WO1999041368A3 - Optimization of immunomodulatory properties of genetic vaccines - Google Patents
Optimization of immunomodulatory properties of genetic vaccines Download PDFInfo
- Publication number
- WO1999041368A3 WO1999041368A3 PCT/US1999/003020 US9903020W WO9941368A3 WO 1999041368 A3 WO1999041368 A3 WO 1999041368A3 US 9903020 W US9903020 W US 9903020W WO 9941368 A3 WO9941368 A3 WO 9941368A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optimization
- immunomodulatory properties
- genetic vaccines
- molecules
- immune response
- Prior art date
Links
- 230000002068 genetic effect Effects 0.000 title abstract 2
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 238000005457 optimization Methods 0.000 title 1
- 230000028993 immune response Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002320960A CA2320960A1 (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of genetic vaccines |
MXPA00007889A MXPA00007889A (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of genetic vaccines. |
AU26741/99A AU2674199A (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of genetic vaccines |
EP99906948A EP1053312A2 (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of genetic vaccines |
JP2000531549A JP2002507392A (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of gene vaccines |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2176998A | 1998-02-11 | 1998-02-11 | |
US7429498P | 1998-02-11 | 1998-02-11 | |
US60/074,294 | 1998-02-11 | ||
US09/021,769 | 1998-02-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999041368A2 WO1999041368A2 (en) | 1999-08-19 |
WO1999041368A3 true WO1999041368A3 (en) | 1999-12-16 |
Family
ID=26695070
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/003020 WO1999041368A2 (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of genetic vaccines |
PCT/US1999/003023 WO1999041402A2 (en) | 1998-02-11 | 1999-02-10 | Targeting of genetic vaccine vectors |
PCT/US1999/003022 WO1999041369A2 (en) | 1998-02-11 | 1999-02-10 | Genetic vaccine vector engineering |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/003023 WO1999041402A2 (en) | 1998-02-11 | 1999-02-10 | Targeting of genetic vaccine vectors |
PCT/US1999/003022 WO1999041369A2 (en) | 1998-02-11 | 1999-02-10 | Genetic vaccine vector engineering |
Country Status (6)
Country | Link |
---|---|
EP (3) | EP1053343A2 (en) |
JP (3) | JP2002507392A (en) |
AU (3) | AU3291099A (en) |
CA (3) | CA2320431A1 (en) |
MX (3) | MXPA00007891A (en) |
WO (3) | WO1999041368A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6821957B2 (en) | 1997-05-20 | 2004-11-23 | University Of Iowa Research Foundation | Vectors and methods for immunization or therapeutic protocols |
US9512382B2 (en) | 2009-10-16 | 2016-12-06 | Bunge Global Innovation, Llc | Oil degumming methods |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
US6399383B1 (en) | 1997-10-28 | 2002-06-04 | Maxygen, Inc. | Human papilloma virus vectors |
WO1999023107A1 (en) | 1997-10-31 | 1999-05-14 | Maxygen, Incorporated | Modification of virus tropism and host range by viral genome shuffling |
US6908757B1 (en) | 1998-03-26 | 2005-06-21 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
KR20010052894A (en) | 1998-06-17 | 2001-06-25 | 맥시겐, 인크. | Method for producing polynucleotides with desired properties |
US6605430B1 (en) | 1998-08-12 | 2003-08-12 | Maxygen, Inc. | DNA shuffling of monooxygenase genes for production of industrial chemicals |
JP2002526107A (en) | 1998-10-07 | 2002-08-20 | マキシジェン, インコーポレイテッド | DNA shuffling to generate nucleic acids for mycotoxin detoxification |
US6913749B2 (en) | 1998-11-02 | 2005-07-05 | Resistentia Pharmaceuticals Ab | Immunogenic polypeptides for inducing anti-self IgE responses |
AU1619400A (en) | 1998-11-10 | 2000-05-29 | Maxygen, Inc. | Modified adp-glucose pyrophosphorylase for improvement and optimization of plantphenotypes |
US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
EP1108783A3 (en) | 1999-01-19 | 2001-09-05 | Maxygen, Inc. | Oligonucleotide-mediated nucleic acid recombination |
EP1073710A4 (en) * | 1999-02-04 | 2007-12-19 | Verenium Corp | Non-stochastic generation of genetic vaccines and enzymes |
IL144657A0 (en) | 1999-02-11 | 2002-06-30 | Maxygen Inc | High throughput mass spectrometry |
US6531316B1 (en) | 1999-03-05 | 2003-03-11 | Maxyag, Inc. | Encryption of traits using split gene sequences and engineered genetic elements |
CZ2002171A3 (en) | 1999-07-22 | 2002-06-12 | The Procter & Gamble Company | Proteinase conjugate, cleansing agent and preparation for personal hygiene |
US6946128B1 (en) | 1999-07-22 | 2005-09-20 | The Procter & Gamble Company | Protease conjugates having sterically protected epitope regions |
BR0012660A (en) | 1999-07-22 | 2002-04-09 | Procter & Gamble | Protease variant of subtilisin type; cleaning composition; and personal care composition |
CN1373802A (en) | 1999-07-22 | 2002-10-09 | 宝洁公司 | Subtilisin protease variants having amino acid deletions and substitutions in defined epitope regions |
US6686515B1 (en) | 1999-11-23 | 2004-02-03 | Maxygen, Inc. | Homologous recombination in plants |
US7115712B1 (en) * | 1999-12-02 | 2006-10-03 | Maxygen, Inc. | Cytokine polypeptides |
WO2001059071A2 (en) | 2000-02-09 | 2001-08-16 | Genvec, Inc. | Methods of preparing and using a viral vector library |
AU2001259957B2 (en) * | 2000-05-26 | 2006-06-15 | Savine Therapeutics Pty Ltd | Synthetic peptides and uses therefore |
AUPQ776100A0 (en) | 2000-05-26 | 2000-06-15 | Australian National University, The | Synthetic molecules and uses therefor |
AU2001272978A1 (en) | 2000-06-23 | 2002-01-08 | Maxygen, Inc. | Novel co-stimulatory molecules |
AU2001268716A1 (en) | 2000-06-23 | 2002-01-08 | Maxygen, Inc. | Novel chimeric promoters |
AU2001273009A1 (en) * | 2000-06-26 | 2002-01-08 | Maxygen, Inc. | Methods and compositions for developing spore display systems for medicinal and industrial applications |
US6858422B2 (en) | 2000-07-13 | 2005-02-22 | Codexis, Inc. | Lipase genes |
AU2004260931B9 (en) | 2003-04-29 | 2012-01-19 | E.I. Du Pont De Nemours And Company | Novel glyphosate-N-acetyltransferase (GAT) genes |
DE10060959A1 (en) * | 2000-12-06 | 2002-06-20 | Aventis Res & Tech Gmbh & Co | Processes for isolating and identifying effectors |
AU2002314712C1 (en) * | 2001-02-02 | 2008-10-02 | Novici Biotech Llc | A method of increasing complementarity in a heteroduplex polynucleotide |
WO2002094992A2 (en) | 2001-05-18 | 2002-11-28 | Rigel Pharmaceuticals, Incorporated | Directed evolution of protein in mammalian cells |
AU2002326437A1 (en) * | 2001-07-19 | 2003-03-03 | Icogen Corporation | Methods for the identification of peptidyl compounds interacting with extracellular target molecules |
EP2301553A1 (en) * | 2001-11-21 | 2011-03-30 | The Board Of Trustees Of The Leland Stanford Junior University | Polynucleotide therapy |
CA2481479C (en) | 2002-02-26 | 2012-12-11 | Maxygen, Inc. | Novel flavivirus antigens |
ES2564570T3 (en) | 2002-03-01 | 2016-03-23 | Codexis Mayflower Holdings, Llc | Methods, systems and software for the identification of functional biomolecules |
JP4851687B2 (en) | 2002-03-09 | 2012-01-11 | マキシジェン, インコーポレイテッド | Crossover optimization for directed evolution |
US7226771B2 (en) | 2002-04-19 | 2007-06-05 | Diversa Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
EP2298871A1 (en) | 2002-04-19 | 2011-03-23 | Verenium Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
CA2494798A1 (en) | 2002-08-06 | 2005-01-13 | Verdia, Inc. | Ap1 amine oxidase variants |
AU2003297155B2 (en) | 2002-12-16 | 2010-03-18 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant vaccine viruses expressing IL-15 and methods of using the same |
EP3023498B1 (en) | 2003-03-06 | 2018-11-28 | BASF Enzymes LLC | Amylases, nucleic acids encoding them and methods for making and using them |
EP3299465A1 (en) | 2003-03-07 | 2018-03-28 | DSM IP Assets B.V. | Hydrolases, nucleic acids encoding them and methods for making and using them |
EP1613733B1 (en) | 2003-04-04 | 2015-06-03 | BASF Enzymes LLC | Pectate lyases, nucleic acids encoding them and methods for making and using them |
NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
JP2007529993A (en) | 2003-07-02 | 2007-11-01 | シンジェンタ パーティシペーションズ アーゲー | Glucanases, nucleic acids encoding them and methods for making and using them |
WO2005021714A2 (en) | 2003-08-11 | 2005-03-10 | Diversa Corporation | Laccases, nucleic acids encoding them and methods for making and using them |
CA2734624A1 (en) | 2004-06-09 | 2005-12-29 | Pioneer Hi-Bred International, Inc. | Plastid transit peptides |
EP2468853B1 (en) | 2004-06-16 | 2015-04-01 | DSM IP Assets B.V. | Method for enzymatic decolorization of pheophytin |
GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
EP1869174B1 (en) | 2005-03-10 | 2015-02-18 | BASF Enzymes LLC | Lyase enzymes, nucleic acids encoding them and methods for making and using them |
EP1861506B1 (en) | 2005-03-15 | 2015-04-15 | BP Corporation North America Inc. | Cellulases, nucleic acids encoding them and methods for making and using them |
US8715988B2 (en) | 2005-03-28 | 2014-05-06 | California Institute Of Technology | Alkane oxidation by modified hydroxylases |
WO2007092314A2 (en) | 2006-02-02 | 2007-08-16 | Verenium Corporation | Esterases and related nucleic acids and methods |
NZ595501A (en) | 2006-02-10 | 2013-05-31 | Verenium Corp | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them |
US8043839B2 (en) | 2006-02-14 | 2011-10-25 | Verenium Corporation | Xylanases, nucleic acids encoding them and methods for making and using them |
CN101437954B (en) | 2006-03-07 | 2015-09-09 | 嘉吉公司 | The nucleic acid of zymohexase and coding zymohexase and their preparation and application |
CN101443446B (en) | 2006-03-07 | 2013-08-21 | 维莱尼姆公司 | Aldolases, nucleic acids encoding them and methods for making and using them |
MX369001B (en) | 2006-08-04 | 2019-10-24 | Basf Enzymes Llc | Glucanases, nucleic acids encoding them and methods for making and using them. |
PT2397486E (en) | 2006-09-21 | 2015-03-23 | Basf Enzymes Llc | Phytases, nucleic acids encoding them and methods for making and using them |
MX2009003034A (en) | 2006-09-21 | 2009-11-18 | Verenium Corp | Phospholipases, nucleic acids encoding them and methods for making and using them. |
ES2620288T3 (en) | 2006-12-21 | 2017-06-28 | Basf Enzymes Llc | Amylases and glucoamylases, nucleic acids that encode them and methods to form and use them |
BRPI0807132A2 (en) | 2007-01-30 | 2018-12-04 | Syngenta Participations Ag | enzymes for the treatment of lignocellulosics, nucleic acids encoding them, and methods and use thereof |
EP2205744B1 (en) | 2007-10-03 | 2015-01-14 | BP Corporation North America Inc. | Xylanases, nucleic acids encoding them and methods for making and using them |
ES2399088T3 (en) | 2007-11-01 | 2013-03-25 | Perseid Therapeutics Llc | Immunosuppressive polypeptides and nucleic acids |
JP5563990B2 (en) | 2008-01-03 | 2014-07-30 | ヴェレニウム コーポレイション | Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them |
US8541220B2 (en) | 2008-01-03 | 2013-09-24 | Verenium Corporation | Isomerases, nucleic acids encoding them and methods for making and using them |
EP3115459A3 (en) | 2008-05-23 | 2017-04-26 | E. I. du Pont de Nemours and Company | Novel dgat genes for increased seed storage lipid production and altered fatty acid profiles in oilseed plants |
US8198062B2 (en) | 2008-08-29 | 2012-06-12 | Dsm Ip Assets B.V. | Hydrolases, nucleic acids encoding them and methods for making and using them |
NZ592070A (en) | 2008-09-26 | 2012-07-27 | Tocagen Inc | Gene therapy vectors and humanized yeast cytosine deaminase triple mutant |
CN106011159A (en) | 2009-05-21 | 2016-10-12 | 巴斯夫酶有限责任公司 | Phytases, nucleic acids encoding them and methods for making and using them |
CA2770854A1 (en) | 2009-08-20 | 2011-02-24 | Pioneer Hi-Bred International, Inc. | Functional expression of shuffled yeast nitrate transporter (ynt1) in maize to improve nitrate uptake under low nitrate environment |
UA109884C2 (en) | 2009-10-16 | 2015-10-26 | A POLYPEPTIDE THAT HAS THE ACTIVITY OF THE PHOSPHATIDYLINOSYTOL-SPECIFIC PHOSPHOLIPASE C, NUCLEIC ACID, AND METHOD OF METHOD | |
CA2786001A1 (en) | 2009-12-31 | 2011-07-07 | Pioneer Hi-Bred International, Inc. | Engineering plant resistance to diseases caused by pathogens |
US9187762B2 (en) | 2010-08-13 | 2015-11-17 | Pioneer Hi-Bred International, Inc. | Compositions and methods comprising sequences having hydroxyphenylpyruvate dioxygenase (HPPD) activity |
US20150184173A1 (en) | 2012-05-04 | 2015-07-02 | E I Du Pont De Nemours And Company | Compositions and methods comprising sequences having meganuclease activity |
US20140289906A1 (en) | 2013-03-14 | 2014-09-25 | Pioneer Hi-Bred International, Inc. | Compositions Having Dicamba Decarboxylase Activity and Methods of Use |
US20160040149A1 (en) | 2013-03-14 | 2016-02-11 | Pioneer Hi-Bred International Inc. | Compositions Having Dicamba Decarboxylase Activity and Methods of Use |
EP2971000A4 (en) | 2013-03-15 | 2016-11-23 | Pioneer Hi Bred Int | Phi-4 polypeptides and methods for their use |
US10006045B2 (en) | 2013-08-16 | 2018-06-26 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
CA3175967A1 (en) | 2013-09-13 | 2015-03-19 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
CA2939156A1 (en) | 2014-02-07 | 2015-08-13 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2015120270A1 (en) | 2014-02-07 | 2015-08-13 | Pioneer Hi Bred International, Inc. | Insecticidal proteins and methods for their use |
CA2960102C (en) * | 2014-09-11 | 2023-10-24 | Vlp Therapeutics, Llc | Flavivirus virus like particle |
CN113372421A (en) | 2014-10-16 | 2021-09-10 | 先锋国际良种公司 | Insecticidal proteins and methods of use thereof |
CN107529763B (en) | 2015-03-11 | 2021-08-20 | 先锋国际良种公司 | Insecticidal combinations of PIP-72 and methods of use |
CN116333064A (en) | 2015-05-19 | 2023-06-27 | 先锋国际良种公司 | Insecticidal proteins and methods of use thereof |
US11198709B2 (en) | 2015-08-06 | 2021-12-14 | E. I. Du Pont De Nemours And Company | Plant derived insecticidal proteins and methods for their use |
EP3390431A1 (en) | 2015-12-18 | 2018-10-24 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
MX2018013249A (en) | 2016-05-04 | 2019-02-13 | Pioneer Hi Bred Int | Insecticidal proteins and methods for their use. |
MX2018015540A (en) * | 2016-06-20 | 2019-04-11 | Janssen Vaccines & Prevention Bv | Potent and balanced bidirectional promoter. |
US11155829B2 (en) | 2016-07-01 | 2021-10-26 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
US11021716B2 (en) | 2016-11-01 | 2021-06-01 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
CA3044404A1 (en) | 2016-12-14 | 2018-06-21 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2018118811A1 (en) | 2016-12-22 | 2018-06-28 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
US20190390219A1 (en) | 2017-02-08 | 2019-12-26 | Pioneer Hi-Bred International, Inc. | Insecticidal combinations of plant derived insecticidal proteins and methods for their use |
CN110621780B (en) | 2017-05-11 | 2024-03-19 | 先锋国际良种公司 | Insecticidal proteins and methods of use thereof |
WO2020198731A2 (en) | 2019-03-28 | 2020-10-01 | Danisco Us Inc | Engineered antibodies |
US20230235352A1 (en) | 2020-07-14 | 2023-07-27 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995016027A1 (en) * | 1993-12-06 | 1995-06-15 | Bioinvent International Ab | Method of selecting specific bacteriophages |
WO1996011279A2 (en) * | 1994-10-03 | 1996-04-18 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Enhanced immune response by introduction of cytokine gene and/or costimulatory molecule b7 gene in a recombinant virus expressing system |
WO1997007128A1 (en) * | 1995-08-21 | 1997-02-27 | Duke University | A method to increase the density of antigen on antigen presenting cells |
WO1997020078A1 (en) * | 1995-11-30 | 1997-06-05 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
WO1997032987A1 (en) * | 1996-03-08 | 1997-09-12 | University Of Toronto | Methods and nucleic immunogenic compositions encoding antigens and co-stimulatory molecules for immunization |
WO1997035957A1 (en) * | 1996-03-25 | 1997-10-02 | Maxygen, Inc. | Evolving cellular dna uptake by recursive sequence recombination |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4882278A (en) * | 1983-04-29 | 1989-11-21 | President And Fellows Of Harvard College | Non-toxinogenic vibrio cholerae mutants |
IL96475A0 (en) * | 1989-11-29 | 1991-08-16 | Innovative Tech Center | Chimeric proteins |
JPH08510639A (en) * | 1993-04-19 | 1996-11-12 | メディソーブ・テクノロジーズ・インターナショナル・リミテッド・パートナーシップ | Encapsulation of conjugates and nucleic acids for enhanced cellular uptake and gene expression and targeting |
SG54115A1 (en) * | 1993-04-27 | 1998-11-16 | Gerber Scient Products Inc | Thermal printing apparatus with improved power supply |
WO1994026787A1 (en) * | 1993-05-07 | 1994-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Method for generating cell type specific phage antibody libraries |
WO1996013250A1 (en) * | 1994-10-27 | 1996-05-09 | Amgem Inc. | Compositions for increased bioavailability of orally delivered therapeutic agents |
AU716056B2 (en) * | 1995-01-31 | 2000-02-17 | Rockefeller University, The | Identification of DEC, (dentritic and epithelial cells, 205 kDa), a receptor with C-type lectin domains, nucleic acids encoding DEC, and uses thereof |
CZ92998A3 (en) * | 1995-09-28 | 1998-09-16 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Process of stimulating cellularly mediated immunity response by making use of immunization through gene material bound on particles |
US6489145B1 (en) * | 1996-07-09 | 2002-12-03 | Diversa Corporation | Method of DNA shuffling |
-
1999
- 1999-02-10 WO PCT/US1999/003020 patent/WO1999041368A2/en not_active Application Discontinuation
- 1999-02-10 CA CA002320431A patent/CA2320431A1/en not_active Abandoned
- 1999-02-10 JP JP2000531549A patent/JP2002507392A/en not_active Withdrawn
- 1999-02-10 EP EP99906949A patent/EP1053343A2/en not_active Withdrawn
- 1999-02-10 MX MXPA00007891A patent/MXPA00007891A/en unknown
- 1999-02-10 EP EP99932508A patent/EP1056842A2/en not_active Withdrawn
- 1999-02-10 MX MXPA00007889A patent/MXPA00007889A/en unknown
- 1999-02-10 MX MXPA00007893A patent/MXPA00007893A/en unknown
- 1999-02-10 AU AU32910/99A patent/AU3291099A/en not_active Abandoned
- 1999-02-10 JP JP2000531550A patent/JP2002503461A/en not_active Withdrawn
- 1999-02-10 CA CA002320960A patent/CA2320960A1/en not_active Abandoned
- 1999-02-10 AU AU26742/99A patent/AU2674299A/en not_active Abandoned
- 1999-02-10 AU AU26741/99A patent/AU2674199A/en not_active Abandoned
- 1999-02-10 WO PCT/US1999/003023 patent/WO1999041402A2/en not_active Application Discontinuation
- 1999-02-10 CA CA002320626A patent/CA2320626A1/en not_active Abandoned
- 1999-02-10 JP JP2000531583A patent/JP2002503478A/en not_active Withdrawn
- 1999-02-10 EP EP99906948A patent/EP1053312A2/en not_active Withdrawn
- 1999-02-10 WO PCT/US1999/003022 patent/WO1999041369A2/en not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995016027A1 (en) * | 1993-12-06 | 1995-06-15 | Bioinvent International Ab | Method of selecting specific bacteriophages |
WO1996011279A2 (en) * | 1994-10-03 | 1996-04-18 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Enhanced immune response by introduction of cytokine gene and/or costimulatory molecule b7 gene in a recombinant virus expressing system |
WO1997007128A1 (en) * | 1995-08-21 | 1997-02-27 | Duke University | A method to increase the density of antigen on antigen presenting cells |
WO1997020078A1 (en) * | 1995-11-30 | 1997-06-05 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
WO1997032987A1 (en) * | 1996-03-08 | 1997-09-12 | University Of Toronto | Methods and nucleic immunogenic compositions encoding antigens and co-stimulatory molecules for immunization |
WO1997035957A1 (en) * | 1996-03-25 | 1997-10-02 | Maxygen, Inc. | Evolving cellular dna uptake by recursive sequence recombination |
Non-Patent Citations (14)
Title |
---|
BENHAM A.M. & NEEFJES J.J.: "Proteasome activity limits the assembly f MHC class I molecules after IFN-gamma stimulation.", J. IMMUNOL., vol. 159, no. 2, 15 December 1997 (1997-12-15), pages 5896 - 5904, XP002117254 * |
CONRY R M ET AL: "SELECTED STRATEGIES TO AUGMENT POLYNUCLEOTIDE IMMUNIZATION", GENE THERAPY, vol. 3, no. 1, 1 January 1996 (1996-01-01), pages 67 - 74, XP002035090, ISSN: 0969-7128 * |
DAVIS H L ET AL: "DNA-based immunization against hepatitis B surface antigen (HBsAg) in normal and HBsAg-transgenic mice", VACCINE, vol. 15, no. 8, 1 June 1997 (1997-06-01), pages 849-852, XP004075668, ISSN: 0264-410X * |
HOURVITZ A. ET AL.: "Reactogenicity and immunogenicity of a new recombinant hepatitis B vaccine containing Pre S antigens: a preliminary report", J. VIRAL HEPATITIS, vol. 3, 1996, pages 37 - 42, XP002117256 * |
IRVINE K R ET AL: "CYTOKINE ENHANCEMENT OF DNA IMMUNIZATION LEADS TO EFFECTIVE TREATMENT OF ESTABLISHED PULMONARY METASTASES", JOURNAL OF IMMUNOLOGY, vol. 156, 1 January 1996 (1996-01-01), pages 238 - 245, XP002030631, ISSN: 0022-1767 * |
KLINMAN D.M. ET AL.: "Contribution of CpG motifs to the immunogenicity of DNA vaccines", J. IMMUNOLOGY, vol. 158, 1997, pages 3635 - 3639, XP002108454 * |
KRIEGER M ET AL: "MOLECULAR FLYPAPER, ATHEROSCLEROSIS, AND HOST DEFENSE: STRUCTURE AND FUNCTION OF THE MACROPHAGE SCAVENGER RECEPTOR", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, vol. 57, 1 January 1992 (1992-01-01), pages 605 - 609, XP000561876 * |
MARCO DI A ET AL: "AGONISTIC AND ANTAGONISTIC VARIANTS OF CILIARY NEUROTROPHIC FACTOR (CNTF) REVEAL FUNCTIONAL DIFFERENCES BETWEEN MEMBRANE-BOUND AND SOLUBLE CNTF ALPHA-RECEPTOR", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 37, 12 September 1997 (1997-09-12), pages 23069 - 23075, XP002069814, ISSN: 0021-9258 * |
PATTEN P A ET AL: "APPLICATIONS OF DNA SHUFFLING TO PHARMACEUTICALS AND VACCINES", CURRENT OPINION IN BIOTECHNOLOGY, vol. 8, 1997, pages 724 - 733, XP002916609, ISSN: 0958-1669 * |
SAGGIO I ET AL: "CNTF VARIANTS WITH INCREASED BIOLOGICAL POTENCY AND RECEPTOR SELECTIVITY DEFINE A FUNCTIONAL SITE OF RECEPTOR INTERACTION", EMBO JOURNAL, vol. 14, no. 13, 1 January 1995 (1995-01-01), pages 3045 - 3054, XP002056939, ISSN: 0261-4189 * |
SHEU S.Y. & LO S.J.: "Deletion or alteration of hydrophobic amino acids at the third transmembrane domains of Hepatitis B surface antigen enhances its production in Escherichia coli.", GENE, vol. 160, no. 2, 28 July 1995 (1995-07-28), pages 179 - 184, XP002117290 * |
SHOUVAL D. ET AL.: "Improved immunogenicity in mice of a mammalian cell-derived recombinant hepatitis B vaccine containing pre-S1 and pre-S2 antigens as compared with conventional yeast-derived vaccines", VACCINE, vol. 12, no. 15, November 1994 (1994-11-01), pages 1453 - 1459, XP002117255 * |
XIANG Z ET AL: "MANIPULATION OF THE IMMUNE RESP0NSE TO A PLASMID-ENCODED VIRAL ANTIGEN BY COINOCULATION WITH PLASMIDS EXPRESSING CYTOKINES", IMMUNITY, vol. 2, no. 2, 1 February 1995 (1995-02-01), pages 129 - 135, XP000670098, ISSN: 1074-7613 * |
ZOU J.J. ET AL.: "Structure-function analysis of the p35 subunit of mouse interleukin 12", J. BIOL.CHEM., vol. 270, no. 11, 17 March 1995 (1995-03-17), pages 5864 - 5871, XP002117289 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6821957B2 (en) | 1997-05-20 | 2004-11-23 | University Of Iowa Research Foundation | Vectors and methods for immunization or therapeutic protocols |
US9512382B2 (en) | 2009-10-16 | 2016-12-06 | Bunge Global Innovation, Llc | Oil degumming methods |
Also Published As
Publication number | Publication date |
---|---|
WO1999041402A3 (en) | 1999-11-11 |
JP2002503478A (en) | 2002-02-05 |
CA2320960A1 (en) | 1999-08-19 |
JP2002503461A (en) | 2002-02-05 |
WO1999041369A3 (en) | 1999-09-23 |
MXPA00007889A (en) | 2002-09-18 |
CA2320626A1 (en) | 1999-08-19 |
WO1999041368A2 (en) | 1999-08-19 |
MXPA00007893A (en) | 2002-10-23 |
AU2674199A (en) | 1999-08-30 |
EP1056842A2 (en) | 2000-12-06 |
EP1053343A2 (en) | 2000-11-22 |
AU2674299A (en) | 1999-08-30 |
JP2002507392A (en) | 2002-03-12 |
WO1999041402A2 (en) | 1999-08-19 |
WO1999041369A2 (en) | 1999-08-19 |
MXPA00007891A (en) | 2002-09-18 |
EP1053312A2 (en) | 2000-11-22 |
AU3291099A (en) | 1999-08-30 |
CA2320431A1 (en) | 1999-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1999041368A3 (en) | Optimization of immunomodulatory properties of genetic vaccines | |
WO2004075829A3 (en) | Adjuvanted influenza vaccine | |
WO2000002522A3 (en) | Anthrax vaccine | |
WO2003059381A3 (en) | Immunogenic preparations and vaccines on the basis of mrna | |
MY125202A (en) | Vaccine | |
WO2004006837A3 (en) | Mesothelin vaccines and model systems | |
EP1032417A4 (en) | Bacterial vaccines comprising auxotrophic, attenuated strains of listeria expressing heterologous antigens | |
AU2002355677A1 (en) | Antigenic polypeptides | |
WO2001034801A3 (en) | Recombinant gelatin in vaccines | |
DE69929444D1 (en) | CPG COMPOSITIONS, SAPONIN ADJUVANTIES, AND METHOD OF USE THEREOF | |
WO1999036544A3 (en) | Neisseria meningitidis antigens | |
EP1203817A3 (en) | Compounds and methods for immunotherapy and diagnosis of tuberculosis | |
DE60335010D1 (en) | IMMUNOSTIMULATORY COMPOSITIONS AND METHOD FOR STIMULATING AN IMMUNE RESPONSE | |
NO20001768D0 (en) | Virus encapsulation vaccine, method of preparation and use thereof | |
AU2002365508A1 (en) | Apparatus and method for modification of magnetically immobilized biomolecules | |
WO2003051392A3 (en) | Streptococcus pneumoniae vaccine | |
WO2004062597A3 (en) | Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector | |
WO1999042076A3 (en) | Compounds and methods for immunotherapy and diagnosis of tuberculosis | |
CY1107950T1 (en) | NAVIGATION VACCINE COMPOSITIONS AND METHODS | |
EP1364037A4 (en) | Methods and compositions useful for stimulating an immune response | |
WO2004005476A3 (en) | Nucleic acid compositions for stimulating immune responses | |
WO2002024739A3 (en) | Spas-1 cancer antigen | |
WO2003051288A3 (en) | Mycobacterial vaccine | |
HK1056292A1 (en) | Method of culturing zooplankton, apparatus for culturing by the same, and culture obtained by the same. | |
IL154776A0 (en) | Method for the preparation of 21-hydroxy-6, 19-oxidoprogesterone and derivatives thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
ENP | Entry into the national phase |
Ref document number: 2320960 Country of ref document: CA Ref country code: CA Ref document number: 2320960 Kind code of ref document: A Format of ref document f/p: F Ref country code: JP Ref document number: 2000 531549 Kind code of ref document: A Format of ref document f/p: F |
|
NENP | Non-entry into the national phase |
Ref country code: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2000/007889 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 26741/99 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1999906948 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1999906948 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1999906948 Country of ref document: EP |