WO1999042139A3 - Hydroxyethyl starch conjugate, method for the production thereof and pharmaceuticals containing the same - Google Patents

Hydroxyethyl starch conjugate, method for the production thereof and pharmaceuticals containing the same Download PDF

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Publication number
WO1999042139A3
WO1999042139A3 PCT/EP1999/000853 EP9900853W WO9942139A3 WO 1999042139 A3 WO1999042139 A3 WO 1999042139A3 EP 9900853 W EP9900853 W EP 9900853W WO 9942139 A3 WO9942139 A3 WO 9942139A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
same
hydroxyethyl starch
pharmaceuticals containing
starch conjugate
Prior art date
Application number
PCT/EP1999/000853
Other languages
German (de)
French (fr)
Other versions
WO1999042139A2 (en
Inventor
Peter Mareski
Johannes Platzek
Bernd Raduechel
Ulrich Niedballa
Hanns-Joachim Weinmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Priority to AU28328/99A priority Critical patent/AU2832899A/en
Publication of WO1999042139A2 publication Critical patent/WO1999042139A2/en
Publication of WO1999042139A3 publication Critical patent/WO1999042139A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/08—Ethers
    • C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The invention relates to novel hydroxyethyl starch conjugates and their use in medical diagnosis.
PCT/EP1999/000853 1998-02-20 1999-02-09 Hydroxyethyl starch conjugate, method for the production thereof and pharmaceuticals containing the same WO1999042139A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU28328/99A AU2832899A (en) 1998-02-20 1999-02-09 Hydroxyethyl starch conjugate, method for the production thereof and pharmaceuticals containing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1998108079 DE19808079A1 (en) 1998-02-20 1998-02-20 New hydroxyethyl starch conjugates useful as X-ray, NMR and blood-pool diagnostic agents, e.g. for diagnosis of tumors, cardiovascular disorders and inflammation
DE19808079.4 1998-02-20

Publications (2)

Publication Number Publication Date
WO1999042139A2 WO1999042139A2 (en) 1999-08-26
WO1999042139A3 true WO1999042139A3 (en) 1999-09-30

Family

ID=7858971

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/000853 WO1999042139A2 (en) 1998-02-20 1999-02-09 Hydroxyethyl starch conjugate, method for the production thereof and pharmaceuticals containing the same

Country Status (3)

Country Link
AU (1) AU2832899A (en)
DE (1) DE19808079A1 (en)
WO (1) WO1999042139A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112825A1 (en) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylation of active ingredients in aqueous solution
DE10209822A1 (en) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Coupling of low molecular weight substances to a modified polysaccharide
DE10209821A1 (en) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Coupling of proteins to a modified polysaccharide
CA2496317C (en) 2002-09-11 2014-02-18 Fresenius Kabi Deutschland Gmbh Method of producing hydroxyalkyl starch derivatives
AU2003273413A1 (en) 2002-10-08 2004-05-04 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
SG151261A1 (en) 2004-03-11 2009-04-30 Fresenius Kabi De Gmbh Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
DE102007015282B4 (en) * 2007-03-29 2017-10-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Viscosity regulator, process for its preparation and its use
EP2070950A1 (en) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkyl starch derivatives and process for their preparation
US10383958B2 (en) 2011-04-06 2019-08-20 Cedars-Sinai Medical Center Polymalic acid based nanoconjugates for imaging
CN102321185B (en) * 2011-08-09 2012-12-19 武汉华科大生命科技有限公司 Synthesis method of middle-molecular-weight hydroxyethyl starch
RU2655810C2 (en) * 2016-10-12 2018-05-29 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) Means for cerebral blood flow increase

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0250358A2 (en) * 1986-06-20 1987-12-23 Schering Aktiengesellschaft Novel complex compounds
WO1989006979A1 (en) * 1988-01-26 1989-08-10 Cockbain, Julian, Roderick, Michaelson Paramagnetic compounds
EP0361960A2 (en) * 1988-09-29 1990-04-04 RANNEY, David F. Methods and compositions for magnetic resonance imaging
EP0391621A1 (en) * 1989-04-03 1990-10-10 Nippon Universal Pharmaceutical Co., Ltd., Iodized hydroxyethyl starch of low viscosity and process for preparing the same
US4986980A (en) * 1984-11-01 1991-01-22 Nycomed As Water-soluble, carrier-bound paramagnetic metal containing diagnostic agents
WO1992007259A1 (en) * 1990-10-16 1992-04-30 Biomedical Frontiers, Inc. Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging
US5336762A (en) * 1985-11-18 1994-08-09 Access Pharmaceuticals, Inc. Polychelating agents for image and spectral enhancement (and spectral shift)
WO1995005669A1 (en) * 1993-08-12 1995-02-23 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
US5458870A (en) * 1991-08-05 1995-10-17 Mallinckrodt Medical, Inc. Compositions for magnetic resonance imaging using a manganese oxalate

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4986980A (en) * 1984-11-01 1991-01-22 Nycomed As Water-soluble, carrier-bound paramagnetic metal containing diagnostic agents
US5336762A (en) * 1985-11-18 1994-08-09 Access Pharmaceuticals, Inc. Polychelating agents for image and spectral enhancement (and spectral shift)
EP0250358A2 (en) * 1986-06-20 1987-12-23 Schering Aktiengesellschaft Novel complex compounds
WO1989006979A1 (en) * 1988-01-26 1989-08-10 Cockbain, Julian, Roderick, Michaelson Paramagnetic compounds
EP0361960A2 (en) * 1988-09-29 1990-04-04 RANNEY, David F. Methods and compositions for magnetic resonance imaging
EP0391621A1 (en) * 1989-04-03 1990-10-10 Nippon Universal Pharmaceutical Co., Ltd., Iodized hydroxyethyl starch of low viscosity and process for preparing the same
WO1992007259A1 (en) * 1990-10-16 1992-04-30 Biomedical Frontiers, Inc. Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging
US5458870A (en) * 1991-08-05 1995-10-17 Mallinckrodt Medical, Inc. Compositions for magnetic resonance imaging using a manganese oxalate
WO1995005669A1 (en) * 1993-08-12 1995-02-23 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RONGVED P ET AL: "WATER-SOLUBLE POLYSACCHARIDES AS CARRIERS OF PARAMAGNETIC CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING: SYNTHESIS AND RELAXATION PROPERTIES", CARBOHYDRATE RESEARCH, vol. 214, no. 2, 30 July 1991 (1991-07-30), pages 315 - 323, XP000217853, ISSN: 0008-6215 *

Also Published As

Publication number Publication date
AU2832899A (en) 1999-09-06
DE19808079A1 (en) 1999-08-26
WO1999042139A2 (en) 1999-08-26

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