WO1999054954A3 - Cd4 radio-immunological pharmaceuticals for the treatment of hiv infections - Google Patents

Cd4 radio-immunological pharmaceuticals for the treatment of hiv infections Download PDF

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Publication number
WO1999054954A3
WO1999054954A3 PCT/DE1999/001177 DE9901177W WO9954954A3 WO 1999054954 A3 WO1999054954 A3 WO 1999054954A3 DE 9901177 W DE9901177 W DE 9901177W WO 9954954 A3 WO9954954 A3 WO 9954954A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
pharmaceuticals
radio
radioimmunological
eliminated
Prior art date
Application number
PCT/DE1999/001177
Other languages
German (de)
French (fr)
Other versions
WO1999054954A2 (en
Inventor
Wolfgang Bergter
Ingrid Corinna Bergter
Original Assignee
Wolfgang Bergter
Ingrid Corinna Bergter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1998126307 external-priority patent/DE19826307A1/en
Application filed by Wolfgang Bergter, Ingrid Corinna Bergter filed Critical Wolfgang Bergter
Priority to AU44971/99A priority Critical patent/AU4497199A/en
Priority to JP2000545211A priority patent/JP2002512261A/en
Priority to EP99927685A priority patent/EP1071475A2/en
Priority to DE19980721T priority patent/DE19980721D2/en
Publication of WO1999054954A2 publication Critical patent/WO1999054954A2/en
Publication of WO1999054954A3 publication Critical patent/WO1999054954A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The disadvantages of standard HIV therapies are as follows: currently used medicaments must be taken in large quantities each day during an entire lifetime according to a strict timetable and have a large number of side effects. Traditional medicaments only manage to restrict virus replication. Host cells infected with HIV are not eliminated. For this reason it was not previously possible to cure HIV infections. The current application describes, as an additional application to PCT patent application (PCT/DE99/00598) dated 8.3.99, radio-immunological pharmaceuticals consisting of a CD4 molecule or a fragment derived therefrom and a radionuclide for in-vivo elimination of HIV replicating cells in HIV-1 and HIV-2 infected patients. The combination of HIV affine CD4 receptor molecules or fragments with radionuclides for therapeutic purposes, especially for use in radioimmunological anti-HIV therapy is totally novel. The radioimmunological pharmaceuticals are to be administered intravenously to HIV-1 or HIV-2 infected patients once or in several cycles in order to cause sustained damage to HIV replicating cells in a targeted manner so that the latter can be fully eliminated.
PCT/DE1999/001177 1998-04-15 1999-04-15 Cd4 radio-immunological pharmaceuticals for the treatment of hiv infections WO1999054954A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU44971/99A AU4497199A (en) 1998-04-15 1999-04-15 Cd4 radio-immunological pharmaceuticals for the treatment of hiv infections
JP2000545211A JP2002512261A (en) 1998-04-15 1999-04-15 CD4 radioimmune drug for treating HIV infection
EP99927685A EP1071475A2 (en) 1998-04-15 1999-04-15 Cd4 radio-immunological pharmaceuticals for the treatment of hiv infections
DE19980721T DE19980721D2 (en) 1998-04-15 1999-04-15 CD4 radioimmunopharmaceuticals used to treat HIV infection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19826307.4 1998-04-15
DE1998126307 DE19826307A1 (en) 1998-03-08 1998-04-15 CD4 radio immunological pharmaceuticals

Publications (2)

Publication Number Publication Date
WO1999054954A2 WO1999054954A2 (en) 1999-10-28
WO1999054954A3 true WO1999054954A3 (en) 2000-01-20

Family

ID=7870747

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/001177 WO1999054954A2 (en) 1998-04-15 1999-04-15 Cd4 radio-immunological pharmaceuticals for the treatment of hiv infections

Country Status (5)

Country Link
EP (1) EP1071475A2 (en)
JP (1) JP2002512261A (en)
AU (1) AU4497199A (en)
DE (1) DE19980721D2 (en)
WO (1) WO1999054954A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004050A1 (en) * 1989-09-14 1991-04-04 Board Of Regents, The University Of Texas System Therapeutic compositions; methods for treatment of hiv infections
WO1991011461A1 (en) * 1990-01-26 1991-08-08 Biogen, Inc. C4 binding protein fusion proteins
WO1994004191A1 (en) * 1992-08-13 1994-03-03 Antisoma Limited Medical treatment
WO1997003198A2 (en) * 1995-07-07 1997-01-30 Texas A & M University System Nucleotide and amino acid sequence and uses thereof
WO1999045969A2 (en) * 1998-03-08 1999-09-16 Wolfgang Bergter Radioimmuno-pharmacon for treating the hiv-1 infection

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004050A1 (en) * 1989-09-14 1991-04-04 Board Of Regents, The University Of Texas System Therapeutic compositions; methods for treatment of hiv infections
WO1991011461A1 (en) * 1990-01-26 1991-08-08 Biogen, Inc. C4 binding protein fusion proteins
WO1994004191A1 (en) * 1992-08-13 1994-03-03 Antisoma Limited Medical treatment
WO1997003198A2 (en) * 1995-07-07 1997-01-30 Texas A & M University System Nucleotide and amino acid sequence and uses thereof
WO1999045969A2 (en) * 1998-03-08 1999-09-16 Wolfgang Bergter Radioimmuno-pharmacon for treating the hiv-1 infection

Also Published As

Publication number Publication date
JP2002512261A (en) 2002-04-23
AU4497199A (en) 1999-11-08
WO1999054954A2 (en) 1999-10-28
EP1071475A2 (en) 2001-01-31
DE19980721D2 (en) 2001-03-29

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