WO1999041368A2 - Optimization of immunomodulatory properties of genetic vaccines - Google Patents
Optimization of immunomodulatory properties of genetic vaccines Download PDFInfo
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- WO1999041368A2 WO1999041368A2 PCT/US1999/003020 US9903020W WO9941368A2 WO 1999041368 A2 WO1999041368 A2 WO 1999041368A2 US 9903020 W US9903020 W US 9903020W WO 9941368 A2 WO9941368 A2 WO 9941368A2
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA00007889A MXPA00007889A (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of genetic vaccines. |
JP2000531549A JP2002507392A (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of gene vaccines |
AU26741/99A AU2674199A (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of genetic vaccines |
EP99906948A EP1053312A2 (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of genetic vaccines |
CA002320960A CA2320960A1 (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of genetic vaccines |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US2176998A | 1998-02-11 | 1998-02-11 | |
US7429498P | 1998-02-11 | 1998-02-11 | |
US60/074,294 | 1998-02-11 | ||
US09/021,769 | 1998-02-11 |
Publications (2)
Publication Number | Publication Date |
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WO1999041368A2 true WO1999041368A2 (en) | 1999-08-19 |
WO1999041368A3 WO1999041368A3 (en) | 1999-12-16 |
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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PCT/US1999/003022 WO1999041369A2 (en) | 1998-02-11 | 1999-02-10 | Genetic vaccine vector engineering |
PCT/US1999/003020 WO1999041368A2 (en) | 1998-02-11 | 1999-02-10 | Optimization of immunomodulatory properties of genetic vaccines |
PCT/US1999/003023 WO1999041402A2 (en) | 1998-02-11 | 1999-02-10 | Targeting of genetic vaccine vectors |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/US1999/003022 WO1999041369A2 (en) | 1998-02-11 | 1999-02-10 | Genetic vaccine vector engineering |
Family Applications After (1)
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PCT/US1999/003023 WO1999041402A2 (en) | 1998-02-11 | 1999-02-10 | Targeting of genetic vaccine vectors |
Country Status (6)
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EP (3) | EP1053312A2 (en) |
JP (3) | JP2002507392A (en) |
AU (3) | AU2674199A (en) |
CA (3) | CA2320431A1 (en) |
MX (3) | MXPA00007889A (en) |
WO (3) | WO1999041369A2 (en) |
Cited By (89)
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EP1073710A2 (en) * | 1999-02-04 | 2001-02-07 | Diversa Corporation | Non-stochastic generation of genetic vaccines and enzymes |
WO2001040257A2 (en) * | 1999-12-02 | 2001-06-07 | Maxygen, Inc. | Modified il-12 subunits and nucleic acids encoding them |
WO2001090197A1 (en) * | 2000-05-26 | 2001-11-29 | The Australian National University | Synthetic peptides and uses therefore |
WO2002000232A2 (en) * | 2000-06-26 | 2002-01-03 | Maxygen, Inc. | Methods and compositions for developing spore display systems for medicinal and industrial applications |
US6337186B1 (en) | 1998-06-17 | 2002-01-08 | Maxygen, Inc. | Method for producing polynucleotides with desired properties |
US6339068B1 (en) | 1997-05-20 | 2002-01-15 | University Of Iowa Research Foundation | Vectors and methods for immunization or therapeutic protocols |
US6399383B1 (en) | 1997-10-28 | 2002-06-04 | Maxygen, Inc. | Human papilloma virus vectors |
WO2002046397A1 (en) * | 2000-12-06 | 2002-06-13 | Phylos, Inc. | Method for isolating and identifying effectors |
US6423542B1 (en) | 1999-01-19 | 2002-07-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
US6483011B1 (en) | 1998-11-10 | 2002-11-19 | Maxygen, Inc. | Modified ADP-glucose pyrophosphorylase for improvement and optimization of plant phenotypes |
US6500639B2 (en) | 1998-10-07 | 2002-12-31 | Maxygen, Inc. | DNA shuffling to produce nucleic acids for mycotoxin detoxification |
WO2003008436A2 (en) * | 2001-07-19 | 2003-01-30 | Icogen Corporation | Methods for the identification of peptidyl compounds interacting with extracellular target molecules |
US6531316B1 (en) | 1999-03-05 | 2003-03-11 | Maxyag, Inc. | Encryption of traits using split gene sequences and engineered genetic elements |
US6596539B1 (en) | 1997-10-31 | 2003-07-22 | Maxygen, Inc. | Modification of virus tropism and host range by viral genome shuffling |
WO2003075129A2 (en) | 2002-03-01 | 2003-09-12 | Maxygen, Inc. | Methods, systems, and software for identifying functional bio-molecules |
WO2003078583A2 (en) | 2002-03-09 | 2003-09-25 | Maxygen, Inc. | Optimization of crossover points for directed evolution |
US6686515B1 (en) | 1999-11-23 | 2004-02-03 | Maxygen, Inc. | Homologous recombination in plants |
US6723537B2 (en) | 2001-05-18 | 2004-04-20 | Rigel Pharmaceuticals, Incorporated | Directed evolution of protein in mammalian cells |
WO2004090099A2 (en) | 2003-04-04 | 2004-10-21 | Diversa Corporation | Pectate lyases, nucleic acids encoding them and methods for making and using them |
US6858422B2 (en) | 2000-07-13 | 2005-02-22 | Codexis, Inc. | Lipase genes |
WO2005021714A2 (en) | 2003-08-11 | 2005-03-10 | Diversa Corporation | Laccases, nucleic acids encoding them and methods for making and using them |
JP2005507641A (en) * | 2001-02-02 | 2005-03-24 | ラージ スケール バイオロジー コーポレイション | Method for increasing heteroduplex complementarity |
WO2006009676A2 (en) | 2004-06-16 | 2006-01-26 | Diversa Corporation | Compositions and methods for enzymatic decolorization of chlorophyll |
US6998263B2 (en) | 2000-02-09 | 2006-02-14 | Genvec, Inc. | Methods of preparing and using a viral vector library |
US7074590B2 (en) | 2000-06-23 | 2006-07-11 | Maxygen, Inc. | Chimeric promoters |
US7094875B2 (en) | 2000-06-23 | 2006-08-22 | Maxygen, Inc. | Co-stimulatory polypeptides |
WO2006101584A2 (en) | 2005-03-15 | 2006-09-28 | Diversa Corporation | Cellulases, nucleic acids encoding them and methods for making and using them |
WO2007095398A2 (en) | 2006-02-14 | 2007-08-23 | Verenium Corporation | Xylanases, nucleic acids encoding them and methods for making and using them |
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US7384387B1 (en) | 1999-02-11 | 2008-06-10 | Maxygen, Inc. | High throughput mass spectrometry |
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Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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WO2000009682A1 (en) | 1998-08-12 | 2000-02-24 | Maxygen, Inc. | Dna shuffling of monooxygenase genes for production of industrial chemicals |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995016027A1 (en) * | 1993-12-06 | 1995-06-15 | Bioinvent International Ab | Method of selecting specific bacteriophages |
WO1996011279A2 (en) * | 1994-10-03 | 1996-04-18 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Enhanced immune response by introduction of cytokine gene and/or costimulatory molecule b7 gene in a recombinant virus expressing system |
WO1997007128A1 (en) * | 1995-08-21 | 1997-02-27 | Duke University | A method to increase the density of antigen on antigen presenting cells |
WO1997020078A1 (en) * | 1995-11-30 | 1997-06-05 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
WO1997032987A1 (en) * | 1996-03-08 | 1997-09-12 | University Of Toronto | Methods and nucleic immunogenic compositions encoding antigens and co-stimulatory molecules for immunization |
WO1997035957A1 (en) * | 1996-03-25 | 1997-10-02 | Maxygen, Inc. | Evolving cellular dna uptake by recursive sequence recombination |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4882278A (en) * | 1983-04-29 | 1989-11-21 | President And Fellows Of Harvard College | Non-toxinogenic vibrio cholerae mutants |
IL96475A0 (en) * | 1989-11-29 | 1991-08-16 | Innovative Tech Center | Chimeric proteins |
CA2160878A1 (en) * | 1993-04-19 | 1994-10-27 | Sandra Gertrude Mcelligott | Encapsulation of nucleic acids with conjugates that facilitate and target cellular uptake and gene expression |
SG54115A1 (en) * | 1993-04-27 | 1998-11-16 | Gerber Scient Products Inc | Thermal printing apparatus with improved power supply |
WO1994026787A1 (en) * | 1993-05-07 | 1994-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Method for generating cell type specific phage antibody libraries |
WO1996013250A1 (en) * | 1994-10-27 | 1996-05-09 | Amgem Inc. | Compositions for increased bioavailability of orally delivered therapeutic agents |
EP0808366A1 (en) * | 1995-01-31 | 1997-11-26 | The Rockefeller University | IDENTIFICATION OF DEC, (DENTRITIC AND EPITHELIAL CELLS, 205 kDa), A RECEPTOR WITH C-TYPE LECTIN DOMAINS, NUCLEIC ACIDS ENCODING DEC, AND USES THEREOF |
HUP9802651A3 (en) * | 1995-09-28 | 2001-08-28 | Univ Pittsburgh | Stimulation of cell-mediated immune responses by targeted particulate genetic immunization |
US6489145B1 (en) * | 1996-07-09 | 2002-12-03 | Diversa Corporation | Method of DNA shuffling |
-
1999
- 1999-02-10 JP JP2000531549A patent/JP2002507392A/en not_active Withdrawn
- 1999-02-10 EP EP99906948A patent/EP1053312A2/en not_active Withdrawn
- 1999-02-10 WO PCT/US1999/003022 patent/WO1999041369A2/en not_active Application Discontinuation
- 1999-02-10 CA CA002320431A patent/CA2320431A1/en not_active Abandoned
- 1999-02-10 EP EP99906949A patent/EP1053343A2/en not_active Withdrawn
- 1999-02-10 AU AU26741/99A patent/AU2674199A/en not_active Abandoned
- 1999-02-10 MX MXPA00007889A patent/MXPA00007889A/en unknown
- 1999-02-10 WO PCT/US1999/003020 patent/WO1999041368A2/en not_active Application Discontinuation
- 1999-02-10 WO PCT/US1999/003023 patent/WO1999041402A2/en not_active Application Discontinuation
- 1999-02-10 MX MXPA00007893A patent/MXPA00007893A/en unknown
- 1999-02-10 JP JP2000531583A patent/JP2002503478A/en not_active Withdrawn
- 1999-02-10 JP JP2000531550A patent/JP2002503461A/en not_active Withdrawn
- 1999-02-10 CA CA002320626A patent/CA2320626A1/en not_active Abandoned
- 1999-02-10 EP EP99932508A patent/EP1056842A2/en not_active Withdrawn
- 1999-02-10 CA CA002320960A patent/CA2320960A1/en not_active Abandoned
- 1999-02-10 MX MXPA00007891A patent/MXPA00007891A/en unknown
- 1999-02-10 AU AU26742/99A patent/AU2674299A/en not_active Abandoned
- 1999-02-10 AU AU32910/99A patent/AU3291099A/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995016027A1 (en) * | 1993-12-06 | 1995-06-15 | Bioinvent International Ab | Method of selecting specific bacteriophages |
WO1996011279A2 (en) * | 1994-10-03 | 1996-04-18 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Enhanced immune response by introduction of cytokine gene and/or costimulatory molecule b7 gene in a recombinant virus expressing system |
WO1997007128A1 (en) * | 1995-08-21 | 1997-02-27 | Duke University | A method to increase the density of antigen on antigen presenting cells |
WO1997020078A1 (en) * | 1995-11-30 | 1997-06-05 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
WO1997032987A1 (en) * | 1996-03-08 | 1997-09-12 | University Of Toronto | Methods and nucleic immunogenic compositions encoding antigens and co-stimulatory molecules for immunization |
WO1997035957A1 (en) * | 1996-03-25 | 1997-10-02 | Maxygen, Inc. | Evolving cellular dna uptake by recursive sequence recombination |
Non-Patent Citations (14)
Title |
---|
BENHAM A.M. & NEEFJES J.J.: "Proteasome activity limits the assembly f MHC class I molecules after IFN-gamma stimulation." J. IMMUNOL., vol. 159, no. 2, 15 December 1997 (1997-12-15), pages 5896-5904, XP002117254 * |
CONRY R M ET AL: "SELECTED STRATEGIES TO AUGMENT POLYNUCLEOTIDE IMMUNIZATION" GENE THERAPY, vol. 3, no. 1, 1 January 1996 (1996-01-01), pages 67-74, XP002035090 ISSN: 0969-7128 * |
DAVIS H L ET AL: "DNA-based immunization against hepatitis B surface antigen (HBsAg) in normal and HBsAg-transgenic mice" VACCINE, vol. 15, no. 8, 1 June 1997 (1997-06-01), page 849-852 XP004075668 ISSN: 0264-410X * |
HOURVITZ A. ET AL.: "Reactogenicity and immunogenicity of a new recombinant hepatitis B vaccine containing Pre S antigens: a preliminary report" J. VIRAL HEPATITIS, vol. 3, 1996, pages 37-42, XP002117256 * |
IRVINE K R ET AL: "CYTOKINE ENHANCEMENT OF DNA IMMUNIZATION LEADS TO EFFECTIVE TREATMENT OF ESTABLISHED PULMONARY METASTASES" JOURNAL OF IMMUNOLOGY, vol. 156, 1 January 1996 (1996-01-01), pages 238-245, XP002030631 ISSN: 0022-1767 * |
KLINMAN D.M. ET AL.: "Contribution of CpG motifs to the immunogenicity of DNA vaccines" J. IMMUNOLOGY, vol. 158, 1997, pages 3635-3639, XP002108454 * |
KRIEGER M ET AL: "MOLECULAR FLYPAPER, ATHEROSCLEROSIS, AND HOST DEFENSE: STRUCTURE AND FUNCTION OF THE MACROPHAGE SCAVENGER RECEPTOR" COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, vol. 57, 1 January 1992 (1992-01-01), pages 605-609, XP000561876 * |
MARCO DI A ET AL: "AGONISTIC AND ANTAGONISTIC VARIANTS OF CILIARY NEUROTROPHIC FACTOR (CNTF) REVEAL FUNCTIONAL DIFFERENCES BETWEEN MEMBRANE-BOUND AND SOLUBLE CNTF ALPHA-RECEPTOR" JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 37, 12 September 1997 (1997-09-12), pages 23069-23075, XP002069814 ISSN: 0021-9258 * |
PATTEN P A ET AL: "APPLICATIONS OF DNA SHUFFLING TO PHARMACEUTICALS AND VACCINES" CURRENT OPINION IN BIOTECHNOLOGY, vol. 8, 1997, pages 724-733, XP002916609 ISSN: 0958-1669 * |
SAGGIO I ET AL: "CNTF VARIANTS WITH INCREASED BIOLOGICAL POTENCY AND RECEPTOR SELECTIVITY DEFINE A FUNCTIONAL SITE OF RECEPTOR INTERACTION" EMBO JOURNAL, vol. 14, no. 13, 1 January 1995 (1995-01-01), pages 3045-3054, XP002056939 ISSN: 0261-4189 * |
SHEU S.Y. & LO S.J.: "Deletion or alteration of hydrophobic amino acids at the third transmembrane domains of Hepatitis B surface antigen enhances its production in Escherichia coli." GENE, vol. 160, no. 2, 28 July 1995 (1995-07-28), pages 179-184, XP002117290 * |
SHOUVAL D. ET AL.: "Improved immunogenicity in mice of a mammalian cell-derived recombinant hepatitis B vaccine containing pre-S1 and pre-S2 antigens as compared with conventional yeast-derived vaccines" VACCINE, vol. 12, no. 15, November 1994 (1994-11), pages 1453-1459, XP002117255 * |
XIANG Z ET AL: "MANIPULATION OF THE IMMUNE RESP0NSE TO A PLASMID-ENCODED VIRAL ANTIGEN BY COINOCULATION WITH PLASMIDS EXPRESSING CYTOKINES" IMMUNITY, vol. 2, no. 2, 1 February 1995 (1995-02-01), pages 129-135, XP000670098 ISSN: 1074-7613 * |
ZOU J.J. ET AL.: "Structure-function analysis of the p35 subunit of mouse interleukin 12" J. BIOL.CHEM., vol. 270, no. 11, 17 March 1995 (1995-03-17), pages 5864-5871, XP002117289 * |
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US6423542B1 (en) | 1999-01-19 | 2002-07-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6426224B1 (en) | 1999-01-19 | 2002-07-30 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
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US6521453B1 (en) | 1999-01-19 | 2003-02-18 | Maxygen, Inc. | Oligonucloetide mediated nucleic acid recombination |
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US7384387B1 (en) | 1999-02-11 | 2008-06-10 | Maxygen, Inc. | High throughput mass spectrometry |
US6531316B1 (en) | 1999-03-05 | 2003-03-11 | Maxyag, Inc. | Encryption of traits using split gene sequences and engineered genetic elements |
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US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
US6686515B1 (en) | 1999-11-23 | 2004-02-03 | Maxygen, Inc. | Homologous recombination in plants |
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WO2001040257A2 (en) * | 1999-12-02 | 2001-06-07 | Maxygen, Inc. | Modified il-12 subunits and nucleic acids encoding them |
US6998263B2 (en) | 2000-02-09 | 2006-02-14 | Genvec, Inc. | Methods of preparing and using a viral vector library |
US7820786B2 (en) | 2000-05-26 | 2010-10-26 | Savine Therapeutics Pty Ltd | Synthetic peptides and uses therefore |
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US7612170B2 (en) | 2000-06-23 | 2009-11-03 | Maxygen, Inc. | Co-stimulatory polypeptides |
US7094875B2 (en) | 2000-06-23 | 2006-08-22 | Maxygen, Inc. | Co-stimulatory polypeptides |
US7074590B2 (en) | 2000-06-23 | 2006-07-11 | Maxygen, Inc. | Chimeric promoters |
WO2002000232A2 (en) * | 2000-06-26 | 2002-01-03 | Maxygen, Inc. | Methods and compositions for developing spore display systems for medicinal and industrial applications |
WO2002000232A3 (en) * | 2000-06-26 | 2002-06-20 | Maxygen Inc | Methods and compositions for developing spore display systems for medicinal and industrial applications |
US6858422B2 (en) | 2000-07-13 | 2005-02-22 | Codexis, Inc. | Lipase genes |
US7407786B2 (en) | 2000-07-13 | 2008-08-05 | Codexis, Inc. | Lipase genes |
WO2002046397A1 (en) * | 2000-12-06 | 2002-06-13 | Phylos, Inc. | Method for isolating and identifying effectors |
JP2005507641A (en) * | 2001-02-02 | 2005-03-24 | ラージ スケール バイオロジー コーポレイション | Method for increasing heteroduplex complementarity |
US7193052B2 (en) | 2001-05-18 | 2007-03-20 | Rigel Pharmaceuticals, Incorporated | Discosoma red fluorescent proteins |
US6723537B2 (en) | 2001-05-18 | 2004-04-20 | Rigel Pharmaceuticals, Incorporated | Directed evolution of protein in mammalian cells |
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EP2322629A2 (en) | 2003-04-29 | 2011-05-18 | Pioneer Hi-Bred International Inc. | Novel glyphosate-n-acetyltransferase (GAT) genes |
EP2292634A3 (en) * | 2003-06-13 | 2012-08-08 | The Trustees of The University of Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
EP2404928A1 (en) | 2003-07-02 | 2012-01-11 | Verenium Corporation | Glucanases, nucleic acids encoding them and methods for making and using them |
EP2404929A1 (en) | 2003-07-02 | 2012-01-11 | Verenium Corporation | Glucanases, nucleic acids encoding them and methods for making and using them |
EP2404931A1 (en) | 2003-07-02 | 2012-01-11 | Verenium Corporation | Glucanases, nucleic acids encoding them and methods for making and using them |
EP2404930A1 (en) | 2003-07-02 | 2012-01-11 | Verenium Corporation | Glucanases, nucleic acids encoding them and methods for making and using them |
EP2409981A1 (en) | 2003-07-02 | 2012-01-25 | Verenium Corporation | Glucanases, nucleic acids encoding them and methods for making and using them |
WO2005021714A2 (en) | 2003-08-11 | 2005-03-10 | Diversa Corporation | Laccases, nucleic acids encoding them and methods for making and using them |
EP3190182A1 (en) | 2004-03-08 | 2017-07-12 | DSM IP Assets B.V. | Phospholipases, nucleic acids encoding them and methods for making and using them |
EP2468853A1 (en) | 2004-06-16 | 2012-06-27 | Verenium Corporation | Composition and methods for enzymatic decolorization of chlorophyll |
WO2006009676A2 (en) | 2004-06-16 | 2006-01-26 | Diversa Corporation | Compositions and methods for enzymatic decolorization of chlorophyll |
US9765140B2 (en) | 2004-08-05 | 2017-09-19 | Novartis Ag | IL-17 antagonistic antibodies |
US8119131B2 (en) | 2004-08-05 | 2012-02-21 | Novartis Ag | IL-17 antagonistic antibodies |
US10344084B2 (en) | 2004-08-05 | 2019-07-09 | Novartis Ag | IL-17 antagonistic antibodies |
US8617552B2 (en) | 2004-08-05 | 2013-12-31 | Novarts Ag | IL-17 antibodies |
US7807155B2 (en) | 2004-08-05 | 2010-10-05 | Novartis Ag | IL-17 antagonistic antibodies |
EP2886658A1 (en) | 2005-03-10 | 2015-06-24 | BASF Enzymes LLC | Lyase enzymes, nucleic acids encoding them and methods for making and using them |
WO2006101584A2 (en) | 2005-03-15 | 2006-09-28 | Diversa Corporation | Cellulases, nucleic acids encoding them and methods for making and using them |
EP2949756A2 (en) | 2005-03-15 | 2015-12-02 | BP Corporation North America Inc. | Cellulases, nucleic acids encoding them and methods for making and using them |
EP2216403A2 (en) | 2006-02-02 | 2010-08-11 | Verenium Corporation | Esterases and related nucleic acids and methods |
EP2447363A1 (en) | 2006-02-10 | 2012-05-02 | Verenium Corporation | Cellucloytic enzymes, nucleic acids encoding them and methods for making and using them |
EP2450439A1 (en) | 2006-02-10 | 2012-05-09 | Verenium Corporation | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them |
EP2420570A1 (en) | 2006-02-10 | 2012-02-22 | Verenium Corporation | Arabinofuranosidase enzymes, nucleic acids encoding them and methods for making and using them |
EP2444487A1 (en) | 2006-02-10 | 2012-04-25 | Verenium Corporation | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them |
EP2444490A1 (en) | 2006-02-10 | 2012-04-25 | Verenium Corporation | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them |
EP2444488A1 (en) | 2006-02-10 | 2012-04-25 | Verenium Corporation | Cellucloytic enzymes, nucleic acids encoding them and methods for making and using them |
EP2444489A1 (en) | 2006-02-10 | 2012-04-25 | Verenium Corporation | Cellucloytic enzymes, nucleic acids encoding them and methods for making and using them |
EP2415864A1 (en) | 2006-02-10 | 2012-02-08 | Verenium Corporation | Oligomerase-2 (or beta-xylosidase) enzymes, nucleic acids encoding them and methods for making and using them |
WO2007095398A2 (en) | 2006-02-14 | 2007-08-23 | Verenium Corporation | Xylanases, nucleic acids encoding them and methods for making and using them |
EP2548955A1 (en) | 2006-02-14 | 2013-01-23 | Verenium Corporation | Xylanases, nucleic acids encoding them and methods for making and using them |
EP2548956A1 (en) | 2006-02-14 | 2013-01-23 | Verenium Corporation | Xylanases, nucleic acids encoding them and methods for making and using them |
EP2548954A1 (en) | 2006-02-14 | 2013-01-23 | Verenium Corporation | Xylanases, nucleic acids encoding them and methods for making and using them |
EP2112227A1 (en) | 2006-03-07 | 2009-10-28 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
EP3153580A2 (en) | 2006-03-07 | 2017-04-12 | BASF Enzymes LLC | Aldolases, nucleic acids encoding them and methods for making and using them |
EP2322643A1 (en) | 2006-03-07 | 2011-05-18 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
EP2316962A1 (en) | 2006-03-07 | 2011-05-04 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
EP2388316A2 (en) | 2006-03-07 | 2011-11-23 | Verenium Corporation | Aldolases, nucleic acids encoding them and methods for making and using them |
EP2385108A1 (en) | 2006-03-07 | 2011-11-09 | Verenium Corporation | Aldolases, nucleic acids encoding them and methods for making and using them |
EP2444413A1 (en) | 2006-08-04 | 2012-04-25 | Verenium Corporation | Methods for oil or gas well drilling, washing and/or fracturing |
EP2397486A1 (en) | 2006-09-21 | 2011-12-21 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
EP2617815A2 (en) | 2006-09-21 | 2013-07-24 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
WO2008036863A2 (en) | 2006-09-21 | 2008-03-27 | Verenium Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
EP2620495A2 (en) | 2006-09-21 | 2013-07-31 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
EP2617729A2 (en) | 2006-09-21 | 2013-07-24 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
EP2617820A2 (en) | 2006-09-21 | 2013-07-24 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
EP2617817A2 (en) | 2006-09-21 | 2013-07-24 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
EP2617823A2 (en) | 2006-09-21 | 2013-07-24 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
EP2617728A2 (en) | 2006-09-21 | 2013-07-24 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
EP2617821A2 (en) | 2006-09-21 | 2013-07-24 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
EP2617819A2 (en) | 2006-09-21 | 2013-07-24 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
EP2617816A2 (en) | 2006-09-21 | 2013-07-24 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
WO2008080093A2 (en) | 2006-12-21 | 2008-07-03 | Verenium Corporation | Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them |
EP3101128A1 (en) | 2006-12-21 | 2016-12-07 | BASF Enzymes LLC | Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them |
EP3540053A1 (en) | 2006-12-21 | 2019-09-18 | BASF Enzymes, LLC | Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them |
EP2479267A1 (en) | 2006-12-21 | 2012-07-25 | Verenium Corporation | Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them |
EP2479266A1 (en) | 2006-12-21 | 2012-07-25 | Verenium Corporation | Amylases and glucoamylases, nucleic acids encoding them and methods for making and using them |
WO2008095033A2 (en) | 2007-01-30 | 2008-08-07 | Verenium Corporation | Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them |
EP2559704A1 (en) | 2007-02-08 | 2013-02-20 | Domantis Limited | Antibody single variable domains against serum albumin |
WO2008098198A2 (en) | 2007-02-08 | 2008-08-14 | The California Institute Of Technology | Alkane oxidation by modified hydroxylases |
EP2559702A1 (en) | 2007-02-08 | 2013-02-20 | Domantis Limited | Antibody single variable domains against serum albumin |
EP2559703A1 (en) | 2007-02-08 | 2013-02-20 | Domantis Limited | Antibody single variable domains against serum albumin |
WO2009045627A2 (en) | 2007-10-03 | 2009-04-09 | Verenium Corporation | Xylanases, nucleic acids encoding them and methods for making and using them |
EP2708602A2 (en) | 2007-10-03 | 2014-03-19 | Verenium Corporation | Xylanases, nucleic acids encoding them and methods for making and using them |
WO2009088949A1 (en) | 2008-01-03 | 2009-07-16 | Verenium Corporation | Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them |
EP2706122A2 (en) | 2008-01-03 | 2014-03-12 | Verenium Corporation | Isomerases, nucleic acids encoding them and methods for making and using them |
EP2865750A2 (en) | 2008-01-03 | 2015-04-29 | BASF Enzymes LLC | Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them |
EP3115459A2 (en) | 2008-05-23 | 2017-01-11 | E. I. du Pont de Nemours and Company | Novel dgat genes for increased seed storage lipid production and altered fatty acid profiles in oilseed plants |
WO2010025395A2 (en) | 2008-08-29 | 2010-03-04 | Verenium Corporation | Hydrolases, nucleic acids encoding them and methods for making and using them |
EP3460061A1 (en) | 2008-09-26 | 2019-03-27 | Tocagen Inc. | Recombinant replication competent murine leukemia gamma-retrovirus (mlv) for the expression of heat-stabilized cytosine deaminase |
EP2698374A1 (en) | 2009-05-21 | 2014-02-19 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
WO2010135588A2 (en) | 2009-05-21 | 2010-11-25 | Verenium Corporation | Phytases, nucleic acids encoding them and methods for making and using them |
WO2011022597A1 (en) | 2009-08-20 | 2011-02-24 | Pioneer Hi-Bred International, Inc. | Functional expression of shuffled yeast nitrate transporter (ynti) in maize to improve nitrate uptake under low nitrate environment |
WO2011046815A1 (en) | 2009-10-16 | 2011-04-21 | Bunge Oils, Inc. | Oil degumming methods |
WO2011046812A1 (en) | 2009-10-16 | 2011-04-21 | Verenium Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
US9045712B2 (en) | 2009-10-16 | 2015-06-02 | Bunge Global Innovation, Llc | Oil degumming methods |
WO2011082304A1 (en) | 2009-12-31 | 2011-07-07 | Pioneer Hi-Bred International, Inc. | Engineering plant resistance to diseases caused by pathogens |
WO2012021785A1 (en) | 2010-08-13 | 2012-02-16 | Pioneer Hi-Bred International, Inc. | Compositions and methods comprising sequences having hydroxyphenylpyruvate dioxygenase (hppd) activity |
WO2013166113A1 (en) | 2012-05-04 | 2013-11-07 | E. I. Du Pont De Nemours And Company | Compositions and methods comprising sequences having meganuclease activity |
WO2014153242A1 (en) | 2013-03-14 | 2014-09-25 | Pioneer Hi-Bred International, Inc. | Compositions having dicamba decarboxylase activity and methods of use |
WO2014153234A1 (en) | 2013-03-14 | 2014-09-25 | Pioneer Hi-Bred International, Inc. | Compositions having dicamba decarboxylase activity and methods of use |
WO2014150914A2 (en) | 2013-03-15 | 2014-09-25 | Pioneer Hi-Bred International, Inc. | Phi-4 polypeptides and methods for their use |
WO2015023846A2 (en) | 2013-08-16 | 2015-02-19 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
EP4159028A1 (en) | 2013-09-13 | 2023-04-05 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2015038734A2 (en) | 2013-09-13 | 2015-03-19 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
EP3692786A1 (en) | 2013-09-13 | 2020-08-12 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2015120276A1 (en) | 2014-02-07 | 2015-08-13 | Pioneer Hi Bred International Inc | Insecticidal proteins and methods for their use |
EP3705489A1 (en) | 2014-02-07 | 2020-09-09 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2015120270A1 (en) | 2014-02-07 | 2015-08-13 | Pioneer Hi Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2016061206A1 (en) | 2014-10-16 | 2016-04-21 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2016144688A1 (en) | 2015-03-11 | 2016-09-15 | Pioneer Hi Bred International Inc | Insecticidal combinations of pip-72 and methods of use |
WO2016186986A1 (en) | 2015-05-19 | 2016-11-24 | Pioneer Hi Bred International Inc | Insecticidal proteins and methods for their use |
EP3943602A1 (en) | 2015-08-06 | 2022-01-26 | Pioneer Hi-Bred International, Inc. | Plant derived insecticidal proteins and methods for their use |
WO2017023486A1 (en) | 2015-08-06 | 2017-02-09 | Pioneer Hi-Bred International, Inc. | Plant derived insecticidal proteins and methods for their use |
WO2017105987A1 (en) | 2015-12-18 | 2017-06-22 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2017192560A1 (en) | 2016-05-04 | 2017-11-09 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
EP3960863A1 (en) | 2016-05-04 | 2022-03-02 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
EP3954202A1 (en) | 2016-07-01 | 2022-02-16 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
WO2018005411A1 (en) | 2016-07-01 | 2018-01-04 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins from plants and methods for their use |
WO2018084936A1 (en) | 2016-11-01 | 2018-05-11 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
EP4050021A1 (en) | 2016-11-01 | 2022-08-31 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2018111551A1 (en) | 2016-12-14 | 2018-06-21 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2018118811A1 (en) | 2016-12-22 | 2018-06-28 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2018148001A1 (en) | 2017-02-08 | 2018-08-16 | Pioneer Hi-Bred International Inc | Insecticidal combinations of plant derived insecticidal proteins and methods for their use |
WO2018208882A1 (en) | 2017-05-11 | 2018-11-15 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
WO2020198731A2 (en) | 2019-03-28 | 2020-10-01 | Danisco Us Inc | Engineered antibodies |
WO2022015619A2 (en) | 2020-07-14 | 2022-01-20 | Pioneer Hi-Bred International, Inc. | Insecticidal proteins and methods for their use |
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WO1999041369A3 (en) | 1999-09-23 |
JP2002507392A (en) | 2002-03-12 |
WO1999041368A3 (en) | 1999-12-16 |
MXPA00007893A (en) | 2002-10-23 |
EP1053312A2 (en) | 2000-11-22 |
AU3291099A (en) | 1999-08-30 |
MXPA00007891A (en) | 2002-09-18 |
WO1999041369A2 (en) | 1999-08-19 |
AU2674199A (en) | 1999-08-30 |
CA2320626A1 (en) | 1999-08-19 |
CA2320960A1 (en) | 1999-08-19 |
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AU2674299A (en) | 1999-08-30 |
EP1053343A2 (en) | 2000-11-22 |
JP2002503461A (en) | 2002-02-05 |
CA2320431A1 (en) | 1999-08-19 |
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JP2002503478A (en) | 2002-02-05 |
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