WO1999034652A1 - Milieu d'irrigation pour canaux radiculaires - Google Patents

Milieu d'irrigation pour canaux radiculaires Download PDF

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Publication number
WO1999034652A1
WO1999034652A1 PCT/US1998/027380 US9827380W WO9934652A1 WO 1999034652 A1 WO1999034652 A1 WO 1999034652A1 US 9827380 W US9827380 W US 9827380W WO 9934652 A1 WO9934652 A1 WO 9934652A1
Authority
WO
WIPO (PCT)
Prior art keywords
solution
aqueous
anion
electro
cation
Prior art date
Application number
PCT/US1998/027380
Other languages
English (en)
Inventor
Jacobus Theodorus Marais
Original Assignee
Radical Waters Ip (Pty) Ltd.
Davis, Joanne, T.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radical Waters Ip (Pty) Ltd., Davis, Joanne, T. filed Critical Radical Waters Ip (Pty) Ltd.
Priority to US09/582,700 priority Critical patent/US7014465B1/en
Priority to AU20918/99A priority patent/AU2091899A/en
Priority to JP2000527130A priority patent/JP2002500055A/ja
Priority to EP98965457A priority patent/EP1042943A4/fr
Publication of WO1999034652A1 publication Critical patent/WO1999034652A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C5/00—Filling or capping teeth
    • A61C5/40—Implements for surgical treatment of the roots or nerves of the teeth; Nerve needles; Methods or instruments for medication of the roots
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/52—Cleaning; Disinfecting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Definitions

  • This invention relates to the use of antiseptics in root canal treatment so as
  • Sodium hypochlorite is universally used as an antiseptic for root canal
  • sodium hypochlorite is that it is highly toxic to human tissues and cells in
  • aqueous solution characterised in that
  • aqueous anion-containing solution may consist of an aqueous anion-containing and/or an aqueous cation-containing solution.
  • aqueous cation-containing solution may be prepared by means of
  • the salt may be sodium
  • chloride In particular, it may be non-iodated sodium chloride or potassium
  • the anion-containing and the associated cation-containing solution may be
  • the anion-containing solution is referred to hereinafter for brevity as the
  • anolyte solution and the cation-containing solution is referred to
  • the catholyte solution are preferably provided from an electro-chemical
  • reactor comprising a through-flow, electro-chemical cell having two co-axial
  • the anolyte solution may be produced from a 10% aqueous NaCI solution,
  • the anolyte solution may include activated radical species such as CIO;
  • the activated radical species have been found to have a synergistic anti ⁇
  • viral organisms including Gram positive and
  • Gram negative bacteria such as Enterococcus faecalis and Pseudomonas
  • the catholyte solution generally may have a pH of up to about 7-13 and a
  • the catholyte solution may include
  • activated radical species such as NaOH; KOH; Ca(OH) 2 ; Mg (OH) 2 ; HO ' ;
  • anolyte solution act synergistically as a biocidal and virucidal
  • catholyte solution in the preparation of an irrigating medium for use in the
  • ORP ORP
  • the exposure time i.e. the contact time between the root canal
  • Anolyte has been found to be more effective at lower than at
  • the irrigating medium comprising an
  • aqueous solution being substantially as hereinbefore defined.
  • irrigating root canals including the step of applying an clectro-chemically
  • the method of irrigating root canals may include the steps of first applying
  • catholyte solution to the root canal aimed at removing organic biofilm
  • Group A sodium hypochlorite
  • the root canals of Group A were prepared, using a series of K-
  • STEDS produced included two separate solutions, namely
  • the catholyte and anolyte solutions had a pH
  • the catholyte solution had a pH of about 9,5 and a redox potential
  • Root canals in Group B were prepared using the same
  • the specimens were placed into a dust-free incubator and allowed to air-dry for 10 days.
  • the air-dried specimens were mounted with conductive
  • metal spreader over the surface of the plates. After overnight
  • tuberculin syringe 30 ⁇ i saline was then aspirated from the root canals, serially diluted and spread plated onto 10% blood
  • hypoclorite for 5 and 10 minutes respectively. After 5 minutes
  • the broth was shown to contain 4.4 x 10 10 cfus after 7 days'
  • catholyte is known to act in a similar way to a detergent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dentistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)

Abstract

Cette invention concerne des antiseptiques que l'on utilise dans le traitement de canaux radiculaires. Ces antiseptiques permettent de freiner la prolifération de bactéries et d'autres micro-organismes restant dans un canal radiculaire après obturation de celui-ci.
PCT/US1998/027380 1997-12-30 1998-12-24 Milieu d'irrigation pour canaux radiculaires WO1999034652A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US09/582,700 US7014465B1 (en) 1997-12-30 1998-12-24 Irrigating medium for root canals and method
AU20918/99A AU2091899A (en) 1997-12-30 1998-12-24 An irrigating medium for root canals
JP2000527130A JP2002500055A (ja) 1997-12-30 1998-12-24 根管用潅注媒体
EP98965457A EP1042943A4 (fr) 1997-12-30 1998-12-24 Milieu d'irrigation pour canaux radiculaires

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA97/11702 1997-12-30
ZA9711702 1997-12-30

Publications (1)

Publication Number Publication Date
WO1999034652A1 true WO1999034652A1 (fr) 1999-07-08

Family

ID=25586798

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/027380 WO1999034652A1 (fr) 1997-12-30 1998-12-24 Milieu d'irrigation pour canaux radiculaires

Country Status (4)

Country Link
EP (1) EP1042943A4 (fr)
JP (1) JP2002500055A (fr)
AU (1) AU2091899A (fr)
WO (1) WO1999034652A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426066B1 (en) 2000-01-12 2002-07-30 California Pacific Labs, Inc. Use of physiologically balanced, ionized, acidic solution in wound healing
WO2003049750A1 (fr) * 2001-12-10 2003-06-19 Radical Waters (Ip) (Pty) Limited Traitement des pathologies infectieuses des muqueuses et des tissus cutaneo-muqueux
WO2003088930A1 (fr) * 2000-12-15 2003-10-30 Radical Waters Ip (Pty) Ltd Fluide de refroidissement et d'irrigation utilise dans la chirurgie dentaire
US7393522B2 (en) 2000-01-12 2008-07-01 Novabay Pharmaceuticals, Inc. Physiologically balanced, ionized, acidic solution and methodology for use in wound healing
US8632823B2 (en) 1999-08-23 2014-01-21 Puricore, Inc. Treatment of infected tissues with hypochlorous acid
US8871278B2 (en) 2011-03-18 2014-10-28 Puricore, Inc. Stabilized hypohalous acid solutions
US9381214B2 (en) 2011-03-18 2016-07-05 Puricore, Inc. Methods for treating skin irritation
CN109475396A (zh) * 2016-07-22 2019-03-15 皇家飞利浦有限公司 口腔护理抗菌剂的给药
US11452778B2 (en) 2011-03-18 2022-09-27 Urgo Us, Inc. Stabilized hypohalous acid solutions

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2376016A1 (fr) * 2008-11-05 2011-10-19 Medicn.r.g. Ltd. Dispositif et procédé de traitement d'une cavité dentaire

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002271A1 (fr) * 1994-07-15 1996-02-01 Medical Discoveries, Inc. Solutions salines hydrolysees de façon electrique en tant que microbicides in vivo destines au traitement de la cardiomyopathie et de la sclerose en plaque

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3616355A (en) * 1968-08-05 1971-10-26 Kdi Chloro Guard Corp Method of generating enhanced biocidal activity in the electroylsis of chlorine containing solutions and the resulting solutions
FR2131816A1 (en) * 1971-03-29 1972-11-17 Caillot Jean Perchloric acid and salts - for clearing and disinfecting dental canals
DE3637887A1 (de) * 1986-11-06 1988-05-19 Wolf Schillinger Vorrichtung zum transport dissoziierender medikamente
US5507932A (en) * 1994-08-26 1996-04-16 Schlumberger Technology Corporation Apparatus for electrolyzing fluids
ITGE950132A1 (it) * 1995-11-29 1997-05-29 Marco Rotondi Composto ad uso odontostomatologico per la detersione e disinfezione dei canali radicolari e della dentina vitale.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002271A1 (fr) * 1994-07-15 1996-02-01 Medical Discoveries, Inc. Solutions salines hydrolysees de façon electrique en tant que microbicides in vivo destines au traitement de la cardiomyopathie et de la sclerose en plaque

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE STN WPIDS 1 January 1900 (1900-01-01), XP002920653, Database accession no. 96-105648 *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8632823B2 (en) 1999-08-23 2014-01-21 Puricore, Inc. Treatment of infected tissues with hypochlorous acid
US6426066B1 (en) 2000-01-12 2002-07-30 California Pacific Labs, Inc. Use of physiologically balanced, ionized, acidic solution in wound healing
US7393522B2 (en) 2000-01-12 2008-07-01 Novabay Pharmaceuticals, Inc. Physiologically balanced, ionized, acidic solution and methodology for use in wound healing
WO2003088930A1 (fr) * 2000-12-15 2003-10-30 Radical Waters Ip (Pty) Ltd Fluide de refroidissement et d'irrigation utilise dans la chirurgie dentaire
WO2003049750A1 (fr) * 2001-12-10 2003-06-19 Radical Waters (Ip) (Pty) Limited Traitement des pathologies infectieuses des muqueuses et des tissus cutaneo-muqueux
US9414584B2 (en) 2011-03-18 2016-08-16 Puricore, Inc. Stabilized hypohalous acid solutions
US9381214B2 (en) 2011-03-18 2016-07-05 Puricore, Inc. Methods for treating skin irritation
US9392787B2 (en) 2011-03-18 2016-07-19 Puricore, Inc. Stabilized hypohalous acid solutions
US8871278B2 (en) 2011-03-18 2014-10-28 Puricore, Inc. Stabilized hypohalous acid solutions
US9925217B2 (en) 2011-03-18 2018-03-27 Realm Therapeutics, Inc. Methods for treating inflammation associated with allergic reaction
US10034942B2 (en) 2011-03-18 2018-07-31 Realm Therapeutics, Inc. Stabilized hypohalous acid solutions
US10576152B2 (en) 2011-03-18 2020-03-03 Urgo Us, Inc. Stabilized hypohalous acid solutions
US10702549B2 (en) 2011-03-18 2020-07-07 Urgo Us, Inc. Methods for treating skin irritation
US11452778B2 (en) 2011-03-18 2022-09-27 Urgo Us, Inc. Stabilized hypohalous acid solutions
CN109475396A (zh) * 2016-07-22 2019-03-15 皇家飞利浦有限公司 口腔护理抗菌剂的给药
CN109475396B (zh) * 2016-07-22 2021-07-16 皇家飞利浦有限公司 口腔护理抗菌剂的给药

Also Published As

Publication number Publication date
EP1042943A1 (fr) 2000-10-11
EP1042943A4 (fr) 2002-05-02
JP2002500055A (ja) 2002-01-08
AU2091899A (en) 1999-07-19

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