WO1999045126A3 - Activation amelioree de promedicaments - Google Patents
Activation amelioree de promedicaments Download PDFInfo
- Publication number
- WO1999045126A3 WO1999045126A3 PCT/GB1999/000672 GB9900672W WO9945126A3 WO 1999045126 A3 WO1999045126 A3 WO 1999045126A3 GB 9900672 W GB9900672 W GB 9900672W WO 9945126 A3 WO9945126 A3 WO 9945126A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- prodrug activation
- enhanced
- prodrug
- enhanced prodrug
- activation
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/14—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (1.14.14)
- C12Y114/14001—Unspecific monooxygenase (1.14.14.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000534657A JP2002505341A (ja) | 1998-03-06 | 1999-03-05 | プロドラッグの活性化の増強 |
AU32668/99A AU3266899A (en) | 1998-03-06 | 1999-03-05 | Enhanced prodrug activation |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9804841.6A GB9804841D0 (en) | 1998-03-06 | 1998-03-06 | Enhanced pro-drug activation |
GB9804841.6 | 1998-03-06 | ||
GBGB9818103.5A GB9818103D0 (en) | 1998-08-19 | 1998-08-19 | Enhanced pro-drug activation |
GB9818103.5 | 1998-08-19 | ||
GBGB9902081.0A GB9902081D0 (en) | 1999-01-29 | 1999-01-29 | Enhanced prodrug activation |
GB9902081.0 | 1999-01-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999045126A2 WO1999045126A2 (fr) | 1999-09-10 |
WO1999045126A3 true WO1999045126A3 (fr) | 2000-02-10 |
Family
ID=27269233
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1999/000674 WO1999045127A2 (fr) | 1998-03-06 | 1999-03-05 | Activation amelioree de promedicaments |
PCT/GB1999/000672 WO1999045126A2 (fr) | 1998-03-06 | 1999-03-05 | Activation amelioree de promedicaments |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1999/000674 WO1999045127A2 (fr) | 1998-03-06 | 1999-03-05 | Activation amelioree de promedicaments |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1068338A2 (fr) |
JP (1) | JP2002505341A (fr) |
CN (1) | CN1357048A (fr) |
AU (2) | AU3266899A (fr) |
CA (1) | CA2322664A1 (fr) |
WO (2) | WO1999045127A2 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002530059A (ja) * | 1998-11-13 | 2002-09-17 | サイクラセル・リミテッド | 輸送ベクター |
GB0400443D0 (en) * | 2004-01-09 | 2004-02-11 | Oxford Biomedica Ltd | Cascade |
DE19933492B4 (de) * | 1999-07-16 | 2008-01-10 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Konjugat zur Vermittlung eines zell-, kompartiment- oder membranspezifischen Transports von Wirksubstanzen, Verfahren zu dessen Herstellung und dessen Verwendung |
GB2371803A (en) * | 1999-11-18 | 2002-08-07 | Oxford Biomedica Ltd | Antibodies |
JP2003515323A (ja) * | 1999-11-18 | 2003-05-07 | オックスフォード バイオメディカ(ユーケイ)リミテッド | 抗 体 |
EP1244796A2 (fr) * | 2000-01-07 | 2002-10-02 | ARTEMIS Pharmaceuticals GmbH | Transduction de recombinases pour ciblage genetique inductible |
EP1272663B1 (fr) * | 2000-02-09 | 2009-12-30 | Epidauros Biotechnologie AG | Polymorphismes dans le gene humain cyp2b6 et leur utilisation dans des applications diagnostiques et therapeutiques |
CN1312283A (zh) * | 2000-03-07 | 2001-09-12 | 上海博德基因开发有限公司 | 一种新的多肽——人细胞色素组成蛋白14和编码这种多肽的多核苷酸 |
EP1504108B1 (fr) | 2002-02-01 | 2013-04-17 | Oxford Biomedica (UK) Limited | Vecteur lentivirale |
WO2007041546A2 (fr) * | 2005-10-03 | 2007-04-12 | Genetix Pharmaceuticals, Inc. | Methode de depletion selective de cellules hypoxiques |
GB0608941D0 (en) * | 2006-05-05 | 2006-06-14 | Univ Montfort | Methods |
WO2009120396A2 (fr) * | 2008-01-08 | 2009-10-01 | The University Of California | Compositions et procédés permettant de réguler l’expression de l’érythropoïétine, d’améliorer une anémie et de stimuler l’érythropoïèse |
JP5488204B2 (ja) * | 2010-05-31 | 2014-05-14 | 三菱電機株式会社 | サイクロン分離装置及びこれを備えた電気掃除機 |
CN109553688A (zh) * | 2012-12-05 | 2019-04-02 | 生控基因疫苗股份有限公司 | 用作诱发抗原特异性t细胞反应的免疫原性增强剂的融合蛋白 |
GB201318804D0 (en) | 2013-10-24 | 2013-12-11 | Adaptimmune Ltd | Vectors for transgene expression |
JP2017512068A (ja) * | 2014-02-17 | 2017-05-18 | ネステク ソシエテ アノニム | マイトフュージンの方法及び使用 |
MX2015006813A (es) * | 2015-05-29 | 2016-11-28 | Univ Nac Autónoma De México | Nanoparticulas biocataliticas cyp-p22 con actividad citocromo p450 para la activacion de profarmacos. |
EP3214092A1 (fr) * | 2016-03-04 | 2017-09-06 | Bayer Pharma Aktiengesellschaft | Promédicaments du modulateur du récepteur de progesterone (sprm) (11.bêta.,17.bêta.)-17-hydroxy-11-[4-(méthylsulphonyle)phenyle]-17-(pentafluoroéthyl)estra-4,9-dièn-3-one |
WO2018085586A1 (fr) * | 2016-11-02 | 2018-05-11 | David Kiewlich | Vecteurs plasmidiques pour l'expression de transgènes d'acide nucléique de grande taille |
LT7046B (lt) | 2022-04-15 | 2024-02-12 | Vilniaus Universitetas | Hidrolazės ir jų panaudojimas |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0590530A2 (fr) * | 1992-10-02 | 1994-04-06 | BEHRINGWERKE Aktiengesellschaft | Protéines de fusion pour l'activation de pro-médicaments |
WO1996003515A2 (fr) * | 1994-07-27 | 1996-02-08 | Cancer Research Campaign Technology Limited | Expression en surface d'une enzyme dans la therapie genique a base de promedicaments |
WO1996006166A1 (fr) * | 1994-08-20 | 1996-02-29 | Medical Research Council | Ameliorations concernant des proteines de liaison permettant de reconnaitre l'adn |
WO1997026918A2 (fr) * | 1996-01-26 | 1997-07-31 | Cancer Research Campaign Technology Limited | Therapie par promedicament a enzyme dirige par ligand |
-
1999
- 1999-03-05 WO PCT/GB1999/000674 patent/WO1999045127A2/fr not_active Application Discontinuation
- 1999-03-05 WO PCT/GB1999/000672 patent/WO1999045126A2/fr active Application Filing
- 1999-03-05 EP EP99937944A patent/EP1068338A2/fr not_active Withdrawn
- 1999-03-05 AU AU32668/99A patent/AU3266899A/en not_active Abandoned
- 1999-03-05 JP JP2000534657A patent/JP2002505341A/ja active Pending
- 1999-03-05 CA CA002322664A patent/CA2322664A1/fr not_active Abandoned
- 1999-03-05 CN CN99805649A patent/CN1357048A/zh active Pending
- 1999-03-05 AU AU32670/99A patent/AU763020B2/en not_active Ceased
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0590530A2 (fr) * | 1992-10-02 | 1994-04-06 | BEHRINGWERKE Aktiengesellschaft | Protéines de fusion pour l'activation de pro-médicaments |
WO1996003515A2 (fr) * | 1994-07-27 | 1996-02-08 | Cancer Research Campaign Technology Limited | Expression en surface d'une enzyme dans la therapie genique a base de promedicaments |
WO1996006166A1 (fr) * | 1994-08-20 | 1996-02-29 | Medical Research Council | Ameliorations concernant des proteines de liaison permettant de reconnaitre l'adn |
WO1997026918A2 (fr) * | 1996-01-26 | 1997-07-31 | Cancer Research Campaign Technology Limited | Therapie par promedicament a enzyme dirige par ligand |
Non-Patent Citations (2)
Title |
---|
AKHLYNINA ET AL: "Nuclear Targeting of Chlorin e6 Enhances Its Photosensitizing Activity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 33, 15 August 1997 (1997-08-15), pages 20328 - 20331, XP000198745, ISSN: 0021-9258 * |
CHEN ET AL: "Potentiation of Cytochrome P450/Cyclophosphamide-based Cancer Gene Therapy by Coexpression of the P450 Reductase Gene", CANCER RESEARCH, vol. 57, 1 November 1997 (1997-11-01), pages 4830 - 4837, XP002113681 * |
Also Published As
Publication number | Publication date |
---|---|
AU3266899A (en) | 1999-09-20 |
CN1357048A (zh) | 2002-07-03 |
WO1999045127A2 (fr) | 1999-09-10 |
EP1068338A2 (fr) | 2001-01-17 |
WO1999045126A2 (fr) | 1999-09-10 |
JP2002505341A (ja) | 2002-02-19 |
WO1999045127A3 (fr) | 2000-02-24 |
CA2322664A1 (fr) | 1999-09-10 |
AU3267099A (en) | 1999-09-20 |
AU763020B2 (en) | 2003-07-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1999045126A3 (fr) | Activation amelioree de promedicaments | |
AU2002221550A1 (en) | Multi-layered body, in particular a multi-layered film and method for increasing the forgery protection of multi-layered body | |
AU2001261150A1 (en) | Methods and systems for compliance program assessment | |
AU5150500A (en) | Trocar for use in deploying an anastomisis device | |
AU2002227248A1 (en) | Low work function material | |
AU2001244302A1 (en) | Assessment methods and systems | |
MXPA03004758A (es) | Pelicula y laminado biodegradable con capacidad de respirar. | |
AU5419300A (en) | Simplified storage barge | |
AU2002215116A1 (en) | Expander | |
AU3678500A (en) | Semi-optimal path finding in a wholly unknown environment | |
AU2000262575A1 (en) | Method for localising direction and localisation arrangement | |
EP1151667A3 (fr) | Agent d'activation de plantes | |
AU2001262216A1 (en) | Apoptotic agents | |
AU2001264504A1 (en) | Random identity management in scatternets | |
AU2002215741A1 (en) | Semen storage | |
AU2001253104A1 (en) | Methods for altering t cell and macrophage activation | |
AU6737800A (en) | Polymer for chemically amplified resist and a resist composition using the same | |
AU2002234081A1 (en) | Rapid development in a distributed application environment | |
AU2001229439A1 (en) | Bioconjugates and uses thereof | |
AU2001261374A1 (en) | Message authentication using message gates in a distributed computing environment | |
AU2001252062A1 (en) | Steatosis-modulating factors and uses thereof | |
AU2001269257A1 (en) | Target face | |
AU2002241514A1 (en) | Systems and methods for communicating in a business environment | |
AU2611899A (en) | An electricity distribution board having a distribution terminal block, and a distribution terminal block for use in the electricity distribution board | |
WO2000078274A3 (fr) | Composition de colorant capillaire |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 99805649.9 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
NENP | Non-entry into the national phase |
Ref country code: KR |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase |