WO2001078796A3 - Type ii gonadotropin-releasing hormone receptor and polynucleotides encoding therefor - Google Patents

Type ii gonadotropin-releasing hormone receptor and polynucleotides encoding therefor Download PDF

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Publication number
WO2001078796A3
WO2001078796A3 PCT/GB2001/001755 GB0101755W WO0178796A3 WO 2001078796 A3 WO2001078796 A3 WO 2001078796A3 GB 0101755 W GB0101755 W GB 0101755W WO 0178796 A3 WO0178796 A3 WO 0178796A3
Authority
WO
WIPO (PCT)
Prior art keywords
type
gonadotropin
polynucleotides encoding
releasing hormone
hormone receptor
Prior art date
Application number
PCT/GB2001/001755
Other languages
French (fr)
Other versions
WO2001078796A1 (en
WO2001078796A9 (en
Inventor
Robert Peter Millar
Steven Lowe
Darrell Conklin
Original Assignee
Medical Res Council
Robert Peter Millar
Steven Lowe
Darrell Conklin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0009269A external-priority patent/GB0009269D0/en
Priority claimed from GB0014761A external-priority patent/GB0014761D0/en
Priority to KR1020027013776A priority Critical patent/KR20020097218A/en
Priority to IL15201101A priority patent/IL152011A0/en
Priority to BR0110098-0A priority patent/BR0110098A/en
Priority to CA002404127A priority patent/CA2404127A1/en
Priority to AU2001248599A priority patent/AU2001248599A1/en
Priority to EP01921629A priority patent/EP1337282A2/en
Application filed by Medical Res Council, Robert Peter Millar, Steven Lowe, Darrell Conklin filed Critical Medical Res Council
Priority to HU0301666A priority patent/HUP0301666A2/en
Priority to JP2001576095A priority patent/JP2003530837A/en
Publication of WO2001078796A1 publication Critical patent/WO2001078796A1/en
Publication of WO2001078796A9 publication Critical patent/WO2001078796A9/en
Priority to US10/263,872 priority patent/US20030124585A1/en
Priority to NO20024937A priority patent/NO20024937L/en
Publication of WO2001078796A3 publication Critical patent/WO2001078796A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

There is provided polynucleotides encoding the full sequence for the marmoset and human Type II gonadotropin-releasing hormone receptors (Type II GnRH-R). The corresponding amino acid sequences are also provided.
PCT/GB2001/001755 2000-04-15 2001-04-17 Type ii gonadotropin-releasing hormone receptor and polynucleotides encoding therefor WO2001078796A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
HU0301666A HUP0301666A2 (en) 2000-04-15 2001-04-17 Type ii gonadotropin-releasing hormone receptor and polynucleotides encoding therefor
JP2001576095A JP2003530837A (en) 2000-04-15 2001-04-17 Type II gonadotropin-releasing hormone receptor (type II GnRH-R) and polynucleotide encoding the same
IL15201101A IL152011A0 (en) 2000-04-15 2001-04-17 Type ii gonadotropin-releasing hormone and polynucleotides encoding therefor
BR0110098-0A BR0110098A (en) 2000-04-15 2001-04-17 Polynucleotide, recombinant genetic construct, expression vector, host cell, transgenic animal, peptide, methods for screening an agent for pharmacological activity, inhibiting the binding of gnrh to its native receptor in vivo, and contraception, and uses of type ii gnrh-r or an extracellular domain thereof
CA002404127A CA2404127A1 (en) 2000-04-15 2001-04-17 Type ii gonadotropin-releasing hormone receptor and polynucleotides encoding therefor
AU2001248599A AU2001248599A1 (en) 2000-04-15 2001-04-17 Type ii gonadotropin-releasing hormone receptor and polynucleotides encoding therefor
EP01921629A EP1337282A2 (en) 2000-04-15 2001-04-17 Type ii gonadotropin-releasing hormone receptor and polynucleotides encoding therefor
KR1020027013776A KR20020097218A (en) 2000-04-15 2001-04-17 Type ii gonadotropin-releasing hormone receptor and polynucleotides encoding therefor
US10/263,872 US20030124585A1 (en) 2000-04-15 2002-10-02 Type II gonadotropin-releasing hormone receptor and polynucleotides encoding therefor
NO20024937A NO20024937L (en) 2000-04-15 2002-10-14 Type II gonadotropin-releasing hormone receptor and polynucleotides encoding it

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0009269A GB0009269D0 (en) 2000-04-15 2000-04-15 Receptor
GB0014761A GB0014761D0 (en) 2000-06-17 2000-06-17 Receptor
US21523200P 2000-06-30 2000-06-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/263,872 Continuation-In-Part US20030124585A1 (en) 2000-04-15 2002-10-02 Type II gonadotropin-releasing hormone receptor and polynucleotides encoding therefor

Publications (3)

Publication Number Publication Date
WO2001078796A1 WO2001078796A1 (en) 2001-10-25
WO2001078796A9 WO2001078796A9 (en) 2002-02-28
WO2001078796A3 true WO2001078796A3 (en) 2003-04-24

Family

ID=27255670

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/001755 WO2001078796A1 (en) 2000-04-15 2001-04-17 Type ii gonadotropin-releasing hormone receptor and polynucleotides encoding therefor

Country Status (11)

Country Link
EP (1) EP1337282A2 (en)
JP (1) JP2003530837A (en)
KR (1) KR20020097218A (en)
AU (1) AU2001248599A1 (en)
BR (1) BR0110098A (en)
CA (1) CA2404127A1 (en)
HU (1) HUP0301666A2 (en)
IL (1) IL152011A0 (en)
NO (1) NO20024937L (en)
PL (1) PL357684A1 (en)
WO (1) WO2001078796A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001281882A1 (en) * 2000-06-26 2002-01-08 Bayer Aktiengesellschaft Regulation of human gonadotropin releasing hormone receptor-like g protein-coupled receptor
AU2002249304A1 (en) * 2001-03-01 2002-09-19 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Novel human gnrh receptor
US20050282745A1 (en) * 2001-08-28 2005-12-22 Siler-Khodr Theresa M Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
ATE316246T1 (en) 2002-07-22 2006-02-15 Ardana Bioscience Ltd SCREENING METHODS AND ANTITUMOR AGENTS OBTAINED THEREFROM
AU2003248955A1 (en) * 2002-07-22 2004-02-09 Ardana Bioscience Limited Screening method
WO2004009636A2 (en) * 2002-07-22 2004-01-29 Ardana Bioscience Limited Gnrh modulator
KR101038183B1 (en) * 2010-12-27 2011-06-01 강범준 Waveblock and a covering method of the incline plane using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000590A1 (en) * 1992-06-23 1994-01-06 The Mt. Sinai School Of Medicine Of The City University Of New York Cloning and expression of gonadotropin-releasing hormone receptor
WO1997047743A1 (en) * 1996-06-13 1997-12-18 Zymogenetics, Inc. Human type ii gonadotropin-releasing hormone receptor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000590A1 (en) * 1992-06-23 1994-01-06 The Mt. Sinai School Of Medicine Of The City University Of New York Cloning and expression of gonadotropin-releasing hormone receptor
WO1997047743A1 (en) * 1996-06-13 1997-12-18 Zymogenetics, Inc. Human type ii gonadotropin-releasing hormone receptor

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
B. BYRNE ET AL.: "Isolation and characterization of the marmoset gonatrophin releasing hormone receptor: Ser(140) of the DRS motif is substituted by Phe", J. ENDOCRINOL., vol. 163, no. 3, December 1999 (1999-12-01), pages 447 - 456, XP001021870 *
B. TROSKIE ET AL.,: "Identification of three putative GnRH receptor subtypes in vertebrates", GEN. COMP. ENDOCRINOL., vol. 112, no. 3, December 1998 (1998-12-01), pages 296 - 302, XP001018687 *
MILLAR ROBERT ET AL: "A novel mammalian receptor for the evolutionarily conserved type II GnRH.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 98, no. 17, 14 August 2001 (2001-08-14), August 14, 2001, pages 9636 - 9641, XP002178834, ISSN: 0027-8424 *
N. ILLING ET AL.,: "Two gonadotrophin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish (Carassius auratus)", PROC. NATL. ACAD. SCI. USA, vol. 96, no. 5, 2 March 1999 (1999-03-02), pages 2526 - 2531, XP002178832 *
NEILL JIMMY D ET AL: "A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 282, no. 4, 13 April 2001 (2001-04-13), pages 1012 - 1018, XP002178833, ISSN: 0006-291X *
R. GROSSE ET AL.,: "Inhibition of Gonadotropin-Releasing Hormone Receptor signaling by expression of a splice variant of the human receptor", MOLECULAR ENDOCRINOLOGY, vol. 11, no. 9, 1997, pages 1305 - 1318, XP002186858 *
ZHOU W ET AL: "STRUCTURE OF THE MOUSE GONADOTROPIN-RELEASING HORMONE RECEPTOR GENE: VARIANT TRANSCRIPTS GENERATED BY ALTERNATIVE PROCESSING", DNA AND CELL BIOLOGY, NEW YORK, NY, US, vol. 13, no. 6, June 1994 (1994-06-01), pages 605 - 614, XP000991212, ISSN: 1044-5498 *

Also Published As

Publication number Publication date
IL152011A0 (en) 2003-04-10
AU2001248599A1 (en) 2001-10-30
CA2404127A1 (en) 2001-10-25
BR0110098A (en) 2003-01-14
HUP0301666A2 (en) 2003-08-28
NO20024937L (en) 2002-12-09
WO2001078796A1 (en) 2001-10-25
PL357684A1 (en) 2004-07-26
JP2003530837A (en) 2003-10-21
WO2001078796A9 (en) 2002-02-28
KR20020097218A (en) 2002-12-31
EP1337282A2 (en) 2003-08-27
NO20024937D0 (en) 2002-10-14

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