WO1999042088A3 - Verfahren zur behandlung von erkrankungen oder störungen des innenohrs - Google Patents

Verfahren zur behandlung von erkrankungen oder störungen des innenohrs Download PDF

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Publication number
WO1999042088A3
WO1999042088A3 PCT/EP1999/001153 EP9901153W WO9942088A3 WO 1999042088 A3 WO1999042088 A3 WO 1999042088A3 EP 9901153 W EP9901153 W EP 9901153W WO 9942088 A3 WO9942088 A3 WO 9942088A3
Authority
WO
WIPO (PCT)
Prior art keywords
inner ear
sensory cells
disorders
cells
diseases
Prior art date
Application number
PCT/EP1999/001153
Other languages
English (en)
French (fr)
Other versions
WO1999042088A2 (de
Inventor
Hubert Loewenheim
Original Assignee
Otogene Ag
Hubert Loewenheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2000532105A priority Critical patent/JP2002503687A/ja
Priority to AU29281/99A priority patent/AU763868B2/en
Priority to DK99910259T priority patent/DK1056467T3/da
Priority to US09/622,719 priority patent/US7087581B1/en
Priority to AT99910259T priority patent/ATE250936T1/de
Priority to DE59907195T priority patent/DE59907195D1/de
Application filed by Otogene Ag, Hubert Loewenheim filed Critical Otogene Ag
Priority to CA002320717A priority patent/CA2320717C/en
Priority to EP99910259A priority patent/EP1056467B1/de
Publication of WO1999042088A2 publication Critical patent/WO1999042088A2/de
Publication of WO1999042088A3 publication Critical patent/WO1999042088A3/de
Priority to US10/458,108 priority patent/US7132406B2/en
Priority to US11/588,910 priority patent/US7741303B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Bei einem Verfahren zur Behandlung von Erkrankungen oder Störungen des Innenohrs, die mit einer Schädigung oder Zerstörung von Sinneszellen des Innenohrs im Zusammenhang stehen, wird zur Regeneration der Sinneszellen mindestens ein Wirkstoff eingesetzt, der mindestens einen im Innenohr vorhandenen sogenannten Zellzyklus-Inhibitor in seiner inhibierenden Wirkung mindestens teilweise hemmt oder ausschaltet. Die Regeneration der Sinneszellen des Innenohrs erfolgt bei diesem Verfahren vorzugsweise durch Stimulation der Proliferation von Stützzellen. Bei den Sinneszellen des Innenohrs handelt es sich um die sogenannten Haarsinneszellen. Als Zellzyklus-Inhibitoren kommen Zyklinkinase-Inhibitoren wie insbesondere der Zyklinkinase-Inhibitor P27Kip1 in Frage.
PCT/EP1999/001153 1998-02-23 1999-02-23 Verfahren zur behandlung von erkrankungen oder störungen des innenohrs WO1999042088A2 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU29281/99A AU763868B2 (en) 1998-02-23 1999-02-23 Method for the treatment of diseases or disorders of the inner ear
DK99910259T DK1056467T3 (da) 1998-02-23 1999-02-23 Metode til behandling af sygdomme eller lidelser i det indre øre
US09/622,719 US7087581B1 (en) 1998-02-23 1999-02-23 Method for the treatment of diseases or disorders of the inner ear
AT99910259T ATE250936T1 (de) 1998-02-23 1999-02-23 Verfahren zur behandlung von erkrankungen oder störungen des innenohrs
DE59907195T DE59907195D1 (de) 1998-02-23 1999-02-23 Verfahren zur behandlung von erkrankungen oder störungen des innenohrs
JP2000532105A JP2002503687A (ja) 1998-02-23 1999-02-23 内耳の疾患又は機能障害の治療方法
CA002320717A CA2320717C (en) 1998-02-23 1999-02-23 Method for the treatment of diseases or disorders of the inner ear
EP99910259A EP1056467B1 (de) 1998-02-23 1999-02-23 Verfahren zur behandlung von erkrankungen oder störungen des innenohrs
US10/458,108 US7132406B2 (en) 1998-02-23 2003-06-09 Stimulation of cellular regeneration and differentiation in the inner ear
US11/588,910 US7741303B2 (en) 1998-02-23 2006-10-27 Stimulation of cellular regeneration and differentiation in the inner ear

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19807426A DE19807426A1 (de) 1998-02-23 1998-02-23 Verfahren zur Behandlung von Erkrankungen oder Störungen des Innenohrs
DE19807426.3 1998-02-23

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024829 Continuation-In-Part WO2000023084A1 (en) 1998-02-23 1999-10-21 Methods for stimulating the regeneration of inner ear cells

Related Child Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2000/005736 Continuation-In-Part WO2000054583A1 (en) 1998-02-23 2000-03-03 Methods for culturing fluid-filled sensory organs
US61409900A Continuation-In-Part 1998-02-23 2000-07-11

Publications (2)

Publication Number Publication Date
WO1999042088A2 WO1999042088A2 (de) 1999-08-26
WO1999042088A3 true WO1999042088A3 (de) 2000-03-02

Family

ID=7858563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/001153 WO1999042088A2 (de) 1998-02-23 1999-02-23 Verfahren zur behandlung von erkrankungen oder störungen des innenohrs

Country Status (11)

Country Link
US (1) US7087581B1 (de)
EP (1) EP1056467B1 (de)
JP (1) JP2002503687A (de)
AT (1) ATE250936T1 (de)
AU (1) AU763868B2 (de)
CA (1) CA2320717C (de)
DE (2) DE19807426A1 (de)
DK (1) DK1056467T3 (de)
ES (1) ES2211055T3 (de)
PT (1) PT1056467E (de)
WO (1) WO1999042088A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6838444B1 (en) 1999-06-01 2005-01-04 Baylor College Of Medicine Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
DE10027777A1 (de) * 2000-06-07 2001-12-13 Otogene Ag Transfektionsverfahren
AU8821901A (en) * 2000-07-11 2002-01-21 Otogene Usa Inc Stimulation of cellular regeneration and differentiation in the inner ear
WO2004030702A1 (ja) 2002-10-02 2004-04-15 Anges Mg, Inc. 聴覚機能障害用医薬
WO2004055154A2 (en) * 2002-12-17 2004-07-01 Centre National De La Recherche Scientifique (Cnrs) Use of purine derivatives for inducing differentiation of supernumerary hair cells and deiters' cells in the developing organ of corti for treating deafness
WO2009147684A2 (en) 2008-06-06 2009-12-10 Quark Pharmaceuticals, Inc. Compositions and methods for treatment of ear disorders
DE102010007281A1 (de) * 2010-02-08 2011-08-11 EMC microcollections GmbH, 72070 Neue Aminoalkyl-oxazol- und Aminoalkyl-thiazolcarbonsäureamide und ihre Anwendung zur Stimulation der endogenen situ Regeneration von Haarsinneszellen im Corti'schen Organ des Innenohres beim Säuger
RU2480195C1 (ru) * 2011-11-02 2013-04-27 Федеральное государственное учреждение "Российский научный центр восстановительной медицины и курортологии Федерального агентства по здравоохранению и социальному развитию РФ" (ФГУ "РНЦВМиК Росздрава РФ") Способ лечения заболеваний внутреннего уха
KR20140111673A (ko) 2012-01-12 2014-09-19 쿠아크 파마수티칼스 인코퍼레이티드 청력 및 균형 장애를 치료하기 위한 조합요법
WO2013134022A1 (en) * 2012-03-05 2013-09-12 Wake Forest University Health Sciences Regeneration of inner ear cells
TWI710635B (zh) 2014-10-09 2020-11-21 美商珍維克公司 編碼人類無調同源物-1(hath1)之腺病毒載體

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017983A1 (en) * 1995-11-13 1997-05-22 Cambridge Neuroscience, Inc. Methods of treating disorders of non-visual sensory epithelia
WO1997022255A1 (en) * 1995-12-19 1997-06-26 Dana-Farber Cancer Institute p62 POLYPEPTIDES, RELATED POLYPEPTIDES, AND USES THEREFOR
WO1998000014A1 (en) * 1996-06-28 1998-01-08 The Regents Of The University Of California Transformation and genetherapy of cells of the inner ear
WO1998013048A1 (en) * 1996-09-27 1998-04-02 Trustees Of The University Of Pennsylvania Novel methods for inducing proliferation in auditory receptor epithelium
WO1999006064A1 (en) * 1997-07-30 1999-02-11 Amgen Inc. Method for preventing and treating hearing loss using a neurturin protein product

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528388A1 (de) 1995-08-02 1997-02-06 Hans Peter Prof Dr Med Zenner Verwendung von Adamantan-Derivaten zur Behandlung von Erkrankungen des Innenohrs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017983A1 (en) * 1995-11-13 1997-05-22 Cambridge Neuroscience, Inc. Methods of treating disorders of non-visual sensory epithelia
WO1997022255A1 (en) * 1995-12-19 1997-06-26 Dana-Farber Cancer Institute p62 POLYPEPTIDES, RELATED POLYPEPTIDES, AND USES THEREFOR
WO1998000014A1 (en) * 1996-06-28 1998-01-08 The Regents Of The University Of California Transformation and genetherapy of cells of the inner ear
WO1998013048A1 (en) * 1996-09-27 1998-04-02 Trustees Of The University Of Pennsylvania Novel methods for inducing proliferation in auditory receptor epithelium
WO1999006064A1 (en) * 1997-07-30 1999-02-11 Amgen Inc. Method for preventing and treating hearing loss using a neurturin protein product

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BUJIA J. ET AL: "Immunohistochemical detection of proliferating cell nuclear antigen in middle ear cholesteatoma.", EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, (1996) 253/1-2 (21-24)., XP002123938 *
CHEN, P. ET AL: "p27/Kip1, a cyclin -dependent kinase inhibitor, is required for the normal development of the mouse auditory sense organ.", SOCIETY FOR NEUROSCIENCE ABSTRACTS, (1998) VOL. 24, NO. 1-2, PP. 809. MEETING INFO.: 28TH ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE, PART 1 LOS ANGELES, CALIFORNIA, USA NOVEMBER 7-12, 1998 SOCIETY FOR NEUROSCIENCE., XP002123936 *
SCHWEITZER V G: "Cisplatin-induced ototoxicity: the effect of pigmentation and inhibitory agents.", LARYNGOSCOPE, (1993 APR) 103 (4 PT 2) 1-52. REF: 151, XP002123937 *
UMEMOTO M ET AL: "HAIR CELL REGENERATION IN THE CHICK INNER EAR FOLLOWING ACOUSIC TRAUMA: ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDIES", CELL AND TISSUE RESEARCH,DE,BERLIN, vol. 3, pages 435-443, XP002060017 *
YAMAGUCHI T ET AL: "The effect of chalone on the cell cycle in the epidermis during wound healing.", EXPERIMENTAL CELL RESEARCH, (1974 DEC) 89 (2) 247-54., XP002123939 *

Also Published As

Publication number Publication date
DK1056467T3 (da) 2004-02-09
JP2002503687A (ja) 2002-02-05
WO1999042088A2 (de) 1999-08-26
EP1056467A2 (de) 2000-12-06
DE19807426A1 (de) 1999-10-14
ATE250936T1 (de) 2003-10-15
US7087581B1 (en) 2006-08-08
PT1056467E (pt) 2004-02-27
AU2928199A (en) 1999-09-06
AU763868B2 (en) 2003-07-31
ES2211055T3 (es) 2004-07-01
DE59907195D1 (de) 2003-11-06
CA2320717C (en) 2009-03-24
CA2320717A1 (en) 1999-08-26
EP1056467B1 (de) 2003-10-01

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