WO1999052538A1 - Composition containing a herbal medicinal substance and a pharmaceutical drug - Google Patents

Composition containing a herbal medicinal substance and a pharmaceutical drug Download PDF

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Publication number
WO1999052538A1
WO1999052538A1 PCT/US1999/007747 US9907747W WO9952538A1 WO 1999052538 A1 WO1999052538 A1 WO 1999052538A1 US 9907747 W US9907747 W US 9907747W WO 9952538 A1 WO9952538 A1 WO 9952538A1
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Prior art keywords
composition
medicinal
drug
herbal
substance
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PCT/US1999/007747
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French (fr)
Inventor
Humbart D. Santillo, Jr.
Original Assignee
Santillo Humbart D Jr
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Publication date
Application filed by Santillo Humbart D Jr filed Critical Santillo Humbart D Jr
Priority to GB0024326A priority Critical patent/GB2353216A/en
Priority to AU34828/99A priority patent/AU3482899A/en
Priority to DE19983109T priority patent/DE19983109T1/en
Publication of WO1999052538A1 publication Critical patent/WO1999052538A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • the present invention relates to chemical compositions for promoting health and well-being, relieving pain, or ameliorating disease, more particularly to chemical compositions containing naturally-occurring medicinal substances, and most particularly to chemical compositions containing naturally-occurring herbal medicinal substances and pharmaceutical drugs.
  • herbal medicinal substance means a non-refined or non-purified substance derived from and containing portions or all of a plant, fungus, or micro-organism, for example, an extract, juice, residue, oil, essential oil, tincture, sap, or powder, having medicinal properties when ingested by or otherwise administered to an animal, for example, a human being.
  • Medicinal means tending or used to cure disease, promote well-being, and/or relieve pain.
  • “Pharmaceutical drug” means any substantially pure single chemical compound or mixture of compounds having medicinal properties, especially such compounds as are generally available through pharmacies, and more especially such compounds as are available only through doctors' prescriptions.
  • a pharmaceutical drug may itself be derived as a substantially pure chemical compound from an herbal, fungal, animal, or micro-organism source; in such cases, the drug generally has far greater medicinal potency per unit weight than does the parent source.
  • a pharmaceutical drug may also be a synthetic version of a naturally-occurring drug; it also may be a chemical compound which mimics the medicinal action of a naturally-occurring drug; and it also may be a chemical compound, either naturally— occurring or synthetic, having its own medicinal properties which may be unrelated to those of any known herbal medicinal substance.
  • Disease means any biological dysfunction having a pathogenic, nutritional, hormonal, metabolic, or idiopathic cause.
  • Major means greater in amount by weight or volume; “minor” means lesser in amount by weight or volume.
  • a drug may have one cr more significant adverse side effects, which may limit the dosage sustainable by any given patient or may make the drug unusable with that patient; or a drug may be unpalatable, which may make oral delivery impractical; or a drug in pure form, particularly a drug derived from an herbal medicinal, may lack cofactors present in the parent medicinal which can potentiate the medicinal action of the drug.
  • Herbal medicinal substances may typically contain, in addition to identifiable drug moieties, many other chemical entities known to enhance health and, in some cases, potentiate the effect of the natural drug.
  • beneficial chemical entities are phytochemicals such as isothiocyanates found in cabbage which can inhibit growth of lung tumors; garlic extracts which can reduce the incidence of colon tumors; curcumin from turmeric which can reduce the frequency of tumors in tumor- prone animals, relieve arthritis and rheumatism, and lower serum cholesterol; ginegerol from the ginger plant which can reduce arthritis inflammation while relieving stomach ulcers; antioxidant ⁇ such as epigallochatechin gallate from green tea leaves which can prevent the growth and spead of some tumor cells, and lycopenes from tomatoes which can provide protection 114912 3 against lung and prostate tumors; carotenoids such as lutein and zeaxanthin which are antioxidants from crucifers such as spinach and kale which can prevent onset of macular degeneration; enzymes such as glut ⁇ thione peroxidase; mineral elements such as
  • Gin ⁇ er Derived from the fleshy rhizome of ZingiJer offi cinal e , ginger i ⁇ a known anti -nausea remedy. Because it appears to act on the digestive system rather that the brain, ginger does net produce ⁇ ome of the side effects, such as drowsiness, caused by anti-nausea pharmaceutical drugs such a ⁇ dramamine .
  • Garlic Derived from the bulb of Allium sativum, garlic i ⁇ known to have an antibiotic effect similar to that of the drugs penicillin and streptomycin.
  • Gink ⁇ o extract Derived from the leaves of the Ginkgo biloba tree, ginkgo extract is known to enhance brain function by enhancing utilization of oxygen and glucose, stabilizing cell membranes, acting a ⁇ an antioxidant, inhibiting lipid percxidation, enhancing membrane transport of potassium into cells, normalizing circulation in the hippocampus, increasing nerve transmi ⁇ ion rate and improving turnover of neurctran ⁇ mitt ⁇ r ⁇ ⁇ uch a ⁇ acetylcholine, and inhibiting platelet 114212 aggregation.
  • Echincacea Derived from plant parts of various Echinacea species, for example, Echinacea ang ⁇ tifolia , echinacea is known for its effect on arthritis and other inflammatory diseases and for strengthening the immune system against infection by viruses.
  • St. John's Wort Derived from Hyperi cum perfora tion, St. John's wort is known for its effect on mental depression and feelings of well-being.
  • Licorice Derived from the root of the licorice plant, Glycyrrhiza glabra , licorice contains glycyrrhizin which i ⁇ converted in the gut to glycyrretinic acid and is known to have many pharmacological actions, including estrogenic, antiinflammatory (cortisol-like) , antiallergenic, antibacterial, antiviral, anti-Trichomonas, antihepatotoxic, anticonvulsive, choleretic, anticancer, expectorant, and antitussive.
  • a substance may contain a relatively low concentration of a naturally-occurring drug, limiting the amount of the drug available to a patient in a practical dose of the substance; or, the naturally-occurring drug in the herbal substance may be less powerful than a similar synthetic drug; or the herbal substance may be less specific in its action than a comparable pharmaceutical drug.
  • a chemical composition in accordance with the invention for promoting health and well-being, relieving pain, or ameliorating disease includes a first ingredient comprising any of various forms of non-refined or non-purified preparations known commonly as herbs, dried herbs, herbal extracts, herbais, and the like, and a second ingredient comprising one or more pharmaceutical drug compounds or mixtures of compounds.
  • Compositions in accordance with the invention may be administered to animals, and especially to human beings, by any known medical means, including but not limited to ingestion, injection, topical application, inhalation, rectal or vaginal insertion, and smoking.
  • compositions wherein the drug component is present i n a major amount are within the scope of the invention.
  • a composition in accordance with the invention may be presented for consumption by a user in any convenient form, for example, as a pill, tablet, capsule, powder, liquid, or suspension.
  • the components of the composition need not necessarily be mixed before being administered to a user, but may be administered separately within the scope of the invention, for example, in succession a few seconds or minutes apart, to form the novel chemical combination within the body of the user and to provide thereby the novel benefits afforded by the combination.
  • Example 1 An adult human exhibiting symptoms of mental depression is treated with a chemical composition comprising 20 mg of the pharmaceutical drug ProzacTM and between 300 and 1000 ro of Hypericum perforatum (St. John's wort) prepared by drying and powdering the entire plant.
  • the composition is provided orally in capsule form on a once-a-day basis.
  • the amount of Prozac is less than might be prescribed for treatment by the drug alone.
  • symptoms are diminished to an extent equivalent to that which might be expected for a higher dosage of ProzacTM alone.
  • Example 2 An adult human exhibiting symptoms of asthma is treated with a chemical composition comprising 50 mg of forskohlin, derived by drying and powdering leaves and stems of
  • composition 114912 CoJeus forsJohJii, and 4 mg of the pharmaceutical drug albuterol.
  • the composition is provided in capsule form orally on a once-a- day basis.
  • symptoms are diminished to a degree greater than might be expected from either forskohlin or albuterol administered independently.
  • Forskohlin and albuterol can act synergistically to reduce asthma symptoms because forskohlin is known to lower blood pressure, improve heart function, relax smooth muscles surrounding bronchial passageways, and inhibit release of histamines, and albuterol is known also to relax smooth muscles which improves air flow through bronchial passageways .
  • Example 3 An adult human exhibiting symptoms of breakdown of mental function (dementia and/or Alzheimer's disease) is treated with a chemical composition comprising 140 mg of extract from the leaves of Ginkgo bil oba and 2 mg of the pharmaceutical drug hydergine .
  • the composition is provided in pill form orally on a thrice-daily basis, one-third of the dose being administered each time.
  • mental function is restored to an extent equivalent to that which might be expected for a higher dosage of hydergine alone.
  • Ginkgo biloba extract and hydergine provides to the patient the known broad • therapeutic benefit of Ginkgo biloba and a lower dosage of hydergine than would be required to achieve the same relief by administration of hydergine alone.
  • Example An adult human exhibiting symptoms of arthritis or other joint inflammatory disease is treated with a chemical composition comprising 600 mg of Echinacea angustifolia , derived by drying and powdering of the leaves, 100 mg of the pharmaceutical drug cortisone, 1000 mg of the mineral supplement calcium gluconate, and 200 mg of the mineral supplement magnesium oxide.
  • the composition is provided in capsule form orally on a once-a-day basis. Within a few days, symptoms are diminished to 114912 an extent equivalent to that which might be expected for a higher dosage of cortisone alone.
  • Example 5 Four hours before beginning a sea voyage, an adult human known to be susceptible to motion sickness is treated with a chemical composition comprising 600 mg of dried, powdered rhizomes of Zingiber officinal e and 50 mg of the pharmaceutical drug dramamine.
  • the composition continues to be provided in pill form orally on a once-a-day basis during the entire voyage. Symptoms of motion sickness are prevented or diminished to an extent equivalent to that which might be expected for a higher dosage (about 100 mg) of dramamine alone. Side effects attributable to dramamine, such a ⁇ drowsiness, are substantially reduced because of the lowered dosage of the drug.
  • Example 6 An adult human exhibiting symptoms of bacterial infection is treated with a chemical composition comprising 225 mg of aged powdered garlic derived from bulbs of Alli um sativum and 100,000 units of the pharmaceutical drug Penicillin G.
  • the composition i ⁇ provided in capsule form orally on a twice-daily basis.
  • symptoms are diminished to an extent equivalent to that which might be expected for a higher dosage of Penicillin G alone.
  • the patient experiences a reduction in the known side effects of penicillin as a result of the lower dosage of the drug afforded by its combination with garlic, and also undergoes a known antibiotic benefit of garlic in combatting 114912 9 infection by ether bacteria which may have become resistant to penicillin and similar antibiotics.
  • Example ⁇ An adult human experiencing inflammation of tissue or joints i ⁇ treated with a daily oral dose of 100 mg of corticosteroi ⁇ alone and begins to exhibit symptoms characteristic of hepatic cholesterol synthesis, thymus atrophy, and adrenal atrophy.
  • the patient is then treated with a chemical composition comprising 100 mg of the pharmaceutical corticosteroic and 400 mg of dried, powdered root of Glycyrrhiza glabra .
  • the cemposition is provided in capsule form orally on a once-a-day basis. After a period of several days, adverse symptoms are diminished. In addition, the patient experiences enhanced inhibition of antibody formation, stress reaction, and inflammation.
  • Example S An adult human exhibiting symptoms of mental depression is treated with a chemical composition comprising 20 mg of the pharmaceutical drug ProzacTM and between 300 and 1000 ra 9 of Hyperi cum perfora tum (St. John's wort) prepared by drying and powdering the leafy portion of the plant.
  • the composition is provided orally in capsule form on a once-a-day basis.
  • the amount of ProzacTM is less than might be prescribed for treatment by the drug alone. After a period of between several days and several weeks, symptoms are diminished to an extent equivalent to that which might be expected for a higher dosage of ProzacTM alone.
  • a ccroination may be provided for consumption by a ser in a form including but not limited to a pill, tablet, capsule, powder, liquid, or suspension, and further, that the combinations may be administered to a user by oral, injection, topical, rectal or vaginal insertion, or inhalation means.

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Abstract

A chemical composition for promoting health and well-being, relieving pain, or ameliorating disease including a first ingredient comprising a herbal medicinal substance and a second ingredient comprising one or more pharmaceutical drug coumpounds or mixtures of such compounds. A herbal medicinal substance may include any of various forms of non-refined or non-purified preparations known commonly as herbs, dried herbs, herbal extracts, and the like, and may be derived from whole plants, portions of plants, fungi, and micro-organisms. A pharmaceutical drug may be derived as a substantially purified chemical compound from a herbal, fungal, animal, or micro-organism source, or it may be a synthetic version of a naturally-occurring drug, or it may be a chemical compound which mimics the medicinal action of a naturally-occurring drug, or it may be a chemical compound, either naturally-occurring or synthetic, having its own medicinal properties which may be unrelated to those of any known herbal medicinal substance. Compositions in accordance with the invention may be administered to animals, and especially to human beings, by any known medical means, including but not limited to ingestion, injection, topical application, inhalation, suppository rectal or vaginal insertion, and smoking.

Description

1
COMPOSITION CONTAINING AN HERBAL MEDICINAL SUBSTANCE AND A
PHARMACEUTICAL DRUG
Description
The present invention relates to chemical compositions for promoting health and well-being, relieving pain, or ameliorating disease, more particularly to chemical compositions containing naturally-occurring medicinal substances, and most particularly to chemical compositions containing naturally-occurring herbal medicinal substances and pharmaceutical drugs.
As used herein, "herbal medicinal substance" means a non-refined or non-purified substance derived from and containing portions or all of a plant, fungus, or micro-organism, for example, an extract, juice, residue, oil, essential oil, tincture, sap, or powder, having medicinal properties when ingested by or otherwise administered to an animal, for example, a human being. "Medicinal" means tending or used to cure disease, promote well-being, and/or relieve pain. "Pharmaceutical drug" means any substantially pure single chemical compound or mixture of compounds having medicinal properties, especially such compounds as are generally available through pharmacies, and more especially such compounds as are available only through doctors' prescriptions. A pharmaceutical drug may itself be derived as a substantially pure chemical compound from an herbal, fungal, animal, or micro-organism source; in such cases, the drug generally has far greater medicinal potency per unit weight than does the parent source. A pharmaceutical drug may also be a synthetic version of a naturally-occurring drug; it also may be a chemical compound which mimics the medicinal action of a naturally-occurring drug; and it also may be a chemical compound, either naturally— occurring or synthetic, having its own medicinal properties which may be unrelated to those of any known herbal medicinal substance. "Disease" means any biological dysfunction having a pathogenic, nutritional, hormonal, metabolic, or idiopathic cause. "Major" means greater in amount by weight or volume; "minor" means lesser in amount by weight or volume.
The use of pharmaceutical drugs for promoting physical and mental health and well-being, curing disease, and relieving pain is well known and is the basis for a very large, world-wide pharmaceutical drug industry. However, the administration of drugs can be subject to several problems. For example, a drug may have one cr more significant adverse side effects, which may limit the dosage sustainable by any given patient or may make the drug unusable with that patient; or a drug may be unpalatable, which may make oral delivery impractical; or a drug in pure form, particularly a drug derived from an herbal medicinal, may lack cofactors present in the parent medicinal which can potentiate the medicinal action of the drug.
The use of herbal medicinal substances to relieve a wide variety of physical and mental conditions is also well known. See, for example, "The Healing Power of Herbs," by Michael Murray, N.D., Prima Publishing Co., 1995; "Miracle Cures," by Jean Carper, HarperCollins Publishers, Inc., 1997; and "Natural Healing With Herbs," by Humbart Santillo, N.D., Hohm Press, 1984.
Herbal medicinal substances may typically contain, in addition to identifiable drug moieties, many other chemical entities known to enhance health and, in some cases, potentiate the effect of the natural drug. Some examples of such beneficial chemical entities are phytochemicals such as isothiocyanates found in cabbage which can inhibit growth of lung tumors; garlic extracts which can reduce the incidence of colon tumors; curcumin from turmeric which can reduce the frequency of tumors in tumor- prone animals, relieve arthritis and rheumatism, and lower serum cholesterol; ginegerol from the ginger plant which can reduce arthritis inflammation while relieving stomach ulcers; antioxidantε such as epigallochatechin gallate from green tea leaves which can prevent the growth and spead of some tumor cells, and lycopenes from tomatoes which can provide protection 114912 3 against lung and prostate tumors; carotenoids such as lutein and zeaxanthin which are antioxidants from crucifers such as spinach and kale which can prevent onset of macular degeneration; enzymes such as glutάthione peroxidase; mineral elements such as selenium and zinc; phytoestrogen hormone precursors such as iεoflavonoidε from soybeans and lignans from seeds and grains; and flavonoidε such as guercetin which can relieve many common allergies.
It is widely believed in naturopathic medicine that the broad salutory effects of herbal εubεtances are directly related to the presence and interactions of such ancillary chemical entities which, of course, are lacking in pharmaceutical drugs. Further, it iε a principle of naturopathic medicine that herbal substances act to promote health and well-being by correcting the cauεe of diεeaεe or dyεfucnction, whereas pharmaceutical drugs treat the effects.
Examples of some herbal medicinal substances which lend themselves readily for use in accordance with the invention are:
1. Ginσer: Derived from the fleshy rhizome of ZingiJer offi cinal e , ginger iε a known anti -nausea remedy. Because it appears to act on the digestive system rather that the brain, ginger does net produce εome of the side effects, such as drowsiness, caused by anti-nausea pharmaceutical drugs such aε dramamine .
2. Garlic: Derived from the bulb of Allium sativum, garlic iε known to have an antibiotic effect similar to that of the drugs penicillin and streptomycin.
Ξ. Ginkσo extract: Derived from the leaves of the Ginkgo biloba tree, ginkgo extract is known to enhance brain function by enhancing utilization of oxygen and glucose, stabilizing cell membranes, acting aε an antioxidant, inhibiting lipid percxidation, enhancing membrane transport of potassium into cells, normalizing circulation in the hippocampus, increasing nerve transmiεεion rate and improving turnover of neurctranεmittεrε εuch aε acetylcholine, and inhibiting platelet 114212 aggregation.
4. Echincacea: Derived from plant parts of various Echinacea species, for example, Echinacea angυεtifolia , echinacea is known for its effect on arthritis and other inflammatory diseases and for strengthening the immune system against infection by viruses.
5. St. John's Wort: Derived from Hyperi cum perfora tion, St. John's wort is known for its effect on mental depression and feelings of well-being.
6. Licorice: Derived from the root of the licorice plant, Glycyrrhiza glabra , licorice contains glycyrrhizin which iε converted in the gut to glycyrretinic acid and is known to have many pharmacological actions, including estrogenic, antiinflammatory (cortisol-like) , antiallergenic, antibacterial, antiviral, anti-Trichomonas, antihepatotoxic, anticonvulsive, choleretic, anticancer, expectorant, and antitussive.
Other herbal medicinal substances suitable for use in accordance with the invention will undoubtedly occur to those skilled in the art; therefore, the above-discussed substances should be considered as only illustrative and in no way limiting.
The administration of herbal medicinal substances can be subject to problems. For example, a substance may contain a relatively low concentration of a naturally-occurring drug, limiting the amount of the drug available to a patient in a practical dose of the substance; or, the naturally-occurring drug in the herbal substance may be less powerful than a similar synthetic drug; or the herbal substance may be less specific in its action than a comparable pharmaceutical drug.
It is a principal object of the invention to provide a chemical composition containing an herbal medicinal substance and a pharmaceutical drug wherein the medicinal effect of the composition is superior to that of either of the components alone.
It is a further obj ect of the invention to provide a chemical composition containing an herbal medicinal substance and
114912 5 a pharmaceutical drug wherein known side effects of the drug when taken alone are reduced.
It is a still further object of the invention to provide a chemical composition containing and herbal medicinal substance and a pharmaceutical drug wherein the medicinal action of the combination iε equivalent to that of a more potent drug taken alone .
It is a still further object of the invention to provide a chemical composition containing an herbal medicinal substance and a pharmaceutical drug wherein the medicinal effect of the herbal medicinal substance iε potentiated by the pharmaceutical drug.
It is a still further object of the invention to provide a method for modifying medical treatment wherein a chemical composition ccr.taining an herbal medicinal substance and a pharmaceutical drug is substituted for the drug alone and wherein successive chemical compositions having progressively lower percentages of the drug are administered sequentially over the course of treatment to reduce or eliminate the amount of the drug required for treatment.
Briefly described, a chemical composition in accordance with the invention for promoting health and well-being, relieving pain, or ameliorating disease includes a first ingredient comprising any of various forms of non-refined or non-purified preparations known commonly as herbs, dried herbs, herbal extracts, herbais, and the like, and a second ingredient comprising one or more pharmaceutical drug compounds or mixtures of compounds. Compositions in accordance with the invention may be administered to animals, and especially to human beings, by any known medical means, including but not limited to ingestion, injection, topical application, inhalation, rectal or vaginal insertion, and smoking. Generally, the herbal component of such compositions is present in a major amount by weight or by volume, although compositions wherein the drug component is present in a major amount are within the scope of the invention. 114912 A composition in accordance with the invention may be presented for consumption by a user in any convenient form, for example, as a pill, tablet, capsule, powder, liquid, or suspension. Further, the components of the composition need not necessarily be mixed before being administered to a user, but may be administered separately within the scope of the invention, for example, in succession a few seconds or minutes apart, to form the novel chemical combination within the body of the user and to provide thereby the novel benefits afforded by the combination.
The foregoing and other objects, features, and advantages of the invention, as well as presently preferred embodiments thereof, will become more apparent from a reading of the following detailed description wherein representative chemical compositions in accordance with the invention are disclosed in detail in representative Examples.
Example 1 : An adult human exhibiting symptoms of mental depression is treated with a chemical composition comprising 20 mg of the pharmaceutical drug Prozac™ and between 300 and 1000 ro of Hypericum perforatum (St. John's wort) prepared by drying and powdering the entire plant. The composition is provided orally in capsule form on a once-a-day basis. The amount of Prozac" is less than might be prescribed for treatment by the drug alone. After a period of between several days and several weeks, symptoms are diminished to an extent equivalent to that which might be expected for a higher dosage of Prozac™ alone. The patient experiences a reduction in the known side effects of Prozac™ as a result of the lower dosage of. the drug afforded by its combination with Hypericum.
Example 2: An adult human exhibiting symptoms of asthma is treated with a chemical composition comprising 50 mg of forskohlin, derived by drying and powdering leaves and stems of
114912 CoJeus forsJohJii, and 4 mg of the pharmaceutical drug albuterol. The composition is provided in capsule form orally on a once-a- day basis. Within a few days, symptoms are diminished to a degree greater than might be expected from either forskohlin or albuterol administered independently. Forskohlin and albuterol can act synergistically to reduce asthma symptoms because forskohlin is known to lower blood pressure, improve heart function, relax smooth muscles surrounding bronchial passageways, and inhibit release of histamines, and albuterol is known also to relax smooth muscles which improves air flow through bronchial passageways .
Example 3: An adult human exhibiting symptoms of breakdown of mental function (dementia and/or Alzheimer's disease) is treated with a chemical composition comprising 140 mg of extract from the leaves of Ginkgo bil oba and 2 mg of the pharmaceutical drug hydergine . The composition is provided in pill form orally on a thrice-daily basis, one-third of the dose being administered each time. Within a few weeks, mental function is restored to an extent equivalent to that which might be expected for a higher dosage of hydergine alone. The combination of Ginkgo biloba extract and hydergine provides to the patient the known broad • therapeutic benefit of Ginkgo biloba and a lower dosage of hydergine than would be required to achieve the same relief by administration of hydergine alone.
Example : An adult human exhibiting symptoms of arthritis or other joint inflammatory disease is treated with a chemical composition comprising 600 mg of Echinacea angustifolia , derived by drying and powdering of the leaves, 100 mg of the pharmaceutical drug cortisone, 1000 mg of the mineral supplement calcium gluconate, and 200 mg of the mineral supplement magnesium oxide. The composition is provided in capsule form orally on a once-a-day basis. Within a few days, symptoms are diminished to 114912 an extent equivalent to that which might be expected for a higher dosage of cortisone alone. The patient experiences a reduction in the known side effects of cortisone as a result of the lower dosage of the drug afforded by its combination with Echinacea ; also undergoes a known strengthening of the immune system for resisting infection by viruses, which strengthening would not occur absent Echinacea ; and also undergoes a strengthening of bones and neutralization of tissue acidity, which strengthening would not occur absent the mineral supplements calcium and/or magnesium.
Example 5: Four hours before beginning a sea voyage, an adult human known to be susceptible to motion sickness is treated with a chemical composition comprising 600 mg of dried, powdered rhizomes of Zingiber officinal e and 50 mg of the pharmaceutical drug dramamine. The composition continues to be provided in pill form orally on a once-a-day basis during the entire voyage. Symptoms of motion sickness are prevented or diminished to an extent equivalent to that which might be expected for a higher dosage (about 100 mg) of dramamine alone. Side effects attributable to dramamine, such aε drowsiness, are substantially reduced because of the lowered dosage of the drug.
Example 6: An adult human exhibiting symptoms of bacterial infection is treated with a chemical composition comprising 225 mg of aged powdered garlic derived from bulbs of Alli um sativum and 100,000 units of the pharmaceutical drug Penicillin G. The composition iε provided in capsule form orally on a twice-daily basis. Within a short time, symptoms are diminished to an extent equivalent to that which might be expected for a higher dosage of Penicillin G alone. The patient experiences a reduction in the known side effects of penicillin as a result of the lower dosage of the drug afforded by its combination with garlic, and also undergoes a known antibiotic benefit of garlic in combatting 114912 9 infection by ether bacteria which may have become resistant to penicillin and similar antibiotics.
Example ~ : An adult human experiencing inflammation of tissue or joints iε treated with a daily oral dose of 100 mg of corticosteroiα alone and begins to exhibit symptoms characteristic of hepatic cholesterol synthesis, thymus atrophy, and adrenal atrophy. The patient is then treated with a chemical composition comprising 100 mg of the pharmaceutical corticosteroic and 400 mg of dried, powdered root of Glycyrrhiza glabra . The cemposition is provided in capsule form orally on a once-a-day basis. After a period of several days, adverse symptoms are diminished. In addition, the patient experiences enhanced inhibition of antibody formation, stress reaction, and inflammation.
Example S: : An adult human exhibiting symptoms of mental depression is treated with a chemical composition comprising 20 mg of the pharmaceutical drug Prozac™ and between 300 and 1000 ra9 of Hyperi cum perfora tum (St. John's wort) prepared by drying and powdering the leafy portion of the plant. The composition is provided orally in capsule form on a once-a-day basis. The amount of Prozac™ is less than might be prescribed for treatment by the drug alone. After a period of between several days and several weeks, symptoms are diminished to an extent equivalent to that which might be expected for a higher dosage of Prozac™ alone. The patient experiences a reduction in the known side effects of Prozac™ as a result of the lower dosage of the drug afforded by its combination with Hypericum.
It should be understood that although the chemical combinations m the specific foregoing examples are provided in powder form in a pill or capsule for ingestion, in other 10 applications of chemical combinations within the scope of the invention, a ccroination may be provided for consumption by a ser in a form including but not limited to a pill, tablet, capsule, powder, liquid, or suspension, and further, that the combinations may be administered to a user by oral, injection, topical, rectal or vaginal insertion, or inhalation means.
From th fcregoing description it will be apparent that there have bι;er. provided improved chemical compositions for promoting health and well-being, relieving pain, or ameliorating disease, wherein an herbal medicinal substance and a pharmaceutical drug are combined to provide a medicinal response superior to that obtainable with either component alone and/or a response ha ing fewer side effects than would be experienced in using the pharmaceutical drug alone. Variations and modification:-, cf the herein described chemical compositions, in accordance with the invention, will undoubtedly suggest themselves t those skilled in this art. Accordingly, the foregoing de cription should be taken aε illustrative and not in a limiting sonεe.

Claims

U What is claimed is:
1. A cc poεition for promoting health and/or well-being in animals, including human beings, comprising: a) an herbal medicinal substance; and b) a pharmaceutical drug, said composition being characterized by having an overall medicinal effect on a user which is superior to the medicinal effect afford by either of said components a) or b) when administered alone.
2. A composition in accordance with Claim 1 wherein said herbal medicinal substance is in a form selected from the group consisting of an extract, residue, oil, essential oil, tincture, sap, and powder.
3. A composition in accordance with Claim 1 wherein said pharmaceutical drug is selected from the group consisting of naturally-occurring and synthetic.
4. A composition in accordance with Claim 1 wherein said composition is a physical mixture of components a) and b) .
5. A composition in accordance with Claim 1 wherein =aιd herbal medicinal substance is present in a major amount and said pharmaceutical drug is present in a minor amount.
6. A composition in accordance with Claim 1 wherein said herbal medicinal substance is present in a minor amount and said pharmaceutical drug is present in a major amount.
1. A composition in accordance with Claim 1 wherein •said composition is presented for consumption by a user in a form selected from the group consisting of pill, tablet, capsule, 114912 12 powder, liquid, and suspension.
8. A composition in accordance with Claim 1 wherein said composition is admmistrable to a user by means selected from the group consisting of orally, injectably, topically, rectally, vagmally, and by inhalation.
9. A composition in accordance with Claim 1 further comprising a mineral substance.
10. A composition for promoting health and well-being in animals, lnc-aαing human beings, comprising: a) a first amount of an herbal medicinal substance; and b) a seconc amount of a pharmaceutical drug; wherein the amount of at least one of said components a) and b) is an effective amount such that the promotive action of said composition on a user is superior to the promotive action of either of components a) or b) when taken alone or separately m the same respective amounts.
11. A composition for relieving pain, ameliorating a diseased condition, or improving the health and well-being of animals, including human beings, comprising: a) a first amount of an herbal medicinal substance; and b) a seconc amount of a pharmaceutical drug; wherein the amount of at least one of said components a) and b) is an effective amount such that the medicinal action of said composition on a user is superior to the medicinal action of either of components a) or b) when taken alone in the same respective amounts.
12. A method for improving the health and well-being of an animal, including a human being, in an impaired state of health, comprising the steps of: 13 a) selecting an herbal medicinal substance having known medicinal properties for improving said impaired state of health; b) selecting a pharmaceutical drug having known medicinal properties for improving said impaired state of health; and c) combining said effective amounts to provide a chemical combination; and d) administering said chemical combination to an animal to improve the state cf health of said animal.
14
AMENDED CLAIMS
[received by the International Bureau on 01 July 1999 (01.07.99); original claims 1 and 10-12 amended; new claims 13-17 added; remaining claims unchanged (4 pages)]
I (amended) . A composition for promoting health and/or well-being in animals, including human beings, comprising: a) an herbal substance having known medicinal properties; and b) a pharmaceutical drug having substantially the same medicinal properties as said herbal substance, said composition having an overall medicinal effect on a user which is superior to the medicinal effect afforded by either of said components a) or b) when administered alone.
10 (amended) . A composition for promoting health and well-being in animals, including human beings, comprising: a) a first amount of an herbal substance having known medicinal properties; and b) a second amount of a pharmaceutical drug having substantially the same known medicinal properties as said herbal substance; wherein the amount of at least one of said components a) and b) is an effective amount such that the promotive action of said composition on a user is superior to the promotive action of either of components a) or b) when taken alone or separately in the same respective amounts.
15
11 (amended) . A composition for relieving pain, ameliorating a diseased condition, or improving tne health and well-being of animals, including human beings, comprising: a) a first amount of an herbal substance having known ledicinal properties; and b) a second amount of a pharmaceutical drug laving substantially the same known medicinal properties as said herbal substance; wherein tne amount of at least one of said components a) and b) _s an effective amount such that the medicinal action of said composition on a user is superior to the medicma± action of either of components a) or b) when taken alone m the same respective amounts.
12 (amended) . A method for improving the healtn and well-being of an animal, including a human being, m an impaired state of health, comprising the steps of: a) selecting an herbal medicinal substance navmg known -nedicinal properties for improving said impaired state of health;
D) selecting a pharmaceutical drug having suDStantially the same <no n medicinal properties for improving said impaired state of health; and c) combining effective amounts of said herbal substance and said pnarmaceutical drug to provide a chemical combination; and 16
d) administering said chemical combination to an animal to improve the state of health of said animal.
13. A composition in accordance with Claim 1 wherein said herbal substance comprises at least one phytochem cal .
14. A composition in accordance with Claim 13 wherein said phytochemical is selected from the group consisting of isoth ocyanates, garlic extracts, curcumm, gmegerol, antioxidants, carotenoids, plant enzymes, phytoestrogen hormone precursors, flavonoids, and any combinations thereof.
15. A composition in accordance with Claim 13 wherein said phytochemical is known to be beneficial to health and wherein said overall medicinal effect of said composition includes an improvement in health and increased resistance to disease .
16. A composition in accordance with Claim 1 wherein said pharmaceutical drug is known to produce side effects in some patients and wherein said overall medicinal effect of said composition includes reduction m occurrence or intensity of said side effects.
17
17. A method for modifying the medical treatment of a
patient being treated with a pharmaceutical drug to reduce the dosage of the drug being administered, comprising the steps of: a) substituting for said drug a first composition including an herbal substance having a medicinal effect substantially the same as the medicinal effect of said drug and said drug in a first substance-tc-drug ratio wherein the actual dosage of said drug is reduced; and b) sequentially substituting further compositions including said herbal substance and said drug, said sequential compositions having progressively lower percentages of said drug, until a desired treatment level of said drug is reached.
PCT/US1999/007747 1998-04-09 1999-04-08 Composition containing a herbal medicinal substance and a pharmaceutical drug WO1999052538A1 (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001078649A2 (en) * 2000-04-17 2001-10-25 Alexandr Andreevich Zarubin Pharmaceutical curative compound
DE10029770A1 (en) * 2000-06-16 2001-12-20 Transmit Technologietransfer Treatment of solid tumors, especially brain tumors, using curcumin or derivative to inhibit peritumoral edema and tumor growth and kill the tumor cells

Citations (1)

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US4521411A (en) * 1983-11-04 1985-06-04 Theodora Koloff Analgesic composition

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Publication number Priority date Publication date Assignee Title
US4521411A (en) * 1983-11-04 1985-06-04 Theodora Koloff Analgesic composition

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Title
BALCH J F, ET AL.: "PRESCRIPTION FOR NUTRITIONAL HEALING, 2ND EDITION", PRESCIPTION FOR NUTRITIONAL HEALING, AVERY PUBLISHING, NEW YORK,, US, 1 January 1997 (1997-01-01), US, pages 171 - 174 + 472, XP002921342 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001078649A2 (en) * 2000-04-17 2001-10-25 Alexandr Andreevich Zarubin Pharmaceutical curative compound
WO2001078649A3 (en) * 2000-04-17 2002-03-07 Alexandr Andreevich Zarubin Pharmaceutical curative compound
DE10029770A1 (en) * 2000-06-16 2001-12-20 Transmit Technologietransfer Treatment of solid tumors, especially brain tumors, using curcumin or derivative to inhibit peritumoral edema and tumor growth and kill the tumor cells

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GB2353216A (en) 2001-02-21
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GB0024326D0 (en) 2000-11-15

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