WO1999054465A3 - Gene encoding syntaxin interacting protein - Google Patents

Gene encoding syntaxin interacting protein Download PDF

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Publication number
WO1999054465A3
WO1999054465A3 PCT/US1999/008568 US9908568W WO9954465A3 WO 1999054465 A3 WO1999054465 A3 WO 1999054465A3 US 9908568 W US9908568 W US 9908568W WO 9954465 A3 WO9954465 A3 WO 9954465A3
Authority
WO
WIPO (PCT)
Prior art keywords
interacting protein
gene
novel
gene encoding
syntaxin interacting
Prior art date
Application number
PCT/US1999/008568
Other languages
French (fr)
Other versions
WO1999054465A2 (en
WO1999054465A9 (en
Inventor
Jing Min
Jeffrey Eugene Pessin
Alan Robert Saltiel
Li-Jyun Syu
Original Assignee
Warner Lambert Co
Univ Iowa Res Found
Jing Min
Jeffrey Eugene Pessin
Alan Robert Saltiel
Syu Li Jyun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, Univ Iowa Res Found, Jing Min, Jeffrey Eugene Pessin, Alan Robert Saltiel, Syu Li Jyun filed Critical Warner Lambert Co
Priority to EP99918680A priority Critical patent/EP1071771A2/en
Priority to NZ507640A priority patent/NZ507640A/en
Priority to AU36535/99A priority patent/AU769825B2/en
Priority to CA002326623A priority patent/CA2326623A1/en
Priority to KR1020007011597A priority patent/KR20010042834A/en
Priority to JP2000544797A priority patent/JP2002512031A/en
Priority to BR9909732-0A priority patent/BR9909732A/en
Publication of WO1999054465A2 publication Critical patent/WO1999054465A2/en
Publication of WO1999054465A9 publication Critical patent/WO1999054465A9/en
Publication of WO1999054465A3 publication Critical patent/WO1999054465A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to novel genes and polypeptides derived therefrom encoding a syntaxin interacting protein. The invention also describes vectors and host cells comprising the novel gene. The invention further describes methods for using the novel gene, polypeptides, and antibodies specifically targeting polypeptides derived from the novel genes, in the detection of genetic deletions of the gene, subcellular localization of the polypeptide, isolation of discrete classes of RNA, gene therapy applications, diagnostics for syndromes involving insulin resistance, development of proprietary screening strategies for inhibitors of syntaxin interacting protein.
PCT/US1999/008568 1998-04-20 1999-04-19 Gene encoding syntaxin interacting protein WO1999054465A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP99918680A EP1071771A2 (en) 1998-04-20 1999-04-19 Gene encoding syntaxin interacting protein
NZ507640A NZ507640A (en) 1998-04-20 1999-04-19 Gene encoding syntaxin interacting protein
AU36535/99A AU769825B2 (en) 1998-04-20 1999-04-19 Gene encoding syntaxin interacting protein
CA002326623A CA2326623A1 (en) 1998-04-20 1999-04-19 Gene encoding syntaxin interacting protein
KR1020007011597A KR20010042834A (en) 1998-04-20 1999-04-19 Gene Encoding Syntaxin Interacting Protein
JP2000544797A JP2002512031A (en) 1998-04-20 1999-04-19 Genes encoding syntaxin interacting proteins
BR9909732-0A BR9909732A (en) 1998-04-20 1999-04-19 Gene encoding syntaxin interaction protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8245498P 1998-04-20 1998-04-20
US60/082,454 1998-04-20

Publications (3)

Publication Number Publication Date
WO1999054465A2 WO1999054465A2 (en) 1999-10-28
WO1999054465A9 WO1999054465A9 (en) 2000-01-27
WO1999054465A3 true WO1999054465A3 (en) 2000-03-02

Family

ID=22171326

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/008568 WO1999054465A2 (en) 1998-04-20 1999-04-19 Gene encoding syntaxin interacting protein

Country Status (9)

Country Link
EP (1) EP1071771A2 (en)
JP (1) JP2002512031A (en)
KR (1) KR20010042834A (en)
AU (1) AU769825B2 (en)
BR (1) BR9909732A (en)
CA (1) CA2326623A1 (en)
NZ (2) NZ526016A (en)
WO (1) WO1999054465A2 (en)
ZA (1) ZA200005845B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503756B1 (en) 2000-09-22 2003-01-07 Isis Pharmaceuticals, Inc. Antisense modulation of syntaxin 4 interacting protein expression
CA2509494A1 (en) * 2002-12-11 2004-06-24 University Of Massachusetts Method of introducing sirna into adipocytes
FR2890859B1 (en) * 2005-09-21 2012-12-21 Oreal DOUBLE-STRANDED RNA OLIGONUCLEOTIDE INHIBITING TYROSINASE EXPRESSION

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045436A2 (en) * 1997-04-10 1998-10-15 Genetics Institute, Inc. SECRETED EXPRESSED SEQUENCE TAGS (sESTs)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045436A2 (en) * 1997-04-10 1998-10-15 Genetics Institute, Inc. SECRETED EXPRESSED SEQUENCE TAGS (sESTs)

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002124924, Database accession no. AA756269 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002124925, Database accession no. AA652491 *
MACAULAY, S.L. ET AL.: "Functional studies in 3T3L1 cells support a role for SNARE proteins in insulin stimulation of GLUT4 translocation", BIOCHEMICAL JOURNAL, vol. 324, no. 1, 15 May 1997 (1997-05-15), pages 217 - 224, XP002124923 *
MIN, J. ET AL.: "Published Erratum", MOLECULAR CELL, vol. 4, no. 1, July 1999 (1999-07-01), pages 192 *
MIN, J. ET AL.: "Synip: A Novel Insulin-Regulated Syntaxin 4-Binding Protein Mediating GLUT4 Translocation in Adipocytes", MOLECULAR CELL, vol. 3, no. 6, June 1999 (1999-06-01), pages 751 - 760, XP002124922 *

Also Published As

Publication number Publication date
NZ507640A (en) 2003-12-19
CA2326623A1 (en) 1999-10-28
WO1999054465A2 (en) 1999-10-28
JP2002512031A (en) 2002-04-23
BR9909732A (en) 2000-12-19
ZA200005845B (en) 2002-04-19
AU3653599A (en) 1999-11-08
AU769825B2 (en) 2004-02-05
KR20010042834A (en) 2001-05-25
NZ526016A (en) 2004-10-29
WO1999054465A9 (en) 2000-01-27
EP1071771A2 (en) 2001-01-31

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