-19 California Institute Of Technology Compositions and methods for screening T cells with antigens for specific populations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997015390A1 (fr) * 1995-10-26 1997-05-01 University Of Hertfordshire Particles codees destinees permettant de suivre des sequences de procedes industriels lors de la preparation de banques de composes combinatoires
WO1999055456A1 (fr) * 1998-04-25 1999-11-04 Central Research Laboratories Limited Procede de synthese d'une pluralite de produits
US6136274A (en) * 1996-10-07 2000-10-24 Irori Matrices with memories in automated drug discovery and units therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997015390A1 (fr) * 1995-10-26 1997-05-01 University Of Hertfordshire Particles codees destinees permettant de suivre des sequences de procedes industriels lors de la preparation de banques de composes combinatoires
US6136274A (en) * 1996-10-07 2000-10-24 Irori Matrices with memories in automated drug discovery and units therefor
WO1999055456A1 (fr) * 1998-04-25 1999-11-04 Central Research Laboratories Limited Procede de synthese d'une pluralite de produits

Non-Patent Citations (3)

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Title
G]NTHER JUNG & ANNETTE G. BECK-SICKINGER: "MULTIPLE PEPTIDE SYNTHESIS METHODS AND THEIR APPLICATIONS" ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, VERLAG CHEMIE, vol. 31, no. 4, 1 April 1992 (1992-04-01), pages 367-383, XP000325208 WEINHEIM, DE ISSN: 0570-0833 *
JOSEPH W. GUILES ET AL.: "A Visual Tagging Process for Mix and Sort Combinatorial Chemistry" ANGEWANDTE CHEMIE. INTERNATIONAL EDITION., vol. 37, no. 7, 1998, pages 926-928, XP002220516 VERLAG CHEMIE. WEINHEIM., DE ISSN: 0570-0833 *
ROBERT W. ARMSTRONG ET AL.: "MICROCHIP ENCODED COMBINATORIAL LIBRARIES: GENERATION OF A SPATIALLY ENCODED LIBRARY FROM A POOL SYNTHESIS" CHIMIA, vol. 50, no. 6, 1 June 1996 (1996-06-01), pages 258-260, XP000617072 AARAU, CH ISSN: 0009-4293 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119408B2 (en) * 2004-03-31 2012-02-21 Kabushiki Kaisha Toshiba Encoded carrier and a method of monitoring an encoded carrier
US7745092B2 (en) 2005-09-13 2010-06-29 Affymetrix, Inc. Multiple step printing methods for microbarcodes
US7745091B2 (en) 2005-09-13 2010-06-29 Affymetrix, Inc. Miniaturized microparticles
US8088555B2 (en) 2005-09-13 2012-01-03 Affymetrix, Inc. Multiple step printing methods for microbarcodes
US8168368B2 (en) 2005-09-13 2012-05-01 Affymetrix, Inc. Miniaturized microparticles
US8178278B2 (en) 2005-09-13 2012-05-15 Affymetrix, Inc. Miniaturized microparticles
US8592136B2 (en) 2005-09-13 2013-11-26 Affymetrix, Inc. Methods for producing codes for microparticles
US8748079B2 (en) 2005-09-13 2014-06-10 Affymetrix, Inc. Multiple step printing methods for microbarcodes
US8945811B2 (en) 2005-09-13 2015-02-03 Affymetrix, Inc. Miniaturized microparticles
US10481158B2 (en) 2015-06-01 2019-11-19 California Institute Of Technology Compositions and methods for screening T cells with antigens for specific populations

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WO2002083292A3 (fr) 2003-01-16
GB0109545D0 (en) 2001-06-06

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