Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
  • A61K8/362—Polycarboxylic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/31—Hydrocarbons
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/37—Esters of carboxylic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/60—Sugars; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/89—Polysiloxanes
  • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
  • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q5/00—Preparations for care of the hair

Definitions

• the present invention relates to cosmetic compositions.
• cosmetic compositions which provide improved moisturization, skin feel, skin softness, skin smoothness benefits, together with excellent rub-in and absorption characteristics.
• the compositions also display excellent stability characteristics at normal and elevated temperatures.
• Skin is made up of several layers of cells which coat and protect the keratin and collagen fibrous proteins that form the skeleton of its structure.
• the outermost of these layers, referred to as the stratum corneum is known to be composed of 25nm protein bundles surrounded by 8nm thick layers.
• Anionic surfactants and organic solvents typically penetrate the stratum corneum membrane and, by delipidization (i.e. removal of the lipids from the stratum corneum), destroy its integrity. This destruction of the skin surface topography leads to a rough feel and may eventually permit the surfactant or solvent to interact with the keratin, creating irritation.
• compositions which will assist the stratum corneum in maintaining its barrier and water-retention functions at optimum performance in spite of deleterious interactions which the skin may encounter in washing, work, and recreation.
• compositions which will assist the stratum corneum in maintaining its water gradient, but which do so with improved skin feel, skin softness and skin smoothness and improved absorption into the skin.
• Polyol fatty acid polyester compounds are known for use in skin care compositions.
• EP-A-458600, EP-A-466410, EP-A-519727 and EP-A-587288 disclose compositions containing polyol fatty acid polyester compounds for use in skin care compositions.
• branched chain hydrocarbon such as isohexadecane are known for use in skin care compositions.
• compositions herein also providing excellent moisturisation, rub-in and absorption characteristics.
• a cosmetic composition suitable for topical application to the skin or hair comprising:
• each carboxylic acid moiety has from about 8 to about 22 carbon atoms, and wherein said liquid polyol carboxylic acid ester has a complete melting point of less than about 30°C;
• compositions of the invention provide improved skin feel, skin softness and skin smoothness benefits and/or improved rub-in/absorption characteristics.
• a cosmetic method of treatment of the skin comprising applying to the skin a composition according to the present invention.
• compositions of the present invention comprises a liquid polyol carboxylic acid ester component together with a branched chain hydrocarbon as well as various optional ingredients as indicated below. All levels and ratios are by weight of total composition, unless otherwise indicated. Chain length and degrees of ethoxylation are also specified on a weight average basis.
• skin conditioning agent means a material which provides a “skin conditioning benefit”.
• skin conditioning benefit means any cosmetic conditioning benefit to the skin including, but not limited to, moisturization, humectancy (i.e. the ability to retain or hold water or moisture in the skin), emolliency, visual improvement of the skin surface, soothing of the skin, softening of the skin, improvement in skin feel, and the like.
• complete melting point means a melting point as measured by the well-known technique of Differential Scanning Calorimetry (DSC).
• the complete melting point is the temperature at the intersection of the baseline, i.e. the specific heat line, with the line tangent to the trailing edge of the endothermic peak.
• a scanning temperature of 5°C/minute is generally suitable in the present invention for measuring the complete melting points. However, it should be recognised that more frequent scanning rates may be deemed appropriate by the analytical chemist skilled in the art in specific circumstances.
• a DSC technique for measuring complete melting points is also described in US Patent No. 5,306,514, to Letton et al., issued, April 26, 1994.
• nonocclusive means that the component as so described does not substantially or block the passage of air and moisture through the skin surface.
• compositions herein comprise a liquid, r c»ao-rrb/o".xVy7ll ⁇ irc» atrc>itAd o ecsttoerr.
• compositions of the present invention preferably comprise from about 0.01% to about 20%, more preferably from about 0.1% to about 15%, and especially from about 0.5% to about 10% by weight of the polyol ester.
• the level of polyol ester by weight of the oil in the composition is preferably from about 1% to about 85%, more preferably from about 5% to about 75%.
• the weight ratio of the liquid carboxylic acid polyol ester to the emollient material is preferably in the range of from about 5: 1 to about 1 :5, more preferably in the range of from 3: 1 to about 1 :3.
• the polyol ester preferred for use herein is a nonocclusive liquid or liquifiable polyol carboxylic acid ester.
• These polyol esters are derived from a polyol radical or moiety and one or more carboxylic acid radicals or moieties. In other words, these esters contain a moiety derived from a polyol and one or more moieties derived from a carboxylic acid.
• These carboxylic acid esters can also be derived from a carboxylic acid.
• These carboxylic acid esters can also be described as liquid polyol fatty acid esters, because the terms carboxylic acid and fatty acid are often used interchangeably by those skilled in the art.
• the preferred liquid polyol polyesters employed in this invention comprise certain polyols, especially sugars or sugar alcohols, esterified with at least four fatty acid groups. Accordingly, the polyol starting material must have at least four esterifiable hydroxyl groups.
• preferred polyols are sugars, including monosaccharaides and disaccharides, and sugar alcohols. Examples of monosacchandes containing four hydroxyl groups are xylose and arabinose and the sugar alcohol derived from xylose, which has five hydroxyl groups, i.e., xylitol.
• the monosaccharide, erythrose is not suitable in the practice of this invention since it only contains three hydroxyl groups, but the sugar alcohol derived from erythrose, i.e., erythritol, contains four hydroxyl groups and accordingly can be used. Suitable five hydroxyl group-containing monosacchandes are galactose, fructose, and sorbose. Sugar alcohols containing six -OH groups derived from the hydrolysis products of sucrose, as well as glucose and sorbose, e.g., sorbitol, are also suitable. Examples of disaccharide polyols which can be used include maltose, lactose, and sucrose, all of which contain eight hydroxyl groups.
• Preferred polyols for preparing the polyesters for use in the present invention are selected from the group consisting of erythritol, xylitol, sorbitol, glucose, and sucrose. Sucrose is especially preferred.
• the polyol starting material having at least four hydroxyl groups is esterified on at least four of the -OH groups with a fatty acid containing from about 8 to about 22 carbon atoms.
• fatty acids include caprylic, capric, lauric, myristic, myristoleic, palmitic, palmitoleic, stearic, oleic, ricinoleic, linoleic, linolenic, eleostearic, arachidic, arachidonic, behenic, and erucic acid.
• the fatty acids can be derived from naturally occurring or synthetic fatty acids; they can be saturated or unsaturated, including positional and geometrical isomers. However, in order to provide liquid polyesters preferred for use herein, at least about 50% by weight of the fatty acid incorporated into the polyester molecule should be unsaturated. Oleic and linoleic acids, and mixtures thereof, are especially preferred.
• the polyol fatty acid polyesters useful in this invention should contain at least four fatty acid ester groups. It is not necessary that all of the hydroxyl groups of the polyol be esterified with fatty acid, but it is preferable that the polyester contain no more than two unesterified hydroxyl groups. Most preferably, substantially all of the hydroxyl groups of the polyol are esterified with fatty acid, i.e., the polyol moiety is substantially completely esterified.
• the fatty acids esterified to the polyol molecule can be the same or mixed, but as noted above, a substantial amount of the unsaturated acid ester groups must be present to provide liquidity.
• sucrose fatty triester would not be suitable for use herein because it does not contain the required four fatty acid ester groups.
• a sucrose tetra-fatty acid ester would be suitable, but is not preferred because it has more than two unesterified hydroxyl groups.
• a sucrose hexa-fatty acid ester would be preferred because it has no more than two unesterified hydroxyl groups.
• Highly preferred compounds in which all the hydroxyl groups are esterified with fatty acids include the liquid sucrose octa-substituted fatty acid esters.
• polyol fatty acid polyesters containing at least four fatty acid ester groups suitable for use in the present invention: glucose tetraoleate, the glucose tetraesters of soybean oil fatty acids (unsaturated), the mannose tetraesters of mixed soybean oil fatty acids, the galactose tetraesters of oleic acid, the arabinose tetraesters of linoleic acid, xylose tetralinoleate, galactose pentaoleate, sorbitol tetraoleate, the sorbitol hexaesters of unsaturated soybean oil fatty acids, xylitol pentaoleate, sucrose tetraoleate, sucrose pentaoletate, sucrose hexaoleate, sucrose hepatoleate, sucrose octaoleate, and mixtures thereof.
• the preferred liquid polyol polyesters preferred for use herein have complete melting points below about 30°C, preferably below about 27.5°C, more preferably below about 25°C. Complete melting points reported herein are measured by Differential Scanning Calorimetry (DSC).
• the polyol fatty acid polyesters suitable for use herein can be prepared by a variety of methods well known to those skilled in the art. These methods include: transesterification of the polyol with methyl, ethyl or glycerol fatty acid esters using a variety of catalysts; acylation of the polyol with a fatty acid chloride; acylation of the polyol with a fatty acid anhydride; and acylation of the polyol with a fatty acid, per se. See U.S. Patent No. 2,831,854; U.S. Patent No. 4,005,196, to Jandacek, issued January 25, 1977.
• a second essential component of the present invention is a branched chain hydrocarbon having an weight average molecular weight of from about 100 to about 15,000 , preferably from about 100 to 1000.
• Preferred for use in the compositions herein are branched chain hydrocarbons selected from isododecane, isohexadecane, isoeicosane, isooctahexacontane, isohexapentacontahectane, isopentacontaoctactane, and mixture thereof, especially isohexadecane and isooctacontane, and mixtures thereof.
• the branched chain aliphatic hydrocarbon is preferred herein from the viewpoint of providing improved skin feel and absorption characteristics.
• Suitable for use herein are branched chain aliphatic hydrocarbons sold under the trade name Permethyl (RTM) and commercially available from Presperse Inc., P.O. Box 735, South Plainfield, N.J. 07080, U.S.A. Particularly suitable from the viewpoint of improved skin fell, spreadability and application characteristics is a mixture of isohexadecane and isooctahexacontane.
• RTM Permethyl
• the branched chain hydrocarbon is present in the compositions herein at a level of from about 0.1% to about 15%, preferably from about 0.1% to about 10%, especially from about 0.1% to about 5% by weight of composition.
• the present compositions can be used for any suitable purpose.
• the present compositions are suitable for topical application to the skin or hair.
• the skin care compositions can be in the form of creams, lotions, gels, and the like.
• the cosmetic compositions herein are in the form of an oil-in-water emulsion of one or more oil phases in an aqueous continuous phase, each oil phase comprising a single oily component or a mixture of oily components in miscible or homogeneous form but said different oil phases containing different materials or combinations of materials from each other.
• the overall level of oil phase components in the compositions of the invention is preferably from about 0.1% to about 60%, preferably from about 1% to about 30% and more preferably from about 1% to about 10% by weight.
• compositions preferably comprise, as either all or a portion of the oil phase or oil phases referred to above a first silicone-containing phase comprising a crosslinked polyorganosiloxane polymer and a silicone oil, wherein the composition comprises 0.1% to about 20%, preferably from about 0.5% to about 10%, more preferably from about 0.5% to about 5%, by weight of composition, of the combination of crosslinked silicone and silicone oil.
• the first silicone-containing phase comprises from about 10% to about 40%, more preferably from about 20% to about 30%, by weight of the first silicone-containing phase, of the crosslinked polyorganosiloxane polymer and from about 60% to about 90%, preferably from about 70% to about 80%, by weight of the first silicone-containing phase, of the silicone oil.
• the crosslinked polyorganosiloxane polymer comprises polyorganosiloxane polymer crosslinked by a crosslinking agent.
• Crosslinking agents for use herein include any crosslinking agents useful for the preparation of crosslinked silicones. Suitable crosslinking agents herein include those represented by the following general formula: (R) 3 Si - O Si Si(R) 3
• R ⁇ is methyl, ethyl, propyl or phenyl
• crosslinking agent has the general formula
• the crosslinking agent has the following general formula:
• z is in the range of from about 1 to about 1000, preferably from about 1 to about 100.
• the crosslinked polysiloxane polymer preferably comprises from about 10% to about 50%, more preferably from about 20% to about 30%, by weight the crosslinked polysiloxane polymer, of crosslinking agent.
• Any polyorganosiloxane polymers suitable for use in skin care compositions can be used herein.
• Suitable polyorganosiloxane polymers for use herein include those represented by the following general formula:
• R ⁇ is methyl, ethyl, propyl or phenyl
• R3 and R4 are independently selected from methyl, ethyl, propyl and phenyl
• R is an end-gap, such as an optionally hydroxy-substituted alkyl group having from 1 to 50 carbon atoms, preferably an alkyl group having from 1 to 5 carbon atoms, more preferably an alkyl group having 1 or 2 carbon atoms
• p is an integer in the range of from about 1 to about 2000, preferably from about 1 to about 500
• q is an integer in the range of from about 1 to about 1000, preferably from about 1 to about 500.
• R1 , R2, R3, R4, p and q are as defined above.
• p and q reflect the number of Si-O linkages in the polymer chain and R ⁇ and R2 and R3 and R4 may vary going from one monomer unit to the next.
• suitable polyorganosiloxane polymers for use herein include methyl vinyl dimethicone, methyl vinyl diphenyl dimethicone and methyl vinyl phenyl methyl diphenyl dimethicone.
• the polyorganosiloxane polymer is selected from an alkylarylpolysiloxane polymer having the general formula:
• n is as defined above.
• m is in the range of from about 1 to about 1000, preferably from about 200 to about 800.
• the first silicone-containing phase also comprises a silicone oil.
• a silicone oil Any straight chain, branched and cyclic silicones suitable for use in skin care compositions can be used herein.
• the silicone oils can be volatile or nonvolatile. Suitable silicone oils for use herein include silicone oils having a weight average molecular weight of about 100,000 or less, preferably about 50,000 or less.
• the silicone oil is selected from silicone oils having a weight average molecular weight in the range from about 100 to about 50,000, and preferably from about 200 to about 40,000.
• the silicone oil is selected from dimethicone, decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane and phenyl methicone, and mixtures thereof, most preferably phenyl methicone.
• Suitable materials for use in the first silicone-containing phase are available under the tradename KSG supplied by Shinetsu Chemical Co., Ltd, for example KSG- 15, KSG- 16, KSG- 17, KSG- 18. These materials contain a combination of crosslinked polyoragnosiloxane polymer and silicone oil. Particularly preferred for use herein especially in combination with the organic amphiphilic emulsifier material is KSG- 18.
• KSG- 18, is Cyclomethicone Dimethicone/Vinyl Dimethicone Crosspolymer, Dimethicone
• compositions herein preferably also comprise a second non-crosslinked silicone-containing phase.
• the second silicone- containing phase is present in a level of from about 0.1% to about 20%, especially from about 0.1% to about 10% by weight of composition.
• Suitable silicone fluids for use in the second silicone-containing phase herein include water-insoluble silicones inclusive of non-volatile polyalkyl and polyaryl siloxane gums and fluids, volatile cyclic and linear polyalkylsiloxanes, polyalkoxylated silicones, amino and quaternary ammonium modified silicones, and mixtures thereof.
• the second silicone-containing phase comprises a silicone gum or a mixture of silicones including the silicone gum.
• silicone gum means high molecular weight silicone-based fluids having a mass-average molecular weight in excess of about 200,000 and preferably from about 200,000 to about 400,000. Silicone oils generally have a molecular weight of less than about 200,000. Typically, silicone gums have a viscosity at 25°C in excess of about 1,000,000 mm ⁇ .s-l .
• the silicone gums include dimethicones as described by Petrarch and others including US-A-4, 152,416, May 1, 1979 to Spitzer, et al, and Noll, Walter, Chemistry and Technology of Silicones. New York: Academic Press 1968. Also describing silicone gums are General Electric Silicone Rubber Product Data Sheets SE 30, SE 33, SE 54 and SE 76.
• Silicone gums for use herein include any silicone gum suitable for use in a skin care composition. Suitable silicone gums for use herein are silicone gums having a molecular weight of from about 200,000 to about 4,000,000 selected from dimethiconol, fluorosilicone and dimethicone and mixtures thereof.
• Dimethiconol-based silicones suitable for use herein can have the chemical structure (II):
• n is from about 2000 to about 40,000, preferably from about 3000 to about 30,000.
• Exemplary fluorosilicones useful herein can have a molecular weight of from about 200,000 to about 300,000, preferably from about 240,000 to about 260,000 and most preferably about 250,000.
• silicone gums include polydimethylsiloxane, (polydimethylsiloxane)(methylvinylsiloxane) copolymer, poly(dimethylsiloxane)(diphenyl)(methylvinylsiloxane) copolymer and mixtures thereof.
• the silicone gum used herein can be incorporated into the composition as part of a mixture of silicones.
• the silicone gum preferably constitutes from about 5% to about 40%, especially from about 10% to 20% by weight of the silicone mixture.
• the silicone or silicone mixture preferably constitutes from about 0.1% to about 20%, more preferably from about 0.1% to about 15%, and especially from about 0.1% to about 10% by weight of composition.
• Suitable silicone gum-based silicone mixtures for use in the second silicone- containing phase of the compositions herein include mixtures consisting essentially of:
• the ratio of i) to ii) is from about 10:90 to about 20:80 and wherein said silicone gum-based component has a final viscosity of from about 500 mm ⁇ .s'l to about 10,000 mm ⁇ .s-l.
• the silicone-based carriers suitable for use herein include certain silicone fluids.
• the silicone fluid can be either a polyalkyl siloxane, a polyaryl siloxane, a polyalkylaryl siloxane or a polyether siloxane copolymer. Mixtures of these fluids can also be used and are preferred in certain executions.
• the polyalkyl siloxane fluids that can be used include, for example, polydimethylsiloxanes with viscosities ranging from about 0.65 to 600,000 mm 2 .s _ 1 , preferably from about 0.65 to about 10,000 mm 2 .s-l at 25°C. These siloxanes are available, for example, from the General Electric Company as the Viscasil (RTM) series and from Dow Corning as the Dow Corning 200 series.
• the essentially non-volatile polyalkylarylsiloxane fluids that can be used include, for example, polymethylphenylsiloxanes, having viscosities of about 0.65 to 30,000 mm 2 .s-l at 25°C.
• siloxanes are available, for example, from the General Electric Company as SF 1075 methyl phenyl fluid or from Dow Corning as 556 Cosmetic Grade Fluid. Also suitable for use herein are certain volatile cyclic polydimethylsiloxanes having a ring structure inco ⁇ orating from about 3 to about 7 (CH3)2SiO moieties.
• the viscosity can be measured by means of a glass capillary viscometer as set forth in Dow Corning Corporate Test Method CTM0004, July 29, 1970.
• the viscosity of the silicone blend constituting the second fluid phase ranges from about 500 mm 2 .s"l to about 100,000 mm 2 . s ⁇ l,. preferably from about 1000 mm 2 .s"l to about 10,000 mm 2 .s ⁇ l .
• An especially preferred silicone-gum based component for use in the compositions herein is a dimethiconol gum having a molecular weight of from about 200,000 to about 4,000,000 along with a silicone carrier with a viscosity of about 0.65 to 100 mm 2 .s ⁇ l .
• An example of this silicone component is Dow Corning Q2-1403 (85% 5 mm ⁇ .s-' Dimethicone Fluid/15%) Dimethiconol) and Dow Corning Q2-1401 available from Dow Corning.
• silicone suitable for use in the second silicone-containing phase herein include polydiorganosiloxane-polyoxyalkylene copolymers containing at least one polydiorganosiloxane segment and at least one polyoxyalkylene segment, said polydiorganosiloxane segment consisting essentially of
• RbSiO(4_b)/2 siloxane units wherein b has a value of from about 0 to about 3, inclusive, there being an average value of approximately 2 R radicals per silicon for all siloxane units in the copolymer, and R denotes a radical selected from methyl, ethyl, vinyl, phenyl and a divalent radical bonding said polyoxyalkylene segment to the polydiorganosiloxane segment, at least about 95% of all R radicals being methyl; and said polyoxyalkylene segment having an average molecular weight of at least about 1000 and consisting of from about 0 to about 50 mol percent polyoxypropylene units and from about 50 to about 100 mol percent polyoxyethylene units, at least one terminal portion of said polyoxyalkylene segment being bonded to said polydiorganosiloxane segment, any terminal portion of said polyoxyalkylene segment not bonded to said polydiorganosiloxane segment being satisfied by a terminating radical; the weight ratio of
• Preferred for use herein are polydiorganosiloxane-polyoxyalkylene copolymers having the general formula:
• x and y are selected such that the weight ratio of polydiorganosiloxane segments to polyoxalkalkylene segments is from about 2 to about 8, the mol ratio of a:(a+b) is from about 0.5 to about 1, and R is a chain terminating group, especially selected from hydrogen; hydroxyl; alkyl, such as methyl, ethyl, propyl, butyl, benzyl; aryl, such as phenyl; alkoxy such as methoxy, ethoxy, propoxy, butoxy; benzyloxy; aryloxy, such as phenoxy; alkenyloxy, such as vinyloxy and allyloxy; acyloxy, such as acetoxy, acryloxy and propionoxy and amino, such as dimethylamino.
• the number of and average molecular weights of the segments in the copolymer are such that the weight ratio of polydiorganosiloxane segments to polyoxyalkylene segments in the copolymer is preferably from about 2.5 to about 4.0.
• Suitable copolymers are available commercially under the tradenames Belsil (RTM) from Wacker-Chemie GmbH, Geschafts Buffalo S, Postfach D-8000 Kunststoff 22 and Abil (RTM) from Th. Goldschmidt Ltd., Tego House, Victoria Road, Ruislip, Middlesex, HA4 OYL, for example Belsil (RTM) 6031 and Abil (RTM) B88183.
• RTM Belsil
• a particularly preferred copolymer for use herein includes Dow Corning DC3225C which has the CTFA designation Dimethicone/Dimethicone copolyol.
• a third oil phase is present in an amount of from about 0.1% to about 15%, more preferably from about 1% to about 10% by weight of composition.
• the third oil phase can be either a separate phase or can form one phase together with either or both of the first and second silicone phases.
• the third oil phase is a separate phase.
• the third oil phase preferably comprises a non-silicone organic oil, such as a natural or synthetic oil selected from mineral, vegetable, and animal oils, fats and waxes, fatty acid esters, fatty alcohols, fatty acids and mixtures thereof, which ingredients are useful for achieving emollient cosmetic properties.
• the first oil phase component is preferably essentially silicone- free, i.e., it contains no more than about 10%, preferably no more than about 5% by weight of silicone-based materials. It will be understood that the oil phase may contain, for example, up to about 25%, preferably up to only about 10% of oil phase soluble emulsifier ingredients. Such ingredients are not to be considered as oil phase components from the viewpoint of determining the oil phase level and required HLB.
• the overall required HLB of the oil phase is from about 8 to about 12, especially from about 9 to about 11, required HLB being determined by summing the individual required HLB values for each component of the oil phase multiplied by its W/W percentage in the oil phase (see ICI Literature on HLB system; ICI reference paper ref 51/0010/303/15m., first printed in 1976, revised in 1984 and May 1992).
• Suitable first oil phase components for use herein include, for example, optionally hydroxy-substituted C8-C50 unsaturated fatty acids and esters thereof, beeswax, saturated and unsaturated fatty alcohols such as behenyl alcohol and cetyl alcohol, hydrocarbons such as mineral oils, petrolatum and squalane, fatty sorbitan esters (see US-A-3988255, Seiden, issued October 26 1976), oils consisting of greater than 20% cholesterol esters, lanolin and lanolin derivatives, animal and vegetable triglycerides such as almond oil, peanut oil, wheat germ oil, linseed oil, jojoba oil, oil of apricot pits, walnuts, palm nuts, pistachio nuts, sesame seeds, rapeseed, cade oil, corn oil, peach pit oil, poppyseed oil, pine oil, castor oil, soybean oil, avocado oil, safflower oil, coconut oil, hazelnut oil, olive oil, grapeseed
• Preferred embodiments herein comprise from about 0.1% to about 10% by weight of an unsaturated fatty acid or ester.
• Preferred unsaturated fatty acids and esters for use herein are optionally hydroxy substituted C8-C50 unsaturated fatty acids and esters, especially esters of ricinoleic acid.
• the unsaturated fatty acid or ester component is valuable herein in combination with the liquid crystal-forming emulsifier for improving the skin feel and rub-in characteristics of the compositon. Highly preferred in this respect is cetyl ricinoleate.
• a further preferred component of the compositions herein is an organic amphiphilic surfactant which is capable of forming smectic lyotropic crystals in product or when the product is being applied to the skin at ambient or elevated temperatures.
• the amphiphilic surfactant is capable of forming liquid crystals at a temperature in the range from about 20°C to about 40°C.
• the amphiphilic surfactant is capable of forming smectic lyotropic liquid crystals.
• liquid crystals may not be identifiable on the skin surface or. stratum corneum.
• the amphiphilic surfactant is preferably present at a level of from about 0.1 % to about 20% , preferably from about 0.1 % to about 10% , by weight.
• liquid-crystal forming amphiphilic surfactants suitable for use herein contain both hydrophilic and lipophilic groupings and exhibit a marked tendency to adsorb at a surface or interface, i.e. they are surface-active.
• Amphiphilic surface-active materials for use herein include nonionic (no charge), anionic (negative charge), cationic (positive charge) and amphoteric (both charges) based on whether or not they ionize in aqueous media.
• liquid crystals are also referred to as anisotropic fluids, a fourth state of matter, surfactant association structure or mesophases. Those terms are often used interchangeably.
• the term "lyotropic" means a liquid crystalline system containing a polar solvent, such as water.
• the liquid crystals used herein are preferably lamellar, hexagonal, rod or vesicle structures or mixtures thereof.
• liquid crystalline phase utilized in the compositions of the invention can be identified in various ways.
• a liquid crystal phase flows under shear and is characterised by a viscosity that is significantly different from the viscosity of its isotropic solution phase.
• Rigid gels do not flow under shear like liquid crystals.
• liquid crystals show identifiable birefringence, as, for example, planar lamellar birefringence, whereas when isotropic solutions and rigid gels are viewed under polarized light, both show dark fields.
• Suitable means for identifying liquid crystals include X-ray diffraction, NMR spectroscopy and transmission electron microscopy.
• organic amphiphilic surfactant preferred for use herein can be described as a liquid, semi-solid or waxy water-dispersible material having the formula X-Y where X represents a hydrophilic, especially nonionic moiety and Y represents a lipophilic moiety.
• Organic amphiphilic surfactants suitable for use herein include those having a weight average HLB (Hydrophilic Lipophilic Balance) in the range from about 2 to about 12, preferably from about 4 to about 8.
• HLB Hydrophilic Lipophilic Balance
• Preferred organic amphiphilic surfactants employed herein have a long saturated or unsaturated branched or linear lipophilic chain having from about 12 to about 30 carbon atoms such as oleic, lanolic, tetradecylic, hexadecylic, isostearylic, lauric, coconut, stearic or alkyl phenyl chains.
• the hydrophilic group of the amphiphilic material forming the liquid crystal phase is a nonionic group, a polyoxyethylene, a polyglycerol, a polyol ester, oxyalkylated or not, and, for example, a polyoxyalkylated sorbitol or sugar ester, can be employed.
• the hydrophilic group of the amphiphilic surfactant forming the liquid crystal phase is an ionic group, advantageously there can be used, as the hydrophilic group, a phosphatidylcholine residue as found in lecithin.
• Hydrophilic moieties suitable for use herein are selected from:
• R is selected from aliphatic, linear or branched, saturated or unsaturated chains of 12 to 30 carbon atoms, the hydrocarbon radicals of lanolin alcohols and the 2-hydroxy alkyl residue of long chain, alpha-diols, and Gly represents a glycerol residue;
• Rl (C2 R4 ⁇ ) x OH wherein R* is C12-C30 linear or branched alkyl or alkenyl and x averages from about 0 to about 20, preferably from about 0.1 to about 6, more preferably from about 1 to about 4; (3) polyol esters and polyalkoxylated polyol esters, and mixtures thereof, the polyols preferably being selected from sugars, C2-C6 alkylene glycols, glycerol, polyglycerols, sorbitol, sorbitan, polyethylene glycols and polypropylene glycols and wherein the polyalkoxylated polyol esters contain from about 2 to about 20 preferably from about 2 to about 4 moles of alkylene oxide (especially ethylene oxide) per mole of polyol ester;
• amphiphilic surfactants suitable for use herein include C8-C30 alkyl and acyl-containing amphoteric, anionic, cationic and nonionic surfactants as set out below.
• N-alkyl amino acids e.g., sodium N-alkylaminoacetate
• N-lauroylglutamic acid cholesterol ester e.g., Eldew CL-301 Ajinomoto
• Acylglutamates e.g., disodium N-lauroylglutamate
• Sarcosinates e.g., sodium lauryl sarcosinate. Grace, Seppic;
• Taurates e.g., sodium lauryl taurate. sodium methyl cocoyl taurate
• Carboxylic acids and salts e.g., potassium oleate; potassium laurate; potassium- 10-undecenoate; potassium l l-(p-styryl) - undecanoate);
• Ethoxylated carboxylic salts e.g., sodium carboxy methyl alkyl ethoxylate
• Phosphoric acid esters and salts e.g., lecithin; DEA-oleth-10 phosphate
• Acyl isethionates e.g., sodium 2-lauroyloxy ethane sulfonate
• Alkane sulfonates e.g., branched sodium x-alkane sulfonate (x/1);
• Disodium laureth sulfosuccinate (MacKanate El, Mclntyre Group
• Sulfuric acid esters e.g., sodium 2-ethylhept-6-enyl sulfate; sodium 11- heneicosyl sulfate; sodium 9-heptadecyl sulfate).
• Alkyl sulfates e.g. , ME A alkyl sulfate such as MEA-lauryl sulfate
• Alkyl Imidazolines e.g. , alkyl hydroxyethyl imidazoline, stearyl hydroxyethyl imidazoline (supplier Akzo, Finetex and Hoechst));
• Ethoxylated Amines e.g. , PEG-n alkylamine, PEG-n alkylamino propylamine, Poloxamine, PEG-cocopolyamine, PEG- 15 tallow amine
• Alkylamines e.g., dimethyl alkylamine; dihydroxyethyl alkylamine dioleate
• Alkylbenzyl dimethylammonium salts e.g., stearalkonium chloride
• Alkyl betaines e.g., dodecyl dimethyl ammonio acetate, oleyl betaine
• Heterocylic ammonium salts e.g. , alkylethyl morpholinium ethosulfate
• Tetraalkylammonium salts e.g., dimethyl distearyl quaternary ammonium chloride (Witco)
• Witco dimethyl distearyl quaternary ammonium chloride
• Monoglycerides e.g., monoolein; monolinolein; monolaurin; 1- dodecanoyl-glycerol monolaurin; 1, 13-docosenoyl-glycerol monoerucin diglyceride fatty acid (e.g., diglycerol monoisostearate Cosmol 41, fractionated. Nisshin Oil Mills Ltd.);
• Polyglyceryl esters e.g., triglycerol monooleate (Grindsted TS-T122), diglycerol monooleate (Grindsted TST-T101);
• Polyhydric alcohol esters and ethers e.g., sucrose cocoate, cetostearyl glucoside (Montanol, Seppic), ⁇ octyl glucofuranoside esters, alkyl glucoside such C10-C16 (Henkel));
• Diesters of phosphoric acid e.g., sodium dioleyl phosphate
• Alkylamido propyl betaine e.g. , cocoamido propyl betaine
• Amide e.g. , N-(dodecanoylaminoethyl)-2-pyrrolidone
• Amide oxide e.g. , 1 , 1 Dihydroperfluorooctyldimethylamine oxide
• N-trimethy lammoniododecanamidate Ammonio carboxy lates e.g., dodecy ldimethy lammonioacetate ,
• Ethoxylated alcohols Polyoxyethylene (Cs) e.g., pentaoxyethylene glycol p-n-octylphenyl ether hexaoxyethylene glycol p-n-octylphenyl ether nonaoxyethylene glycol p-n-octylphenyl ether
• Polyoxyethylene (Cio) e.g., pentaoxyethylene glycol p-n-decylphenyl ether, decyl glyceryl ether, 4-oxatetradecan-l , 2-diol, nonaoxyethylene glycol p-n-decylphenyl ether
• Polyoxyethylene ( Cn) e.g.,
• Preferred organic amphiphilic surfactants for use herein are nonionic amphiphilic surfactants having a hydrophilic moiety selected from polyol esters and polyalkoxylated polyol esters, and mixtures thereof, the polyols preferably being selected from sugars, C2-C6 alkylene glycols, glycerol, polyglycerols, sorbitol, sorbitan, polyethylene glycols and polypropylene glycols and wherein the polyalkoxylated polyol esters contain from about 2 to about 20 preferably from about 2 to about 4 moles of alkylene oxide (especially ethylene oxide) per mole of polyol ester, and a lipophilic moiety selected from long saturated or unsaturated branched chain or linear lipophilic chains having from about 12 to about 30 carbon atoms such as oleic, lanolic, tetradecylic, hexadecylic, isostearylic, lauric, coconut, stearic
• Highly preferred organic amphiphilic surfactants for use herein are selected from polyhydric alcohol esters and ethers.
• Especially preferred amphiphilic surfactants for use herein are sugar esters and polyalkoxylated sugar esters.
• the sugar esters for use in this invention can be classified as hydrocarbyl and alkyl polyoxyalkylene esters of cyclic polyhydroxy saccharides wherein one or more of the hydroxyl groups on the saccharide moiety is substituted with an acyl or polyoxyalkylene group.
• Hydrocarbyl sugar esters can be prepared in well-known fashion by heating an acid or acid halide with sugar, i.e. , by a simple esterification reaction.
• the sugars employed in the preparation of the sugar esters include monosaccharides, di-saccharides and oligo-saccharides well known in the art, for example, the dextrorotatory and levorotatory forms of glucose, fructose, mannose, galactose, arabinose and xylose.
• Typical di-saccharides include maltose, cellibiose, lactose, and trehalose.
• Typical tri-saccharides include raffinose and gentianose. The di-saccharides are preferred for use herein, especially sucrose.
• Sucrose can be esterified at one or more of its eight hydroxyl groups to provide the sucrose esters useful herein.
• sucrose When sucrose is combined with an esterification agent in a 1 : 1 mole ratio, sucrose monoesters are formed; when the ratio of esterification agent to sucrose is 2: 1, or greater, the di-, tri-, etc. , esters are formed, up to a maximum of the octa-ester.
• Preferred sugar esters herein are those prepared by the esterification of sugars at a mole ratio of esterification agent: sugar of 1 : 1 and 3: 1 i.e., the mono-acyl and di- or higher acyl sugar esters.
• the respective esters of di-saccharide sugars, especially sucrose, wherein the acyl groups contain from about 8 to about 20 carbon atoms are especially preferred.
• Preferred sugar esters herein are sucrose cocoate, sucrose monooctanoate, sucrose monodecanoate, sucrose monolaurate, sucrose monomyristate, sucrose monopalmitate, sucrose monostearate, sucrose monooleate, sucrose monolinoleate, sucrose dioleate, sucrose dipalmitate, sucrose distearate, sucrose dilaurate and sucrose dilinoleate, and mixtures thereof.
• Sucrose cocoate has been found to be particularly efficacious in the compositions herein.
• the mono- and di- acyl esters preferably comprise at least about 40% , more preferably from about 50% to about 95 % by weight of the total sugar ester mixture.
• Other sugar esters suitable for use in the compositions of this invention are the alkyl polyoxyalkylene sugar esters wherein one hydroxyl group is substituted with a Cg-Cig alkyl group and wherein one or more of the hydroxyl groups on the sugar molecule are replaced by an ester or ether substituent containing the moiety [(CH2) x -0]y wherein x is an integer from
• sugar esters wherein the polyoxyalkylene substituent is a polyoxyethylene substituent containing from about 8 to about 30 polyoxyethylene groups.
• Such materials wherein sorbitan is the sugar moiety are commercially available under the tradename "Tweens" .
• Such mixed esters can be prepared by first acylating a sugar at a 1 : 1 mole ratio with a hydrocarbyl acid halide followed by reaction with the corresponding polyoxyalkylene acid halide or alkylene oxide to provide the desired material.
• the simple polyoxyalkylene ester of di-saccharides, especially sucrose, wherein the polyoxyalkylene groups contain up to about 20 alkylene oxide moieties are another useful class of sugar esters herein.
• a preferred sugar ester of this class is sorbitol trioleate ethoxylated with 20 moles of ethylene oxide.
• Mixtures of sugar esters with other polyol esters, eg. glycerol esters, are also suitable for use herein, for example, Palm Oil Sucroglyceride (Rhone-Poulenc).
• lecithin refers to a material which is a phosphatide.
• Naturally occurring or synthetic phosphatides can be used.
• Phosphatidylcholine or lecithin is a glycerine esterified with a choline ester of phosphoric acid and two fatty acids, usually a long chain saturated or unsaturated fatty acid having 16-20 carbons and up to 4 double bonds.
• Other phosphatides capable of forming lamellar or hexagonal liquid crystals can be used in place of the lecithin or in combination with it.
• phosphatides are glycerol esters with two fatty acids as in the lecithin, but the choline is replaced by ethanolamine (a cephalin), or serine ( -aminopropanoic acid; phosphatidyl serine) or an inositol (phosphatidyl inositol). While the invention herein is exemplified with lecithin, it is understood that these other phosphatides can be used herein. A variety of lecithins can be used. American Lecithin Company supplies a Nattermann Phospholipid, Phospholipan 80 and Phosal 75.
• lecithins which can be used alone or in combination with these are: Actifla Series, Centrocap series, Central Ca, Centrol series, Centrolene, Centrolex, Centromix, Centrophase and Centrolphil Series from Central Soya; Alcolec and Alcolec 439-C from American Lecithin; Canaspersa from Canada Packers, Lexin K and Natipide from American Lecithin; and L-Clearate, Clearate LV and Clearate WD from the W.A. Cleary Co.
• Lecithins are supplied dissolved in ethanol, fatty acids, triglycerides and other solvents. They are usually mixtures of lecithins and range from 15 % to 50% of the solution as supplied.
• Natural lecithins are derived from oilseeds such as sunflower seeds, soybeans, safflower seeds and cottonseed. The lecithins are separated from the oil during the refining process.
• the organic amphiphilic surfactant has been found to be especially valuable herein for improving the stability and skin feel of the compositions of the invention.
• amphiphilic surfactant is preferably incorporated into the composition in an amount of from about 0.1 % to about 20% , preferably from about 0.1% to about 10%, and more preferably from about 0.1% to about 8% by weight of composition.
• a fatty acid ester blend based on a mixture of sorbitan or sorbitol fatty acid ester and sucrose fatty acid ester, the fatty acid in each instance being preferably C8-C24, more preferably Cio-C20-
• the preferred fatty acid ester emulsifier from the viewpoint of moisturisation is a blend of sorbitan or sorbitol C16-C20 f attv acid ester with sucrose C10-C16 fatty acid ester, especially sorbitan stearate and sucrose cocoate. This is commercially available from ICI under the trade name Arlatone 2121.
• a highly preferred ingredient of the compositions herein is urea which is preferably present in a level of from about 0.1% to about 20%, more preferably from about 0.5% to about 10% and especially from about 1% to about 5% by weight of composition.
• the oil phase and organic amphiphilic surfactant when present are premixed in water at a temperature above the Kraft Point of the organic amphiphilic surfactant (but preferably below about 60°C) to form a liquid crystal/oil in water dispersion prior to addition of the urea.
• the urea is found to be especially effective herein in combination with the amphiphilic emulsifier surfactant and the polyol fatty acid polyester for providing outstanding skin moisturisation and softening in the context of an oil-in-water skin care emulsion composition. Moreover, it is surprisingly found that the urea is rendered more stable to hydrolytic degradation, thereby allowing an increase in compositional pH.
• non-occlusive moisturizers such as non-occlusive moisturizers, humectants, gelling agents, neutralizing agents, perfumes, colouring agents and surfactants, can be added to the skin compositions herein.
• compositions herein can comprise a humectant.
• Suitable humectants for use herein include sorbitol, propylene glycol, butylene glycol, hexylene glycol, ethoxylated glucose derivatives, hexanetriol, glycerine, glycine, hyaluronic acid, arginine, Ajidew (NaPCA), water-soluble polyglycerylmethacrylate lubricants and panthenols.
• a preferred humectant herein is glycerine (sometimes known as glycerol or glycerin). Chemically, glycerine is 1,2,3-propanetriol and is a product of commerce.
• Glycerine is especially preferred in the compositions of the invention from the viewpoint of boosting moisturisation. Also preferred for use herein is butylene glycol. Particularly preferred from the viewpoint of boosting moisturisation is a combination of glycerine and urea.
• the humectant is preferably present at a level of from about 0.1% to about 20%, more preferably from about 1% to about 15%, and especially from about 5% to about 15% by weight of composition.
• Suitable polyglycerylmethacrylate lubricants for use in the compositions of this invention are available under the trademark Lubrajel (RTM) from Guardian Chemical Corporation, 230 Marcus Boulevard., Hauppage, N.Y. 1 1787.
• Lubrajels can be described as hydrates or clathrates which are formed by the reaction of sodium glycerate with a methacrylic acid polymer.
• Lubrajels are marketed in a number of grades of varying glycerate: polymer ratio and viscosity. Suitable Lubrajels include Lubrajel TW, Lubrajel CG and Lubrajel MS, Lubrajel WA, Lubrajel DV and so-called Lubrajel Oil.
• At least part (up to about 5% by weight of composition) of the humectant can be incorporated in the form of an admixture with a particulate lipophilic or hydrophobic carrier material.
• the carrier material and humectant can be added either to the aqueous or disperse phase.
• the crosslinked hydrophobic polymer is preferably in the form of a copolymer lattice with at least one active ingredient dispersed uniformly throughout and entrapped within the copolymer lattice.
• the hydrophobic polymer can take the form of a porous particle having a surface area (N2,BET) in the range from about 50 to 500, preferably 100 to 300m 2 .g- 1 and having the active ingredient absorbed therein.
• the cross-linked hydrophobic polymer is preferably present in an amount of from about 0.1% to about 10% by weight and is preferably incorporated in the external aqueous phase.
• the active ingredient can be one or more or a mixture of skin compatible oils, skin compatible humectants, emollients, moisturizing agents and sunscreens.
• the polymer material is in the form of a powder, the powder being a combined system of particles.
• the system of powder particles forms a lattice which includes unit particles of less than about one micron in average diameter, agglomerates of fused unit particles of sized in the range of about 20 to 100 microns in average diameter and aggregates of clusters of fused agglomerates of sizes in the range of about 200 to 1,200 microns in average diameter.
• the powder material of this embodiment can be broadly described as a cross-linked "post absorbed" hydrophobic polymer lattice.
• the powder preferably has entrapped and dispersed therein, an active which may be in the form of a solid, liquid or gas.
• the lattice is in particulate form and constitutes free flowing discrete solid particles when loaded with the active material.
• the lattice may contain a predetermined quantity of the active material.
• a suitable polymer has the structural formula:
• the hydrophobic polymer is a highly crosslinked polymer, more particularly a highly cross-linked polymethacrylate copolymer.
• the material is manufactured by the Dow Corning Corporation, Midland. Michigan, USA, and sold under the trademark POLYTRAP (RTM). It is an ultralight free- flowing white powder and the particles are capable of absorbing high levels of lipophilic liquids and some hydrophilic liquids while at the same time maintaining a free-flowing powder character.
• the powder structure consists of a lattice of unit particles less than one micron that are fused into agglomerates of 20 to 100 microns and the agglomerates are loosely clustered into macro-particles or aggregates of about 200 to about 1200 micron size.
• the polymer powder is capable of containing as much as four times its weight of fluids, emulsions, dispersion or melted solids.
• Adsorption of actives onto the polymer powder can be accomplished using a stainless steel mixing bowl and a spoon, wherein the active is added to the powder and the spoon is used to gently fold the active into the polymer powder.
• Low viscosity fluids may be adsorbed by addition of the fluids to a sealable vessel containing the polymer and then tumbling the materials until a consistency is achieved. More elaborate blending equipment such as ribbon or twin cone blenders can also be employed.
• the preferred active ingredient for use herein is glycerine.
• the weight ratio of humectant : carrier is from about 1 :4 to about 3:1.
• Microsponges 5647 is also suitable as a highly cross-linked polymethacrylate copolymer. This takes the form of generally spherical particles of cross-linked hydrophobic polymer having a pore size of from about 0.01 to about 0.05 ⁇ m and a surface area of 200-300m 2 /g. Again, it is preferably loaded with humectant in the levels described above.
• compositions of the invention can also contain a hydrophilic gelling agent at a level preferably from about 0.01% to about 10%, more preferably from about 0.02% to about 2%, and especially from about 0.02% to about 0.5%.
• the gelling agent preferably has a viscosity (1% aqueous solution,
• Suitable hydrophilic gelling agents can generally be described as water- soluble or colloidally water-soluble polymers, and include cellulose ethers (e.g. hydroxyethyl cellulose, methyl cellulose, hydroxypropylmethyl cellulose), polyvinylpyrrolidone, polyvinylalcohol, guar gum, hydroxypropyl guar gum and xanthan gum.
• cellulose ethers e.g. hydroxyethyl cellulose, methyl cellulose, hydroxypropylmethyl cellulose
• polyvinylpyrrolidone polyvinylalcohol
• guar gum hydroxypropyl guar gum
• xanthan gum xanthan gum
• Preferred hydrophilic gelling agents herein are acrylic acid/ethyl acrylate copolymers and the carboxyvinyl polymers sold by the B.F. Goodrich Company under the trade mark of Carbopol resins. These resins consist essentially of a colloidally water-soluble polyalkenyl polyether crosslinked polymer of acrylic acid crosslinked with from 0.75% to 2.00% of a crosslinking agent such as for example polyallyl sucrose or polyallyl pentaerythritol. Examples include Carbopol 934, Carbopol 940, Carbopol 950, Carbopol 954, Carbopol 980, Carbopol 951 and Carbopol 981.
• Carbopol 934 is a water-soluble polymer of acrylic acid crosslinked with about 1% of a polyallyl ether of sucrose having an average of about 5.8 allyl groups for each sucrose molecule.
• a most preferred polymer is Carbopol 954.
• CFA Designation Acrylates/ 10-30 Alkyl Acrylate Crosspolymer
• a combination of the polyalkenyl polyether cross-linked acrylic acid polymer and the hydrophobically modified cross-linked acrylic acid polymer is also suitable and is preferred for use herein.
• the gelling agents herein are particularly valuable for providing excellent stability characteristics over both normal and elevated temperatures.
• Neutralizing agents suitable for use in neutralizing acidic group containing hydrophilic gelling agents herein include sodium hydroxide, potassium hydroxide, ammonium hydroxide, monoethanolamine, diethanolamine and triethanolamine.
• compositions of the invention are in emulsion form and are preferably formulated so as to have a product viscosity of at least about 4,000 mPa.s and preferably in the range from about 4,000 to about 300,000 mPa.s, more preferably from about 8,000 to about 200,000 mPa.s and especially from about 10,000 to about 100,000 mPa.s and even more especially from about
• compositions of the invention can also contain from about 0.1% to about 10%, preferably from about 1% to about 5% of a panthenol moisturizer.
• the panthenol moisturizer can be selected from D-panthenol ([R]-2,4-dihydroxy-N-[3-hydroxypropyl)]-3,3-dimethylbutamide), DL- panthenol, calcium pantothenate, royal jelly, panthetine, pantotheine, panthenyl ethyl ether, pangamic acid, pyridoxin, pantoyl lactose and Vitamin B complex.
• Highly preferred from the viewpoint of skin care and tack reduction is D-panthenol.
• compositions of the present invention can additionally comprise from about 0.001% to about 0.5%, preferably from about 0.002% to about 0.05%, more preferably from about 0.005% to about 0.02% by weight of carboxymethylchitin.
• Chitin is a polysaccharide which is present in the integument of lobsters and crabs and is a mucopolysaccharide having beta (1-4) linkages of N-acetyl-D-glucosamine.
• Carboxymethylchitin is prepared by treating the purified chitin material with alkali followed by monochloracetic acid. It is sold commercially in the form of a dilute (approximately 0.1% to 0.5% by weight) aqueous solution under the name Chitin Liquid available from A & E Connock Ltd., Fordingbridge, Hampshire, England.
• keratolytic agents/desquamation agents such as salicylic acid; proteins and polypeptides and derivatives thereof; water-soluble or solubilizable preservatives preferably at a level of from about 0.1% to about 5%, such as Germall 115, methyl, ethyl, propyl and butyl esters of hydroxybenzoic acid, benzyl alcohol, EDTA, Euxyl (RTM) K400, Bromopol (2-bromo-2-nitropropane-l,3-diol) and phenoxypropanol; anti-bacterials such as Irgasan (RTM) and phenoxyethanol (preferably at levels of from 0.1% to about 5%); soluble or colloidally-soluble moisturising agents such as hylaronic acid and starch-grafted sodium polyacrylates such as Sanwet (RTM) IM-1000, IM-1500 and IM-2500 available from Celanese Superabsorbent Materials, Portsmith, VA,
• sunscreening agents examples include glyceryl monohydroxy stearate and stearyl alcohol ethoxylated with an average of from 10 to 200 moles of ethyleneoxide per mole of alcohol and PEG-6 caprylic/capric glycerides.
• sunscreening agents A wide variety of sunscreening agents are described in U.S. Patent No. 5,087,445, to Haffey et al., issued February 1 1, 1992; U.S. Patent No. 5,073,372, to Turner et al., issued December 17, 1991 ; U.S. Patent No. 5,073,371, to Turner et al. issued December 17, 1991 ; and Segarin, et al., at Chapter VIII, pages 189 et seq., of Cosmetics Science and Technology.
• sunscreens which are useful in the compositions of the instant invention are those selected from 2-ethylhexyl p-methoxycinnamate, 2-ethylhexyl N,N- dimethyl-p-aminobenzoate, p-aminobenzoic acid, 2-phenylbenzimidazole-5- sulfonic acid, octocrylene, oxybenzone, homomenthyl salicylate, octyl salicylate, 4,4'-methoxy-t-butyldibenzoylmethane, 4-isopropyl dibenzoylmethane, 3-benzylidene camphor, 3-(4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, Parsol MCX, Eusolex 6300, Octocrylene, Parsol 1789, and mixtures thereof.
• sunscreening agents disclosed therein have, in a single molecule, two distinct chromophore moieties which exhibit different ultra-violet radiation absorption spectra.
• One of the chromophore moieties absorbs predominantly in the UVB radiation range and the other absorbs strongly in the UVA radiation range.
• sunscreens include those selected from 4-N,N-(2-ethylhexyl)methyl- aminobenzoic acid ester of 2,4-dihydroxybenzophenone, 4-N,N-(2- ethylhexyl)methylaminobenzoic acid ester with 4- hydroxydibenzoylmethane, 4-N,N- (2-ethylhexyl)methylaminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, 4-N,N-(2- ethylhexyl)-methylaminobenzoic acid ester of 4-(2-hydroxyeth- oxy)dibenzoylmethane, and mixtures thereof.
• the sunscreens can comprise from about 0.5% to about 20% of the compositions useful herein. Exact amounts will vary depending upon the sunscreen chosen and the desired Sun Protection Factor (SPF). SPF is a commonly used measure of photoprotection of a sunscreen against erythema. See Federal Register. Vol. 43, No. 166, pp. 38206-38269, August 25, 1978.
• compositions of the present invention can additionally comprise from about 0.1% to about 5% by weight of aluminium starch octenylsuccinate.
• Aluminium starch octenylsuccinate is the aluminium salt of the reaction product of octenylsuccinic anhydride with starch and is commercially available under the trade name from Dry Flo National Starch & Chemical Ltd. Dry Flo is useful herein from the viewpoint of skin feel and application characteristics.
• pigments which, where water- insoluble, contribute to and are included in the total level of oil phase ingredients.
• Pigments suitable for use in the compositions of the present invention can be organic and/or inorganic. Also included within the term pigment are materials having a low colour or lustre such as matte finishing agents, and also light scattering agents. Examples of suitable pigments are iron oxides, acyglutamate iron oxides, ultramarine blue, D&C dyes, carmine, and mixtures thereof. Depending upon the type of composition, a mixture of pigments will normally be used.
• the preferred pigments for use herein from the viewpoint of moisturisation, skin feel, skin appearance and emulsion compatibility are treated pigments.
• the pigments can be treated with compounds such as amino acids, silicones, lecithin and ester oils.
• the pH of the compositions is preferably from about 4 to about 9, more preferably from about 6 to about 8.0.
• the balance of the composition is water or an aqueous carrier suitable for topical application to the skin.
• the water content of the compositions herein is generally from about 30% to about 98.89%, preferably from about 50% to about 95%> and especially from about 60% to about 90% by weight.
• compositions of the invention are preferably in the form of a moisturising cream or lotion, which can be applied to the skin as a leave-on product.
• the invention is illustrated by the following examples
• Oil in water emulsions are prepared from the following ingredients using conventional formulating techniques.
• Arlatone 212l ' 1.0 1.0 1.0 1.0
• Arlatone 2121 0.0 0.50 1.50 0.60 0.50 Carbopol 1382 5 0.05 0.20 0.08 0.12 0.05
• compositions as set out in examples I to IX are made as follows:
• a first premix of thickening agents, methyl paraben, glycerine/Ti02 premix, Arlatone 2121 when present, and other water soluble ingredients apart from urea is prepared by admixing in water and heating to about 80°C.
• a second premix of the oil phase ingredients including the emulsifiers, oil-soluble preservatives, other than silicone gum is prepared by mixing and heating and is added to the aqueous premix.
• the silicone gum is added to the resulting mixture which is then cooled to about 60°C.
• the NaOH solution, EDTA, silicone gum, and then urea solution (lg dissolved in 1ml of water) are then added to the resulting oil-in- water emulsion and the mixture is cooled before adding minor ingredients.
• the composition is ready for packaging.
• compositions as set out in examples X and XI are made as follows:
• a first premix of thickening agents (except Sepigel when present), methyl paraben, glycerine/Ti02 premix, Arlatone 2121 when present, and other water soluble ingredients apart from urea, is prepared by admixing in water and heating to about 80°C.
• a second premix of the oil phase ingredients including the emulsifiers, oil-soluble preservatives, other than silicone gum and cyclomethicone is prepared by mixing and heating and is added to the aqueous premix and the mixture homogenised.
• the silicone gum is added to the resulting mixture which is then cooled to about 60°C.
• Sepigel and cyclomethicone are added between 60° and 55°C to the resulting oil-in- water emulsion.
• EDTA and urea solution (lg dissolved in 1ml of water) are added and the mixture is neutralised with NaOH when necessary.
• the mixture is further cooled under stirring before adding minor ingredients.
• the composition is ready for packaging.
• compositions display improved skin feel, skin smoothness, skin softness and skin care characteristics together with reduced greasiness and ' excellent rub-in and fast absorption characteristics.

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• 1998
  • 1998-01-30 WO PCT/US1998/001746 patent/WO1999038485A1/en not_active Application Discontinuation
  • 1998-01-30 AU AU62562/98A patent/AU6256298A/en not_active Withdrawn
  • 1998-10-13 KR KR1020007008360A patent/KR20010024893A/ko not_active Application Discontinuation
  • 1998-10-13 CN CN98813893A patent/CN1286627A/zh active Pending
  • 1998-10-13 EP EP98952257A patent/EP1051149A1/en not_active Withdrawn
  • 1998-10-13 AU AU98002/98A patent/AU9800298A/en not_active Abandoned
  • 1998-10-13 CA CA002319161A patent/CA2319161A1/en not_active Abandoned
  • 1998-10-13 JP JP2000529221A patent/JP2003517996A/ja active Pending
  • 1998-10-13 WO PCT/US1998/021521 patent/WO1999038486A1/en not_active Application Discontinuation
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