WO1999051636A3 - Gaba b receptor - Google Patents

Gaba b receptor Download PDF

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Publication number
WO1999051636A3
WO1999051636A3 PCT/US1999/007352 US9907352W WO9951636A3 WO 1999051636 A3 WO1999051636 A3 WO 1999051636A3 US 9907352 W US9907352 W US 9907352W WO 9951636 A3 WO9951636 A3 WO 9951636A3
Authority
WO
WIPO (PCT)
Prior art keywords
gababr2
gaba
receptor
seq
figures
Prior art date
Application number
PCT/US1999/007352
Other languages
French (fr)
Other versions
WO1999051636A2 (en
WO1999051636A9 (en
Inventor
James E Garrett
Rachel T Simin
James G Busby
Thomas M Stormann
Original Assignee
Nps Pharma Inc
James E Garrett
Rachel T Simin
James G Busby
Thomas M Stormann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nps Pharma Inc, James E Garrett, Rachel T Simin, James G Busby, Thomas M Stormann filed Critical Nps Pharma Inc
Priority to AU34685/99A priority Critical patent/AU3468599A/en
Publication of WO1999051636A2 publication Critical patent/WO1999051636A2/en
Publication of WO1999051636A3 publication Critical patent/WO1999051636A3/en
Publication of WO1999051636A9 publication Critical patent/WO1999051636A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention features a novel GABAB receptor subtype ('GABABR2'). The cDNA sequence encoding GABABR2 is shown in Figures (1a-1n) as SEQ. ID. NO: 1. The GABABR2 amino acid sequence is provided in Figures (2a-2f) as SEQ. ID NO: 4.
PCT/US1999/007352 1998-04-03 1999-04-02 Gaba b receptor WO1999051636A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU34685/99A AU3468599A (en) 1998-04-03 1999-04-02 Gaba b receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8067698P 1998-04-03 1998-04-03
US60/080,676 1998-04-03

Publications (3)

Publication Number Publication Date
WO1999051636A2 WO1999051636A2 (en) 1999-10-14
WO1999051636A3 true WO1999051636A3 (en) 1999-11-18
WO1999051636A9 WO1999051636A9 (en) 2000-01-13

Family

ID=22158916

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/007352 WO1999051636A2 (en) 1998-04-03 1999-04-02 Gaba b receptor

Country Status (2)

Country Link
AU (1) AU3468599A (en)
WO (1) WO1999051636A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021890A1 (en) * 1997-10-27 1999-05-06 Astrazeneca Ab New nucleotide sequences
AUPP438498A0 (en) * 1998-06-29 1998-07-23 Garvan Institute Of Medical Research Novel Gaba-B receptor
AU5695899A (en) * 1998-08-27 2000-03-21 Synaptic Pharmaceutical Corporation Dna encoding a gaba beta R2 polypeptide and uses thereof
JP2002523070A (en) * 1998-09-01 2002-07-30 スミスクライン ビーチャム コーポレーション GABAB1AA receptor
AU5639799A (en) * 1998-09-07 2000-03-27 Glaxo Group Limited Gaba beta receptor subtypes gaba beta -R1c and GABA beta-R2 and heterodimers thereof
GB9819420D0 (en) 1998-09-07 1998-10-28 Glaxo Group Ltd Novel receptor
EP1112363A1 (en) * 1998-09-14 2001-07-04 BASF-LYNX Bioscience AG Metabotropic gaba receptor complex issued from the central nervous system
DE19955408A1 (en) * 1999-11-18 2001-05-23 Bayer Ag New invertebrate gamma-aminobutyric acid receptor proteins, useful in screening for potential insecticides, for plant protection or medicine, also related nucleic acid
CN1849336A (en) * 2003-09-12 2006-10-18 詹森药业有限公司 Chimeric gabab receptor
US20110003711A1 (en) * 2008-02-01 2011-01-06 Chromocell Corporation Cell lines expressing gaba receptor and methods using them

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046675A1 (en) * 1996-05-30 1997-12-11 Novartis Ag Metabotropic gaba[b] receptors, receptor-specific ligands and their uses
WO1999020751A1 (en) * 1997-10-17 1999-04-29 Synaptic Pharmaceutical Corporation Dna encoding a gababr2 polypeptide and uses thereof
EP0937777A2 (en) * 1998-02-20 1999-08-25 Smithkline Beecham Plc GABA receptors and their uses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046675A1 (en) * 1996-05-30 1997-12-11 Novartis Ag Metabotropic gaba[b] receptors, receptor-specific ligands and their uses
WO1999020751A1 (en) * 1997-10-17 1999-04-29 Synaptic Pharmaceutical Corporation Dna encoding a gababr2 polypeptide and uses thereof
EP0937777A2 (en) * 1998-02-20 1999-08-25 Smithkline Beecham Plc GABA receptors and their uses

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 10 October 1998 (1998-10-10), HINXTON, GB, XP002114719 *
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 21 December 1998 (1998-12-21), HINXTON, GB, XP002116150 *
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 4 January 1999 (1999-01-04), HINXTON, GB, XP002116151 *
JONES, K.A. ET AL.,: "GABAB receptors function as heteromeric assembly of the subunits GABABR1 and GABABR2", NATURE, vol. 396, 17 December 1998 (1998-12-17), pages 674 - 679, XP002116148 *
KAUPMANN K ET AL: "EXPRESSION CLONING OF GABAB RECEPTORS UNCOVERS SIMILARITY TO METABOTROPIC GLUTAMATE RECEPTORS", NATURE, vol. 386, no. 6622, 20 March 1997 (1997-03-20), pages 239 - 246, XP002032306, ISSN: 0028-0836 *
KAUPMANN K. ET AL.,: "GABAB-receptor subtypes assemble into functional heteromeric complexes", NATURE, vol. 396, 17 December 1998 (1998-12-17), pages 683 - 687, XP002105268 *
WHITE J.H. ET AL.,: "Heterodimerization is required for the formation of a functional GABAB receptor.", NATURE, vol. 396, 17 December 1998 (1998-12-17), pages 679-682, XP002116149 *

Also Published As

Publication number Publication date
WO1999051636A2 (en) 1999-10-14
AU3468599A (en) 1999-10-25
WO1999051636A9 (en) 2000-01-13

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